Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2.

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Published in J Biol Chem on December 11, 2000

Authors

Z Yang1, D K Strickland, P Bornstein

Author Affiliations

1: Department of Biochemistry, the University of Washington, Seattle, Washington 98195, USA.

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A unique, pepsin-sensitive collagen synthesized by aortic endothelial cells in culture. Biochemistry (1980) 1.23

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Transcytosis of lipoprotein lipase across cultured endothelial cells requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor. J Biol Chem (2000) 1.21

Structure of rat skin collagen 1-CB8. Amino acid sequence of the hydroxylamine-produced fragment HA1. Biochemistry (1971) 1.21