Published in J Neurosci on August 24, 2011
Leptin mediates the increase in blood pressure associated with obesity. Cell (2014) 3.09
GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell (2012) 2.34
Central neural regulation of brown adipose tissue thermogenesis and energy expenditure. Cell Metab (2014) 1.85
Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab (2014) 1.81
Selective leptin resistance revisited. Am J Physiol Regul Integr Comp Physiol (2013) 1.21
FOXO1 in the ventromedial hypothalamus regulates energy balance. J Clin Invest (2012) 1.13
Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake. Mol Metab (2014) 1.11
Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell (2015) 1.11
Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice. J Neurosci (2013) 1.03
The brain and brown fat. Ann Med (2014) 1.02
Sympathetic and catecholaminergic alterations in sleep apnea with particular emphasis on children. Front Neurol (2012) 0.99
Structure, production and signaling of leptin. Metabolism (2014) 0.98
Anterograde transneuronal viral tract tracing reveals central sensory circuits from brown fat and sensory denervation alters its thermogenic responses. Am J Physiol Regul Integr Comp Physiol (2012) 0.97
Brain regulation of energy balance and body weight. Rev Endocr Metab Disord (2013) 0.96
Neural melanocortin receptors in obesity and related metabolic disorders. Biochim Biophys Acta (2013) 0.96
Direct and indirect effects of leptin on adipocyte metabolism. Biochim Biophys Acta (2013) 0.95
Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice. J Neurosci (2013) 0.94
The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab (2014) 0.93
Estrogen receptor-α in medial amygdala neurons regulates body weight. J Clin Invest (2015) 0.93
Central nervous system regulation of brown adipose tissue. Compr Physiol (2014) 0.93
Cognitive and autonomic determinants of energy homeostasis in obesity. Nat Rev Endocrinol (2015) 0.91
Glutamate release mediates leptin action on energy expenditure. Mol Metab (2013) 0.91
Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models. J Comp Neurol (2013) 0.91
Hypothalamic control of brown adipose tissue thermogenesis. Front Syst Neurosci (2015) 0.90
The role of leptin in glucose homeostasis. J Diabetes Investig (2012) 0.90
Chemoreceptors, baroreceptors, and autonomic deregulation in children with obstructive sleep apnea. Respir Physiol Neurobiol (2012) 0.88
Dynamic GABAergic afferent modulation of AgRP neurons. Nat Neurosci (2016) 0.87
Leptin acts in the forebrain to differentially influence baroreflex control of lumbar, renal, and splanchnic sympathetic nerve activity and heart rate. Hypertension (2013) 0.87
Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism. Mol Metab (2012) 0.87
Role of the Paraventricular Nucleus of the Hypothalamus in the Sympathoexcitatory Effects of Leptin. Hypertension (2015) 0.86
Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. Am J Physiol Regul Integr Comp Physiol (2014) 0.85
Physiological Roles of GPR10 and PrRP Signaling. Front Endocrinol (Lausanne) (2013) 0.85
Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver. Cell Metab (2015) 0.85
Leptin activates oxytocin neurons of the hypothalamic paraventricular nucleus in both control and diet-induced obese rodents. PLoS One (2013) 0.85
Expanding neurotransmitters in the hypothalamic neurocircuitry for energy balance regulation. Protein Cell (2011) 0.84
Ascent to altitude as a weight loss method: the good and bad of hypoxia inducible factor activation. Obesity (Silver Spring) (2013) 0.84
Integration of sensory information via central thermoregulatory leptin targets. Physiol Behav (2013) 0.84
Rapid onset and reversal of peripheral and central leptin resistance in rats offered chow, sucrose solution, and lard. Appetite (2012) 0.83
Central mechanisms of adiposity in adult female mice with androgen excess. Obesity (Silver Spring) (2014) 0.82
Comparison of blood monocytes and adipose tissue macrophages in a mouse model diet-induced weight gain. Comp Med (2012) 0.82
Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin. Clin Auton Res (2012) 0.82
Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism. Mol Metab (2015) 0.81
Central Leptin Regulation of Obesity and Fertility. Curr Obes Rep (2012) 0.81
Differences in the metabolic status of healthy adults with and without active brown adipose tissue. Wien Klin Wochenschr (2013) 0.80
