Published in Bioorg Med Chem on December 04, 2010
Synthesis of nucleoside phosphate and phosphonate prodrugs. Chem Rev (2014) 1.13
Efficient synthesis of exo-N-carbamoyl nucleosides: application to the synthesis of phosphoramidate prodrugs. Org Lett (2012) 0.79
Effective manipulation of the electronic effects and its influence on the emission of 5-substituted tris(8-quinolinolate) aluminum(III) complexes. Chemistry (2006) 1.49
Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. Biochemistry (2007) 1.18
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. J Med Chem (2002) 1.16
C-nucleosides: synthetic strategies and biological applications. Chem Rev (2009) 1.12
Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*. Antimicrob Agents Chemother (2002) 0.98
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines. Bioorg Med Chem (2011) 0.98
Modular and practical synthesis of 6-substituted pyridin-3-yl C-nucleosides. J Org Chem (2007) 0.97
Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett (2005) 0.95
Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds. Bioorg Med Chem (2004) 0.93
Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides. J Med Chem (2005) 0.90
Herpes simplex virus-1 DNA primase: a remarkably inaccurate yet selective polymerase. Biochemistry (2009) 0.88
New modular and efficient approach to 6-substituted pyridin-2-yl C-nucleosides. J Org Chem (2006) 0.88
An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR. Chemistry (2007) 0.86
Synthesis of aldehyde-linked nucleotides and DNA and their bioconjugations with lysine and peptides through reductive amination. Chemistry (2012) 0.86
Direct polymerase synthesis of reactive aldehyde-functionalized DNA and its conjugation and staining with hydrazines. Angew Chem Int Ed Engl (2010) 0.85
General and modular synthesis of isomeric 5-substituted pyridin-2-yl and 6-substituted pyridin-3-yl C-ribonucleosides bearing diverse alkyl, aryl, hetaryl, amino, carbamoyl, and hydroxy groups. J Org Chem (2011) 0.85
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities. Eur J Med Chem (2011) 0.84
Aminophenyl- and nitrophenyl-labeled nucleoside triphosphates: synthesis, enzymatic incorporation, and electrochemical detection. Angew Chem Int Ed Engl (2008) 0.84
Inhibition of SAH-hydrolase activity during seed germination leads to deregulation of flowering genes and altered flower morphology in tobacco. Mol Genet Genomics (2011) 0.84
Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication. Chembiochem (2008) 0.84
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines. J Med Chem (2011) 0.84
Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines. Org Biomol Chem (2006) 0.83
Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620. Antimicrob Agents Chemother (2014) 0.83
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity. J Med Chem (2007) 0.83
Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer. Pharmacol Res (2006) 0.83
The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization. J Biol Chem (2010) 0.83
Synthesis of oligoribonucleotides with phosphonate-modified linkages. Org Biomol Chem (2011) 0.82
Ferrocene-modified purines as potential electrochemical markers: synthesis, crystal structures, electrochemistry and cytostatic activity of (ferrocenylethynyl)- and (ferrocenylethyl)purines. Chemistry (2004) 0.82
Direct C-H arylation of purines: development of methodology and its use in regioselective synthesis of 2,6,8-trisubstituted purines. Org Lett (2006) 0.82
Synthesis of enantiomerically pure (purin-6-yl)phenylalanines and their nucleosides, a novel type of purine-amino acid conjugates. J Org Chem (2005) 0.82
Proline zwitterion dynamics in solution, glass, and crystalline state. J Am Chem Soc (2006) 0.82
N-phosphonocarbonylpyrrolidine derivatives of guanine: a new class of bi-substrate inhibitors of human purine nucleoside phosphorylase. J Med Chem (2012) 0.81
6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents. J Med Chem (2010) 0.81
A general and efficient synthesis of pyridin-2-yl C-ribonucleosides bearing diverse alkyl, aryl, amino, and carbamoyl groups in position 6. J Org Chem (2010) 0.81
Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate. Biochemistry (2010) 0.81
Furan-oxidation-triggered inducible DNA cross-linking: acyclic versus cyclic furan-containing building blocks--on the benefit of restoring the cyclic sugar backbone. Chemistry (2011) 0.81
B family DNA polymerases asymmetrically recognize pyrimidines and purines. Biochemistry (2011) 0.81
Synthesis of C-aryldeoxyribosides by [2 + 2 + 2]-cyclotrimerization catalyzed by Rh, Ni, Co, and Ru complexes. Org Lett (2006) 0.81
Ferrocenylethynyl derivatives of nucleoside triphosphates: synthesis, incorporation, electrochemistry, and bioanalytical applications. Chemistry (2007) 0.80
Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases. Nucleic Acids Res (2009) 0.80
Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7. Org Biomol Chem (2008) 0.80
Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells. Anticancer Res (2010) 0.80
The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon. Antivir Chem Chemother (2004) 0.80
Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. Bioorg Med Chem (2010) 0.80
Preparation of covalent long-chain trialkylstannyl and trialkylsilyl salts and an examination of their adsorption on gold. Langmuir (2010) 0.79
Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). Chembiochem (2009) 0.79
Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates. Biochem Pharmacol (2005) 0.79
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides. J Med Chem (2014) 0.79
GFP-like fluorophores as DNA labels for studying DNA-protein interactions. J Org Chem (2012) 0.79
Nucleobase protection strategy for gene cloning and expression. Chembiochem (2013) 0.79
Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2'-deoxyribose C-nucleosides. Org Biomol Chem (2011) 0.79
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity. Bioorg Med Chem (2006) 0.79
Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins. Chem Commun (Camb) (2015) 0.79
Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase. Bioorg Med Chem Lett (2009) 0.79
Cleavage of functionalized DNA containing 5-modified pyrimidines by type II restriction endonucleases. Chembiochem (2011) 0.79
Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations. Org Biomol Chem (2008) 0.79
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. J Med Chem (2010) 0.79
Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides. Bioorg Med Chem (2007) 0.79
Transient and switchable (triethylsilyl)ethynyl protection of DNA against cleavage by restriction endonucleases. Angew Chem Int Ed Engl (2011) 0.79
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells. Biochem Pharmacol (2007) 0.79
Tail-labelling of DNA probes using modified deoxynucleotide triphosphates and terminal deoxynucleotidyl transferase. Application in electrochemical DNA hybridization and protein-DNA binding assays. Org Biomol Chem (2011) 0.78
Rapid access to dibenzohelicenes and their functionalized derivatives. Angew Chem Int Ed Engl (2013) 0.78
Covalent analogues of DNA base-pairs and triplets. Part 2: synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds. Bioorg Med Chem Lett (2002) 0.78
N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates. Biochem Pharmacol (2006) 0.78
Regioselective direct C-H arylations of protected uracils. Synthesis of 5- and 6-aryluracil bases. J Org Chem (2011) 0.78
CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases. ChemMedChem (2010) 0.78
Preparation of highly substituted 6-arylpurine ribonucleosides by Ni-catalyzed cyclotrimerization. Scope of the reaction. J Org Chem (2006) 0.78
Preparation of short cytosine-modified oligonucleotides by nicking enzyme amplification reaction. Chem Commun (Camb) (2012) 0.78
Cross-coupling reaction of saccharide-based alkenyl boronic acids with aryl halides: the synthesis of bergenin. Chemistry (2014) 0.78
Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins. Angew Chem Int Ed Engl (2013) 0.78