Published in Cell Cycle on October 16, 2006
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Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum Mol Genet (2009) 2.35
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Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.51
Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PLoS One (2009) 1.48
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
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Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer. Cancer Res (2010) 1.13
Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7. Mol Cancer Res (2011) 1.11
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Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol Cancer Res (2014) 1.10
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Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia (2012) 1.01
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Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS One (2010) 0.99
Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. Int J Cancer (2009) 0.98
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A framework for significance analysis of gene expression data using dimension reduction methods. BMC Bioinformatics (2007) 0.95
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The Effects of EPA+DHA and Aspirin on Inflammatory Cytokines and Angiogenesis Factors. World J Cardiovasc Dis (2011) 0.91
Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions. Mitochondrion (2009) 0.89
ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Mol Cancer Res (2010) 0.88
Colorectal cancer occurs earlier in those exposed to tobacco smoke: implications for screening. J Cancer Res Clin Oncol (2008) 0.88
From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene (2010) 0.87
Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. Cancer Res (2009) 0.87
Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. PLoS One (2014) 0.86
Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway. Eur J Hum Genet (2013) 0.85
Impact of smoking status at diagnosis on disease recurrence and death in upper tract urothelial carcinoma. BJU Int (2012) 0.84
Kidney function and tobacco smoke exposure in US adolescents. Pediatrics (2013) 0.84
A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. Cancer Epidemiol Biomarkers Prev (2011) 0.84
TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes. Cell Cycle (2012) 0.84
Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability. Br J Cancer (2014) 0.83
From smoking to cancers: novel targets to neuronal nicotinic acetylcholine receptors. J Oncol (2011) 0.82
Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC. Oncotarget (2014) 0.82
Genome-wide expression analysis reveals diverse effects of acute nicotine exposure on neuronal function-related genes and pathways. Front Psychiatry (2011) 0.82
The pro-proliferative effects of nicotine and its underlying mechanism on rat airway smooth muscle cells. PLoS One (2014) 0.81
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease. Front Aging Neurosci (2015) 0.80
Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther (2009) 0.80
Exposure to environmental tobacco smoke induces angiogenesis and leukocyte trafficking in lung microvessels. Exp Lung Res (2009) 0.80
CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS. FASEB J (2015) 0.80
The α7-nicotinic acetylcholine receptor and MMP-2/-9 pathway mediate the proangiogenic effect of nicotine in human retinal endothelial cells. Invest Ophthalmol Vis Sci (2011) 0.80
The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression. Cancers (Basel) (2015) 0.80
Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population. PLoS One (2013) 0.80
NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas. Mol Biol Cell (2014) 0.78
Nicotine overrides DNA damage-induced G1/S restriction in lung cells. PLoS One (2011) 0.77
Anticancer actions of PPARγ ligands: Current state and future perspectives in human lung cancer. World J Biol Chem (2010) 0.77
Role of a genetic variant on the 15q25.1 lung cancer susceptibility locus in smoking-associated nasopharyngeal carcinoma. PLoS One (2014) 0.77
Prdm6 is essential for cardiovascular development in vivo. PLoS One (2013) 0.76
PET Imaging of the Human Nicotinic Cholinergic Pathway in Atherosclerosis. Curr Cardiol Rep (2015) 0.76
Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment. Clin Cancer Res (2015) 0.76
Mapping cigarettes similarities using cluster analysis methods. Int J Environ Res Public Health (2007) 0.75
β-arrestin1 at the cross-road of endothelin-1 signaling in cancer. J Exp Clin Cancer Res (2016) 0.75
Biomarkers of tobacco smoke exposure in racial/ethnic groups at high risk for lung cancer. Am J Public Health (2015) 0.75
Genetic and environmental factors influencing the Placental Growth Factor (PGF) variation in two populations. PLoS One (2012) 0.75
Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers. Oncotarget (2017) 0.75
Ameliorative effects of Achillea millefolium inflorescences alcoholic extract on nicotine-induced reproductive toxicity in male rat: Apoptotic and biochemical evidences. Vet Res Forum (2017) 0.75
Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene (2002) 2.23
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer. Mol Cancer (2012) 1.63
Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol (2004) 1.40
Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev (2005) 1.25
ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. J Natl Cancer Inst (2011) 1.15
Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Res (2011) 1.12
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol Cancer Res (2014) 1.10
A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochem Biophys Res Commun (2003) 1.08
Genetic and biochemical alterations in non-small cell lung cancer. Biochem Res Int (2012) 1.05
Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia (2012) 1.01
βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer. PLoS One (2013) 0.96
Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. Methods Mol Biol (2009) 0.91
The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells. Mol Cancer Ther (2002) 0.91
CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner. J Biol Chem (2010) 0.90
ChIP on chip assays: genome-wide analysis of transcription factor binding and histone modifications. Methods Mol Biol (2009) 0.90
Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. Mol Cancer (2012) 0.89
Chromatin immunoprecipitation assays: molecular analysis of chromatin modification and gene regulation. Methods Mol Biol (2007) 0.86
A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC. PLoS One (2012) 0.85
TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes. Cell Cycle (2012) 0.84
Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity. Biochem Biophys Res Commun (2012) 0.83
Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity. Mol Cancer Ther (2013) 0.79
In vitro replication assay with mammalian cell extracts. Methods Mol Biol (2009) 0.77
Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. Methods Mol Biol (2015) 0.76
ChIP on chip and ChIP-Seq assays: genome-wide analysis of transcription factor binding and histone modifications. Methods Mol Biol (2015) 0.76
In vitro replication assay with mammalian cell extracts. Methods Mol Biol (2015) 0.75