Published in Acad Med on April 01, 2010
Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study. Acad Med (2014) 4.17
A national cohort study of MD-PhD graduates of medical schools with and without funding from the National Institute of General Medical Sciences' Medical Scientist Training Program. Acad Med (2011) 2.71
Bridging the translational research gap: a successful partnership involving a physician and a basic scientist. J Invest Dermatol (2010) 2.11
Clinician-investigators as translational bioscientists: shaping a seamless identity. Sci Transl Med (2012) 1.84
Should MD-PhD programs encourage graduate training in disciplines beyond conventional biomedical or clinical sciences? Acad Med (2015) 1.49
Rescuing the physician-scientist workforce: the time for action is now. J Clin Invest (2015) 1.25
Individual characteristics and student's engagement in scientific research: a cross-sectional study. BMC Med Educ (2012) 1.24
Medical Student Research: An Integrated Mixed-Methods Systematic Review and Meta-Analysis. PLoS One (2015) 1.16
Challenges and opportunities for reinvigorating the physician-scientist pipeline. J Clin Invest (2015) 1.11
Advancing pharmacist scholarship and research within academic pharmacy. Am J Pharm Educ (2012) 1.03
Predictors of full-time faculty appointment among MD-PhD program graduates: a national cohort study. Med Educ Online (2016) 0.99
The emerging physician-scientist workforce: demographic, experiential, and attitudinal predictors of MD-PhD program enrollment. Acad Med (2014) 0.93
An innovative portfolio of research training programs for medical students. Immunol Res (2012) 0.90
Incubating the research independence of a medical scientist training program graduate: a case study. Acad Med (2015) 0.88
Clinician-Investigator Training and the Need to Pilot New Approaches to Recruiting and Retaining This Workforce. Acad Med (2017) 0.86
Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers. BMC Med Educ (2017) 0.86
Characteristics and outcomes of Canadian MD/PhD program graduates: a cross-sectional survey. CMAJ Open (2017) 0.85
Do research activities during college, medical school, and residency mediate racial/ethnic disparities in full-time faculty appointments at U.S. Medical schools? Acad Med (2012) 0.84
Integrating clinical medicine into biomedical graduate education to promote translational research: strategies from two new PhD programs. Acad Med (2013) 0.82
Validity of the Medical College Admission Test for predicting MD-PhD student outcomes. Adv Health Sci Educ Theory Pract (2015) 0.81
Outcomes From the NIH Clinical Research Training Program: A Mentored Research Experience to Enhance Career Development of Clinician-Scientists. Acad Med (2016) 0.81
Clinician-scientist MB/PhD training in the UK: a nationwide survey of medical school policy. BMJ Open (2015) 0.81
Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training. Acad Med (2013) 0.80
A clinical refresher course for medical scientist trainees. Med Teach (2014) 0.79
Publication activities of German junior researchers in academic medicine: which factors impact impact factors? BMC Med Educ (2016) 0.78
Editorial: The vulnerable physician-scientist. Mol Endocrinol (2014) 0.76
The urgent need to increase support for the NIH's MD-PhD student fellowships. Acad Med (2011) 0.75
Low immediate scientific yield of the PhD among medical doctors. BMC Med Educ (2016) 0.75
Advanced degrees in academic colorectal surgery. Clin Colon Rectal Surg (2013) 0.75
[Professional paths of alumni from doctorate programs in health and biological sciences]. Rev Saude Publica (2014) 0.75
The first nationwide survey of MD-PhDs in the social sciences and humanities: training patterns and career choices. BMC Med Educ (2017) 0.75
Factors associated with physicians' choice of a career in research: a retrospective report 15 years after medical school graduation. Adv Health Sci Educ Theory Pract (2016) 0.75
Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship. J Grad Med Educ (2016) 0.75
The Rockefeller University Graduate Tracking Survey System. Clin Transl Sci (2014) 0.75
Developing physician-scientists: a perspective. Trans Am Clin Climatol Assoc (2013) 0.75
[MD PhD programs: Providing basic science education for ophthalmologists]. Ophthalmologe (2015) 0.75
History and Outcomes of 50 Years of Physician-Scientist Training in Medical Scientist Training Programs. Acad Med (2017) 0.75
Cross-sectional-derived determinants of satisfaction with physician-scientist training among Canadian MD/PhD graduates. PLoS One (2017) 0.75
Influence of controllable lifestyle on recent trends in specialty choice by US medical students. JAMA (2003) 14.06
The physician-scientist career pipeline in 2005: build it, and they will come. JAMA (2005) 8.22
Characteristics and career intentions of the emerging MD/PhD workforce. JAMA (2008) 5.96
The clinical investigator: bewitched, bothered, and bewildered--but still beloved. J Clin Invest (1997) 4.09
Effect of two Howard Hughes Medical Institute research training programs for medical students on the likelihood of pursuing research careers. Acad Med (2003) 3.65
The physician-scientist: career issues and challenges at the year 2000. FASEB J (2000) 3.38
The physician-scientist: an essential--and fragile--link in the medical research chain. J Clin Invest (1999) 3.09
