Published in Pharmacol Res on September 29, 2006
Chemical decomposition of 5-aza-2'-deoxycytidine (Decitabine): kinetic analyses and identification of products by NMR, HPLC, and mass spectrometry. Chem Res Toxicol (2009) 1.11
Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer. Oncol Lett (2011) 0.81
2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential. Epigenetics (2011) 0.77
Sequence of events leading to near-complete genome turnover in allopolyploid Nicotiana within five million years. New Phytol (2007) 2.07
Long-term genome diploidization in allopolyploid Nicotiana section Repandae (Solanaceae). New Phytol (2005) 1.52
Rapid chromosome evolution in recently formed polyploids in Tragopogon (Asteraceae). PLoS One (2008) 1.37
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. J Med Chem (2002) 1.16
A genetic appraisal of a new synthetic Nicotiana tabacum (Solanaceae) and the Kostoff synthetic tobacco. Am J Bot (2006) 1.08
The origin of tobacco's T genome is traced to a particular lineage within Nicotiana tomentosiformis (Solanaceae). Am J Bot (2002) 1.06
Comparative genomics and repetitive sequence divergence in the species of diploid Nicotiana section Alatae. Plant J (2006) 1.06
Epigenetic switch from posttranscriptional to transcriptional silencing is correlated with promoter hypermethylation. Plant Physiol (2003) 1.03
Repeated reunions and splits feature the highly dynamic evolution of 5S and 35S ribosomal RNA genes (rDNA) in the Asteraceae family. BMC Plant Biol (2010) 1.03
Cell culture-induced gradual and frequent epigenetic reprogramming of invertedly repeated tobacco transgene epialleles. Plant Physiol (2009) 1.03
Dedifferentiation of tobacco cells is associated with ribosomal RNA gene hypomethylation, increased transcription, and chromatin alterations. Plant Physiol (2005) 1.01
Similar patterns of rDNA evolution in synthetic and recently formed natural populations of Tragopogon (Asteraceae) allotetraploids. BMC Evol Biol (2010) 0.98
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines. Bioorg Med Chem (2011) 0.98
Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*. Antimicrob Agents Chemother (2002) 0.98
Diploidization and genome size change in allopolyploids is associated with differential dynamics of low- and high-copy sequences. Plant J (2013) 0.96
Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett (2005) 0.95
Immediate unidirectional epigenetic reprogramming of NORs occurs independently of rDNA rearrangements in synthetic and natural forms of a polyploid species Brassica napus. Chromosoma (2011) 0.95
Fall and rise of satellite repeats in allopolyploids of Nicotiana over c. 5 million years. New Phytol (2009) 0.94
Differential impact of retrotransposon populations on the genome of allotetraploid tobacco (Nicotiana tabacum). Mol Genet Genomics (2007) 0.94
Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds. Bioorg Med Chem (2004) 0.93
Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides. J Med Chem (2005) 0.90
Parental origin and genome evolution in the allopolyploid Iris versicolor. Ann Bot (2007) 0.90
Antibodies to selected viral disease agents in wild boars from the Czech Republic. J Wildl Dis (2008) 0.89
Inhibition of SAH-hydrolase activity during seed germination leads to deregulation of flowering genes and altered flower morphology in tobacco. Mol Genet Genomics (2011) 0.84
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines. J Med Chem (2011) 0.84
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities. Eur J Med Chem (2011) 0.84
The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization. J Biol Chem (2010) 0.83
Endogenous pararetrovirus sequences associated with 24 nt small RNAs at the centromeres of Fritillaria imperialis L. (Liliaceae), a species with a giant genome. Plant J (2014) 0.83
Seroprevalence of Toxoplasma gondii in donkeys (Equus asinus) in Italy. J Vet Med Sci (2013) 0.83
Low abundant spacer 5S rRNA transcripts are frequently polyadenylated in Nicotiana. Mol Genet Genomics (2007) 0.82
Ferrocene-modified purines as potential electrochemical markers: synthesis, crystal structures, electrochemistry and cytostatic activity of (ferrocenylethynyl)- and (ferrocenylethyl)purines. Chemistry (2004) 0.82
6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents. J Med Chem (2010) 0.81
Studies on the effects of a flanking repetitive sequence on the expression of single-copy transgenes in Nicotiana sylvestris and in N. sylvestris-N. tomentosiformis hybrids. Plant Mol Biol (2003) 0.81
Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7. Org Biomol Chem (2008) 0.80
Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. Bioorg Med Chem (2010) 0.80
The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon. Antivir Chem Chemother (2004) 0.80
Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells. Anticancer Res (2010) 0.80
Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). Chembiochem (2009) 0.79
Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase. Bioorg Med Chem Lett (2009) 0.79
Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations. Org Biomol Chem (2008) 0.79
Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates. Biochem Pharmacol (2005) 0.79
Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides. Bioorg Med Chem (2007) 0.79
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells. Biochem Pharmacol (2007) 0.79
N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates. Biochem Pharmacol (2006) 0.78
CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases. ChemMedChem (2010) 0.78
Covalent analogues of DNA base-pairs and triplets. Part 2: synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds. Bioorg Med Chem Lett (2002) 0.78
Analysis of two abundant, highly related satellites in the allotetraploid Nicotiana arentsii using double-strand conformation polymorphism analysis and sequencing. New Phytol (2011) 0.78
Plant 5S rDNA has multiple alternative nucleosome positions. Genome (2006) 0.78
Facile and efficient synthesis of 6-(hydroxymethyl)purines. Org Lett (2004) 0.77
2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential. Epigenetics (2011) 0.77
The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides. Org Biomol Chem (2005) 0.77
5-azacytosine compounds in medicinal chemistry: current stage and future perspectives. Future Med Chem (2012) 0.77
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. Biochem Pharmacol (2008) 0.77
Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides. J Med Chem (2014) 0.77
Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides. Bioorg Med Chem (2010) 0.77
In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG. Anticancer Res (2009) 0.76
In vitro activities of 3-(halogenated phenyl)-5-acyloxymethyl- 2,5-dihydrofuran-2-ones against common and emerging yeasts and molds. Antimicrob Agents Chemother (2004) 0.75
Synthesis of 2'-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions. Org Biomol Chem (2007) 0.75
Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. Anticancer Res (2013) 0.75
Seroprevalence of Neospora caninum in cats from the Czech Republic. Acta Parasitol (2014) 0.75
8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett (2010) 0.75
Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Nucleosides Nucleotides Nucleic Acids (2007) 0.75
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP. Eur J Pharmacol (2010) 0.75
Synthesis and biological activity of desmethoxy analogues of coruscanone A. Bioorg Med Chem Lett (2011) 0.75
Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides. Bioorg Med Chem (2012) 0.75
PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions. Anticancer Res (2004) 0.75
Cocyclotrimerization of 6-alkynylpurines with alpha,omega-diynes as a novel approach to biologically active 6-arylpurines. J Org Chem (2004) 0.75
Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates. Anticancer Res (2012) 0.75
3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic. Bioorg Med Chem Lett (2010) 0.75
An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli. Bioorg Med Chem (2012) 0.75
Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase. Nucleic Acids Symp Ser (Oxf) (2008) 0.75
High penetrance of a pan-canina type rDNA family in intersection Rosa hybrids suggests strong selection of bivalent chromosomes in the section Caninae. Cytogenet Genome Res (2014) 0.75
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG. Biochem Pharmacol (2011) 0.75
Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides. Bioorg Med Chem (2007) 0.75
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase. Bioorg Med Chem Lett (2008) 0.75
Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem (2007) 0.75
9-Norbornyl-6-chloropurine is a novel antileukemic compound interacting with cellular GSH. Anticancer Res (2013) 0.75
Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants. Antiviral Res (2011) 0.75