Published in Mol Endocrinol on November 09, 2006
Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore. J Med Chem (2010) 2.12
Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer. Steroids (2006) 1.89
X-ray structure of human aromatase reveals an androgen-specific active site. J Steroid Biochem Mol Biol (2009) 1.18
Novel aromatase inhibitors by structure-guided design. J Med Chem (2012) 1.03
Molecular characterization of aromatase. Ann N Y Acad Sci (2009) 0.97
Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS Chem Biol (2011) 0.97
New experimental models for aromatase inhibitor resistance. J Steroid Biochem Mol Biol (2007) 0.96
Antiproliferative effect of exemestane in lung cancer cells. Mol Cancer (2009) 0.92
Epitope characterization of an aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activity. PLoS One (2009) 0.89
Structural basis for the functional roles of critical residues in human cytochrome p450 aromatase. Biochemistry (2013) 0.89
Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention. Proc Natl Acad Sci U S A (2013) 0.88
Detrimental effects of endogenous oestrogens on primary acute myocardial infarction among postmenopausal women. Neth Heart J (2013) 0.88
Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase. J Steroid Biochem Mol Biol (2008) 0.87
The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum. Ann Oncol (2010) 0.86
Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines. J Steroid Biochem Mol Biol (2009) 0.86
Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenes. Arch Biochem Biophys (2010) 0.86
Sequence-function correlation of aromatase and its interaction with reductase. J Steroid Biochem Mol Biol (2009) 0.84
Exemestane in the adjuvant treatment of breast cancer in postmenopausal women. Breast Cancer (Auckl) (2011) 0.83
Growth factor signaling enhances aromatase activity of breast cancer cells via post-transcriptional mechanisms. J Steroid Biochem Mol Biol (2010) 0.82
Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism. Mol Cell Endocrinol (2014) 0.82
High-throughput screen of natural product libraries for hsp90 inhibitors. Biology (Basel) (2014) 0.81
Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development. Mol Cell Endocrinol (2010) 0.81
Binding features of steroidal and nonsteroidal inhibitors. Steroids (2011) 0.81
Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases. Pharmacogenet Genomics (2016) 0.80
Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brain. Front Pharmacol (2012) 0.80
Novel inhibitor discovery against aromatase through virtual screening and molecular dynamic simulation: a computational approach in drug design. EXCLI J (2013) 0.79
Clinical utility of exemestane in the treatment of breast cancer. Int J Womens Health (2015) 0.79
An "omics" approach to determine the mechanisms of acquired aromatase inhibitor resistance. OMICS (2011) 0.78
Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopy. PLoS One (2013) 0.77
Docking and 3D-QSAR studies of diverse classes of human aromatase (CYP19) inhibitors. J Mol Model (2010) 0.77
Binding mode of triazole derivatives as aromatase inhibitors based on docking, protein ligand interaction fingerprinting, and molecular dynamics simulation studies. Res Pharm Sci (2017) 0.75
COX-2 inhibitor nimesulide analogs are aromatase suppressors in breast cancer cells. J Steroid Biochem Mol Biol (2010) 0.75
Exemestane potency is unchanged by common nonsynonymous polymorphisms in CYP19A1: results of a novel anti-aromatase activity assay examining exemestane and its derivatives. Pharmacol Res Perspect (2017) 0.75
Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors. J Chem Inf Model (2017) 0.75
The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA (2002) 15.59
The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. J Natl Cancer Inst (2005) 6.03
Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis. Curr Biol (2005) 5.99
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med (2008) 5.23
Optimal M-estimation in high-dimensional regression. Proc Natl Acad Sci U S A (2013) 4.82
On robust regression with high-dimensional predictors. Proc Natl Acad Sci U S A (2013) 4.79
Simultaneous gene clustering and subset selection for sample classification via MDL. Bioinformatics (2003) 4.74
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. Lancet Oncol (2012) 4.21
Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J Clin Oncol (2006) 3.53
A -defensin mutation causes black coat color in domestic dogs. Science (2007) 3.47
All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res (2003) 3.45
HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide. Nucleic Acids Res (2006) 3.14
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Stat3 regulates genes common to both wound healing and cancer. Oncogene (2005) 2.80
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma. J Clin Oncol (2013) 2.70
Modified implantation of black diaphragm intraocular lens in traumatic aniridia. J Cataract Refract Surg (2013) 2.61
Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer (2011) 2.56
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res (2012) 2.50
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A (2010) 2.36
Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis (2011) 2.34
Intergenic transcription by RNA polymerase II coordinates Pol IV and Pol V in siRNA-directed transcriptional gene silencing in Arabidopsis. Genes Dev (2009) 2.30
Reconstructing visual experiences from brain activity evoked by natural movies. Curr Biol (2011) 2.29
The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol (2011) 2.23
A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood (2011) 2.15
Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China. Zhonghua Liu Xing Bing Xue Za Zhi (2011) 2.15
Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin Cancer Res (2005) 2.14
Single-bundle versus double-bundle anterior cruciate ligament reconstruction: an up-to-date meta-analysis. Int Orthop (2012) 2.14
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. Cancer Res (2005) 2.09
Full-length dominant-negative survivin for cancer immunotherapy. Clin Cancer Res (2003) 2.00
Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol Biomarkers Prev (2011) 1.99
