Published in Mol Ther on September 27, 2006
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Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation. Hum Gene Ther (2001) 0.94
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Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Mol Ther (2011) 2.04
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Structurally mapping the diverse phenotype of adeno-associated virus serotype 4. J Virol (2006) 1.97
Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression. Virology (2008) 1.96
Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer. Mol Ther (2011) 1.86
A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection. Proc Natl Acad Sci U S A (2009) 1.85
Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults. Hum Gene Ther (2006) 1.83
Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism. Biochemistry (2007) 1.83
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina. Mol Ther (2010) 1.77
A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis. Mol Ther (2007) 1.75
Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II. Biochemistry (2007) 1.72
Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry. J Virol (2006) 1.64
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The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice. J Clin Invest (2011) 1.58
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Structure of adeno-associated virus serotype 5. J Virol (2004) 1.50
Combinations of two capsid regions controlling canine host range determine canine transferrin receptor binding by canine and feline parvoviruses. J Virol (2003) 1.48
Structure of adeno-associated virus type 4. J Virol (2005) 1.47
Heparin binding induces conformational changes in Adeno-associated virus serotype 2. J Struct Biol (2008) 1.44
Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle. J Virol (2008) 1.44
Structural characterization of the dual glycan binding adeno-associated virus serotype 6. J Virol (2010) 1.42
Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice. J Virol (2005) 1.41
The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer. Acta Crystallogr D Biol Crystallogr (2002) 1.39
A short, strong hydrogen bond in the active site of human carbonic anhydrase II. Biochemistry (2010) 1.33
Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors. PLoS One (2013) 1.33
Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system. Mol Ther (2005) 1.30
The role of the adeno-associated virus capsid in gene transfer. Methods Mol Biol (2008) 1.29
Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins. J Immunol (2009) 1.28
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease. Biochemistry (2004) 1.28
Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3. Hum Gene Ther (2010) 1.26
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Gene therapy for aromatic L-amino acid decarboxylase deficiency. Sci Transl Med (2012) 1.22
p37 Induces tumor invasiveness. Mol Cancer Ther (2005) 1.21
Structural insight into the unique properties of adeno-associated virus serotype 9. J Virol (2012) 1.18
Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium. Mol Ther (2009) 1.18
Identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation. J Biol Chem (2006) 1.17
Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37. Acta Crystallogr D Biol Crystallogr (2008) 1.17
Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 1.17
Little vector, big gene transduction: fragmented genome reassembly of adeno-associated virus. Mol Ther (2010) 1.16
Comparative analysis of adeno-associated virus capsid stability and dynamics. J Virol (2013) 1.16
Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution. J Biol Chem (2002) 1.15
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Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants. J Virol (2003) 1.10
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Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking. J Virol (2011) 1.04
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Surface loop dynamics in adeno-associated virus capsid assembly. J Virol (2008) 1.04
Assembly and structural analysis of a covalently closed nano-scale DNA cage. Nucleic Acids Res (2007) 1.04
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Identification of the galactose binding domain of the adeno-associated virus serotype 9 capsid. J Virol (2012) 1.03
Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis. J Bacteriol (2009) 1.02
Capsid antibodies to different adeno-associated virus serotypes bind common regions. J Virol (2013) 1.01
Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking. J Virol (2013) 1.01
International efforts for recombinant adeno-associated viral vector reference standards. Mol Ther (2008) 1.00
Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. J Biol Chem (2003) 1.00
Integration frequency and intermolecular recombination of rAAV vectors in non-human primate skeletal muscle and liver. Mol Ther (2012) 0.98
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Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4. Virology (2003) 0.98
Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network. Biochemistry (2009) 0.98
Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes. Acta Crystallogr D Biol Crystallogr (2010) 0.97
Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency. J Biol Chem (2013) 0.96
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.96
Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.96
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.95
Structure of a monoclinic polymorph of human carbonic anhydrase II with a doubled a axis. Acta Crystallogr D Biol Crystallogr (2010) 0.95
High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.94
BAAV transcytosis requires an interaction with beta-1-4 linked- glucosamine and gp96. PLoS One (2010) 0.94
Evidence for pH-dependent protease activity in the adeno-associated virus capsid. J Virol (2012) 0.93
Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae. J Virol (2010) 0.93
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties. Biochemistry (2009) 0.93
Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry (2008) 0.93
Defining the stoichiometry and cargo load of viral and bacterial nanoparticles by Orbitrap mass spectrometry. J Am Chem Soc (2014) 0.93
Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5. J Gen Virol (2011) 0.93
Molecular characterization of the heparin-dependent transduction domain on the capsid of a novel adeno-associated virus isolate, AAV(VR-942). J Virol (2008) 0.92
Structural insights into adeno-associated virus serotype 5. J Virol (2013) 0.92
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Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes. J Virol (2013) 0.88