Mice fed fish oil diet and upregulation of brown adipose tissue thermogenic markers. Eur J Nutr (2015) 0.80
Metabolic transceivers: in tune with the central melanocortin system. Trends Endocrinol Metab (2012) 0.80
Brown adipose tissue thermogenesis in the resistance to and reversal of obesity: A potential new mechanism contributing to the metabolic benefits of proglucagon-derived peptides. Adipocyte (2013) 0.80
Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis. J Neurosci (2016) 0.80
Counterregulation of insulin by leptin as key component of autonomic regulation of body weight. World J Diabetes (2014) 0.79
Leptin increasing sympathetic nerve outflow in obesity: A cure for obesity or a potential contributor to metabolic syndrome? Adipocyte (2012) 0.79
Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity. Front Physiol (2015) 0.78
Living without insulin: the role of leptin signaling in the hypothalamus. Front Neurosci (2015) 0.78
Novel aspects of brown adipose tissue biology. Endocrinol Metab Clin North Am (2012) 0.78
Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus. Am J Physiol Endocrinol Metab (2014) 0.78
Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations. J Clin Invest (2016) 0.77
Evolution of the Marrow Adipose Tissue Microenvironment. Calcif Tissue Int (2016) 0.77
In vivo evidence for unidentified leptin-induced circulating factors that control white fat mass. Am J Physiol Regul Integr Comp Physiol (2015) 0.77
Excess of nerve growth factor in the ovary causes a polycystic ovary-like syndrome in mice, which closely resembles both reproductive and metabolic aspects of the human syndrome. Endocrinology (2014) 0.77
Distinct networks of leptin- and insulin-sensing neurons regulate thermogenic responses to nutritional and cold challenges. Diabetes (2014) 0.77
The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice. Learn Mem (2013) 0.76
Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain. Am J Physiol Endocrinol Metab (2013) 0.76
Neural Control of Energy Expenditure. Handb Exp Pharmacol (2016) 0.76
SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes. Mol Metab (2014) 0.76
Neuronal Control of Adaptive Thermogenesis. Front Endocrinol (Lausanne) (2015) 0.76
Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists. Biochem Biophys Res Commun (2014) 0.76
Metabolic inflexibility of white and brown adipose tissues in abnormal fatty acid partitioning of type 2 diabetes. Int J Obes Suppl (2012) 0.76
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway. Redox Biol (2017) 0.75
Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity. Aging Cell (2014) 0.75
Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life. Cell Rep (2016) 0.75
α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors. Mol Metab (2016) 0.75
Preclinical models for obesity research. Dis Model Mech (2016) 0.75
Determination of the half life of circulating leptin in the mouse. Int J Obes (Lond) (2016) 0.75
Leptin Resistance and the Neuro-Adipose Connection. Front Endocrinol (Lausanne) (2017) 0.75
Leptin action in the brain: How (and when) it makes fat burn. Mol Metab (2013) 0.75
The Role of PVH Circuits in Leptin Action and Energy Balance. Annu Rev Physiol (2016) 0.75
Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity. BMC Obes (2014) 0.75
Preserving of Postnatal Leptin Signaling in Obesity-Resistant Lou/C Rats following a Perinatal High-Fat Diet. PLoS One (2016) 0.75
A quick look at obesity; the enemy within. Gastroenterol Hepatol Bed Bench (2011) 0.75
Sex differences in the effects of androgens acting in the central nervous system on metabolism. Dialogues Clin Neurosci (2016) 0.75
Why leptin keeps you warm. Mol Metab (2014) 0.75
Leptin upregulation in advanced multiple system atrophy with hypocholesterolemia and unexpected fat accumulation. Neurol Sci (2015) 0.75
The role of leptin in health and disease. Temperature (Austin) (2017) 0.75
Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 11.35
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature (2001) 8.95
Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell (2005) 7.04
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology (2004) 4.10
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol (1994) 3.88
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab (2007) 3.43
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37
Studies on the physiological functions of the melanocortin system. Endocr Rev (2006) 3.11
Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci (2003) 3.08
A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes (2010) 3.04
Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med (2008) 2.86
The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab (2010) 2.80
Central control of thermogenesis in mammals. Exp Physiol (2008) 2.74
Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem (2010) 2.53
Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes (2005) 2.24
Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat. Endocrinology (2003) 2.14
The dorsomedial hypothalamus: a new player in thermoregulation. Am J Physiol Regul Integr Comp Physiol (2006) 2.10
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci U S A (2000) 2.02
Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension (1999) 1.82
Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci (2011) 1.82
Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesis. Endocrinology (2007) 1.77
Sympathetic and sensory innervation of brown adipose tissue. Int J Obes (Lond) (2010) 1.71
Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology (2006) 1.71
The melanocortin system and energy balance. Peptides (2006) 1.64
Interactions between leptin and the human sympathetic nervous system. Hypertension (2003) 1.44
The role of leptin in leptin resistance and obesity. Physiol Behav (2006) 1.41
Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence. Am J Physiol Regul Integr Comp Physiol (2008) 1.41
Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes (2002) 1.37
The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes (2002) 1.37
Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. Am J Physiol Regul Integr Comp Physiol (2006) 1.31
Independent and additive effects of central POMC and leptin pathways on murine obesity. Science (1997) 1.31
Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett (1998) 1.29
Cardiovascular responses evoked by leptin acting on neurons in the ventromedial and dorsomedial hypothalamus. Hypertension (2003) 1.24
Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. Am J Physiol (1998) 1.22
Mechanisms mediating renal sympathetic activation to leptin in obesity. Am J Physiol Regul Integr Comp Physiol (2008) 1.20
Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach. J Comp Neurol (2010) 1.19
Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin. FASEB J (2005) 1.15
Central leptin regulates the UCP1 and ob genes in brown and white adipose tissue via different beta-adrenoceptor subtypes. J Biol Chem (2000) 1.08
Diet-induced obese mice are leptin insufficient after weight reduction. Obesity (Silver Spring) (2009) 1.04
Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists. Protein Expr Purif (2005) 1.02
Induction of Fos-immunoreactivity in the rat brain following disinhibition of the dorsomedial hypothalamus. Brain Res (2008) 0.99
High-circulating leptin levels are associated with greater risk of hypertension in men independently of body mass and insulin resistance: results of an eight-year follow-up study. J Clin Endocrinol Metab (2008) 0.95
High fat feeding is associated with increased blood pressure, sympathetic nerve activity and hypothalamic mu opioid receptors. Brain Res Bull (2003) 0.95
Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis. Neuropsychopharmacology (2007) 0.91
A study of VitalView for behavioural and physiological monitoring in laboratory rats. Physiol Behav (2002) 0.91
Gut hormone PYY(3-36) physiologically inhibits food intake. Nature (2002) 8.30
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron (2006) 5.27
Mechanisms of leptin action and leptin resistance. Annu Rev Physiol (2008) 4.72
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature (2007) 4.20
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab (2007) 3.43
Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res (2002) 3.29
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest (2008) 2.77
Activation of central melanocortin pathways by fenfluramine. Science (2002) 2.71
Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron (2006) 2.16
Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci U S A (2010) 2.04
Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes (2012) 1.91
Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circ Res (2002) 1.81
Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesis. Endocrinology (2007) 1.77
Rational design of a combination medication for the treatment of obesity. Obesity (Silver Spring) (2008) 1.71
Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci (2007) 1.66
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest (2014) 1.61
Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest (2007) 1.56
Comparison of combined bupropion and naltrexone therapy for obesity with monotherapy and placebo. J Clin Endocrinol Metab (2009) 1.52
Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons. Endocrinology (2010) 1.45
Leptin resistance and obesity. Obesity (Silver Spring) (2006) 1.41
Regulation of central melanocortin signaling by interleukin-1 beta. Endocrinology (2007) 1.34
Starvation after AgRP neuron ablation is independent of melanocortin signaling. Proc Natl Acad Sci U S A (2008) 1.32
Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet. Endocrinology (2010) 1.25
Central serotonin and melanocortin pathways regulating energy homeostasis. Ann N Y Acad Sci (2003) 1.24
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab (2011) 1.21
The electrophysiology of feeding circuits. Trends Endocrinol Metab (2004) 1.14
Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology (2008) 1.13
Ghrelin--satisfying a hunger for the mechanism. Endocrinology (2004) 1.09
Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss. J Clin Endocrinol Metab (2005) 1.08
Developmental switch in neuropeptide Y and melanocortin effects in the paraventricular nucleus of the hypothalamus. Neuron (2007) 1.06
Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology (2003) 1.00
Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Obesity (Silver Spring) (2006) 0.97
The role of thermogenesis in antipsychotic drug-induced weight gain. Obesity (Silver Spring) (2008) 0.97
Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques. Diabetes (2005) 0.95
Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice. J Neurosci (2013) 0.94
Abdominal fat analyzed by DEXA scan reflects visceral body fat and improves the phenotype description and the assessment of metabolic risk in mice. Am J Physiol Endocrinol Metab (2012) 0.93
Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice. Neuropsychopharmacology (2006) 0.92
Is ghrelin a signal for the development of metabolic systems? J Clin Invest (2005) 0.92
Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis. Neuropsychopharmacology (2007) 0.91
The Diagnosis of Polycystic Ovary Syndrome during Adolescence. Horm Res Paediatr (2015) 0.90
Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y. Endocrinology (2008) 0.90
Estradiol prevents fat accumulation and overcomes leptin resistance in female high-fat diet mice. Endocrinology (2014) 0.89
Hypertension in obesity: is leptin the culprit? Trends Neurosci (2013) 0.88
Serotonergic pathways converge upon central melanocortin systems to regulate energy balance. Peptides (2005) 0.88
Feeding induced by cannabinoids is mediated independently of the melanocortin system. PLoS One (2008) 0.88
Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism. Mol Metab (2012) 0.87
Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity. Metabolism (2009) 0.87
Enhanced water and salt intake in transgenic mice with brain-restricted overexpression of angiotensin (AT1) receptors. Am J Physiol Regul Integr Comp Physiol (2008) 0.87
Characterization of brainstem peptide YY (PYY) neurons. J Comp Neurol (2008) 0.87
Hypothalamic regulatory pathways and potential obesity treatment targets. Endocrine (2006) 0.81
GLP-1 analogs: satiety without malaise? Am J Physiol Regul Integr Comp Physiol (2007) 0.81
Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats. Neuropsychopharmacology (2008) 0.80
Leptin increasing sympathetic nerve outflow in obesity: A cure for obesity or a potential contributor to metabolic syndrome? Adipocyte (2012) 0.79
Transmitter time: synaptic plasticity and metabolic memory in the hypothalamus. Cell Metab (2012) 0.77
Excess of nerve growth factor in the ovary causes a polycystic ovary-like syndrome in mice, which closely resembles both reproductive and metabolic aspects of the human syndrome. Endocrinology (2014) 0.77
Sex differences in the metabolic effects of testosterone in sheep. Endocrinology (2011) 0.77
Does leptin cause an increase in blood pressure in animals and humans? Curr Opin Nephrol Hypertens (2017) 0.76
A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. Cell Metab (2017) 0.75
Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis. Neuroendocrinology (2017) 0.75