Published in Structure on November 01, 2006
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly. Nat Struct Mol Biol (2010) 1.80
Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure (2010) 1.79
In situ proteolysis to generate crystals for structure determination: an update. PLoS One (2009) 1.73
A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction. Protein Sci (2010) 1.66
Structural basis of receptor sharing by interleukin 17 cytokines. Nat Immunol (2009) 1.60
Large-scale evaluation of protein reductive methylation for improving protein crystallization. Nat Methods (2008) 1.55
Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB. Nature (2014) 1.53
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proc Natl Acad Sci U S A (2008) 1.48
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. PLoS Biol (2009) 1.47
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. Nat Struct Mol Biol (2009) 1.45
BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm. Proc Natl Acad Sci U S A (2013) 1.44
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol (2012) 1.41
Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein. Nat Methods (2014) 1.36
Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI. EMBO J (2010) 1.33
Comparative structural biology of eubacterial and archaeal oligosaccharyltransferases. J Biol Chem (2009) 1.31
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1. Nat Struct Mol Biol (2011) 1.21
Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a gram-negative bacterium. Nucleic Acids Res (2011) 1.18
Structures of an alanine racemase from Bacillus anthracis (BA0252) in the presence and absence of (R)-1-aminoethylphosphonic acid (L-Ala-P). Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 1.15
Protein camouflage in cytochrome c-calixarene complexes. Nat Chem (2012) 1.12
The dynamic disulphide relay of quiescin sulphydryl oxidase. Nature (2012) 1.06
(NZ)CH...O contacts assist crystallization of a ParB-like nuclease. BMC Struct Biol (2007) 1.06
Determination of protein structures--a series of fortunate events. Biophys J (2008) 1.06
The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. J Mol Biol (2008) 1.04
Ligand-binding properties and conformational dynamics of autolysin repeat domains in staphylococcal cell wall recognition. J Bacteriol (2012) 1.03
The structure of alanyl-tRNA synthetase with editing domain. Proc Natl Acad Sci U S A (2009) 1.03
Structurally encoded intraclass differences in EphA clusters drive distinct cell responses. Nat Struct Mol Biol (2013) 1.00
Initiation of T cell signaling by CD45 segregation at 'close contacts'. Nat Immunol (2016) 0.99
An approach to crystallizing proteins by metal-mediated synthetic symmetrization. Protein Sci (2011) 0.98
The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket. J Immunol (2012) 0.97
Structures of the Shigella flexneri type 3 secretion system protein MxiC reveal conformational variability amongst homologues. J Mol Biol (2008) 0.96
Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames). BMC Struct Biol (2009) 0.95
Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods. Protein Cell (2010) 0.95
Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD). J Biol Chem (2013) 0.94
The structure and regulation of human muscle α-actinin. Cell (2014) 0.93
To automate or not to automate: this is the question. J Struct Funct Genomics (2010) 0.93
Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions. PLoS Pathog (2014) 0.91
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. Elife (2015) 0.90
Detection of protein-ligand interactions by NMR using reductive methylation of lysine residues. J Biomol NMR (2008) 0.90
Rtr1 is a dual specificity phosphatase that dephosphorylates Tyr1 and Ser5 on the RNA polymerase II CTD. J Mol Biol (2014) 0.89
Selective deuteration of tryptophan and methionine residues in maltose binding protein: a model system for neutron scattering. Eur Biophys J (2008) 0.89
New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization. Protein Sci (2010) 0.88
Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehyde. Acta Crystallogr D Biol Crystallogr (2009) 0.88
Benefits of structural genomics for drug discovery research. Infect Disord Drug Targets (2009) 0.87
Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase. PLoS One (2012) 0.87
Crystal structure of the variable domain of the Streptococcus gordonii surface protein SspB. Protein Sci (2009) 0.86
Optimization of crystallization conditions for biological macromolecules. Acta Crystallogr F Struct Biol Commun (2014) 0.86
Squeezing the most from every crystal: the fine details of data collection. Acta Crystallogr D Biol Crystallogr (2013) 0.85
Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase. Biochem J (2010) 0.85
Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain. J Mol Biol (2009) 0.85
Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima. Protein Sci (2011) 0.84
Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans. J Am Chem Soc (2011) 0.84
Split green fluorescent protein as a modular binding partner for protein crystallization. Acta Crystallogr D Biol Crystallogr (2013) 0.83
Mutagenesis of the crystal contact of acidic fibroblast growth factor. J Synchrotron Radiat (2008) 0.83
Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide. Nat Commun (2016) 0.82
Utilization of lysine ¹³C-methylation NMR for protein-protein interaction studies. J Biomol NMR (2012) 0.82
Characterization and structure of the vaccinia virus NF-κB antagonist A46. J Biol Chem (2013) 0.82
Structural and functional basis for substrate specificity and catalysis of levan fructotransferase. J Biol Chem (2012) 0.82
Structural basis for bacterial quorum sensing-mediated oxalogenesis. J Biol Chem (2014) 0.81
Reversible post-translational carboxylation modulates the enzymatic activity of N-acetyl-L-ornithine transcarbamylase. Biochemistry (2010) 0.81
Reductive methylation to improve crystallization of the putative oxidoreductase Rv0765c from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.81
Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase. Acta Crystallogr D Biol Crystallogr (2013) 0.81
Protein stability: a crystallographer's perspective. Acta Crystallogr F Struct Biol Commun (2016) 0.81
Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins. J Biomol NMR (2009) 0.80
An overview of biological macromolecule crystallization. Int J Mol Sci (2013) 0.80
13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1. J Biomol NMR (2015) 0.80
Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. J Mol Biol (2009) 0.79
Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domain. Acta Crystallogr D Biol Crystallogr (2010) 0.79
Crystallization and preliminary X-ray analysis of the type IV restriction endonuclease ScoMcrA from Streptomyces coelicolor, which cleaves both Dcm-methylated DNA and phosphorothioated DNA. Acta Crystallogr F Struct Biol Commun (2015) 0.79
Preliminary crystallographic analysis of the RNA-binding domain of HuR and its poly(U)-binding properties. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.79
Dimer-dimer interaction of the bacterial selenocysteine synthase SelA promotes functional active-site formation and catalytic specificity. J Mol Biol (2014) 0.79
Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.79
The perforin pore facilitates the delivery of cationic cargos. J Biol Chem (2014) 0.79
Review of methods to assign the nuclear magnetic resonance peaks of reductively methylated proteins. Anal Biochem (2014) 0.79
Methods to identify the NMR resonances of the ¹³C-dimethyl N-terminal amine on reductively methylated proteins. J Vis Exp (2013) 0.78
Structural evidence that colicin A protein binds to a novel binding site of TolA protein in Escherichia coli periplasm. J Biol Chem (2012) 0.78
Post-expression strategies for structural investigations of membrane proteins. Curr Opin Struct Biol (2015) 0.78
Structural basis of myelin-associated glycoprotein adhesion and signalling. Nat Commun (2016) 0.78
Crystallization and preliminary X-ray crystallographic analysis of bacterial tRNA(Sec) in complex with seryl-tRNA synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.77
Structure of a novel winged-helix like domain from human NFRKB protein. PLoS One (2012) 0.77
Protein Crystallography in Vaccine Research and Development. Int J Mol Sci (2015) 0.77
Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1. Cryst Growth Des (2008) 0.77
Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system. J Biol Chem (2014) 0.77
The Structure of Plasmodium falciparum Blood-Stage 6-Cys Protein Pf41 Reveals an Unexpected Intra-Domain Insertion Required for Pf12 Coordination. PLoS One (2015) 0.77
Crystallization and preliminary X-ray crystallographic analysis of Aquifex aeolicus SelA, a bacterial selenocysteine synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.77
Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.76
Salvage of failed protein targets by reductive alkylation. Methods Mol Biol (2014) 0.76
Structural and functional insights into the fly microRNA biogenesis factor Loquacious. RNA (2016) 0.76
Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2. J Biol Chem (2016) 0.76
Tetramerization reinforces the dimer interface of MnSOD. PLoS One (2013) 0.76
Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. EMBO J (2016) 0.75
Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism. J Biol Chem (2017) 0.75
Structure of the kinase domain of Gilgamesh from Drosophila melanogaster. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Trisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus. Proc Natl Acad Sci U S A (2016) 0.75
Protein surface shielding agents in protein crystallization. J Synchrotron Radiat (2010) 0.75
Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
'Seeding' with protease to optimize protein crystallization conditions in in situ proteolysis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.75
Structure of the TIR domain of BCAP which links phosphoinositide metabolism with the negative regulation of the TLR signalosome. J Biol Chem (2016) 0.75
Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions. Sci Rep (2017) 0.75
Expression, crystallization and preliminary crystallographic data analysis of PigI, a putative L-prolyl-AMP ligase from the prodigiosin synthetic pathway in Serratia. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. J Virol (2006) 6.30
Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trial. Lancet (2007) 5.06
Protein production and purification. Nat Methods (2008) 3.97
