Published in Mol Ther on June 02, 2009
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res (2012) 2.14
Recent advances in lentiviral vector development and applications. Mol Ther (2010) 1.89
Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry. Cell Host Microbe (2016) 1.38
Human artificial chromosomes for gene delivery and the development of animal models. Mol Ther (2011) 1.30
Immunization delivered by lentiviral vectors for cancer and infectious diseases. Immunol Rev (2011) 1.18
Zinc-finger nucleases for somatic gene therapy: the next frontier. Hum Gene Ther (2011) 1.11
Genotoxicity of retroviral hematopoietic stem cell gene therapy. Expert Opin Biol Ther (2011) 1.08
A new generation of human artificial chromosomes for functional genomics and gene therapy. Cell Mol Life Sci (2012) 1.06
Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. Hum Gene Ther (2012) 0.97
Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity. Vaccine (2010) 0.96
Focusing brain therapeutic interventions in space and time for Parkinson's disease. Curr Biol (2014) 0.93
Retroviral vectors: post entry events and genomic alterations. Viruses (2011) 0.92
A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Res (2014) 0.91
Gene and cell therapy based treatment strategies for inflammatory bowel diseases. World J Gastrointest Pathophysiol (2011) 0.91
Targeted gene therapies: tools, applications, optimization. Crit Rev Biochem Mol Biol (2012) 0.91
LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectives. Int Arch Med (2010) 0.91
The HIV-1 Rev/RRE system is required for HIV-1 5' UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particles. Retrovirology (2011) 0.90
Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in Hemophilia B mice. Mol Ther (2013) 0.87
Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice. J Biomed Biotechnol (2010) 0.87
Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors. Front Cell Neurosci (2013) 0.86
Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells. Hum Gene Ther (2010) 0.85
Long-term episomal transgene expression from mitotically stable integration-deficient lentiviral vectors. Hum Gene Ther (2014) 0.84
Nonintegrating foamy virus vectors. J Virol (2010) 0.84
Engineered Viruses as Genome Editing Devices. Mol Ther (2015) 0.84
Histone deacetylase inhibition rescues gene knockout levels achieved with integrase-defective lentiviral vectors encoding zinc-finger nucleases. Hum Gene Ther Methods (2013) 0.84
Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease. Mol Ther (2014) 0.83
Hybrid lentiviral vectors. Mol Ther (2010) 0.83
Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Hum Gene Ther (2012) 0.83
Induction of broadly neutralising HCV antibodies in mice by integration-deficient lentiviral vector-based pseudotyped particles. PLoS One (2013) 0.82
Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease. Hum Gene Ther (2014) 0.82
Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines. Retrovirology (2012) 0.81
Pancreatic cancer gene therapy: from molecular targets to delivery systems. Cancers (Basel) (2011) 0.81
S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection. Nucleic Acids Res (2014) 0.81
Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques. Mol Ther (2016) 0.81
A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria. PLoS One (2012) 0.81
Gene Therapy of ABCA4-Associated Diseases. Cold Spring Harb Perspect Med (2015) 0.81
Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors. BMC Biol (2013) 0.80
The novel replication-defective vaccinia virus (Tiantan strain)-based hepatitis C virus vaccine induces robust immunity in macaques. Mol Ther (2013) 0.80
Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector. PLoS One (2014) 0.79
Virally mediated gene manipulation in the adult CNS. Front Mol Neurosci (2011) 0.79
Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors. Mol Ther Methods Clin Dev (2015) 0.79
Lentiviral vector-mediated RNA silencing in the central nervous system. Hum Gene Ther Methods (2013) 0.79
Comparison of transduction efficiency among various lentiviruses containing GFP reporter in bone marrow hematopoietic stem cell transplantation. Exp Hematol (2013) 0.78
Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors. Mol Cell Biol (2013) 0.77
Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors. Genet Vaccines Ther (2011) 0.77
Efficient Expression of Igf-1 from Lentiviral Vectors Protects In Vitro but Does Not Mediate Behavioral Recovery of a Parkinsonian Lesion in Rats. Hum Gene Ther (2015) 0.77
Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant. Mol Ther Nucleic Acids (2014) 0.76
Assessment of Integration-defective HIV-1 and EIAV Vectors In Vitro and In Vivo. Mol Ther Nucleic Acids (2012) 0.76
Transgene expression in various organs post BM-HSC transplantation. Stem Cell Res (2013) 0.76
Tackling obstacles for gene therapy targeting neurons: disrupting perineural nets with hyaluronidase improves transduction. PLoS One (2013) 0.76
Endoglin is necessary for angiogenesis in human ovarian carcinoma-derived primary endothelial cells. Cancer Biol Ther (2013) 0.75
Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles. Hum Gene Ther (2016) 0.75
Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology. Chromosoma (2016) 0.75
The interplay of post-translational modification and gene therapy. Drug Des Devel Ther (2016) 0.75
Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing. Mol Ther Methods Clin Dev (2017) 0.75
Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology. J Neurophysiol (2016) 0.75
Perspectives of Genome-Editing Technologies for HIV Therapy. Curr HIV Res (2016) 0.75
Promising Gene Therapeutics for Salivary Gland Radiotoxicity. AIMS Med Sci (2016) 0.75
Emerging Gene Therapies for Genetic Hearing Loss. J Assoc Res Otolaryngol (2017) 0.75
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95
Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature (2005) 19.15
Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med (2008) 17.21
A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07
Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med (2008) 15.30
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol (2008) 14.75
Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature (1985) 14.39
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell (1978) 13.33
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci U S A (1996) 12.25
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol (1997) 12.11
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol (2007) 9.23
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A (1996) 9.15
Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Hum Gene Ther (2008) 8.83
A quantitative assay for HIV DNA integration in vivo. Nat Med (2001) 8.67
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med (2003) 8.59
The accuracy of reverse transcriptase from HIV-1. Science (1988) 8.24
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol (1998) 8.21
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci U S A (1994) 8.13
Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process. Mol Cell Biol (1984) 7.99
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol (1982) 7.49
Analysis of unintegrated avian RNA tumor virus double-stranded DNA intermediates. J Virol (1978) 7.06
Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration. Proc Natl Acad Sci U S A (1980) 6.73
Development of a self-inactivating lentivirus vector. J Virol (1998) 6.60
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet (2000) 6.12
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (1996) 5.97
HIV-1 genome nuclear import is mediated by a central DNA flap. Cell (2000) 5.87
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proc Natl Acad Sci U S A (1984) 5.81
Zinc-finger nucleases: the next generation emerges. Mol Ther (2008) 5.69
CD8(+) T-cell responses to adeno-associated virus capsid in humans. Nat Med (2007) 5.24
The retrovirus pol gene encodes a product required for DNA integration: identification of a retrovirus int locus. Proc Natl Acad Sci U S A (1984) 4.81
Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr (2007) 4.67
Immune responses to adenovirus and adeno-associated virus in humans. Gene Ther (1999) 4.65
HIV-1: fifteen proteins and an RNA. Annu Rev Biochem (1998) 4.33
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol (1995) 4.27
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet (1997) 4.26
Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae. Mol Cell Biol (1995) 3.96
Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells. J Virol (1992) 3.85
Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc Natl Acad Sci U S A (1986) 3.68
Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection. EMBO J (2001) 3.60
Human immunodeficiency virus cDNA metabolism: notable stability of two-long terminal repeat circles. J Virol (2002) 3.46
Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A (1997) 3.40
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol (1997) 3.37
Cell-surface expression of influenza haemagglutinin from a cloned DNA copy of the RNA gene. Nature (1981) 3.29
Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirus. J Virol (2003) 3.18
Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells (2008) 3.14
Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles. Proc Natl Acad Sci U S A (1996) 3.07
Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus. Proc Natl Acad Sci U S A (1975) 3.07
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. J Virol (1996) 2.82
Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther (2005) 2.81
Manipulating the mammalian genome by homologous recombination. Proc Natl Acad Sci U S A (2001) 2.71
Effective gene therapy with nonintegrating lentiviral vectors. Nat Med (2006) 2.70
Physiological promoters reduce the genotoxic risk of integrating gene vectors. Mol Ther (2008) 2.56
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells. Nucleic Acids Res (2003) 2.49
Site-specific nicking at the avian retrovirus LTR circle junction by the viral pp32 DNA endonuclease. Nucleic Acids Res (1985) 2.42
Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery. Hum Mol Genet (2001) 2.36
Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells. Nucleic Acids Res (1995) 2.36
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol (2007) 2.33
HIV integrase, a brief overview from chemistry to therapeutics. J Biol Chem (2001) 2.33
Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication. J Virol (2002) 2.32
An improved plasmid DNA expression vector for direct injection into skeletal muscle. Hum Gene Ther (1996) 2.23
The road to chromatin - nuclear entry of retroviruses. Nat Rev Microbiol (2007) 2.13
The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity. Nature (2006) 2.02
