Published in Endocr Rev on October 31, 2006
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab (2011) 3.68
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09
Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem (2010) 2.53
Sixteen years and counting: an update on leptin in energy balance. J Clin Invest (2011) 2.21
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev (2010) 2.09
Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci U S A (2010) 2.04
Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci (2011) 1.93
Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J Neurosci (2009) 1.92
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science (2013) 1.76
Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci (2010) 1.73
Leptin revisited: its mechanism of action and potential for treating diabetes. Nat Rev Drug Discov (2012) 1.63
Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metab (2011) 1.61
The melanocortin-3 receptor is required for entrainment to meal intake. J Neurosci (2008) 1.49
Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res (2015) 1.45
Hypothalamic leptin action is mediated by histone deacetylase 5. Nat Commun (2016) 1.39
Leptin and the systems neuroscience of meal size control. Front Neuroendocrinol (2009) 1.35
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009) 1.33
Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics (2007) 1.32
MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A (2009) 1.31
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nat Rev Drug Discov (2012) 1.29
The renaissance of corticotropin therapy in proteinuric nephropathies. Nat Rev Nephrol (2011) 1.28
Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci (2010) 1.25
A beta3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress. Biol Psychiatry (2010) 1.24
Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice. Neuroscience (2009) 1.21
Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions. J Comp Neurol (2010) 1.19
Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Cell Metab (2012) 1.18
Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides (2009) 1.16
Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Sci Signal (2010) 1.08
Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes (2008) 1.07
Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. FASEB J (2009) 1.07
Intracellular leptin-signaling pathways in hypothalamic neurons: the emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway. Neuroendocrinology (2011) 1.05
Melanocortin-4 receptor-regulated energy homeostasis. Nat Neurosci (2016) 1.05
Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area. J Comp Neurol (2012) 1.05
Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus. Endocrinology (2009) 1.03
Regional astrogliosis in the mouse hypothalamus in response to obesity. J Comp Neurol (2013) 1.02
Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. J Biol Chem (2013) 0.99
Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis. J Biol Chem (2011) 0.98
Brain regulation of energy balance and body weight. Rev Endocr Metab Disord (2013) 0.96
Leveraging melanocortin pathways to treat glomerular diseases. Adv Chronic Kidney Dis (2014) 0.95
Dorsomedial hypothalamic NPY and energy balance control. Neuropeptides (2012) 0.95
Identification of an MRAP-independent melanocortin-2 receptor: functional expression of the cartilaginous fish, Callorhinchus milii, melanocortin-2 receptor in CHO cells. Endocrinology (2012) 0.95
RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals. J Clin Endocrinol Metab (2015) 0.94
The role of transcriptional regulators in central control of appetite and body weight. Nat Clin Pract Endocrinol Metab (2009) 0.94
Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling. Peptides (2009) 0.92
Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice. Endocrinology (2007) 0.92
Enhanced blood pressure and appetite responses to chronic central melanocortin-3/4 receptor blockade in dietary-induced obesity. J Hypertens (2010) 0.91
Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research. Endocr Rev (2012) 0.91
Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations. Biochim Biophys Acta (2011) 0.90
Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice. Proc Natl Acad Sci U S A (2013) 0.89
The role of melanocortin neuronal pathways in circadian biology: a new homeostatic output involving melanocortin-3 receptors? Obes Rev (2009) 0.89
Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism. Physiol Behav (2011) 0.88
Estrogen rapidly attenuates cannabinoid-induced changes in energy homeostasis. Eur J Pharmacol (2009) 0.88
Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and -independent mechanisms. Kidney Int (2013) 0.88
Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism. J Mol Biol (2010) 0.88
