Published in Cell Death Differ on November 10, 2006
The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene (2007) 10.08
Targeting mitochondria for cancer therapy. Nat Rev Drug Discov (2010) 4.07
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell (2012) 3.23
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell (2010) 2.96
GSK3beta promotes apoptosis after renal ischemic injury. J Am Soc Nephrol (2010) 1.85
Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. J Cell Biol (2009) 1.83
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. J Cell Sci (2009) 1.70
Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress. Kidney Int (2011) 1.58
Decoding and unlocking the BCL-2 dependency of cancer cells. Nat Rev Cancer (2013) 1.36
Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes. PLoS Biol (2012) 1.26
The role of miRNAs and EBV BARTs in NPC. Semin Cancer Biol (2011) 1.06
Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol (2008) 1.06
The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J Cell Biol (2011) 1.03
Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function. Cell Death Differ (2014) 1.03
Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms. Cell Death Differ (2008) 1.02
Prostaglandins antagonistically control Bax activation during apoptosis. Cell Death Differ (2010) 1.01
Emerging themes from EBV and KSHV microRNA targets. Viruses (2012) 1.00
Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch. J Biol Chem (2014) 0.99
Inner mitochondrial translocase Tim50 interacts with 3β-hydroxysteroid dehydrogenase type 2 to regulate adrenal and gonadal steroidogenesis. J Biol Chem (2011) 0.97
Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem (2012) 0.97
Evidence for a mitochondrial localization of the retinoblastoma protein. BMC Cell Biol (2009) 0.95
ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network. Cell Death Dis (2013) 0.91
Mitochondria and apoptosis: emerging concepts. F1000Prime Rep (2015) 0.91
Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. Oncogene (2015) 0.88
The rubella virus capsid protein inhibits mitochondrial import. J Virol (2010) 0.87
Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells. J Cell Sci (2011) 0.87
Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis. Oxid Med Cell Longev (2016) 0.84
Emerging roles of small Epstein-Barr virus derived non-coding RNAs in epithelial malignancy. Int J Mol Sci (2013) 0.83
EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival. PLoS Pathog (2015) 0.83
The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein. BMC Cancer (2010) 0.78
Optogenetic Apoptosis: Light-Triggered Cell Death. Angew Chem Int Ed Engl (2015) 0.78
Pathogens Use and Abuse MicroRNAs to Deceive the Immune System. Int J Mol Sci (2016) 0.77
The N-terminal helix of Bcl-xL targets mitochondria. Mitochondrion (2013) 0.76
Mitochondrial Ion Channels in Cancer Transformation. Front Oncol (2015) 0.76
Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein-protein interactions by the MDM2 ligand nutlin-3. Proteomics (2016) 0.75
Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) reveals pathway differences between pigs with alternate genotypes for a major host response QTL. BMC Genomics (2016) 0.75
Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells. Sci Rep (2017) 0.75
Characterization of Oyster Voltage-Dependent Anion Channel 2 (VDAC2) Suggests Its Involvement in Apoptosis and Host Defense. PLoS One (2016) 0.75
Yeast as a tool for studying proteins of the Bcl-2 family. Microb Cell (2015) 0.75
Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL. Microb Cell (2016) 0.75
The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat Cell Biol (2000) 9.87
Structurally distinct collagen types. Annu Rev Biochem (1980) 6.43
The elastic fiber. I. The separation and partial characterization of its macromolecular components. J Cell Biol (1969) 4.51
The nature of the intramolecular cross-links in collagen. The separation and characterization of peptides from the cross-link region of rat skin collagen. Biochemistry (1966) 4.04
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia (2004) 3.59
Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J Cell Biol (1998) 3.27
Molecular and cellular biology of cholinesterases. Prog Neurobiol (1993) 3.01
Evidence for procollagen, a biosynthetic precursors of collagen. Proc Natl Acad Sci U S A (1971) 2.96
Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis. Biochemistry (1978) 2.85
Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20. Cell (2000) 2.84
Cleavage at Asn-Gly bonds with hydroxylamine. Methods Enzymol (1977) 2.80
Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast. Cell Death Differ (2005) 2.73
Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability. Proc Natl Acad Sci U S A (1988) 2.73
The biosynthesis of collagen. Annu Rev Biochem (1974) 2.50
Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin. J Biol Chem (1991) 2.47
Thrombospondin: synthesis and secretion by cells in culture. J Cell Biol (1982) 2.33
Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture. Apparent identity with platelet thrombospondin. J Biol Chem (1981) 2.25
Light microscopic immunolocation of thrombospondin in human tissues. J Histochem Cytochem (1985) 2.20
Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. J Biol Chem (2000) 2.18
Characterization of the signal that directs Tom20 to the mitochondrial outer membrane. J Cell Biol (2000) 2.16
Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin. Proc Natl Acad Sci U S A (1986) 2.10
Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn (1997) 2.05
Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells. J Cell Biol (1985) 2.05
Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture. J Biol Chem (1984) 2.01
Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis. Proc Natl Acad Sci U S A (1999) 2.01
Cell surface-associated structural proteins in connective tissue cells. Proc Natl Acad Sci U S A (1977) 1.99
Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn. J Biol Chem (1981) 1.95
Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. J Biol Chem (2001) 1.95
Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro. Proc Natl Acad Sci U S A (1991) 1.94
Effects of antimicrotubular agents on the secretion of collagen. A biochemical and morphological study. J Cell Biol (1974) 1.93
Differential expression of thrombospondin 1, 2, and 3 during murine development. Dev Dyn (1993) 1.92
Matricellular proteins as modulators of cell-matrix interactions: adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2. Mol Biol Cell (2000) 1.85
Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen. J Cell Biol (1984) 1.85
Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin. J Biol Chem (1979) 1.80
Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene. J Invest Dermatol (1999) 1.79
Characterization of the pro- 1 chain of procollagen. J Biol Chem (1972) 1.78
Isolation and characterization of the cyanogen bromide peptides from the alpha-1 chain of rat skin collagen. Biochemistry (1967) 1.77
Structural studies on human type IV collagen. J Biol Chem (1979) 1.77
Regulation of collagen gene expression. Prog Nucleic Acid Res Mol Biol (1989) 1.75
The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism. J Biol Chem (2001) 1.72
Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge. Proc Natl Acad Sci U S A (1992) 1.72
Coordinate transcriptional regulation of type I procollagen genes by Rous sarcoma virus. J Biol Chem (1981) 1.68
Chromosomal localization of the human elastin gene. Am J Hum Genet (1985) 1.68
Molecular cloning and sequencing of cDNA for yeast porin, an outer mitochondrial membrane protein: a search for targeting signal in the primary structure. EMBO J (1985) 1.67
Molten globule of cytochrome c studied by small angle X-ray scattering. J Mol Biol (1993) 1.63
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast. J Cell Biol (2001) 1.63
In vitro synthesis and integration into mitochondria of porin, a major protein of the outer mitochondrial membrane of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1982) 1.62
X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity. N Engl J Med (1980) 1.62
A short amino-terminal segment of microsomal cytochrome P-450 functions both as an insertion signal and as a stop-transfer sequence. EMBO J (1987) 1.61
The nature and location of intramolecular cross-links in collagen. Proc Natl Acad Sci U S A (1966) 1.60
Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation (1998) 1.57
Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization. J Histochem Cytochem (1993) 1.56
Sulfated proteoglycans synthesized by vascular endothelial cells in culture. J Biol Chem (1983) 1.55
The amino acid sequence of peptides from the cross-linking region of rat skin collagen. Biochemistry (1967) 1.54
Microtubules in transcellular movement of procollagen. Nat New Biol (1972) 1.53
Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism. EMBO J (2001) 1.51
Thrombospondin 2, a matricellular protein with diverse functions. Matrix Biol (2000) 1.51
Systematic analysis of stop-transfer sequence for microsomal membrane. J Biol Chem (1991) 1.50
Secretory phenotypes of endothelial cells in culture: comparison of aortic, venous, capillary, and corneal endothelium. Arteriosclerosis (1982) 1.49
