Published in Curr Cancer Drug Targets on November 01, 2008
The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets (2010) 1.85
NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target. Front Biosci (Landmark Ed) (2011) 1.19
Blechnum orientale Linn - a fern with potential as antioxidant, anticancer and antibacterial agent. BMC Complement Altern Med (2010) 1.16
Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells. J Exp Clin Cancer Res (2010) 1.13
(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization. PLoS One (2012) 0.99
Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells. PLoS One (2012) 0.99
Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/β-catenin signaling pathway. PLoS One (2014) 0.94
Anti-inflammatory and analgesic activities of a novel biflavonoid from shells of Camellia oleifera. Int J Mol Sci (2012) 0.93
Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. J Exp Bot (2009) 0.92
ERK/PP1a/PLB/SERCA2a and JNK pathways are involved in luteolin-mediated protection of rat hearts and cardiomyocytes following ischemia/reperfusion. PLoS One (2013) 0.92
Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget (2013) 0.91
Antiproliferative activity and apoptosis induction of crude extract and fractions of avicennia marina. Iran J Basic Med Sci (2013) 0.90
Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75. Metabolomics (2011) 0.90
Receptor-interacting protein 1 increases chemoresistance by maintaining inhibitor of apoptosis protein levels and reducing reactive oxygen species through a microRNA-146a-mediated catalase pathway. J Biol Chem (2014) 0.90
Targeting cell signaling and apoptotic pathways by luteolin: cardioprotective role in rat cardiomyocytes following ischemia/reperfusion. Nutrients (2012) 0.88
A superoxide-mediated mitogen-activated protein kinase phosphatase-1 degradation and c-Jun NH(2)-terminal kinase activation pathway for luteolin-induced lung cancer cytotoxicity. Mol Pharmacol (2012) 0.87
Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease. Sci Rep (2015) 0.87
Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis. Sci Rep (2015) 0.86
Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity. Mol Biol Rep (2013) 0.83
Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells. J Cell Biochem (2009) 0.83
Apoptosis Induction by Polygonum minus is related to antioxidant capacity, alterations in expression of apoptotic-related genes, and S-phase cell cycle arrest in HepG2 cell line. Biomed Res Int (2014) 0.83
Correlation among antioxidant, antimicrobial, hemolytic, and antiproliferative properties of Leiothrix spiralis leaves extract. Int J Mol Sci (2012) 0.83
Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1. PLoS One (2014) 0.83
Systems pharmacology-based approach for dissecting the active ingredients and potential targets of the Chinese herbal Bufei Jianpi formula for the treatment of COPD. Int J Chron Obstruct Pulmon Dis (2015) 0.83
Neurological effects of honey: current and future prospects. Evid Based Complement Alternat Med (2014) 0.82
Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice. Hepatobiliary Surg Nutr (2015) 0.82
Digitoflavone inhibits IκBα kinase and enhances apoptosis induced by TNFα through downregulation of expression of nuclear factor κB-regulated gene products in human pancreatic cancer cells. PLoS One (2013) 0.82
Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells. PLoS One (2013) 0.81
Luteolin nanoparticle in chemoprevention: in vitro and in vivo anticancer activity. Cancer Prev Res (Phila) (2014) 0.81
Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the epithelial-mesenchymal transition. Acta Pharmacol Sin (2012) 0.80
Quality evaluation of snow lotus (Saussurea): quantitative chemical analysis and antioxidant activity assessment. Plant Cell Rep (2010) 0.79
Inhibitory effects and mechanisms of luteolin on proliferation and migration of vascular smooth muscle cells. Nutrients (2013) 0.79
Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells. Curr Cancer Drug Targets (2013) 0.79
Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. Semin Cancer Biol (2015) 0.79
Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition. Oncotarget (2015) 0.78
Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells. PLoS One (2015) 0.78
EBV reactivation as a target of luteolin to repress NPC tumorigenesis. Oncotarget (2016) 0.77
Luteolin is a bioflavonoid that attenuates adipocyte-derived inflammatory responses via suppression of nuclear factor-κB/mitogen-activated protein kinases pathway. Pharmacogn Mag (2015) 0.77
Preparation and characterization of monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) micelles for the solubilization and in vivo delivery of luteolin. Int J Nanomedicine (2013) 0.77
Molecular mechanisms of luteolin induced growth inhibition and apoptosis of human osteosarcoma cells. Iran J Pharm Res (2015) 0.77
Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease. Sci Rep (2015) 0.77
Inhibitory activities of Perilla frutescens britton leaf extract against the growth, migration, and adhesion of human cancer cells. Nutr Res Pract (2015) 0.77
