Published in Br J Pharmacol on May 26, 2008
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat Rev Cancer (2009) 2.92
Nicotine and the Developing Human: A Neglected Element in the Electronic Cigarette Debate. Am J Prev Med (2015) 2.24
Differential release of β-NAD(+) and ATP upon activation of enteric motor neurons in primate and murine colons. Neurogastroenterol Motil (2013) 1.63
Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans. Nat Med (2011) 1.62
Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer. Cancer Prev Res (Phila) (2011) 1.61
Cross-species analysis of nicotine-induced proteomic alterations in pancreatic cells. Proteomics (2013) 1.42
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
The role of α7 nicotinic acetylcholine receptor in modulation of heart rate dynamics in endotoxemic rats. PLoS One (2013) 1.41
Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol (2013) 1.36
Restoring the balance of the autonomic nervous system as an innovative approach to the treatment of rheumatoid arthritis. Mol Med (2011) 1.32
Nicotinic ACh receptors as therapeutic targets in CNS disorders. Trends Pharmacol Sci (2015) 1.26
Biochemical basis of asthma therapy. J Biol Chem (2011) 1.24
Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid. Carcinogenesis (2009) 1.21
MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines. Cell Res (2013) 1.15
Merging old and new perspectives on nicotinic acetylcholine receptors. Biochem Pharmacol (2014) 1.14
Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer. Cancer Res (2010) 1.13
The vagal innervation of the gut and immune homeostasis. Gut (2012) 1.12
Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochem Pharmacol (2009) 1.11
Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7. Mol Cancer Res (2011) 1.11
Role of platelets in neuroinflammation: a wide-angle perspective. J Neuroinflammation (2010) 1.11
The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis. Nat Rev Rheumatol (2009) 1.10
The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog Neurobiol (2010) 1.09
Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology. Int J Mol Sci (2012) 1.09
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. J Oncol (2011) 1.08
Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium. Am J Respir Cell Mol Biol (2010) 1.07
Tumor-promoting activities of nicotine not addressed. Dtsch Arztebl Int (2014) 1.07
CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury. J Leukoc Biol (2014) 1.05
Evidence for bladder urothelial pathophysiology in functional bladder disorders. Biomed Res Int (2014) 1.05
Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation. Cell Commun Signal (2009) 1.05
Non-neuronal release of ACh plays a key role in secretory response to luminal propionate in rat colon. J Physiol (2010) 1.03
Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis. Br J Pharmacol (2010) 1.02
Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. J Immunol (2011) 1.01
Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. J Pathol (2009) 1.00
Neurotransmitter receptors as central regulators of pancreatic cancer. Future Oncol (2010) 1.00
Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. Proc Natl Acad Sci U S A (2013) 0.99
Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases. Am J Physiol Cell Physiol (2010) 0.98
Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper. Neuropharmacology (2010) 0.98
Cholinergic microvillous cells in the mouse main olfactory epithelium and effect of acetylcholine on olfactory sensory neurons and supporting cells. J Neurophysiol (2011) 0.96
Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity. Int J Mol Sci (2014) 0.95
Nicotinic ACh receptors in the hippocampal circuit; functional expression and role in synaptic plasticity. J Physiol (2014) 0.95
Peristalsis in the junction region of the Drosophila larval midgut is modulated by DH31 expressing enteroendocrine cells. BMC Physiol (2010) 0.94
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN. Cancers (Basel) (2014) 0.93
Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters. Carcinogenesis (2012) 0.92
Novel cholinergic peptides SLURP-1 and -2 regulate epithelialization of cutaneous and oral wounds. Wound Repair Regen (2011) 0.91
Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention. PLoS One (2012) 0.91
Structure and composition of pulmonary arteries, capillaries, and veins. Compr Physiol (2012) 0.91
Arterial baroreflex dysfunction impairs ischemia-induced angiogenesis. J Am Heart Assoc (2014) 0.91
Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway. PLoS One (2013) 0.90
Coupling of ionic events to protein kinase signaling cascades upon activation of alpha7 nicotinic receptor: cooperative regulation of alpha2-integrin expression and Rho kinase activity. J Biol Chem (2009) 0.89
