Published in Mol Microbiol on October 27, 2006
Structure, membrane orientation, mechanism, and function of pexiganan--a highly potent antimicrobial peptide designed from magainin. Biochim Biophys Acta (2008) 1.31
Resistance of Neisseria gonorrhoeae to non-oxidative killing by adherent human polymorphonuclear leucocytes. Cell Microbiol (2009) 1.24
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation. J Biol Chem (2008) 1.22
Comparative genomics: from genotype to disease phenotype in the leishmaniases. Int J Parasitol (2007) 1.09
Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes. Infect Immun (2010) 1.07
Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-de pend ent, caspase-independent mitochondrial toxicity. J Biol Chem (2009) 1.06
Impact of Leishmania metalloprotease GP63 on macrophage signaling. Front Cell Infect Microbiol (2012) 0.98
Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival. PLoS Negl Trop Dis (2011) 0.95
Major surface protease of trypanosomatids: one size fits all? Infect Immun (2009) 0.94
Deception and manipulation: the arms of leishmania, a successful parasite. Front Immunol (2014) 0.93
Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation. Infect Immun (2008) 0.92
Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection. Cell Microbiol (2011) 0.88
The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi. Mol Biochem Parasitol (2007) 0.86
Genome evolution in trypanosomatid parasites. Parasitology (2014) 0.85
Therapeutic efficacy of stable analogues of vasoactive intestinal peptide against pathogens. J Biol Chem (2014) 0.82
Downregulation of the goat beta-defensin-2 gene by IL-4 in caprine intestinal epithelial cells infected with Eimeria spp. Parasitol Res (2007) 0.82
The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection. J Parasitol Res (2011) 0.81
Human chemokines as antimicrobial peptides with direct parasiticidal effect on Leishmania mexicana in vitro. PLoS One (2013) 0.79
The plasmid-encoded regulator activates factors conferring lysozyme resistance on enteropathogenic Escherichia coli strains. Appl Environ Microbiol (2008) 0.79
Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity. J Biol Chem (2013) 0.79
Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity. PLoS Pathog (2015) 0.78
The genetics of Leishmania virulence. Med Microbiol Immunol (2015) 0.77
Design of protease-resistant pexiganan enhances antileishmanial activity. Parasitol Res (2014) 0.77
Efficacy of synthetic peptides RP-1 and AA-RP-1 against Leishmania species in vitro and in vivo. Antimicrob Agents Chemother (2011) 0.76
Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture. Parasitol Res (2009) 0.76
Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species. PLoS Negl Trop Dis (2017) 0.75
The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection. Biomed Res Int (2015) 0.75
Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity. Antimicrob Agents Chemother (2016) 0.75
Cutaneous Leishmaniasis Induces a Transmissible Dysbiotic Skin Microbiota that Promotes Skin Inflammation. Cell Host Microbe (2017) 0.75
Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs. Acad Med (2010) 6.51
Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1. J Immunol (2003) 1.80
Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor. Mol Biochem Parasitol (2002) 1.65
MDQC: a new quality assessment method for microarrays based on quality control reports. Bioinformatics (2007) 1.61
Genomic and proteomic expression analysis of Leishmania promastigote and amastigote life stages: the Leishmania genome is constitutively expressed. Mol Biochem Parasitol (2006) 1.57
Flagellar membrane localization via association with lipid rafts. J Cell Sci (2009) 1.49
Molecular mechanisms of protein and lipid targeting to ciliary membranes. J Cell Sci (2010) 1.43
Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps. J Immunol (2010) 1.33
Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells. J Immunol (2010) 1.32
Global gene expression in Leishmania. Int J Parasitol (2007) 1.29
Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction. Circ Res (2013) 1.27
Chagas heart disease pathogenesis: one mechanism or many? Curr Mol Med (2008) 1.26
Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane. J Cell Sci (2009) 1.24
