Published in Curr Gene Ther on October 01, 2006
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat Genet (2009) 3.86
Molecular architecture of the Mos1 paired-end complex: the structural basis of DNA transposition in a eukaryote. Cell (2009) 1.88
Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. Curr Gene Ther (2011) 1.76
Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc (2007) 1.73
Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers. Mob DNA (2011) 1.56
All y'all need to know 'bout retroelements in cancer. Semin Cancer Biol (2010) 1.52
Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. Mamm Genome (2007) 1.51
De novo induction of genetically engineered brain tumors in mice using plasmid DNA. Cancer Res (2009) 1.49
Integration-deficient lentiviral vectors: a slow coming of age. Mol Ther (2009) 1.47
Translating Sleeping Beauty transposition into cellular therapies: victories and challenges. Bioessays (2010) 1.42
Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells. Mol Ther (2010) 1.38
piggyBac transposon-mediated long-term gene expression in mice. Mol Ther (2010) 1.33
Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity. Gene Ther (2009) 1.17
Transposon-mediated mutagenesis in somatic cells: identification of transposon-genomic DNA junctions. Methods Mol Biol (2008) 1.15
Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice. J Clin Invest (2009) 1.11
Gene therapy vectors: the prospects and potentials of the cut-and-paste transposons. Genetica (2009) 1.10
The expanding universe of transposon technologies for gene and cell engineering. Mob DNA (2010) 1.08
Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. Genome Biol (2007) 1.08
Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo. PLoS One (2012) 1.02
Regulated gene insertion by steroid-induced PhiC31 integrase. Nucleic Acids Res (2008) 0.99
A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture. Proc Natl Acad Sci U S A (2012) 0.94
Precise targeted integration by a chimaeric transposase zinc-finger fusion protein. Nucleic Acids Res (2009) 0.89
Crystallization of a Mos1 transposase-inverted-repeat DNA complex: biochemical and preliminary crystallographic analyses. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.89
Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance. AIDS Res Ther (2008) 0.88
Mariner transposons as genetic tools in vertebrate cells. Genetica (2009) 0.82
Viral hybrid vectors for somatic integration - are they the better solution? Viruses (2009) 0.81
High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene. Biochemistry (2010) 0.81
Universal platform for quantitative analysis of DNA transposition. Mob DNA (2010) 0.80
Transposon transgenesis in Xenopus. Methods (2010) 0.78
Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons. Hum Gene Ther Methods (2014) 0.78
Functional characterization of the Bari1 transposition system. PLoS One (2013) 0.77
Intrinsic characteristics of neighboring DNA modulate transposable element activity in Drosophila melanogaster. Genetics (2010) 0.77
Sleeping Beauty Transposon Vectors in Liver-directed Gene Delivery of LDLR and VLDLR for Gene Therapy of Familial Hypercholesterolemia. Mol Ther (2015) 0.77
Faster, cheaper, safer, T-cell engineering. J Immunother (2013) 0.76
Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis. Sci Rep (2014) 0.76
Novel therapeutic approaches for various cancer types using a modified sleeping beauty-based gene delivery system. PLoS One (2014) 0.75
An assay to monitor the activity of DNA transposition complexes yields a general quality control measure for transpositional recombination reactions. Mob Genet Elements (2014) 0.75
Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma. Transl Neurosci (2015) 0.75
In Silico Approach for Characterization and Comparison of Repeats in the Genomes of Oil and Date Palms. Bioinform Biol Insights (2017) 0.75
Adenovirus-Mediated Gene Delivery: Potential Applications for Gene and Cell-Based Therapies in the New Era of Personalized Medicine. Genes Dis (2017) 0.75
Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat Genet (2009) 3.86
Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements. J Mol Biol (2002) 2.56
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system. Blood (2009) 2.15
Development of hyperactive sleeping beauty transposon vectors by mutational analysis. Mol Ther (2004) 2.13
Transposon-mediated genome manipulation in vertebrates. Nat Methods (2009) 1.96
The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends. Mol Cell Biol (2007) 1.74
Comparative analysis of transposable element vector systems in human cells. Mol Ther (2010) 1.66
Targeted Sleeping Beauty transposition in human cells. Mol Ther (2007) 1.61
Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers. Mob DNA (2011) 1.56
The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells. Nucleic Acids Res (2003) 1.52
Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells. Blood (2009) 1.49
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition. Nucleic Acids Res (2003) 1.45
Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives. Genome Biol (2007) 1.29
Hybrid lentivirus-transposon vectors with a random integration profile in human cells. Mol Ther (2009) 1.26
Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome. PLoS One (2011) 1.23
Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1. Proc Natl Acad Sci U S A (2006) 1.19
Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators. Mol Ther (2007) 1.13
Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies. Methods Mol Biol (2004) 1.13
The expanding universe of transposon technologies for gene and cell engineering. Mob DNA (2010) 1.08
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J (2012) 1.07
The Sleeping Beauty transposable element: evolution, regulation and genetic applications. Curr Issues Mol Biol (2004) 1.07
Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery. Stem Cells (2009) 1.05
Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells. Mol Ther (2011) 1.04
Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. Proc Natl Acad Sci U S A (2008) 1.02
Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells. Nucleic Acids Res (2012) 0.98
Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains. Mol Ther (2012) 0.97
Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells. Retrovirology (2013) 0.96
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery. Nucleic Acids Res (2011) 0.96
The Sleeping Beauty transposon toolbox. Methods Mol Biol (2012) 0.93
Retargeting transposon insertions by the adeno-associated virus Rep protein. Nucleic Acids Res (2012) 0.92
Nonviral gene delivery with the sleeping beauty transposon system. Hum Gene Ther (2011) 0.91
Cell division promotes efficient retrotransposition in a stable L1 reporter cell line. Mob DNA (2013) 0.90
Targeted gene insertion for molecular medicine. J Mol Med (Berl) (2008) 0.89
Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells. Invest Ophthalmol Vis Sci (2012) 0.88
A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics. Trends Genet (2005) 0.86
Novel hyperactive transposons for genetic modification of induced pluripotent and adult stem cells: a nonviral paradigm for coaxed differentiation. Stem Cells (2010) 0.85
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains. Genome Res (2009) 0.84
Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells. J RNAi Gene Silencing (2005) 0.84
Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells. Methods (2010) 0.84
Human satellite cells have regenerative capacity and are genetically manipulable. J Clin Invest (2014) 0.82
Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells. Nat Protoc (2011) 0.81
The Sleeping Beauty transposon system for clinical applications. Expert Opin Biol Ther (2011) 0.79
Regulation of DNA transposition by CpG methylation and chromatin structure in human cells. Mob DNA (2013) 0.79
Insertional engineering of chromosomes with Sleeping Beauty transposition: an overview. Methods Mol Biol (2011) 0.79
Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons. Hum Gene Ther Methods (2014) 0.78
Sleeping Beauty Transposition. Microbiol Spectr (2015) 0.78
Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline. Nat Methods (2005) 0.77
Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition. Methods Mol Biol (2008) 0.77
Gateway-compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells. Biotechnol J (2012) 0.77
Repetitive elements and genome instability. Semin Cancer Biol (2010) 0.77
Transposable elements as plasmid-based vectors for long-term gene transfer into tumors. Methods Mol Biol (2009) 0.76
Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo. Hum Gene Ther (2010) 0.76
Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers. Mob DNA (2013) 0.75
Hungary's 'reforms' are threatening basic science. Nature (2006) 0.75