Lentiviral-mediated RNA interference. Hum Gene Ther (2002) 1.99
Gene delivery by lentivirus vectors. Mol Biotechnol (2007) 1.98
Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1. J Virol (1998) 1.97
Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication. J Virol (1989) 1.91
Transient gene expression by nonintegrating lentiviral vectors. Mol Ther (2006) 1.89
Stable gene transfer to the nervous system using a non-primate lentiviral vector. Gene Ther (1999) 1.89
Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. J Gene Med (2001) 1.85
Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues. J Virol (1994) 1.84
In vivo analysis of retroviral integrase structure and function. Adv Virus Res (1999) 1.82
Stable gene transfer to muscle using non-integrating lentiviral vectors. Mol Ther (2007) 1.81
Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci U S A (1999) 1.80
In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA. J Virol (2005) 1.80
The phiC31 integrase system for gene therapy. Curr Gene Ther (2006) 1.79
Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code. EMBO J (2000) 1.78
Human immunodeficiency virus type 1 quasispecies in vivo and ex vivo. Curr Top Microbiol Immunol (1992) 1.77
The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold. Proc Natl Acad Sci U S A (2003) 1.75
Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo. Proc Natl Acad Sci U S A (2006) 1.74
Intermolecular homologous recombination between transfected sequences in mammalian cells is primarily nonconservative. Mol Cell Biol (1987) 1.73
Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells. J Mol Biol (2007) 1.68
Capture of DNA sequences at double-strand breaks in mammalian chromosomes. Genetics (2001) 1.66
Targeted and highly efficient gene transfer into CD4+ cells by a recombinant human immunodeficiency virus retroviral vector. J Clin Invest (1991) 1.64
Retroviral DNA integration. Microbiol Mol Biol Rev (1999) 1.64
High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector. J Clin Invest (2008) 1.61
Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors. Mol Ther (2000) 1.61
Targeted genome modifications using integrase-deficient lentiviral vectors. Mol Ther (2007) 1.60
A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells. Nucleic Acids Res (1999) 1.56
Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants. J Virol (2004) 1.56
Therapeutic gene targeting. Gene Ther (1998) 1.55
Novel integrase-defective lentiviral episomal vectors for gene transfer. Hum Gene Ther (2004) 1.52
Evidence for gene expression by unintegrated human immunodeficiency virus type 1 DNA species. J Virol (2004) 1.49
Retroviral DNA integrated during infection by an integration-deficient mutant of murine leukemia virus is oligomeric. J Virol (1987) 1.44
Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation. J Virol (1998) 1.44
Human immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitro. J Virol (1995) 1.43
Specific and independent recognition of U3 and U5 att sites by human immunodeficiency virus type 1 integrase in vivo. J Virol (1998) 1.42
Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors. Mol Ther (2007) 1.42
Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med (2009) 2.19
A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner. Mol Cell Neurosci (2008) 1.30
Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases. Nucleic Acids Res (2012) 1.09
Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in. Hum Gene Ther (2013) 1.08
Lentiviral vector integration profiles differ in rodent postmitotic tissues. Mol Ther (2011) 1.06
Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury. J Neurosci (2014) 1.05
Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion. Eur J Neurosci (2006) 1.01
Rapid high-resolution karyotyping with precise identification of chromosome breakpoints. Genes Chromosomes Cancer (2007) 0.98
Chromosome rearrangement associated inactivation of tumour suppressor genes in prostate cancer. Am J Cancer Res (2011) 0.97
Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat. PLoS Biol (2010) 0.95
Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase. BMC Biotechnol (2008) 0.93
The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain. Br J Pharmacol (2010) 0.89
Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons. J Neurosci Methods (2011) 0.84
Long-term episomal transgene expression from mitotically stable integration-deficient lentiviral vectors. Hum Gene Ther (2014) 0.84
Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones. J Gene Med (2012) 0.83
African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages. J Virol (2006) 0.83
Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease. Hum Gene Ther (2014) 0.82
Challenges for gene therapy of CNS disorders and implications for Parkinson's disease therapies. Hum Gene Ther (2012) 0.80
Highly potent delivery method of gp160 envelope vaccine combining lentivirus-like particles and DNA electrotransfer. J Control Release (2012) 0.79
Lentiviral vector-mediated RNA silencing in the central nervous system. Hum Gene Ther Methods (2013) 0.79
Identification of a recurrent t(4;6) chromosomal translocation in prostate cancer. J Urol (2007) 0.78
Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors. Mol Cell Biol (2013) 0.77
A southern blot protocol to detect chimeric nuclease-mediated gene repair. Methods Mol Biol (2014) 0.75