Published in Med Res Rev on September 01, 2007
Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res (2010) 1.66
The retinoid X receptors and their ligands. Biochim Biophys Acta (2011) 1.32
Rhein induces apoptosis in human breast cancer cells. Evid Based Complement Alternat Med (2011) 1.01
Inhibitory effect of emodin and Astragalus polysaccharide on the replication of HBV. World J Gastroenterol (2009) 1.00
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol (2010) 0.95
Species and gender differences affect the metabolism of emodin via glucuronidation. AAPS J (2010) 0.94
Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines. Anticancer Agents Med Chem (2013) 0.92
Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem (2010) 0.91
Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice. Mediators Inflamm (2014) 0.91
Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling. PPAR Res (2012) 0.90
Induction of Cell Cycle Arrest and Apoptosis by Physcion, an Anthraquinone Isolated From Rhubarb (Rhizomes of Rheum tanguticum), in MDA-MB-231 Human Breast Cancer Cells. J Cancer Prev (2014) 0.88
Rhein protects pancreatic β-cells from dynamin-related protein-1-mediated mitochondrial fission and cell apoptosis under hyperglycemia. Diabetes (2013) 0.87
A drug-specific nanocarrier design for efficient anticancer therapy. Nat Commun (2015) 0.87
Effects of Rhein lysinate on H2O2-induced cellular senescence of human umbilical vascular endothelial cells. Acta Pharmacol Sin (2011) 0.86
Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice. Acta Pharmacol Sin (2012) 0.84
The Apoptotic Effect of the Hexane Extract of Rheum undulatum L. in Oral Cancer Cells through the Down-regulation of Specificity Protein 1 and Survivin. Lab Anim Res (2011) 0.84
Preparation, characterization, and in vivo study of rhein-loaded poly(lactic-co-glycolic acid) nanoparticles for oral delivery. Drug Des Devel Ther (2015) 0.81
The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia. J Neural Transm (Vienna) (2008) 0.80
Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition. Evid Based Complement Alternat Med (2013) 0.80
Association of a Methanol Extract of Rheum undulatum L. Mediated Cell Death in AGS Cells with an Intrinsic Apoptotic Pathway. J Pharmacopuncture (2015) 0.80
Genetics of Polyketide Metabolism in Aspergillus nidulans. Metabolites (2012) 0.79
Anthraquinone G503 induces apoptosis in gastric cancer cells through the mitochondrial pathway. PLoS One (2014) 0.79
Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB. J Cancer (2016) 0.78
Synergistic effect of rhein in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. Exp Ther Med (2012) 0.78
Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway. Braz J Med Biol Res (2012) 0.78
Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2/CYP2E1 Cells. Evid Based Complement Alternat Med (2011) 0.78
Rhein lysinate inhibits cell growth by modulating various mitogen-activated protein kinases in cervical cancer cells. Oncol Lett (2010) 0.78
Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol (2016) 0.78
Emodin Inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer Cells via ILK/GSK-3β/Slug Signaling Pathway. Biomed Res Int (2016) 0.77
Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget (2016) 0.77
DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling. Oncotarget (2016) 0.77
Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats. Evid Based Complement Alternat Med (2016) 0.77
Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia. Evid Based Complement Alternat Med (2015) 0.76
Emodin suppresses maintenance of stemness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells. Stem Cells Dev (2014) 0.76
Upregulation of Human ST8Sia VI (α2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells. Int J Mol Sci (2016) 0.75
Emodin regulating excision repair cross-complementation group 1 through fibroblast growth factor receptor 2 signaling. World J Gastroenterol (2013) 0.75
Effect of matrine combined with cisplatin on the expression of XIAP in human rhabdomyosarcoma RD cells. Oncol Lett (2016) 0.75
Chrysophanic Acid Induces Necrosis but not Necroptosis in Human Renal Cell Carcinoma Caki-2 Cells. J Cancer Prev (2016) 0.75
Extracts from Vatica diospyroides type SS fruit show low dose activity against MDA-MB-468 breast cancer cell-line via apoptotic action. Biomed Res Int (2014) 0.75
Antiproliferative effects of n-butyl-β-D-fructofuranoside from Kangaisan on Bel-7402 cells. Indian J Pharmacol (2014) 0.75
Ultra-performance liquid chromatography-quadrupole\time-of- flight mass spectrometry with multivariate statistical analysis for exploring potential chemical markers to distinguish between raw and processed Rheum palmatum. BMC Complement Altern Med (2014) 0.75
Hypolipidemic effects of HVC1 in a high cholesterol diet‑induced rat model of hyperlipidemia. Mol Med Rep (2016) 0.75
Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models. Oncotarget (2016) 0.75
Syntheses of 2-substituted 1-amino-4-bromoanthraquinones (bromaminic acid analogues) - precursors for dyes and drugs. Beilstein J Org Chem (2015) 0.75
