Published in EMBO J on December 23, 2011
Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules. PLoS One (2012) 1.15
Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. J Biol Chem (2013) 0.95
Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration. J Biol Chem (2012) 0.95
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance. Nat Commun (2013) 0.92
Dido3-dependent HDAC6 targeting controls cilium size. Nat Commun (2014) 0.88
Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. J Clin Invest (2013) 0.87
Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration. J Cell Biol (2014) 0.86
The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility. Cell Adh Migr (2012) 0.82
Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells. Cancer Biol Ther (2014) 0.81
Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. Biochemistry (2015) 0.80
Specific in vivo labeling of tyrosinated α-tubulin and measurement of microtubule dynamics using a GFP tagged, cytoplasmically expressed recombinant antibody. PLoS One (2013) 0.78
Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy. J Biol Chem (2014) 0.78
Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Sci Rep (2017) 0.78
Histone deacetylase 6 activity is critical for the metastasis of Burkitt's lymphoma cells. Cancer Cell Int (2014) 0.76
Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins. Semin Cell Dev Biol (2016) 0.76
EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation. BMC Cell Biol (2015) 0.75
Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6. Am J Respir Cell Mol Biol (2016) 0.75
HDAC6 and ovarian cancer. Int J Mol Sci (2013) 0.75
G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis. EBioMedicine (2016) 0.75
aPKC phosphorylation of HDAC6 results in increased deacetylation activity. PLoS One (2015) 0.75
HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Microtubule acetylation promotes kinesin-1 binding and transport. Curr Biol (2006) 6.20
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A (2003) 5.56
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell (2002) 4.68
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat Cell Biol (2002) 4.49
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J (2002) 4.28
Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol (2007) 4.17
Post-translational modifications regulate microtubule function. Nat Rev Mol Cell Biol (2003) 4.13
Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci (2009) 4.13
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell (2009) 3.80
Changing directions in the study of chemotaxis. Nat Rev Mol Cell Biol (2008) 3.61
Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J Cell Biol (1999) 3.53
Actin dynamics at the leading edge: from simple machinery to complex networks. Dev Cell (2009) 3.06
The universal dynamics of cell spreading. Curr Biol (2007) 2.74
HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol (2008) 2.71
HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene (2007) 2.67
Regulation of microtubules in cell migration. Trends Cell Biol (2005) 2.29
Microtubule-induced cortical cell polarity. Genes Dev (2007) 2.28
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol (2007) 2.25
The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta (2006) 2.24
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci (2007) 2.22
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17
Cell biology: Tubulin acetylation and cell motility. Nature (2003) 2.10
Quantification of microtubule nucleation, growth and dynamics in wound-edge cells. J Cell Sci (2005) 2.09
Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci U S A (2008) 1.93
Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol (2002) 1.87
Microtubule function in fibroblast spreading is modulated according to the tension state of cell-matrix interactions. Proc Natl Acad Sci U S A (2007) 1.80
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene (2005) 1.79
Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. PLoS One (2008) 1.68
GRKs and arrestins: regulators of migration and inflammation. J Leukoc Biol (2006) 1.66
Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. J Biol Chem (2008) 1.57
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem (1999) 1.56
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol Biol Cell (2009) 1.55
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. J Cell Sci (2009) 1.55
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal (2009) 1.54
G protein-coupled receptors stimulation and the control of cell migration. Cell Signal (2009) 1.46
From signaling pathways to microtubule dynamics: the key players. Curr Opin Cell Biol (2009) 1.42
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J (2006) 1.39
G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton. Mol Biol Cell (2005) 1.36
The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br J Pharmacol (2010) 1.30
Cellular responses to extracellular guidance cues. EMBO J (2010) 1.25
Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression. Clin Cancer Res (2009) 1.23
The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. J Biol Chem (1998) 1.18
G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J (2008) 1.14
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J (2011) 1.12
Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Protein Cell (2011) 1.12
Association of the Ste20-like kinase (SLK) with the microtubule. Role in Rac1-mediated regulation of actin dynamics during cell adhesion and spreading. J Biol Chem (2002) 1.10
Cytoskeletal control of fibroblast length: experiments with linear strips of substrate. J Cell Sci (2001) 1.01
New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration. Cell Adh Migr (2009) 1.01
Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress. J Cell Sci (2011) 1.00
Association of estrogen receptor alpha and histone deacetylase 6 causes rapid deacetylation of tubulin in breast cancer cells. Cancer Res (2009) 0.98
The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta (2006) 2.24
Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal (2003) 1.71
Anti-beta1-adrenergic receptor autoantibodies are potent stimulators of the ERK1/2 pathway in cardiac cells. Cardiovasc Res (2007) 1.60
Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease. Cardiovasc Res (2005) 1.50
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J (2006) 1.39
G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity. Diabetes (2010) 1.32
The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br J Pharmacol (2010) 1.30
Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol (2006) 1.25
Signaling pathways for monocyte chemoattractant protein 1-mediated extracellular signal-regulated kinase activation. Mol Pharmacol (2003) 1.24
Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1alpha. J Cell Sci (2007) 1.20
Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. J Leukoc Biol (2004) 1.16
G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits. Mol Biol Cell (2005) 1.15
G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J (2008) 1.14
TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons. J Struct Biol (2009) 1.11
MAPK-dependent degradation of G protein-coupled receptor kinase 2. J Biol Chem (2003) 1.05
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci U S A (2007) 1.03
The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. J Biol Chem (2003) 1.03
The cell biology of Smo signalling and its relationships with GPCRs. Biochim Biophys Acta (2006) 1.02
New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration. Cell Adh Migr (2009) 1.01
G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel. J Biol Chem (2006) 1.00
G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression. Proc Natl Acad Sci U S A (2009) 0.99
Polymorphism in genes involved in adrenergic signaling associated with Alzheimer's. Neurobiol Aging (2004) 0.94
Cajal's contribution to the knowledge of the neuronal cell nucleus. Chromosoma (2009) 0.94
Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium. J Neurochem (2007) 0.91
Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension. Hypertension (2013) 0.90
Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems. Mol Biol Cell (2006) 0.89
G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). J Biol Chem (2010) 0.89
Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. J Biol Chem (2012) 0.88
β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism. EMBO J (2014) 0.88
Tyrosine phosphorylation of G-protein-coupled-receptor kinase 2 (GRK2) by c-Src modulates its interaction with Galphaq. Cell Signal (2006) 0.87
Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. J Clin Invest (2013) 0.87
G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation. Arch Physiol Biochem (2008) 0.87
Nuclear speckles are involved in nuclear aggregation of PABPN1 and in the pathophysiology of oculopharyngeal muscular dystrophy. Neurobiol Dis (2012) 0.87
Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism. Mol Pharmacol (2002) 0.85
Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. Antivir Ther (2007) 0.85
Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. PLoS Genet (2011) 0.85
GRK2 contribution to the regulation of energy expenditure and brown fat function. FASEB J (2012) 0.83
Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage. Traffic (2010) 0.82
The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility. Cell Adh Migr (2012) 0.82
Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells. Chromosoma (2007) 0.81
Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2. J Biol Chem (2010) 0.80
Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells. Biochem J (2006) 0.80
GRK6, a gatekeeper of visceral hyperalgesia. Brain Behav Immun (2008) 0.77
Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility. Sci Signal (2012) 0.77
A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia. Biochem J (2014) 0.76
Involvement of intramolecular interactions in the regulation of G protein-coupled receptor kinase 2. Mol Pharmacol (2003) 0.75