Auto/paracrine control of inflammatory cytokines by acetylcholine in macrophage-like U937 cells through nicotinic receptors. Int Immunopharmacol (2009) 0.89
Acetylcholine induces mesenchymal stem cell migration via Ca2+ /PKC/ERK1/2 signal pathway. J Cell Biochem (2012) 0.89
Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders. Cell Mol Life Sci (2016) 0.88
ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Mol Cancer Res (2010) 0.88
From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene (2010) 0.87
Muscarinic receptors and their antagonists in COPD: anti-inflammatory and antiremodeling effects. Mediators Inflamm (2012) 0.87
ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation. J Biol Chem (2014) 0.86
Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy. Am J Hum Genet (2014) 0.86
Cholinergic regulation of airway inflammation and remodelling. J Allergy (Cairo) (2012) 0.86
mAChRs activation induces epithelial-mesenchymal transition on lung epithelial cells. BMC Pulm Med (2014) 0.85
Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation. Ann N Y Acad Sci (2014) 0.84
Ion channels in hematopoietic and mesenchymal stem cells. Stem Cells Int (2012) 0.84
Epithelium integrity is crucial for the relaxant activity of brain natriuretic peptide in human isolated bronchi. Br J Pharmacol (2011) 0.84
Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem (2013) 0.84
Bronchodilatory and anti-inflammatory effects of ASM-024, a nicotinic receptor ligand, developed for the treatment of asthma. PLoS One (2014) 0.84
Electrical vagus nerve stimulation attenuates systemic inflammation and improves survival in a rat heatstroke model. PLoS One (2013) 0.84
Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases. Br J Pharmacol (2015) 0.84
Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanisms. J Am Heart Assoc (2013) 0.84
Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure. Am J Med Genet A (2012) 0.83
Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability. Br J Cancer (2014) 0.83
Mechanisms for nicotine in the development and progression of gastrointestinal cancers. Transl Gastrointest Cancer (2012) 0.83
Tumor cell migration is inhibited by a novel therapeutic strategy antagonizing the alpha-7 receptor. Oncotarget (2017) 0.82
Temporally- and spatially-regulated transcriptional activity of the nicotinic acetylcholine receptor beta4 subunit gene promoter. Neuroscience (2010) 0.82
Acetylcholine and the alpha 7 nicotinic receptor: a potential therapeutic target for the treatment of periodontal disease? Inflamm Res (2012) 0.82
From smoking to cancers: novel targets to neuronal nicotinic acetylcholine receptors. J Oncol (2011) 0.82
Early appearance and possible functions of non-neuromuscular cholinesterase activities. Front Mol Neurosci (2012) 0.82
Novel aspects of cholinergic regulation of colonic ion transport. Pharmacol Res Perspect (2015) 0.82
APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma. Mar Drugs (2013) 0.81
Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Cancer Biol Ther (2015) 0.81
NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts. Pflugers Arch (2011) 0.81
Interplay between smoking-induced genotoxicity and altered signaling in pancreatic carcinogenesis. Carcinogenesis (2012) 0.81
Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma. Br J Pharmacol (2012) 0.81
Nicotine induces upregulated expression of beta defensin-2 via the p38MAPK pathway in the HaCaT human keratinocyte cell line. Med Mol Morphol (2011) 0.81
New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer. Life Sci (2012) 0.81
Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice. Am J Physiol Lung Cell Mol Physiol (2014) 0.81
Role of parasympathetic nerves and muscarinic receptors in allergy and asthma. Chem Immunol Allergy (2012) 0.81
Localization of acetylcholine-related molecules in the retina: implication of the communication from photoreceptor to retinal pigment epithelium. PLoS One (2012) 0.80
CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS. FASEB J (2015) 0.80
Auto/paracrine nicotinergic peptides participate in cutaneous stress response to wounding. Dermatoendocrinol (2012) 0.80
Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective. Channels (Austin) (2014) 0.80
Non-neuronal functions of the m2 muscarinic acetylcholine receptor. Genes (Basel) (2013) 0.80
The Oncogenic Functions of Nicotinic Acetylcholine Receptors. J Oncol (2016) 0.80
Possible role of the α7 nicotinic receptors in mediating nicotine's effect on developing lung - implications in unexplained human perinatal death. BMC Pulm Med (2014) 0.80
The Arabidopsis thaliana ortholog of a purported maize cholinesterase gene encodes a GDSL-lipase. Plant Mol Biol (2013) 0.80
Cholinergic transactivation of the EGFR in HaCaT keratinocytes stimulates a flotillin-1 dependent MAPK-mediated transcriptional response. Int J Mol Sci (2015) 0.80