Bioluminescent imaging of Trypanosoma cruzi infection. Int J Parasitol (2008) 1.23
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation. J Biol Chem (2008) 1.22
Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence. J Biol Chem (2002) 1.21
Killing of African trypanosomes by antimicrobial peptides. J Infect Dis (2003) 1.21
Leishmania model for microbial virulence: the relevance of parasite multiplication and pathoantigenicity. Acta Trop (2003) 1.20
Proteomic signatures in plasma during early acute renal allograft rejection. Mol Cell Proteomics (2010) 1.14
Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63. Infect Immun (2003) 1.13
Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. J Cell Sci (2008) 1.10
Infliximab and reactivation of cerebral toxoplasmosis. N Engl J Med (2005) 1.10
Rapid screening of antibiotic toxicity in an automated microdroplet system. Lab Chip (2012) 1.09
A flagellum-specific calcium sensor. J Biol Chem (2005) 1.09
Composition and sensory function of the trypanosome flagellar membrane. Curr Opin Microbiol (2010) 1.08
Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry. Autoimmunity (2006) 1.07
Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-de pend ent, caspase-independent mitochondrial toxicity. J Biol Chem (2009) 1.06
Calflagin inhibition prolongs host survival and suppresses parasitemia in Trypanosoma brucei infection. Eukaryot Cell (2010) 1.05
Evidence for potential functionality of nuclearly-encoded humanin isoforms. Genomics (2009) 1.04
Molecular mechanisms of host cell invasion by Trypanosoma cruzi. Exp Parasitol (2010) 1.04
Functional genomic analysis of peripheral blood during early acute renal allograft rejection. Transplantation (2009) 1.03
Immune response and protection assay of recombinant major surface glycoprotein of Leishmania (rgp63) reconstituted with liposomes in BALB/c mice. Vaccine (2006) 1.03
Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi. J Biol Chem (2008) 1.02
Prophylactic efficacy of topical temporin A and RNAIII-inhibiting peptide in a subcutaneous rat Pouch model of graft infection attributable to staphylococci with intermediate resistance to glycopeptides. Circulation (2003) 1.02
Leishmania major abrogates gamma interferon-induced gene expression in human macrophages from a global perspective. Infect Immun (2007) 1.00
In vitro activity of the histatin derivative P-113 against multidrug-resistant pathogens responsible for pneumonia in immunocompromised patients. Antimicrob Agents Chemother (2005) 1.00
Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J Biol Chem (2010) 0.98
Modulation of autoimmunity by treatment of an infectious disease. Infect Immun (2007) 0.98
Captopril prevents experimental autoimmune myocarditis. J Immunol (2003) 0.98
Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunity. PLoS One (2011) 0.97
Global analysis of protein palmitoylation in African trypanosomes. Eukaryot Cell (2010) 0.97
A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins. Infect Immun (2004) 0.97
Structure activity relationship studies on the antimicrobial activity of novel edeine A and D analogues. J Pept Sci (2006) 0.96
Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival. PLoS Negl Trop Dis (2011) 0.95
Molecular determinants and regulation of Leishmania virulence. Kinetoplastid Biol Dis (2002) 0.95
Responsive microtubule dynamics promote cell invasion by Trypanosoma cruzi. Cell Microbiol (2005) 0.95
Potential therapeutic role of cationic peptides in three experimental models of septic shock. Antimicrob Agents Chemother (2002) 0.94
Efficacy of tachyplesin III, colistin, and imipenem against a multiresistant Pseudomonas aeruginosa strain. Antimicrob Agents Chemother (2007) 0.94
Secreted virulence factors and immune evasion in visceral leishmaniasis. J Leukoc Biol (2012) 0.94
The significance of autoimmunity in the pathogenesis of Chagas heart disease. Front Biosci (2003) 0.94
Molecular determinants of ciliary membrane localization of Trypanosoma cruzi flagellar calcium-binding protein. J Biol Chem (2011) 0.93
Leishmania: conserved evolution--diverse diseases. Trends Parasitol (2008) 0.93
Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation. Infect Immun (2008) 0.92
Computational biomarker pipeline from discovery to clinical implementation: plasma proteomic biomarkers for cardiac transplantation. PLoS Comput Biol (2013) 0.92
