The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions.

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Published in Clin Exp Immunol on April 01, 1991

Authors

Y M Lucisano Valim1, P J Lachmann

Author Affiliations

1: Molecular Immunopathology Unit, Medical Research Council Centre, Cambridge, England.

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Inherited complement deficiencies. Philos Trans R Soc Lond B Biol Sci (1984) 1.04

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Ultrastructure and composition of bovine conglutinin. Biochem J (1986) 1.02

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C6: synthesis by the liver in vivo. J Exp Med (1977) 1.02

Streptococcal infection in young pigs. 3. The immunity of adult pigs investigated by the bactericidal test. J Hyg (Lond) (1969) 1.01

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