A novel systems pharmacology model for herbal medicine injection: a case using Reduning injection. BMC Complement Altern Med (2014) 0.77
Flavone synthases from Lonicera japonica and L. macranthoides reveal differential flavone accumulation. Sci Rep (2016) 0.77
Ethyl acetate extract of Wedelia chinensis inhibits tert-butyl hydroperoxide-induced damage in PC12 cells and D-galactose-induced neuronal cell loss in mice. BMC Complement Altern Med (2014) 0.76
Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Mol Med Rep (2015) 0.76
Luteolin prevents uric acid-induced pancreatic β-cell dysfunction. J Biomed Res (2014) 0.76
Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells. PLoS One (2015) 0.76
Non-targeted Metabolite Profiling and Scavenging Activity Unveil the Nutraceutical Potential of Psyllium (Plantago ovata Forsk). Front Plant Sci (2016) 0.76
Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae). Int Sch Res Notices (2014) 0.76
Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. PLoS One (2016) 0.76
Luteolin potentiates the effects of aminoglycoside and β-lactam antibiotics against methicillin-resistant Staphylococcus aureus in vitro. Exp Ther Med (2016) 0.75
Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay. Aging (Albany NY) (2016) 0.75
SERS-Based Flavonoid Detection Using Ethylenediamine-β-Cyclodextrin as a Capturing Ligand. Nanomaterials (Basel) (2017) 0.75
Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells. Oncol Lett (2017) 0.75
Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer. Bioinformation (2015) 0.75
Luteolin inhibits GABAA receptors in HEK cells and brain slices. Sci Rep (2016) 0.75
Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells. Evid Based Complement Alternat Med (2015) 0.75
Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors. Microorganisms (2016) 0.75
Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450. Oncotarget (2017) 0.75
The flavonoid luteolin enhances doxorubicin-induced autophagy in human osteosarcoma U2OS cells. Int J Clin Exp Med (2015) 0.75
Identity-based High-performance thin Layer Chromatography Fingerprinting Profile and Tumor Inhibitory Potential of Anisochilus carnosus (L.f.) wall Against Ehrlich Ascites Carcinoma. Pharmacogn Mag (2015) 0.75
Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells. PLoS One (2017) 0.75
LZ-207, a Newly Synthesized Flavonoid, Induces Apoptosis and Suppresses Inflammation-Related Colon Cancer by Inhibiting the NF-κB Signaling Pathway. PLoS One (2015) 0.75
Rice Bran Metabolome Contains Amino Acids, Vitamins & Cofactors, and Phytochemicals with Medicinal and Nutritional Properties. Rice (N Y) (2017) 0.75
High Performance Liquid Chromatography-mass Spectrometry Analysis of High Antioxidant Australian Fruits with Antiproliferative Activity Against Cancer Cells. Pharmacogn Mag (2016) 0.75
Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure. J Negat Results Biomed (2014) 0.75
Molecular targets of luteolin in cancer. Eur J Cancer Prev (2016) 0.75
Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation. Int J Mol Sci (2017) 0.75
Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longev (2017) 0.75
Honey and Cancer: Current Status and Future Directions. Diseases (2016) 0.75
Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards? World J Methodol (2017) 0.75
Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems. J Oncol (2017) 0.75
Highly pathogenic avian influenza A virus H5N1 non-structural protein 1 is associated with apoptotic activation of the intrinsic mitochondrial pathway. Exp Ther Med (2017) 0.75
Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTOR signaling pathway. Oncol Lett (2017) 0.75
PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer. Oncogene (2016) 0.75
The hallmarks of cancer. Cell (2000) 113.05
Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med (1995) 26.60
Signaling to NF-kappaB. Genes Dev (2004) 19.78
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell (2004) 15.82
NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol (2005) 13.98
The expanding role of mitochondria in apoptosis. Genes Dev (2001) 9.91
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell (2005) 9.16
Tumor necrosis factor signaling. Cell Death Differ (2003) 8.48
Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev (2006) 7.92
Advances in flavonoid research since 1992. Phytochemistry (2000) 7.78
Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell (2006) 5.97
Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol (2002) 5.73
G1 cell-cycle control and cancer. Nature (2004) 5.72
HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol (2001) 4.58
Redox-dependent downregulation of Rho by Rac. Nat Cell Biol (2003) 4.46
Inflammation and cancer: an ancient link with novel potentials. Int J Cancer (2007) 4.19
Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96
Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr (2002) 3.92
Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med (2004) 3.76
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell (2005) 3.59
Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic Biol Med (1997) 3.23
Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther (2001) 2.51
Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem (2001) 2.47
The antitumor activities of flavonoids. In Vivo (2005) 2.34
Tumour necrosis factor-alpha as a tumour promoter. Eur J Cancer (2006) 2.09
Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med (2004) 2.07
State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc Am Thorac Soc (2006) 1.92
Cancer preventive effects of flavonoids--a review. Biomed Pharmacother (2002) 1.90
Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A (2007) 1.89
The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase. Mol Cell Biol (2000) 1.80
A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer (2007) 1.76
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell (2004) 1.73
The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Radic Biol Med (1994) 1.70
p53 modulation of the DNA damage response. J Cell Biochem (2007) 1.61
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr Pharm Biotechnol (2006) 1.58
Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res (1997) 1.58
Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol (1997) 1.56
Clinical review 92: Phytoestrogens. J Clin Endocrinol Metab (1998) 1.55
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem (2004) 1.55
Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol (1999) 1.55
Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology (2002) 1.54
Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer (2004) 1.47
Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. Cancer Res (2007) 1.46
Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer Res (2006) 1.42
Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer. Oncogene (2006) 1.35
Genistein arrests cell cycle progression at G2-M. Cancer Res (1993) 1.35
Quantitative structure-activity relationship analysis of phenolic antioxidants. Free Radic Biol Med (1999) 1.35
Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci (2007) 1.32
Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J Pharmacol Exp Ther (2001) 1.31
Cytotoxic drugs and the CD95 pathway. Leukemia (1999) 1.30
Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic Res (1998) 1.30
Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids. Cancer Res (1981) 1.29
Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons. Drug Metab Rev (2001) 1.27
Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Lett (1998) 1.23
A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol (2007) 1.23
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis (2004) 1.20
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation. Int J Cancer (2005) 1.19
Effect of flavonoids on cell cycle progression in prostate cancer cells. Cancer Lett (2002) 1.19
Flavonoids activate wild-type p53. Oncogene (1996) 1.19
Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med (2002) 1.18
TRAIL resistance results in cancer progression: a TRAIL to perdition? Oncogene (2006) 1.17
Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. Am J Physiol Gastrointest Liver Physiol (2006) 1.16
Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid. Free Radic Biol Med (1999) 1.16
Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts. Cancer Res (2002) 1.15
Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res (2004) 1.15
Bioflavonoid interaction with rat uterine type II binding sites and cell growth inhibition. J Steroid Biochem (1988) 1.15
Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem Pharmacol (1989) 1.15
Cytotoxicity of flavonoids toward cultured normal human cells. Biol Pharm Bull (2005) 1.14
Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Carcinogenesis (2006) 1.14
Antioxidant activities of different colored sweet bell peppers (Capsicum annuum L.). J Food Sci (2007) 1.14
Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol (2001) 1.13
Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells. Front Biosci (2007) 1.13
Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control (2001) 1.12
Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. J Steroid Biochem Mol Biol (1994) 1.11
Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics. Drug Metabol Drug Interact (2000) 1.10
Increase of Bax/ Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line. Life Sci (2005) 1.10
Estrogen, estrogen plus progestin therapy, and risk of breast cancer. Clin Cancer Res (2005) 1.10
The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology (2005) 1.10
Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. Mol Cell Biochem (2004) 1.09
Phytoestrogens as modulators of steroid action in target cells. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 1.09
Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms. Nutr Cancer (2000) 1.08
Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells. Oncogene (2005) 1.07
Steroid hormone activity of flavonoids and related compounds. Breast Cancer Res Treat (2000) 1.07
Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway. J Neural Transm Suppl (2007) 1.07
Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers. Am J Epidemiol (2004) 1.06
Flavonols and flavones of parsley cell suspension culture change the antioxidative capacity of plasma in rats. Nahrung (1999) 1.05
Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray. FEBS Lett (2005) 1.05
Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Invest New Drugs (2005) 1.05
Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells. Phytother Res (2002) 1.03
Estrogen receptor alpha as a target for indole-3-carbinol. J Nutr Biochem (2005) 1.03
Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. Chem Biol Interact (2006) 1.03
Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. Br J Pharmacol (1999) 1.03
Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Br J Pharmacol (2002) 1.02
Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res (2002) 1.02
Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways. Nutr Cancer (2004) 1.01
Growth inhibitory effects of flavonoids in human thyroid cancer cell lines. Thyroid (1999) 1.01
Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK. Toxicol Appl Pharmacol (2005) 1.00
Antioxidant and prooxidant effects of phenolics on pancreatic beta-cells in vitro. J Agric Food Chem (2002) 1.00
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45
Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem (2003) 3.35
Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol (2007) 2.88
RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery. Plant Cell (2008) 2.72
MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways. J Virol (2008) 2.45
B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. J Biol Chem (2007) 2.44
Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China (2003-11): a national observational cohort study. Lancet (2012) 2.41
Oct4 pseudogenes are transcribed in cancers. Biochem Biophys Res Commun (2005) 2.34
A general strategy for creating "inactive-conformation" abl inhibitors. Chem Biol (2006) 2.27
The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25
Actin filament dynamics are dominated by rapid growth and severing activity in the Arabidopsis cortical array. J Cell Biol (2009) 2.20
Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b. Plant Cell (2008) 2.15
Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet (2012) 1.96
Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host Microbe (2009) 1.93
Anti-cancer properties of anthraquinones from rhubarb. Med Res Rev (2007) 1.90
Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy (2008) 1.77
Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway. Am J Pathol (2004) 1.72
Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci (2011) 1.64
A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer. Proc Natl Acad Sci U S A (2012) 1.64
Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements. Hum Genet (2013) 1.63
Epstein-Barr virus growth/latency III program alters cellular microRNA expression. Virology (2008) 1.63
A ferroelectric-like structural transition in a metal. Nat Mater (2013) 1.54
Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer. Proc Natl Acad Sci U S A (2006) 1.53
Relationship between oxidative stress and embryotoxicity of hydrosalpingeal fluid. Hum Reprod (2002) 1.49
Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett (2004) 1.49
Hepatic repopulation with stably transduced conditionally immortalized hepatocytes in the Gunn rat. J Hepatol (2008) 1.47
IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. J Cell Biol (2006) 1.46
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res (2013) 1.42
Hepatitis C seroconversion in methadone maintenance treatment programs in Wuhan, China. Addiction (2015) 1.42
Overexpression of rice WRKY89 enhances ultraviolet B tolerance and disease resistance in rice plants. Plant Mol Biol (2007) 1.41
NANOGP8 is a retrogene expressed in cancers. FEBS J (2006) 1.40
SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. Plant Cell (2007) 1.39
Transcriptome and targetome analysis in MIR155 expressing cells using RNA-seq. RNA (2010) 1.39
Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev (2018) 1.39
Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis. Mol Cell Proteomics (2006) 1.39
Multipathogen infections in hospitalized children with acute respiratory infections. Virol J (2009) 1.35
Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activity. ChemMedChem (2010) 1.33
Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells. Carcinogenesis (2007) 1.33
Next-generation sequencing-based molecular diagnosis of a Chinese patient cohort with autosomal recessive retinitis pigmentosa. Invest Ophthalmol Vis Sci (2013) 1.32
Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms. Curr Med Chem Anticancer Agents (2005) 1.32
Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease. J Ethnopharmacol (2012) 1.32
Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. J Biol Chem (2007) 1.31
Genomic insights into salt adaptation in a desert poplar. Nat Commun (2013) 1.30
Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy (2009) 1.29
Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains. J Virol (2012) 1.26
MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP-mediated Epstein-Barr virus reactivation. J Virol (2010) 1.23
A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol (2007) 1.23
Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis (2004) 1.21