Acetylcholine receptor pathway in lung cancer: New twists to an old story. World J Clin Oncol (2014) 0.80
Upregulating nonneuronal cholinergic activity decreases TNF release from lipopolysaccharide-stimulated RAW264.7 cells. Mediators Inflamm (2014) 0.79
Non-neuronal cholinergic system in airways and lung cancer susceptibility. Transl Lung Cancer Res (2013) 0.79
Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia. Cancer Prev Res (Phila) (2012) 0.79
Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases. Orthop Rev (Pavia) (2009) 0.79
Nicotinic receptor signaling in nonexcitable epithelial cells: paradigm shifting from ion current to kinase cascade. Focus on "Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases". Am J Physiol Cell Physiol (2010) 0.79
Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature (2002) 12.09
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49
The inflammatory reflex. Nature (2002) 9.10
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol (2005) 4.91
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest (2003) 4.06
The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pharmacol (2007) 2.82
Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun (2007) 2.66
Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. Am J Respir Cell Mol Biol (2002) 2.22
A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest (2002) 2.19
Botulinum toxin: mechanism of presynaptic blockade. Science (1976) 2.19
The cholinergic anti-inflammatory pathway. Brain Behav Immun (2005) 2.13
Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans. Pharmacol Ther (1998) 1.99
Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors. J Neurochem (2004) 1.99
Acetylcholine and molecular components of its synthesis and release machinery in the urothelium. Eur Urol (2006) 1.89
Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors. Mol Pharmacol (2001) 1.89
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.87
Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway. Cancer Res (2004) 1.77
Endothelial progenitor cells participate in nicotine-mediated angiogenesis. J Am Coll Cardiol (2006) 1.70
Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res (2006) 1.69
The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin Exp Pharmacol Physiol (1999) 1.68
Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story. Cell Cycle (2006) 1.66
Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int (1999) 1.61
Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures. J Neurochem (2007) 1.60
Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol Pharmacol (1998) 1.56
Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function. Front Biosci (2004) 1.53
Expression and function of genes encoding cholinergic components in murine immune cells. Life Sci (2007) 1.53
Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man. Naunyn Schmiedebergs Arch Pharmacol (1997) 1.47
Mitogen induction of ion channels in murine T lymphocytes. J Gen Physiol (1987) 1.47
Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Res Commun Mol Pathol Pharmacol (1997) 1.42
Nicotine promotes arteriogenesis. J Am Coll Cardiol (2003) 1.42
Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology (2004) 1.42
Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. Am J Physiol Renal Physiol (2005) 1.42
The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation? Pharmacol Ther (2007) 1.40
Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis. J Biol Chem (2004) 1.37
A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes. J Invest Dermatol (1995) 1.35
Endothelial cells cultured from human umbilical vein release ATP, substance P and acetylcholine in response to increased flow. Proc Biol Sci (1990) 1.35
Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance. J Invest Dermatol (2006) 1.34
The non-neuronal cholinergic system of human skin. Horm Metab Res (2007) 1.34
The Non-neuronal cholinergic system: an emerging drug target in the airways. Pulm Pharmacol Ther (2001) 1.33
Acetylcholinesterase staining and choline acetyltransferase activity in the young adult rat spleen: lack of evidence for cholinergic innervation. Brain Behav Immun (1993) 1.32
Human keratinocytes synthesize, secrete, and degrade acetylcholine. J Invest Dermatol (1993) 1.29
Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia. J Dent Res (2000) 1.29
Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium. Life Sci (2007) 1.29
Activation of muscarinic receptor signaling by bile acids: physiological and medical implications. Dig Dis Sci (2003) 1.28
T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response. J Immunol (2007) 1.27
Non-neuronal acetylcholine and urinary bladder urothelium. Life Sci (2007) 1.27
Biological functions of keratinocyte cholinergic receptors. J Investig Dermatol Symp Proc (1997) 1.27