New physician-investigators receiving National Institutes of Health research project grants: a historical perspective on the "endangered species". JAMA (2007) 2.59
Educating future leaders of medical research: analysis of student opinions and goals from the MD-PhD SAGE (Students' Attitudes, Goals, and Education) survey. Acad Med (2007) 2.35
Educational views and attitudes, and career goals of MD-PhD students at the University of Pennsylvania School of Medicine. Acad Med (2005) 2.13
Trends in career choice by US medical school graduates. JAMA (2003) 2.07
The need to restructure MD-PhD training. Acad Med (2007) 2.01
M.D.-Ph.D. training at the Johns Hopkins University School of Medicine, 1962-1991. Acad Med (1992) 1.96
The other physician-scientist problem: where have all the young girls gone? Nat Med (2002) 1.94
MD/PhD programs--a call for an accounting. JAMA (2008) 1.92
Career characteristics of graduates of a Medical Scientist Training Program, 1970-1990. Acad Med (1996) 1.58
MD-PhD students in a major training program show strong interest in becoming surgeon-scientists. Clin Orthop Relat Res (2004) 1.28
Career choices of graduates from Washington University's Medical Scientist Training Program. Acad Med (1991) 1.18
Training physician-scientists for the 1990s. Acad Med (1991) 1.05
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell (2006) 4.84
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature (2004) 3.12
Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci (2005) 2.91
Energetics of ion conduction through the gramicidin channel. Proc Natl Acad Sci U S A (2003) 2.67
The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol (2006) 2.10
Modeling host responses in ferrets during A/California/07/2009 influenza infection. Virology (2010) 1.93
Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. J Gen Physiol (2004) 1.83
Defining the propofol binding site location on the GABAA receptor. Mol Pharmacol (2004) 1.77
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. J R Soc Interface (2009) 1.77
Structure of gramicidin a in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data. J Am Chem Soc (2003) 1.61
Ion permeation through a narrow channel: using gramicidin to ascertain all-atom molecular dynamics potential of mean force methodology and biomolecular force fields. Biophys J (2006) 1.61
Molecular dynamics - potential of mean force calculations as a tool for understanding ion permeation and selectivity in narrow channels. Biophys Chem (2006) 1.57
Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics. Biochemistry (2003) 1.55
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. Am J Physiol Cell Physiol (2007) 1.52
GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. J Neurosci (2009) 1.50
Key role of T cell defects in age-related vulnerability to West Nile virus. J Exp Med (2009) 1.50
Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop. J Gen Physiol (2008) 1.49
Flagellar membrane localization via association with lipid rafts. J Cell Sci (2009) 1.49
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode. Chem Biol (2012) 1.49
Experience with multimodality telepathology at the University of Pittsburgh Medical Center. J Pathol Inform (2012) 1.49
The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol (2008) 1.48
Docosahexaenoic acid alters bilayer elastic properties. Proc Natl Acad Sci U S A (2007) 1.48
Telepathology for intraoperative neuropathologic consultations at an academic medical center: a 5-year report. J Neuropathol Exp Neurol (2007) 1.47
State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments. J Neurosci (2006) 1.44
Models and mechanistic insight. J Gen Physiol (2008) 1.44
Molecular mechanisms of protein and lipid targeting to ciliary membranes. J Cell Sci (2010) 1.43
The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer Res (2007) 1.42
Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol (2014) 1.39
Fatal fulminant pan-meningo-polioencephalitis due to West Nile virus. Brain Pathol (2003) 1.36
Curcumin is a modulator of bilayer material properties. Biochemistry (2007) 1.34
A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors. J Neurosci (2005) 1.33
Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility. J Biol Chem (2011) 1.33
Systemic distribution of West Nile virus infection: postmortem immunohistochemical study of six cases. Brain Pathol (2007) 1.30
Molecular imaging of microglia/macrophages in the brain. Glia (2012) 1.29
Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction. Circ Res (2013) 1.27
Comparison of telepathology systems in neuropathological intraoperative consultations. Neuropathology (2009) 1.27
Amphiphile regulation of ion channel function by changes in the bilayer spring constant. Proc Natl Acad Sci U S A (2010) 1.26
Chagas heart disease pathogenesis: one mechanism or many? Curr Mol Med (2008) 1.26
Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane. J Cell Sci (2009) 1.24
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. Am J Pathol (2008) 1.23
Bioluminescent imaging of Trypanosoma cruzi infection. Int J Parasitol (2008) 1.23
Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence. J Biol Chem (2002) 1.21
Killing of African trypanosomes by antimicrobial peptides. J Infect Dis (2003) 1.21
