Published in Cell on May 23, 2013
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Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction. Oncotarget (2015) 0.82
Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells. Cell Stress Chaperones (2014) 0.81
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eEF-2 kinase is a critical regulator of Warburg effect through controlling PP2A-A synthesis. Oncogene (2016) 0.81
RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget (2015) 0.80
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Dealing with hunger: Metabolic stress responses in tumors. J Carcinog (2013) 0.79
Translational progress on tumor biomarkers. Thorac Cancer (2015) 0.79
Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival. Mol Cell Biol (2015) 0.78
Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability. J Biol Chem (2014) 0.78
eEF2K--a new target in breast cancers with combined inactivation of p53 and PTEN. EMBO Mol Med (2014) 0.78
Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action. Steroids (2016) 0.77
Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death. PLoS One (2013) 0.77
Adaptation to starvation: translating a matter of life or death. Cancer Cell (2013) 0.77
Protein synthesis during cellular quiescence is inhibited by phosphorylation of a translational elongation factor. Proc Natl Acad Sci U S A (2015) 0.77
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases. Acta Pharmacol Sin (2016) 0.77
Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis. Front Mol Biosci (2015) 0.77
Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity. J Neurosci (2015) 0.77
Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy. Cell Signal (2016) 0.77
Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis. Am J Physiol Endocrinol Metab (2015) 0.77
Translating the anticancer properties of eEF2K. Cell Cycle (2016) 0.77
AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. Mol Cell (2017) 0.76
Pediatric high-grade astrocytomas: a distinct neuro-oncological paradigm. Genome Med (2013) 0.76
AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy. Cardiovasc Pharm Open Access (2015) 0.76
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget (2016) 0.76
An investigation of nutrient-dependent mRNA translation in Drosophila larvae. Biol Open (2014) 0.76
Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation. Can J Cardiol (2014) 0.76
Energy metabolism in neurodevelopment and medulloblastoma. Transl Pediatr (2015) 0.75
Eukaryotic elongation factor 2 is a prognostic marker and its kinase a potential therapeutic target in HCC. Oncotarget (2017) 0.75
Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells. Oncotarget (2017) 0.75
A fully integrated new paradigm for lithium's mode of action - lithium utilizes latent cellular fail-safe mechanisms. Neuropsychiatr Dis Treat (2017) 0.75
Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cell Signal (2016) 0.75
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation. Sci Rep (2016) 0.75
Low carbohydrate diet prevents Mcl-1-mediated resistance to BH3-mimetics. Oncotarget (2016) 0.75
A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors. Acta Pharm Sin B (2016) 0.75
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep (2016) 0.75
Adaptive Stress Responses During Tumor Metastasis and Dormancy. Trends Cancer (2016) 0.75
Signal Integration at Elongation Factor 2 Kinase; the Roles of Calcium, Calmodulin and Ser-500 Phosphorylation. J Biol Chem (2016) 0.75
Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase. Biochemistry (2016) 0.75
Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival. J Biol Chem (2016) 0.75
MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase. Oncotarget (2016) 0.75
Targeting RNA helicases in cancer: The translation trap. Biochim Biophys Acta (2017) 0.75
Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development. Front Oncol (2017) 0.75
A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation. Transl Oncol (2017) 0.75
eEF2K protects MYCN amplified cells from starvation. Cell Cycle (2017) 0.75
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