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. PLoS One (2012) 1.20
Identification of small-molecule inducers of pancreatic beta-cell expansion. Proc Natl Acad Sci U S A (2009) 1.20
Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin). J Biol Chem (2012) 1.19
Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. Mol Pharmacol (2009) 1.18
Systematic review of consistency between adherence to cardiovascular or diabetes medication and health literacy in older adults. Ann Pharmacother (2012) 1.18
The role of autophagy in liver cancer: molecular mechanisms and potential therapeutic targets. Biochim Biophys Acta (2013) 1.17
HIV drug resistance and its impact on antiretroviral therapy in Chinese HIV-infected patients. PLoS One (2013) 1.16
Expression of Nanog gene promotes NIH3T3 cell proliferation. Biochem Biophys Res Commun (2005) 1.16
Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress. PLoS One (2013) 1.16
Detection of murine leukemia virus in the Epstein-Barr virus-positive human B-cell line JY, using a computational RNA-Seq-based exogenous agent detection pipeline, PARSES. J Virol (2012) 1.14
Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells. J Exp Clin Cancer Res (2010) 1.13
Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin. Mol Cell Neurosci (2008) 1.12
Virologic outcomes of first-line HAART and associated factors among Chinese patients with HIV in three sentinel antiretroviral treatment sites. Trop Med Int Health (2010) 1.12
Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. Proc Natl Acad Sci U S A (2007) 1.11
Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China. AIDS (2013) 1.11
Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway. PLoS One (2008) 1.10
The Arabidopsis concentration-dependent influx/efflux transporter ABCB4 regulates cellular auxin levels in the root epidermis. Plant J (2011) 1.10
Differential expression of the miR-200 family microRNAs in epithelial and B cells and regulation of Epstein-Barr virus reactivation by the miR-200 family member miR-429. J Virol (2010) 1.08
Endo-oxacyclizations of polyepoxides: biomimetic synthesis of fused polycyclic ethers. J Org Chem (2002) 1.08
Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Biochem Pharmacol (2006) 1.07
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer. Cancer Res (2008) 1.07
Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation. Mol Cancer Ther (2008) 1.06
Identification of new viral genes and transcript isoforms during Epstein-Barr virus reactivation using RNA-Seq. J Virol (2011) 1.06
Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol (2004) 1.05
To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage. Autophagy (2009) 1.05
Capping protein modulates the dynamic behavior of actin filaments in response to phosphatidic acid in Arabidopsis. Plant Cell (2012) 1.05
Harmonization of health data at national level: a pilot study in China. Int J Med Inform (2010) 1.03
Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation. Toxicol Sci (2012) 1.03
Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. Int J Parasitol (2012) 1.03
Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model. Antimicrob Agents Chemother (2012) 1.03
Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway. Cancer Res (2006) 1.03
Prevalence and genotype distribution of human papillomavirus in women with cervical cancer or high-grade precancerous lesions in Chengdu, western China. Int J Gynaecol Obstet (2010) 1.02
Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation (2009) 1.02
Silver nanoparticles capped by oleylamine: formation, growth, and self-organization. Langmuir (2007) 1.02
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65. Nat Commun (2013) 1.02
Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress. Autophagy (2011) 1.00
Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB. Cancer Lett (2010) 1.00
Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). Bioorg Med Chem Lett (2011) 1.00
RGB-NIR multispectral camera. Opt Express (2014) 1.00
IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells. Mol Cancer Ther (2009) 1.00
(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization. PLoS One (2012) 0.99
Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I. Bioorg Med Chem Lett (2008) 0.99
Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene (2004) 0.99
Interactions between zinc transporter-8 gene (SLC30A8) and plasma zinc concentrations for impaired glucose regulation and type 2 diabetes. Diabetes (2013) 0.98
Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cells. J Cell Biochem (2008) 0.98
Essential role of the oocyte in estrogen amplification of follicle-stimulating hormone signaling in granulosa cells. Endocrinology (2005) 0.98
Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3β-Cyclin D1 pathway. Cancer Lett (2010) 0.98
Correction of hyperoxaluria by liver repopulation with hepatocytes in a mouse model of primary hyperoxaluria type-1. Transplantation (2008) 0.98
Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis. Autophagy (2012) 0.98
The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B. J Genet Genomics (2010) 0.98