Temporin A alone and in combination with imipenem reduces lethality in a mouse model of staphylococcal sepsis. J Infect Dis (2005) 0.91
Comparing selection on S. aureus between antimicrobial peptides and common antibiotics. PLoS One (2013) 0.91
Potential therapeutic role of histatin derivative P-113d in experimental rat models of Pseudomonas aeruginosa sepsis. J Infect Dis (2004) 0.90
Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials. Vaccine (2005) 0.90
Captopril ameliorates myocarditis in acute experimental Chagas disease. Circulation (2003) 0.90
Temporin A is effective in MRSA-infected wounds through bactericidal activity and acceleration of wound repair in a murine model. Peptides (2008) 0.90
The role of Glycyrrhizin, an inhibitor of HMGB1 protein, in anticancer therapy. Arch Immunol Ther Exp (Warsz) (2012) 0.88
Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection. Cell Microbiol (2011) 0.88
Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity. Autoimmunity (2008) 0.87
Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease. J Immunol (2003) 0.87
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. Int J Cardiol (2007) 0.87
In vitro activity and killing effect of the synthetic hybrid cecropin A-melittin peptide CA(1-7)M(2-9)NH(2) on methicillin-resistant nosocomial isolates of Staphylococcus aureus and interactions with clinically used antibiotics. Diagn Microbiol Infect Dis (2004) 0.86
Comparative activities of cecropin A, melittin, and cecropin A-melittin peptide CA(1-7)M(2-9)NH2 against multidrug-resistant nosocomial isolates of Acinetobacter baumannii. Peptides (2003) 0.86
Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection. Infect Immun (2009) 0.86
Mechanisms of cellular invasion by intracellular parasites. Cell Mol Life Sci (2013) 0.86
Safety profile of antimicrobial peptides: camel, citropin, protegrin, temporin a and lipopeptide on HaCaT keratinocytes. Acta Pol Pharm (2013) 0.85
Therapeutic efficacy of the magainin analogue MSI-78 in different intra-abdominal sepsis rat models. J Antimicrob Chemother (2004) 0.85
Temporin A as a prophylactic agent against methicillin sodium-susceptible and methicillin sodium-resistant Staphylococcus epidermidis vascular graft infection. J Vasc Surg (2002) 0.83
Antimicrobial peptides as potential tool to fight bacterial biofilm. Acta Pol Pharm (2014) 0.82
A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers. BMC Bioinformatics (2012) 0.82
Activity of short lipopeptides and conventional antimicrobials against planktonic cells and biofilms formed by clinical strains of Staphylococcus aureus. Future Med Chem (2012) 0.82
Novel multivariate methods for integration of genomics and proteomics data: applications in a kidney transplant rejection study. OMICS (2014) 0.82
In vitro activity of MSI-78 alone and in combination with antibiotics against bacteria responsible for bloodstream infections in neutropenic patients. Int J Antimicrob Agents (2005) 0.82
In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci. Antimicrob Agents Chemother (2007) 0.82
In vitro susceptibility of dermatophytes to conventional and alternative antifungal agents. Med Mycol (2008) 0.82
Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease. Trends Parasitol (2006) 0.82
Modes of action of Leishmanicidal antimicrobial peptides. Future Microbiol (2012) 0.82
Flagellar membrane trafficking in kinetoplastids. Parasitol Res (2006) 0.82
Characterization of the effects of opiorphin and sialorphin and their analogs substituted in position 1 with pyroglutamic acid on motility in the mouse ileum. J Pept Sci (2013) 0.82
Activity of Antimicrobial Peptides and Conventional Antibiotics against Superantigen Positive Staphylococcus aureus Isolated from the Patients with Neoplastic and Inflammatory Erythrodermia. Chemother Res Pract (2011) 0.82
In vitro activity of the synthetic lipopeptide PAL-Lys-Lys-NH(2) alone and in combination with antifungal agents against clinical isolates of Cryptococcus neoformans. Peptides (2007) 0.81
Voriconazole suppresses the growth of Leishmania species in vitro. Parasitol Res (2013) 0.81
Anticancer effects of CAMEL peptide. Lab Invest (2010) 0.81
The role of liposome charge on immune response generated in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63). Exp Parasitol (2009) 0.81