Angiogenesis and the role of the endothelial nicotinic acetylcholine receptor. Life Sci (2007) 1.26
Extraneuronal cholinergic system in lymphocytes. Pharmacol Ther (2000) 1.25
Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice. Mol Pharmacol (2004) 1.25
Increased voltage-gated potassium conductance during interleukin 2-stimulated proliferation of a mouse helper T lymphocyte clone. J Cell Biol (1986) 1.24
M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res (2007) 1.23
Evolutional study on acetylcholine expression. Life Sci (2003) 1.22
Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function. Auton Autacoid Pharmacol (2006) 1.22
The non-neuronal cholinergic system in humans: expression, function and pathophysiology. Life Sci (2003) 1.22
Expression and distribution of cholinergic receptors in the human urothelium. Life Sci (2007) 1.20
Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes. J Cell Sci (2004) 1.19
Nicotine and fibronectin expression in lung fibroblasts: implications for tobacco-related lung tissue remodeling. FASEB J (2004) 1.18
Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. Pulm Pharmacol Ther (2006) 1.17
Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am J Respir Cell Mol Biol (2005) 1.16
Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke. FASEB J (2008) 1.16
Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts. Respir Res (2004) 1.14
Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism. Eur J Pharmacol (2008) 1.13
Progesterone modulates a neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (1992) 1.12
The biological role of non-neuronal acetylcholine in plants and humans. Jpn J Pharmacol (2001) 1.12
Synthesis of acetylcholine by lung cancer. Life Sci (2003) 1.12
Muscarinic receptors mediate stimulation of human lung fibroblast proliferation. Am J Respir Cell Mol Biol (2006) 1.11
Neural-immune interface in the rat area postrema. Neuroscience (2006) 1.10
Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. J Pharm Sci (2002) 1.09
Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells. Respir Res (2005) 1.08
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters. Br J Pharmacol (2001) 1.07
Cholinergic systems in non-nervous tissues. Pharmacol Rev (1978) 1.07
Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization. Exp Cell Res (2007) 1.07
Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator. J Neuroimmunol (1998) 1.07
Differential muscarinic receptor mRNA expression by freshly isolated and cultured bovine aortic endothelial cells. Circ Res (1992) 1.07
The expression and functional role of nicotinic acetylcholine receptors in rat adipocytes. J Pharmacol Exp Ther (2004) 1.07
Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients. Allergy (2005) 1.06
Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin. J Invest Dermatol (2002) 1.05
The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration. J Biol Chem (2005) 1.05
Mechanisms of mitogen-activated protein kinase activation by nicotine in small-cell lung carcinoma cells. Biochem J (1997) 1.04
Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin. J Invest Dermatol (2004) 1.04
M3 muscarinic acetylcholine receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein kinase C isoforms. J Biol Chem (1999) 1.01
Acetylcholine: a novel regulator of airway smooth muscle remodelling? Eur J Pharmacol (2004) 1.01
Acetylcholine in isolated airways of rat, guinea pig, and human: species differences in role of airway mucosa. Am J Physiol (1996) 0.99
Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway. J Neuroimmunol (2005) 0.99
Evidence for functional nicotinic receptors on pancreatic beta cells. Metabolism (2005) 0.99
The role of nicotinic receptors in B-lymphocyte development and activation. Life Sci (2007) 0.98
The chemical component of the mixed GF-TTMn synapse in Drosophila melanogaster uses acetylcholine as its neurotransmitter. Eur J Neurosci (2007) 0.98
Cholinergic regulation of epithelial ion transport in the mammalian intestine. Br J Pharmacol (2006) 0.97
Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro. Respir Med (2007) 0.97
Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-/- mice. Eur J Pharmacol (2004) 0.96
Innervation of the thymus gland by brain stem and spinal cord in mouse and rat. Am J Anat (1981) 0.96
Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res (2006) 0.96
Cholinergic stimulation of amylase secretion from pancreatic acinar cells studied with muscarinic acetylcholine receptor mutant mice. J Pharmacol Exp Ther (2005) 0.96
Muscarinic receptors in human luteinized granulosa cells: activation blocks gap junctions and induces the transcription factor early growth response factor-1. J Clin Endocrinol Metab (2002) 0.95
Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. Am J Physiol (1992) 0.95