MicroRNA profiling of clear cell renal cell carcinoma by whole-genome small RNA deep sequencing of paired frozen and formalin-fixed, paraffin-embedded tissue specimens. J Pathol (2010) 1.98
Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol (2011) 1.87
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers. J Am Chem Soc (2006) 1.79
A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors. Proc Natl Acad Sci U S A (2014) 1.75
Operative versus nonoperative treatment for acute Achilles tendon rupture: a meta-analysis based on current evidence. Int Orthop (2011) 1.73
Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res (2003) 1.73
Identification of a substrate recognition site on Ubc9. J Biol Chem (2002) 1.71
Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. Biochemistry (2003) 1.70
Retracted Tai chi improves physical function in older Chinese women with knee osteoarthritis. J Clin Rheumatol (2010) 1.70
A systematic review with meta-analysis of posterior interbody fusion versus posterolateral fusion in lumbar spondylolisthesis. Eur Spine J (2013) 1.67
Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer. Cancer Res (2009) 1.59
Letrozole-, anastrozole-, and tamoxifen-responsive genes in MCF-7aro cells: a microarray approach. Mol Cancer Res (2005) 1.55
Genome-wide analysis of histone lysine methylation variations caused by diabetic conditions in human monocytes. J Biol Chem (2007) 1.54
Extended dose ipilimumab with a peptide vaccine: immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma. Clin Cancer Res (2010) 1.54
Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci Bull (2014) 1.52
Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity (2004) 1.50
Complete genome sequence of a novel flavivirus, duck tembusu virus, isolated from ducks and geese in china. J Virol (2012) 1.44
Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor. Cancer Res (2008) 1.44
De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer. J Transl Med (2012) 1.40
MicroRNAs play a role in the development of human hematopoietic stem cells. J Cell Biochem (2008) 1.39
Integrative medicine. Model for health care reform. Can Fam Physician (2006) 1.38
EST-analysis of the thermo-acidophilic red microalga Galdieria sulphuraria reveals potential for lipid A biosynthesis and unveils the pathway of carbon export from rhodoplasts. Plant Mol Biol (2004) 1.37
Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res (2003) 1.32
What do we know about the mechanisms of aromatase inhibitor resistance? J Steroid Biochem Mol Biol (2006) 1.30
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer. J Clin Oncol (2012) 1.29
Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses. Int J Cancer (2007) 1.28
Regulation of miRNA abundance by RNA binding protein TOUGH in Arabidopsis. Proc Natl Acad Sci U S A (2012) 1.27
The role of genetic breast cancer susceptibility variants as prognostic factors. Hum Mol Genet (2012) 1.23
CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery. Clin Cancer Res (2009) 1.22
Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res (2011) 1.22
Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J Agric Food Chem (2009) 1.20
Surgical versus nonsurgical treatment of displaced intra-articular calcaneal fracture: a meta-analysis of current evidence base. Int Orthop (2012) 1.20
In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase. Cancer Res (2004) 1.20
The pgp1 mutant locus of Arabidopsis encodes a phosphatidylglycerolphosphate synthase with impaired activity. Plant Physiol (2002) 1.19
Uridylation of miRNAs by hen1 suppressor1 in Arabidopsis. Curr Biol (2012) 1.19
Early second-trimester serum miRNA profiling predicts gestational diabetes mellitus. PLoS One (2011) 1.18
The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells. Breast Cancer Res Treat (2010) 1.17
Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res (2010) 1.16
Genetics of osteoporosis: accelerating pace in gene identification and validation. Hum Genet (2009) 1.14
SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol (2010) 1.11
The efficacy and complications of posterior hemivertebra resection. Eur Spine J (2011) 1.11
Phosphatidylglycerol biosynthesis in chloroplasts of Arabidopsis mutants deficient in acyl-ACP glycerol-3- phosphate acyltransferase. Plant J (2006) 1.10
A role for XRCC2 gene polymorphisms in breast cancer risk and survival. J Med Genet (2011) 1.10
Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res (2006) 1.09
ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res (2007) 1.08
COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis. Nucleic Acids Res (2013) 1.08
Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer. Clin Chem (2009) 1.08
Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues. J Clin Endocrinol Metab (2004) 1.07
Arthroscopic double-row rotator cuff repair: is it the same as single-row repair regarding clinical outcomes? Arthroscopy (2013) 1.07
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma. Cancer Res (2013) 1.07
MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion. Int J Oncol (2009) 1.07
Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. J Immunol (2005) 1.07
Aromatase inhibitors: structural features and biochemical characterization. Ann N Y Acad Sci (2006) 1.06
Enhanced transfection efficiency of a systemically delivered tumor-targeting immunolipoplex by inclusion of a pH-sensitive histidylated oligolysine peptide. Nucleic Acids Res (2004) 1.06
Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor alpha. Cancer Res (2003) 1.06
Early changes of microRNAs expression in the dorsal root ganglia following rat sciatic nerve transection. Neurosci Lett (2011) 1.06
Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability. Am J Hum Genet (2013) 1.05
Spatial expression of transcription factors in Drosophila embryonic organ development. Genome Biol (2013) 1.05
A rapid and consistent near infrared spectroscopic assay for biomass enzymatic digestibility upon various physical and chemical pretreatments in Miscanthus. Bioresour Technol (2012) 1.05
Aromatase destabilizer: novel action of exemestane, a food and drug administration-approved aromatase inhibitor. Cancer Res (2006) 1.05
Regulation of aromatase promoter activity in human breast tissue by nuclear receptors. Oncogene (2002) 1.05