Hydrophobic coupling of lipid bilayer energetics to channel function. J Gen Physiol (2003) 1.20
Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol Biochem Parasitol (2009) 1.20
In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. J Neuroinflammation (2010) 1.20
GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating. J Biol Chem (2002) 1.18
The location of a closed channel gate in the GABAA receptor channel. J Gen Physiol (2007) 1.18
Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. J Neurosci (2002) 1.17
Influence of hydrophobic mismatch on structures and dynamics of gramicidin a and lipid bilayers. Biophys J (2012) 1.15
PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS. J Clin Invest (2004) 1.15
Brain extracellular matrix in neurodegeneration. Brain Pathol (2008) 1.15
Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophys J (2011) 1.15
The preference of tryptophan for membrane interfaces: insights from N-methylation of tryptophans in gramicidin channels. J Biol Chem (2008) 1.14
Psychostimulant abuse and neuroinflammation: emerging evidence of their interconnection. Neurotox Res (2012) 1.14
Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63. Infect Immun (2003) 1.13
The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders. J Neuropathol Exp Neurol (2008) 1.12
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging. Exp Neurol (2007) 1.12
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation. J Neurochem (2007) 1.12
Imaging microglial activation during neuroinflammation and Alzheimer's disease. J Neuroimmune Pharmacol (2008) 1.11
Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. J Cell Sci (2008) 1.10
The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing. Mol Microbiol (2006) 1.10
Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron (2012) 1.09
A flagellum-specific calcium sensor. J Biol Chem (2005) 1.09
Screening for small molecules' bilayer-modifying potential using a gramicidin-based fluorescence assay. Assay Drug Dev Technol (2010) 1.08
Composition and sensory function of the trypanosome flagellar membrane. Curr Opin Microbiol (2010) 1.08
Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment. J Biol Chem (2004) 1.08
Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis. Am J Pathol (2002) 1.07
Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry. Autoimmunity (2006) 1.07
Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8+ T-cell-depleted macaques that develop lentiviral encephalitis. Am J Pathol (2006) 1.06
Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum. J Biol Chem (2008) 1.06
Calflagin inhibition prolongs host survival and suppresses parasitemia in Trypanosoma brucei infection. Eukaryot Cell (2010) 1.05
Molecular mechanisms of host cell invasion by Trypanosoma cruzi. Exp Parasitol (2010) 1.04
Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi. J Biol Chem (2008) 1.02
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. PLoS One (2013) 1.01
GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates. PLoS One (2010) 1.01
Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Mol Biochem Parasitol (2009) 1.01
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiol Aging (2008) 1.00
Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation. Brain Pathol (2011) 0.99
Structural evidence that propofol stabilizes different GABA(A) receptor states at potentiating and activating concentrations. J Neurosci (2002) 0.99
2,3-butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylation-independent mechanisms: the role of bilayer material properties. Mol Pharmacol (2006) 0.99
Alcohol's effects on lipid bilayer properties. Biophys J (2011) 0.99
Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J Biol Chem (2010) 0.98
Human immunodeficiency virus infection of the brain: pitfalls in evaluating infected/affected cell populations. Brain Pathol (2004) 0.98
Comment on "Free energy simulations of single and double ion occupancy in gramicidin A" [J. Chem. Phys. 126, 105103 (2007)]. J Chem Phys (2008) 0.98
Modulation of autoimmunity by treatment of an infectious disease. Infect Immun (2007) 0.98
Captopril prevents experimental autoimmune myocarditis. J Immunol (2003) 0.98
A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection. J Infect Dis (2012) 0.98
An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Math Biosci (2011) 0.98
Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation. J Biol Chem (2004) 0.97
Global analysis of protein palmitoylation in African trypanosomes. Eukaryot Cell (2010) 0.97
Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment. Biophys J (2007) 0.97
Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunity. PLoS One (2011) 0.97
A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins. Infect Immun (2004) 0.97
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery. J Gen Physiol (2011) 0.96
Responsive microtubule dynamics promote cell invasion by Trypanosoma cruzi. Cell Microbiol (2005) 0.95
The significance of autoimmunity in the pathogenesis of Chagas heart disease. Front Biosci (2003) 0.94
Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms. Neuron (2010) 0.93
Molecular determinants of ciliary membrane localization of Trypanosoma cruzi flagellar calcium-binding protein. J Biol Chem (2011) 0.93