Published in Biochim Biophys Acta on September 30, 2006
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Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins. J Biol Chem (2011) 0.95
Ins and outs of GPCR signaling in primary cilia. EMBO Rep (2015) 0.84
Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion. J Cell Biol (2017) 0.75
Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling. PLoS One (2013) 0.75
Contextualizing the Genes Altered in Bladder Neoplasms in Pediatric andTeen Patients Allows Identifying Two Main Classes of Biological ProcessesInvolved and New Potential Therapeutic Targets. Curr Genomics (2016) 0.75
Exposure-QT analysis for sonidegib (LDE225), an oral inhibitor of the hedgehog signaling pathway, for measures of the QT prolongation potential in healthy subjects and in patients with advanced solid tumors. Eur J Clin Pharmacol (2016) 0.75
The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta (2006) 2.24
Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal (2003) 1.71
Anti-beta1-adrenergic receptor autoantibodies are potent stimulators of the ERK1/2 pathway in cardiac cells. Cardiovasc Res (2007) 1.60
Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease. Cardiovasc Res (2005) 1.50
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J (2006) 1.39
G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity. Diabetes (2010) 1.32
The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br J Pharmacol (2010) 1.30
Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol (2006) 1.25
Signaling pathways for monocyte chemoattractant protein 1-mediated extracellular signal-regulated kinase activation. Mol Pharmacol (2003) 1.24
Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1alpha. J Cell Sci (2007) 1.20
Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway. Proc Natl Acad Sci U S A (2004) 1.16
Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. J Leukoc Biol (2004) 1.16
G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits. Mol Biol Cell (2005) 1.15
G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J (2008) 1.14
Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis. Development (2009) 1.12
A novel GRK2/HDAC6 interaction modulates cell spreading and motility. EMBO J (2011) 1.08
MAPK-dependent degradation of G protein-coupled receptor kinase 2. J Biol Chem (2003) 1.05
A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Genetics (2009) 1.04
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci U S A (2007) 1.03
The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. J Biol Chem (2003) 1.03
New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration. Cell Adh Migr (2009) 1.01
G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel. J Biol Chem (2006) 1.00
Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3. Dev Dyn (2005) 0.99
G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression. Proc Natl Acad Sci U S A (2009) 0.99
The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation. Development (2010) 0.98
A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. Genetics (2006) 0.98
The complex tale of the achaete-scute complex: a paradigmatic case in the analysis of gene organization and function during development. Genetics (2009) 0.95
Polymorphism in genes involved in adrenergic signaling associated with Alzheimer's. Neurobiol Aging (2004) 0.94
Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing. Dev Biol (2009) 0.91
Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium. J Neurochem (2007) 0.91
Independent roles of Drosophila Moesin in imaginal disc morphogenesis and hedgehog signalling. Mech Dev (2006) 0.91
Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension. Hypertension (2013) 0.90
Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems. Mol Biol Cell (2006) 0.89
A conserved function of the chromatin ATPase Kismet in the regulation of hedgehog expression. Dev Biol (2010) 0.89
G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). J Biol Chem (2010) 0.89
Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. J Biol Chem (2012) 0.88
β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism. EMBO J (2014) 0.88
Regulation of decapentaplegic expression during Drosophila wing veins pupal development. Mech Dev (2006) 0.88
Tyrosine phosphorylation of G-protein-coupled-receptor kinase 2 (GRK2) by c-Src modulates its interaction with Galphaq. Cell Signal (2006) 0.87
Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. J Clin Invest (2013) 0.87
Drosophila Axud1 is involved in the control of proliferation and displays pro-apoptotic activity. Mech Dev (2008) 0.87
G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation. Arch Physiol Biochem (2008) 0.87
Activation and function of TGFβ signalling during Drosophila wing development and its interactions with the BMP pathway. Dev Biol (2013) 0.87
Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism. Mol Pharmacol (2002) 0.85
Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. PLoS Genet (2011) 0.85
GRK2 contribution to the regulation of energy expenditure and brown fat function. FASEB J (2012) 0.83
Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. Genetics (2010) 0.83
MAP4K3 is a component of the TORC1 signalling complex that modulates cell growth and viability in Drosophila melanogaster. PLoS One (2011) 0.83
The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility. Cell Adh Migr (2012) 0.82
Characterization of dSnoN and its relationship to Decapentaplegic signaling in Drosophila. Dev Biol (2007) 0.81
Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2. J Biol Chem (2010) 0.80
Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility. Sci Signal (2012) 0.77
GRK6, a gatekeeper of visceral hyperalgesia. Brain Behav Immun (2008) 0.77
Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Genetics (2012) 0.77
A cautionary tale on genetic screens based on a gain-of-expression approach: The case of LanB1. Fly (Austin) (2010) 0.76
A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia. Biochem J (2014) 0.76
Involvement of intramolecular interactions in the regulation of G protein-coupled receptor kinase 2. Mol Pharmacol (2003) 0.75