Published in J Neurosci on November 01, 2006
Neurocircuitry of addiction. Neuropsychopharmacology (2010) 14.22
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Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry (2007) 4.37
A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci (2007) 3.16
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Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology (2008) 2.28
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Brain stress systems in the amygdala and addiction. Brain Res (2009) 2.14
Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biol Psychiatry (2010) 2.04
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Cellular and behavioral interactions of gabapentin with alcohol dependence. J Neurosci (2008) 1.91
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Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci (2013) 1.80
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology (Berl) (2007) 1.74
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The role of CRF and CRF-related peptides in the dark side of addiction. Brain Res (2009) 1.74
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Addiction as a stress surfeit disorder. Neuropharmacology (2013) 1.68
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Preclinical studies of alcohol binge drinking. Ann N Y Acad Sci (2011) 1.56
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. Brain Struct Funct (2008) 1.54
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CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. Neuropsychopharmacology (2010) 1.44
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Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis. Neuropsychopharmacology (2009) 1.41
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CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology (Berl) (2007) 1.35
Effects of stress on alcohol drinking: a review of animal studies. Psychopharmacology (Berl) (2011) 1.33
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behav Pharmacol (2008) 1.33
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Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. J Neurosci (2012) 1.30
Development of pharmacotherapies for drug addiction: a Rosetta stone approach. Nat Rev Drug Discov (2009) 1.30
Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Res Health (2008) 1.29
A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. Brain Res (2007) 1.28
Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. Alcohol Clin Exp Res (2008) 1.25
Alcohol dependence as a chronic pain disorder. Neurosci Biobehav Rev (2012) 1.23
Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. J Neurosci (2013) 1.22
Signaling pathways mediating alcohol effects. Curr Top Behav Neurosci (2013) 1.20
Pre-clinical evidence that corticotropin-releasing factor (CRF) receptor antagonists are promising targets for pharmacological treatment of alcoholism. CNS Neurol Disord Drug Targets (2010) 1.19
Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neurosci Biobehav Rev (2009) 1.18
Functional CRH variation increases stress-induced alcohol consumption in primates. Proc Natl Acad Sci U S A (2009) 1.18
Adolescent binge drinking leads to changes in alcohol drinking, anxiety, and amygdalar corticotropin releasing factor cells in adulthood in male rats. PLoS One (2012) 1.17
Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats. Alcohol Clin Exp Res (2008) 1.16
Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. CNS Drugs (2011) 1.15
Corticotropin releasing factor: a key role in the neurobiology of addiction. Front Neuroendocrinol (2014) 1.15
Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol (2010) 1.14
Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Biol Psychiatry (2008) 1.14
Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin. Brain Res (2009) 1.11
Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption. Alcohol Res (2012) 1.10
Ethanol modulation of synaptic plasticity. Neuropharmacology (2010) 1.09
The neurobiology of binge-like ethanol drinking: evidence from rodent models. Physiol Behav (2012) 1.08
Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate. Neuropsychopharmacology (2011) 1.08
Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. Neuropsychopharmacology (2009) 1.08
New insights on neurobiological mechanisms underlying alcohol addiction. Neuropharmacology (2012) 1.07
Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice. Neuropsychopharmacology (2008) 1.06
Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism. Neuropharmacology (2011) 1.05
Craving in response to stress induction in a human laboratory paradigm predicts treatment outcome in alcohol-dependent individuals. Psychopharmacology (Berl) (2011) 1.05
Operant alcohol self-administration in dependent rats: focus on the vapor model. Alcohol (2013) 1.05
The darkness within: individual differences in stress. Cerebrum (2015) 1.05
The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides. Cold Spring Harb Perspect Med (2012) 1.04
Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. Neurosci Biobehav Rev (2011) 1.04
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology (2008) 1.04
Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats. Psychopharmacology (Berl) (2010) 1.03
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Corticotropin-releasing factor receptors in the dorsal raphe nucleus modulate social behavior in Syrian hamsters. Psychopharmacology (Berl) (2007) 1.02
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Amygdala protein kinase C epsilon controls alcohol consumption. Genes Brain Behav (2009) 1.01
The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling. Alcohol Clin Exp Res (2008) 1.01
Effects of acute ethanol on opioid peptide release in the central amygdala: an in vivo microdialysis study. Psychopharmacology (Berl) (2008) 1.01
Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: correlation with behavioral pathology. Neuroscience (2011) 1.01
Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiol Dis (2009) 0.99
Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Neuropsychopharmacology (2012) 0.99
Alcohol dependence, withdrawal, and relapse. Alcohol Res Health (2008) 0.99
Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats. Pharmacol Biochem Behav (2011) 0.98
Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice. Behav Pharmacol (2009) 0.97
Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. Brain Behav Immun (2011) 0.97
Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward. Front Psychiatry (2013) 0.97
Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Med (2010) 0.96
VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat Neurosci (2014) 0.96
Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res (2013) 0.96
The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study. Neuropsychopharmacology (2015) 0.96
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. J Clin Invest (2015) 0.95
Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system. Front Mol Neurosci (2012) 0.95
Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains. Alcohol (2010) 0.94
Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats. Front Psychiatry (2013) 0.94
Neural mechanisms of pain and alcohol dependence. Pharmacol Biochem Behav (2013) 0.93
Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood. Neuroscience (2013) 0.93
The limbic-hypothalamic-pituitary-adrenal axis and the development of alcohol use disorders in youth. Alcohol Clin Exp Res (2011) 0.93
Rodent models for compulsive alcohol intake. Alcohol (2014) 0.93
Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats. Pharmacol Biochem Behav (2011) 0.92