Altered feeding and body weight following melanocortin administration to the ventral tegmental area in adult rats. Psychopharmacology (Berl) (2012) 0.88
Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. Proc Natl Acad Sci U S A (2013) 0.87
Assessment of voluntary ethanol consumption and the effects of a melanocortin (MC) receptor agonist on ethanol intake in mutant C57BL/6J mice lacking the MC-4 receptor. Alcohol Clin Exp Res (2011) 0.87
The melanocortin receptors and their accessory proteins. Front Endocrinol (Lausanne) (2013) 0.87
Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. Eur J Pharmacol (2011) 0.87
Dorsomedial hypothalamic NPY modulation of adiposity and thermogenesis. Physiol Behav (2013) 0.86
Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab (2014) 0.85
Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression. J Biol Chem (2012) 0.85
Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake. Endocrinol Metab (Seoul) (2015) 0.84
Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). Am J Physiol Regul Integr Comp Physiol (2009) 0.83
Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes. J Mol Endocrinol (2010) 0.83
β-Endorphin antagonizes the effects of α-MSH on food intake and body weight. Endocrinology (2012) 0.83
Role of reactive oxygen species in hypothalamic regulation of energy metabolism. Endocrinol Metab (Seoul) (2013) 0.83
Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity. Biochem Pharmacol (2008) 0.83
Targeting protein-protein interfaces using macrocyclic peptides. Biopolymers (2015) 0.83
Signature of balancing selection at the MC1R gene in Kunming dog populations. PLoS One (2013) 0.82
Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans. J Clin Endocrinol Metab (2013) 0.82
Knockdown of neuropeptide Y in the dorsomedial hypothalamus reverses high-fat diet-induced obesity and impaired glucose tolerance in rats. Am J Physiol Regul Integr Comp Physiol (2015) 0.82
Development of the hypothalamic melanocortin system. Front Endocrinol (Lausanne) (2013) 0.82
New Insights in Anorexia Nervosa. Front Neurosci (2016) 0.81
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. J Med Chem (2015) 0.81
Pharmacodynamics and tolerability of repository corticotropin injection in healthy human subjects: A comparison with intravenous methylprednisolone. J Clin Pharmacol (2015) 0.81
NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius, of type-II diabetic patients. PLoS One (2012) 0.81
Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling. Peptides (2010) 0.80
Alpha-melanocyte stimulating hormone: an emerging anti-inflammatory antimicrobial peptide. Biomed Res Int (2014) 0.80
Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance. Physiol Genomics (2016) 0.80
Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells. Mol Cell Endocrinol (2012) 0.80
Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects. J Appl Genet (2013) 0.80
Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems. Curr Top Med Chem (2009) 0.80
Pale and dark reddish melanic tawny owls differentially regulate the level of blood circulating POMC prohormone in relation to environmental conditions. Oecologia (2011) 0.80
Unravelling the mysterious roles of melanocortin-3 receptors in metabolic homeostasis and obesity using mouse genetics. Int J Obes Suppl (2014) 0.80
60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH. J Mol Endocrinol (2016) 0.79
Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J Med Chem (2015) 0.79
The role of rs2237781 within GRM8 in eating behavior. Brain Behav (2013) 0.79
Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. J Med Chem (2009) 0.79
High-fat diet offsets the long-lasting effects of running-wheel access on food intake and body weight in OLETF rats. Am J Physiol Regul Integr Comp Physiol (2011) 0.79
Neurobiology of inflammation-associated anorexia. Front Neurosci (2010) 0.79
Developmental specification of metabolic circuitry. Front Neuroendocrinol (2015) 0.79
Decreased consumption of rewarding sucrose solutions after injection of melanocortins into the ventral tegmental area of rats. Psychopharmacology (Berl) (2014) 0.79
Observations on the evolution of the melanocortin receptor gene family: distinctive features of the melanocortin-2 receptor. Front Neurosci (2013) 0.79
Biological Significance of GPCR Heteromerization in the Neuro-Endocrine System. Front Endocrinol (Lausanne) (2011) 0.78
Living without insulin: the role of leptin signaling in the hypothalamus. Front Neurosci (2015) 0.78
Approaches to the rational design of selective melanocortin receptor antagonists. Expert Opin Drug Discov (2011) 0.78
The melanocortin 3 receptor: a novel mediator of exercise-induced inflammation reduction in postmenopausal women? J Aging Res (2011) 0.78
Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes. BMC Res Notes (2015) 0.77