Altered secretion of type III procollagen in a form of type IV Ehlers-Danlos syndrome. Biochemical studies in cultured fibroblasts. Lab Invest (1981) 1.46
The four cytoplasmically made subunits of yeast mitochondrial cytochrome c oxidase are synthesized individually and not as a polyprotein. Proc Natl Acad Sci U S A (1980) 1.46
Comparative sequence studies of rat skin and tendon collagen. I. Evidence for incomplete hydroxylation of individual prolyl residues in the normal proteins. Biochemistry (1967) 1.46
Altered extracellular matrix remodeling and angiogenesis in sponge granulomas of thrombospondin 2-null mice. Am J Pathol (2001) 1.45
Synthesis of types I and III procollagen and collagen by monkey aortic smooth muscle cells in vitro. Biochemistry (1977) 1.44
Reconstitution of the initial steps of mitochondrial protein import. Nature (1995) 1.44
A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins. EMBO J (1993) 1.42
Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity. Proc Natl Acad Sci U S A (1999) 1.42
Biochemical and ultrastructural studies of proteoheparan sulfates synthesized by PYS-2, a basement membrane-producing cell line. J Cell Biol (1982) 1.41
Collagen synthesis by bovine aortic endothelial cells in culture. Biochemistry (1979) 1.40
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes. Proc Natl Acad Sci U S A (1982) 1.39
Structure of alpha-1-CB8, a large cyanogen bromide produced fragment from the alpha-1 chain of rat collagen. The nature of a hydroxylamine-sensitive bond and composition of tryptic peptides. Biochemistry (1970) 1.39
Long-term biomedical and psychosocial outcomes following DAFNE (Dose Adjustment For Normal Eating) structured education to promote intensive insulin therapy in adults with sub-optimally controlled Type 1 diabetes. Diabetes Res Clin Pract (2010) 1.38
Multicentre quality assurance of intensity-modulated radiotherapy planning: beware the benchmarker. J Med Imaging Radiat Oncol (2008) 1.38
Reconstitution of hepatic microsomal stearoyl-coenzyme A desaturase system from solubilized components. J Biochem (1972) 1.37
Treatment of pyogenic granuloma with a sclerosing agent. Dermatol Surg (2001) 1.37
An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice. Mol Cell Biol (1991) 1.36
Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis. Blood (1995) 1.36
A presumptive subunit of elastic fiber microfibrils secreted by arterial smooth-muscle cells in culture. Eur J Biochem (1976) 1.36
The distribution of antigenic determinants in rat skin collagen. J Exp Med (1971) 1.35
Increased marrow-derived osteoprogenitor cells and endosteal bone formation in mice lacking thrombospondin 2. J Bone Miner Res (2000) 1.35
Isolation and characterization of the cyanogen bromide peptides from the alpha 1 and alpha 2 chains of human skin collagen. Biochemistry (1970) 1.34
NH2-terminal sequence of the chick proalpha1(I) chain synthesized in the reticulocyte lysate system. Evidence for a transient hydrophobic leader sequence. J Biol Chem (1979) 1.34
Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner. J Biol Chem (1982) 1.34
Biosynthetic and structural properties of endothelial cell type VIII collagen. J Biol Chem (1983) 1.34
tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak. Cell Death Differ (2005) 1.33
Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion. J Biol Chem (1997) 1.32
Changes in surface properties of normal and transformed cells caused by tunicamycin, an inhibitor of protein glycosylation. Proc Natl Acad Sci U S A (1977) 1.32
Regulation of thrombospondin secretion by cells in culture. J Cell Physiol (1984) 1.32
Location of a collagen-binding domain in fibronectin. J Biol Chem (1980) 1.31
Trehalose levels and survival ratio of freeze-tolerant versus freeze-sensitive yeasts. Appl Environ Microbiol (1990) 1.30
Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the 'acid chain' hypothesis. EMBO J (1998) 1.30
Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis. J Investig Dermatol Symp Proc (2000) 1.28
Cell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice. J Cell Biol (1994) 1.28
Characterization of a novel collagen chain in human placenta and its relation to AB collagen. Biochemistry (1979) 1.28
Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. J Biol Chem (2000) 1.27
The distribution of the matricellular protein thrombospondin 2 in tissues of embryonic and adult mice. J Histochem Cytochem (1998) 1.27
Structural basis for apparent heterogeneity of collagens in human basement membranes: type IV procollagen contains two distinct chains. Proc Natl Acad Sci U S A (1980) 1.25
Importance of the proline-rich region following signal-anchor sequence in the formation of correct conformation of microsomal cytochrome P-450s. J Biochem (1993) 1.25