Targeted tumor therapy by Rubia tinctorum L.: analytical characterization of hydroxyanthraquinones and investigation of their selective cytotoxic, adhesion and migration modulator effects on melanoma cell lines (A2058 and HT168-M1). Cancer Cell Int (2015) 0.75
Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment. Acta Pharmacol Sin (2016) 0.75
Chrysophanic acid reduces testosterone-induced benign prostatic hyperplasia in rats by suppressing 5α-reductase and extracellular signal-regulated kinase. Oncotarget (2016) 0.75
Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities. Mar Drugs (2016) 0.75
Inhibition of endosomal fusion activity of influenza virus by Rheum tanguticum (da-huang). Sci Rep (2016) 0.75
Synergy of Taxol and rhein lysinate associated with the downregulation of ERK activation in lung carcinoma cells. Oncol Lett (2013) 0.75
Protective effect of Rhei Rhizoma on reflux esophagitis in rats via Nrf2-mediated inhibition of NF-κB signaling pathway. BMC Complement Altern Med (2016) 0.75
Emodin suppresses proliferation, migration and invasion in ovarian cancer cells by down regulating ILK in vitro and in vivo. Onco Targets Ther (2017) 0.75
Relationship between structure and entropy contributions in an anthraquinone mercapto derivative. J Mol Model (2010) 0.75
Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis. Diseases (2016) 0.75
Accuracy of color prediction of anthraquinone dyes in methanol solution estimated from first principle quantum chemistry computations. J Mol Model (2012) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Guidelines for the next 10 years of proteomics. Proteomics (2006) 3.61
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45
Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem (2003) 3.35
Microdevice for the isolation and enumeration of cancer cells from blood. Biomed Microdevices (2009) 2.00
Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets (2008) 1.95
Serum autoantibodies as biomarkers for early cancer detection. FEBS J (2009) 1.94
Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy (2008) 1.77
The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance proteins determine the resistance specificity to Magnaporthe grisea. Mol Plant Microbe Interact (2006) 1.69
"Proteomineering" or not? The debate on biomarker discovery in sera continues. J Proteomics (2011) 1.50
Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett (2004) 1.49
IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. J Cell Biol (2006) 1.46
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res (2013) 1.42
Membrane proteins and membrane proteomics. Proteomics (2008) 1.40
Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis. Mol Cell Proteomics (2006) 1.39
Prediction of RNA-binding proteins from primary sequence by a support vector machine approach. RNA (2004) 1.36
Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms. Curr Med Chem Anticancer Agents (2005) 1.32
The Magnaporthe oryzae avirulence gene AvrPiz-t encodes a predicted secreted protein that triggers the immunity in rice mediated by the blast resistance gene Piz-t. Mol Plant Microbe Interact (2009) 1.30
Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy (2009) 1.29
Large-scale identification of expressed sequence tags involved in rice and rice blast fungus interaction. Plant Physiol (2005) 1.27
Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis (2004) 1.21
Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics. J Clin Endocrinol Metab (2013) 1.20
Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin). J Biol Chem (2012) 1.19
The role of autophagy in liver cancer: molecular mechanisms and potential therapeutic targets. Biochim Biophys Acta (2013) 1.17
Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress. PLoS One (2013) 1.16
Significant biochemical, biophysical and metabolic diversity in circulating human cord blood reticulocytes. PLoS One (2013) 1.15
Quantitative and temporal proteome analysis of butyrate-treated colorectal cancer cells. Mol Cell Proteomics (2008) 1.14
Effect of training datasets on support vector machine prediction of protein-protein interactions. Proteomics (2005) 1.11
A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers. Proteomics (2004) 1.11
Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis. Mol Cell Proteomics (2010) 1.09
Rac1 is required for pathogenicity and Chm1-dependent conidiogenesis in rice fungal pathogen Magnaporthe grisea. PLoS Pathog (2008) 1.08
Network-based pipeline for analyzing MS data: an application toward liver cancer. J Proteome Res (2011) 1.07
Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Biochem Pharmacol (2006) 1.07
Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation. Mol Cancer Ther (2008) 1.06
Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol (2004) 1.05
To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage. Autophagy (2009) 1.05
Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry. Proteomics (2005) 1.05
Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric Oxide (2005) 1.04
A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2'-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction. Biochem J (2004) 1.03
Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation. Toxicol Sci (2012) 1.03
Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway. Cancer Res (2006) 1.03
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65. Nat Commun (2013) 1.02
Identification of key players for colorectal cancer metastasis by iTRAQ quantitative proteomics profiling of isogenic SW480 and SW620 cell lines. J Proteome Res (2011) 1.01
Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress. Autophagy (2011) 1.00
Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB. Cancer Lett (2010) 1.00
Cancer proteomics. Mass Spectrom Rev (2012) 1.00
(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization. PLoS One (2012) 0.99
Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene (2004) 0.99
Serum metabolome and lipidome changes in adult patients with primary dengue infection. PLoS Negl Trop Dis (2013) 0.99
Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol (2005) 0.98
Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3β-Cyclin D1 pathway. Cancer Lett (2010) 0.98
Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis. Autophagy (2012) 0.98
Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells. Mol Cancer Ther (2005) 0.97
Subcellular fractionation methods and strategies for proteomics. Proteomics (2010) 0.97
Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2006) 0.97
Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy (2012) 0.97
Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease. J Biol Chem (2011) 0.96
Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis (2004) 0.95
Overexpression of AtWRKY28 and AtWRKY75 in Arabidopsis enhances resistance to oxalic acid and Sclerotinia sclerotiorum. Plant Cell Rep (2013) 0.95
Biomarkers for male reproductive health hazards: are they available? Toxicol Lett (2002) 0.95
A homeobox gene is essential for conidiogenesis of the rice blast fungus Magnaporthe oryzae. Mol Plant Microbe Interact (2010) 0.95
Metabolomics reveals altered metabolic pathways in experimental asthma. Am J Respir Cell Mol Biol (2012) 0.95
Proteomic analysis of colorectal cancer metastasis: stathmin-1 revealed as a player in cancer cell migration and prognostic marker. J Proteome Res (2012) 0.94
Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. Anal Biochem (2004) 0.94
Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy (2012) 0.94
Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl (2013) 0.94
Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury. Toxicol Appl Pharmacol (2008) 0.94
2-D DIGE profiling of hepatocellular carcinoma tissues identified isoforms of far upstream binding protein (FUBP) as novel candidates in liver carcinogenesis. Proteomics (2008) 0.93
Mining the gastric cancer secretome: identification of GRN as a potential diagnostic marker for early gastric cancer. J Proteome Res (2012) 0.93
Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells. Autophagy (2012) 0.93
mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif. J Biol Chem (2011) 0.93
Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer Lett (2008) 0.93
A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis. Mol Cell Proteomics (2014) 0.92
Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization. Mol Cancer Ther (2007) 0.91
The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutat Res (2003) 0.91
Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochem Pharmacol (2009) 0.91
Association of blood lead and homocysteine levels among lead exposed subjects in Vietnam and Singapore. Occup Environ Med (2007) 0.91
Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein. J Proteome Res (2013) 0.90
Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes. Biochem Biophys Res Commun (2002) 0.90
Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines. Toxicol In Vitro (2010) 0.90
Development of microsatellite markers and construction of genetic map in rice blast pathogen Magnaporthe grisea. Fungal Genet Biol (2008) 0.90
CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma. Hepatology (2015) 0.89
Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry. Mol Biosyst (2013) 0.89
A Rho3 homolog is essential for appressorium development and pathogenicity of Magnaporthe grisea. Eukaryot Cell (2007) 0.89
Peroxyl radical scavenging capacity, polyphenolics, and lipophilic antioxidant profiles of mulberry fruits cultivated in southern China. J Agric Food Chem (2008) 0.89
Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: general principles and applications. Mass Spectrom Rev (2011) 0.89
Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG1: a study of adolescents in a high risk region for hepatocellular carcinoma in China. World J Gastroenterol (2003) 0.88
Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells. Cancer Lett (2011) 0.88
Proteome analysis of butyrate-treated human colon cancer cells (HT-29). Int J Cancer (2002) 0.88
Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. Cancer Lett (2004) 0.88
A Cdc42 ortholog is required for penetration and virulence of Magnaporthe grisea. Fungal Genet Biol (2009) 0.88
Proteomics discovery of biomarkers for mitral regurgitation caused by mitral valve prolapse. J Proteomics (2013) 0.87
Beta-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway. Int J Biochem Cell Biol (2005) 0.87