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature (2002) 3.78
A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization. Acta Crystallogr D Biol Crystallogr (2005) 3.75
A versatile ligation-independent cloning method suitable for high-throughput expression screening applications. Nucleic Acids Res (2007) 3.22
A structural basis for immunodominant human T cell receptor recognition. Nat Immunol (2003) 3.15
Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy. Acta Crystallogr D Biol Crystallogr (2005) 3.13
What does structure tell us about virus evolution? Curr Opin Struct Biol (2005) 3.02
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat Struct Mol Biol (2012) 2.81
Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2. Nat Struct Mol Biol (2008) 2.58
Insights into assembly from structural analysis of bacteriophage PRD1. Nature (2004) 2.47
Crystal structure of a soluble CD28-Fab complex. Nat Immunol (2005) 2.46
The interaction properties of costimulatory molecules revisited. Immunity (2002) 2.43
A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting. Nature (2006) 2.41
Bluetongue virus VP4 is an RNA-capping assembly line. Nat Struct Mol Biol (2007) 2.40
Glycoprotein structural genomics: solving the glycosylation problem. Structure (2007) 2.40
A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol (2002) 2.31
Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction. J Am Coll Cardiol (2010) 2.29
Detection of a fourth orbivirus non-structural protein. PLoS One (2011) 2.11
The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines. Nat Struct Mol Biol (2008) 2.09
Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization. Structure (2004) 1.97
The structure of an RNAi polymerase links RNA silencing and transcription. PLoS Biol (2006) 1.96
In situ macromolecular crystallography using microbeams. Acta Crystallogr D Biol Crystallogr (2012) 1.94
Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res (2009) 1.87
Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. Structure (2011) 1.86
Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation. Cell (2004) 1.86
Comparative study of intrathecal dexmedetomidine with intrathecal magnesium sulfate used as adjuvants to bupivacaine. J Anaesthesiol Clin Pharmacol (2011) 1.83
Effect of intensive versus standard blood pressure lowering on diastolic function in patients with uncontrolled hypertension and diastolic dysfunction. Hypertension (2009) 1.82
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein. J Gen Virol (2007) 1.73
Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutinin. J Cell Biol (2005) 1.70
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell (2008) 1.68
The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D. Nat Struct Biol (2003) 1.68
Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation (2009) 1.66
Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail (2008) 1.65
An in-depth analysis of original antigenic sin in dengue virus infection. J Virol (2010) 1.63
Structure unifies the viral universe. Annu Rev Biochem (2012) 1.58
Picornavirus uncoating intermediate captured in atomic detail. Nat Commun (2013) 1.57
Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis. PLoS Pathog (2008) 1.57
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE. Acta Crystallogr D Biol Crystallogr (2006) 1.56
The nsp9 replicase protein of SARS-coronavirus, structure and functional insights. Structure (2004) 1.55
Membrane structure and interactions with protein and DNA in bacteriophage PRD1. Nature (2004) 1.53
Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element. Proc Natl Acad Sci U S A (2010) 1.51
Evolution of viral structure. Theor Popul Biol (2002) 1.48
Molecular architecture and ligand recognition determinants for T4 RNA ligase. J Biol Chem (2005) 1.47
How baculovirus polyhedra fit square pegs into round holes to robustly package viruses. EMBO J (2009) 1.46
The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory. Acta Crystallogr D Biol Crystallogr (2011) 1.45
A randomized trial of intravenous n-acetylcysteine to prevent contrast induced nephropathy in acute coronary syndromes. Catheter Cardiovasc Interv (2011) 1.45
Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection. J Virol (2011) 1.42
Erythropoietin (EPO): EPO-receptor signaling improves early endochondral ossification and mechanical strength in fracture healing. Life Sci (2006) 1.40
Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2. Mol Cell (2008) 1.37
Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure. PLoS Biol (2009) 1.36
Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design. J Virol (2008) 1.32
Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors. J Exp Med (2006) 1.32
Outrunning free radicals in room-temperature macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2012) 1.32
Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication. J Virol (2009) 1.29
Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling. Structure (2009) 1.29
Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex. PLoS Biol (2010) 1.29
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI. Nat Struct Mol Biol (2011) 1.29
Clinical impact of left ventricular hypertrophy and implications for regression. Prog Cardiovasc Dis (2009) 1.27