Interactions of stress and CRF in ethanol-withdrawal induced anxiety in adolescent and adult rats. Alcohol Clin Exp Res (2010) 0.92
Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats. Neuropharmacology (2010) 0.92
Heterogeneity of alcohol use disorder: understanding mechanisms to advance personalized treatment. Alcohol Clin Exp Res (2015) 4.94
Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcohol Clin Exp Res (2004) 3.19
A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci (2007) 3.16
Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin Exp Res (2002) 3.11
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci U S A (2005) 3.05
Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A (2006) 3.04
Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci Biobehav Rev (2004) 2.97
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Nat Neurosci (2002) 2.83
Conditioned withdrawal drives heroin consumption and decreases reward sensitivity. J Neurosci (2006) 2.74
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biol Psychiatry (2006) 2.70
Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology (2007) 2.61
The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev (2009) 2.35
Measuring meals: structure of prandial food and water intake of rats. Am J Physiol Regul Integr Comp Physiol (2005) 2.32
Escalation of methamphetamine self-administration in rats: a dose-effect function. Psychopharmacology (Berl) (2006) 2.24
The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl) (2010) 2.19
Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biol Psychiatry (2010) 2.04
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proc Natl Acad Sci U S A (2007) 2.01
The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcohol Clin Exp Res (2007) 1.99
Alcohol-related genes: contributions from studies with genetically engineered mice. Addict Biol (2006) 1.95
Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation. J Pharmacol Exp Ther (2004) 1.92
Cellular and behavioral interactions of gabapentin with alcohol dependence. J Neurosci (2008) 1.91
Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology (Berl) (2005) 1.82
Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol (2003) 1.81
Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. Eur J Neurosci (2008) 1.81
Treating cocaine addiction with viruses. Proc Natl Acad Sci U S A (2004) 1.75
Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addict Biol (2011) 1.75
Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci (2007) 1.73
Stress enhancement of craving during sobriety: a risk for relapse. Alcohol Clin Exp Res (2005) 1.71
alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol. Alcohol (2008) 1.71
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. J Neurosci (2012) 1.65
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacol Biochem Behav (2007) 1.63
Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev (2010) 1.61
Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addict Biol (2011) 1.58
CRF system recruitment mediates dark side of compulsive eating. Proc Natl Acad Sci U S A (2009) 1.57
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Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism. Pharmacol Biochem Behav (2004) 1.56
Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. J Neurosci (2005) 1.53
Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. J Neurochem (2003) 1.52
Drug addiction: pathways to the disease and pathophysiological perspectives. Eur Neuropsychopharmacol (2006) 1.48
Enhanced vulnerability to the rewarding effects of nicotine during the adolescent period of development. Pharmacol Biochem Behav (2008) 1.47
A vaccine strategy that induces protective immunity against heroin. J Med Chem (2011) 1.47
Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology (Berl) (2004) 1.47
The therapeutic potential of CRF1 antagonists for anxiety. Expert Opin Investig Drugs (2004) 1.46
Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology (Berl) (2006) 1.45
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Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. Eur Neuropsychopharmacol (2007) 1.43
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The transition from controlled to compulsive drug use is associated with a loss of sensitization. Brain Res (2004) 1.40
MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacol Biochem Behav (2007) 1.39
Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration. Neuropsychopharmacology (2007) 1.38
Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcohol Clin Exp Res (2009) 1.37
Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology (Berl) (2006) 1.37
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Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorg Med Chem (2004) 1.37
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CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology (Berl) (2007) 1.35
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Behavioral and neurochemical responses to cocaine in periadolescent and adult rats. Neuropsychopharmacology (2006) 1.35
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behav Pharmacol (2008) 1.33
Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A (2012) 1.33
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology (Berl) (2009) 1.32
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Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. J Neurosci (2007) 1.32
Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology (2007) 1.31
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What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep (2004) 1.29
Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. Neuropsychopharmacology (2006) 1.29
Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Res Health (2008) 1.29
A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. Brain Res (2007) 1.28
Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuropsychopharmacology (2006) 1.27
A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Mol Pharm (2010) 1.26
Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. Alcohol Clin Exp Res (2008) 1.25
'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration. Pharmacol Biochem Behav (2007) 1.25
Dynamic vaccine blocks relapse to compulsive intake of heroin. Proc Natl Acad Sci U S A (2013) 1.24
Alcohol dependence as a chronic pain disorder. Neurosci Biobehav Rev (2012) 1.23
Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology (2005) 1.23
Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. Pharmacol Biochem Behav (2008) 1.23
Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Addict Biol (2009) 1.23
Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biol Psychiatry (2011) 1.22
Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biol Psychiatry (2008) 1.21
Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake. Psychopharmacology (Berl) (2003) 1.21
Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. J Neurosci (2002) 1.19
A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. J Neurosci (2009) 1.19
Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res (2002) 1.19
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol Ther (2011) 1.18
Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction. Proc Natl Acad Sci U S A (2005) 1.18
Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addict Biol (2011) 1.17
Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. CNS Drugs (2011) 1.15
Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain (2007) 1.14
Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol (2010) 1.14
Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet (2002) 1.13