Effect of acetyl choline on ion transport in sheep tracheal epithelium. Pflugers Arch (1994) 0.94
M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes. J Mol Neurosci (2006) 0.93
Nicotine induces mononuclear leukocyte adhesion and expression of adhesion molecules, VCAM and ICAM, in endothelial cells in vitro. Ann Vasc Surg (2004) 0.93
Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans. Pharmacol Ther (1998) 1.99
The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin Exp Pharmacol Physiol (1999) 1.68
Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. Mol Biol Cell (2007) 1.60
Mechanisms of cell activation by heavy metal ions. J Biomed Mater Res (1998) 1.58
Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man. Naunyn Schmiedebergs Arch Pharmacol (1997) 1.47
The non-neuronal cholinergic system of human skin. Horm Metab Res (2007) 1.34
The Non-neuronal cholinergic system: an emerging drug target in the airways. Pulm Pharmacol Ther (2001) 1.33
Generation of human pulmonary microvascular endothelial cell lines. Lab Invest (2001) 1.31
Dose-related effects of shock waves on rabbit tendo Achillis. A sonographic and histological study. J Bone Joint Surg Br (1998) 1.26
Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues. Int J Cancer (1992) 1.22
Morphogenesis and possible precursor lesions of invasive carcinoma of the papilla of Vater: epithelial dysplasia and adenoma. Hum Pathol (1985) 1.18
Do we truly see what we think we see? The role of cognitive bias in pathological interpretation. J Pathol (2008) 1.15
The biological role of non-neuronal acetylcholine in plants and humans. Jpn J Pharmacol (2001) 1.12
The therapeutic monitoring of antimicrobial agents. Br J Clin Pharmacol (1999) 1.12
PCR testing for Treponema pallidum in paraffin-embedded skin biopsy specimens: test design and impact on the diagnosis of syphilis. J Clin Pathol (2007) 1.07
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters. Br J Pharmacol (2001) 1.07
Endothelialization of a non-woven silk fibroin net for use in tissue engineering: growth and gene regulation of human endothelial cells. Biomaterials (2004) 1.06
Haemangiopericytoma of the thyroid gland in combination with Hashimoto's disease. Virchows Arch (2004) 1.04
Microcirculatory dysfunction in sepsis: a pathogenetic basis for therapy? J Pathol (2000) 1.03
Use of a collagen/elastin-membrane for the tissue engineering of dermis. Burns (1999) 1.03
Porous gelatin hydrogels: 2. In vitro cell interaction study. Biomacromolecules (2007) 1.01
Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Hum Pathol (2000) 0.99
Local and systemic inflammatory mediator release in patients with acute and chronic posttraumatic osteomyelitis. J Trauma (1996) 0.97
Expression of endothelial cell adhesion molecules on heart valves: up-regulation in degeneration as well as acute endocarditis. J Pathol (2000) 0.97
Induction of stress proteins in human endothelial cells by heavy metal ions and heat shock. Am J Physiol (1999) 0.96
Effect of pro-inflammatory stimuli on tumor cell-mediated induction of endothelial cell adhesion molecules in vitro. Exp Mol Pathol (2002) 0.96
Time course of various inflammatory mediators during recurrent endotoxemia. Biochem Pharmacol (1992) 0.96
[Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma]. Pathologe (2010) 0.95
Effect of low molecular weight heparin (Certoparin) versus unfractionated heparin on cancer survival following breast and pelvic cancer surgery: A prospective randomized double-blind trial. Int J Oncol (2000) 0.95
Computed tomography and histologic results in the early stages of endotoxin-injured pig lungs as a model for adult respiratory distress syndrome. Invest Radiol (1993) 0.94
Apoptosis causes lumen formation during angiogenesis in vitro. Microvasc Res (2002) 0.94
Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density. Virchows Arch (2001) 0.92
Systemic kappa light chain deposition and amyloidosis in multiple myeloma: novel morphological observations. Histopathology (1986) 0.92
Influence of nonsteroidal anti-inflammatory agents on lapine articular chondrocyte growth in vitro. Z Rheumatol (1983) 0.91
Expression of fibronectin splice variants and oncofetal glycosylated fibronectin in the synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Rheumatol Int (2003) 0.91
Metallic nanoparticles exhibit paradoxical effects on oxidative stress and pro-inflammatory response in endothelial cells in vitro. Int J Immunopathol Pharmacol (2008) 0.90
From cytotoxicity to biocompatibility testing in vitro: cell adhesion molecule expression defines a new set of parameters. J Mater Sci Mater Med (1997) 0.89
Glucocorticoids mediate reduction of epithelial acetylcholine content in the airways of rats and humans. Eur J Pharmacol (1998) 0.89
