Published in J Phys Chem B on October 19, 2006
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature (2004) 12.75
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res (2006) 7.09
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A (2008) 4.57
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol (2004) 4.43
Swine influenza viruses a North American perspective. Adv Virus Res (2008) 4.28
Productivity is a poor predictor of plant species richness. Science (2011) 4.21
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell (2010) 4.16
Valley-selective circular dichroism of monolayer molybdenum disulphide. Nat Commun (2012) 4.04
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat Biotechnol (2007) 4.02
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell (2011) 3.78
Controlling natural killer cell responses: integration of signals for activation and inhibition. Annu Rev Immunol (2013) 3.38
Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (2010) 3.36
Structural and electronic properties of T graphene: a two-dimensional carbon allotrope with tetrarings. Phys Rev Lett (2012) 3.30
Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry (2007) 3.15
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol Cancer Ther (2008) 3.07
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest (2011) 2.99
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nat Med (2006) 2.94
The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg (2010) 2.78
China's facility-based birth strategy and neonatal mortality: a population-based epidemiological study. Lancet (2011) 2.64
Atomic layers of hybridized boron nitride and graphene domains. Nat Mater (2010) 2.57
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation (2012) 2.55
Super plastic bulk metallic glasses at room temperature. Science (2007) 2.45
Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States. Vet Microbiol (2006) 2.45
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science (2002) 2.33
An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A (2009) 2.20
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nat Immunol (2012) 2.04
Direct laser writing of micro-supercapacitors on hydrated graphite oxide films. Nat Nanotechnol (2011) 2.02
Ivabradine significantly improves cardiac function in patients with ischemic heart disease: a meta-analysis of randomized controlled trials. Int J Cardiol (2013) 1.96
Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Hum Gene Ther (2002) 1.96
Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States. Virus Genes (2009) 1.94
Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J Clin Invest (2008) 1.91
Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma. Mol Cancer (2014) 1.81
Graphene quantum dots derived from carbon fibers. Nano Lett (2012) 1.79
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Nat Struct Mol Biol (2004) 1.78
Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α. Cancer Res (2011) 1.75
Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo. Cancer Res (2004) 1.74
Nrf2 signaling and cell survival. Toxicol Appl Pharmacol (2009) 1.72
mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res (2013) 1.72
Direct, nonoxidative conversion of methane to ethylene, aromatics, and hydrogen. Science (2014) 1.71
HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles. PLoS One (2008) 1.69
Language history questionnaire: A web-based interface for bilingual research. Behav Res Methods (2006) 1.68
PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev (2012) 1.66
nDNA-Prot: identification of DNA-binding proteins based on unbalanced classification. BMC Bioinformatics (2014) 1.65
Cytoplasmic and nuclear retained DMPK mRNAs are targets for RNA interference in myotonic dystrophy cells. J Biol Chem (2005) 1.64
NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer. J Clin Invest (2006) 1.61
Methamphetamine enhances HIV infection of macrophages. Am J Pathol (2008) 1.60
Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer. Mol Cancer (2010) 1.56
Similarity computation strategies in the microRNA-disease network: a survey. Brief Funct Genomics (2015) 1.55
NMDA receptor activation increases free radical production through nitric oxide and NOX2. J Neurosci (2009) 1.54
Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J Immunol (2010) 1.53
ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. J Clin Invest (2012) 1.51
Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting: a multicenter randomized trial. JAMA Surg (2013) 1.49
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains. Mol Cancer Res (2007) 1.49
Secondhand Smoking Is Associated With Vascular Inflammation. Chest (2015) 1.48
Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A (2009) 1.47
Efficacy and safety of tadalafil monotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a meta-analysis. Urol Int (2013) 1.46
Factors associated with weight gain during olanzapine treatment in patients with schizophrenia or bipolar disorder: results from a six-month prospective, multinational, observational study. World J Biol Psychiatry (2009) 1.46
Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest (2011) 1.46
Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis. J Am Acad Dermatol (2006) 1.46
Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis. Cancer Res (2013) 1.46
Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine. Vaccine (2007) 1.45
Granular parakeratosis of eccrine ostia. Am J Dermatopathol (2008) 1.45
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol (2012) 1.43
Direct growth of graphene/hexagonal boron nitride stacked layers. Nano Lett (2011) 1.43
Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease. Mol Neurodegener (2007) 1.42
Mediator complex regulates alternative mRNA processing via the MED23 subunit. Mol Cell (2012) 1.41
Multivoxel MR spectroscopy in acute ischemic stroke: comparison to the stroke protocol MRI. Stroke (2012) 1.41
Small molecule inhibitors that selectively block dengue virus methyltransferase. J Biol Chem (2010) 1.40
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest (2010) 1.40
Comparison of graft patency for off-pump and conventional coronary arterial bypass grafting using 64-slice multidetector spiral computed tomography angiography. Interact Cardiovasc Thorac Surg (2008) 1.38
Emergence of novel reassortant H3N2 swine influenza viruses with the 2009 pandemic H1N1 genes in the United States. Arch Virol (2011) 1.37
Hydration-controlled bacterial motility and dispersal on surfaces. Proc Natl Acad Sci U S A (2010) 1.37
Urinary expression of kidney injury markers in renal transplant recipients. Clin J Am Soc Nephrol (2010) 1.32
Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure. Environ Health Perspect (2006) 1.30
Key role of tissue plasminogen activator in neurovascular coupling. Proc Natl Acad Sci U S A (2008) 1.30
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead. Bioorg Med Chem Lett (2005) 1.30
Knee arthroplasty in the young patient: survival in a community registry. Clin Orthop Relat Res (2007) 1.29
Reproducibility of prefrontal γ-aminobutyric acid measurements with J-edited spectroscopy. NMR Biomed (2011) 1.29
Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell (2009) 1.27
A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages. Immunology (2010) 1.27
Balance between facilitation and resource competition determines biomass-density relationships in plant populations. Ecol Lett (2008) 1.27
In vivo detection of gray and white matter differences in GABA concentration in the human brain. Neuroimage (2006) 1.27
Influence of excitation power and temperature on photoluminescence in InGaN/GaN multiple quantum wells. Opt Express (2012) 1.26
Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways. Mol Cancer Res (2009) 1.26
Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biol Psychiatry (2005) 1.26
Excision of atrial myxoma using robotic technology. J Thorac Cardiovasc Surg (2009) 1.25
The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: Systematic review and meta-analysis. J Allergy Clin Immunol (2012) 1.25
Measurement and automatic correction of high-order B0 inhomogeneity in the rat brain at 11.7 Tesla. Magn Reson Imaging (2004) 1.24
Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries. BMC Genomics (2009) 1.24
Perioperative reactivation of hepatitis B virus replication in patients undergoing partial hepatectomy for hepatocellular carcinoma. J Gastroenterol Hepatol (2012) 1.23
The Mediator complex: a master coordinator of transcription and cell lineage development. Development (2014) 1.23
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors. Bioorg Med Chem Lett (2005) 1.22
The detection of H2S at room temperature by using individual indium oxide nanowire transistors. Nanotechnology (2008) 1.22
Time-resolved ultrafast photocurrents and terahertz generation in freely suspended graphene. Nat Commun (2012) 1.22