Differential expression of cell adhesion molecules in inflamed appendix: correlation with clinical stage. J Pathol (1998) 0.88
Comparative study assessing effects of sonic hedgehog and VEGF in a human co-culture model for bone vascularisation strategies. Eur Cell Mater (2011) 0.87
Maxillary sinus grafting with a nano-structured biomaterial: preliminary clinical and histological results. Eur Surg Res (2009) 0.87
Osteopontin expression in primary sarcomas of the pulmonary artery. Virchows Arch (2001) 0.87
Er:YAG laser osteotomy: preliminary clinical and histological results of a new technique for contact-free bone surgery. Eur Surg Res (2009) 0.86
Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases. Virchows Arch (2008) 0.86
Migration assay for endothelial cells in multiwells. Application to studies on the effect of opioids. J Immunol Methods (1990) 0.86
A new quantitative test method for cell proliferation based on detection of the Ki-67 protein. J Mater Sci Mater Med (2000) 0.85
Macrophages and multicellular tumor spheroids in co-culture: a three-dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration. Am J Pathol (1993) 0.85
Skeletal muscle oedema and muscle fibre necrosis during septic shock. Observations with a porcine septic shock model. Virchows Arch (1994) 0.85
Fibronectin-mediated endothelialisation of chitosan porous matrices. Biomaterials (2009) 0.85
[Extracorporeal shock-wave therapy. Experimental basis, clinical application]. Orthopade (1997) 0.85
In vitro evaluation of biomimetic chitosan-calcium phosphate scaffolds with potential application in bone tissue engineering. Biomed Mater (2013) 0.84
Effects of cytokines on the expression of cell adhesion molecules by cultured human omental mesothelial cells. Pathobiology (1995) 0.84
Vascularization and gene regulation of human endothelial cells growing on porous polyethersulfone (PES) hollow fiber membranes. Biomaterials (2005) 0.84
Interaction between enteroviruses and human endothelial cells in vitro. Alterations in the physical properties of endothelial cell plasma membrane and adhesion of human granulocytes. Am J Pathol (1985) 0.84
Fluid shear induced endothelial cell detachment from glass--influence of adhesion time and shear stress. Med Eng Phys (1994) 0.84
Growth of human cells on polyethersulfone (PES) hollow fiber membranes. Biomaterials (2005) 0.84
Steroid receptor expression in endometria from women treated with tamoxifen. Gynecol Oncol (1998) 0.84
Differential adhesion of polymorphous neutrophilic granulocytes to macro- and microvascular endothelial cells under flow conditions. Pathobiology (2001) 0.83
Comparative studies on vascular endothelium in vitro. 3. Effects of cytokines on the expression of E-selectin, ICAM-1 and VCAM-1 by cultured human endothelial cells obtained from different passages. Pathobiology (1995) 0.83
Interaction of human malignant melanoma (ST-ML-12) tumor spheroids with endothelial cell monolayers. Damage to endothelium by oxygen-derived free radicals. Am J Pathol (1992) 0.83
Expression of KIT (CD117) in biphasic pulmonary blastoma. Novel data on histogenesis. Lung (2003) 0.83
The influence of heat shock protein 70 induction on hemodynamic variables in a porcine model of recurrent endotoxemia. Shock (1997) 0.83
Biomaterial-induced alterations of human neutrophils under fluid shear stress: scanning electron microscopical study in vitro. Biomaterials (1996) 0.83
An injectable bone substitute composed of beta-tricalcium phosphate granules, methylcellulose and hyaluronic acid inhibits connective tissue influx into its implantation bed in vivo. Acta Biomater (2011) 0.83
Myocardial infarction, cardiac rupture, and coronary insufficiency in the industrialised Ruhr valley. An autopsy study. Zentralbl Allg Pathol (1983) 0.83
Characterization of the new bladder cancer cell line HOK-1: expression of transitional, squamous and glandular differentiation patterns. Int J Cancer (1991) 0.83
Isolated erythema (cellulitis) of the breast. Breast (2002) 0.82
Association of different macrophage phenotypes with infiltrating and non-infiltrating areas of tumor-host interface in colorectal carcinoma. Pathol Res Pract (1994) 0.82
Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery. Cancer (2001) 0.82
Release of non-neuronal acetylcholine from the human placenta: difference to neuronal acetylcholine. Naunyn Schmiedebergs Arch Pharmacol (2001) 0.82
Impaired in vivo vasculogenic potential of endothelial progenitor cells in comparison to human umbilical vein endothelial cells in a spheroid-based implantation model. Cell Prolif (2009) 0.82
[Tissue engineering of cartilage and bone : growth factors and signaling molecules]. Orthopade (2009) 0.82
PECAM-1 expression in human mesothelial cells: an in vitro study. Pathobiology (1996) 0.81
Endothelial accumulation of hydroxyethyl starch and functional consequences on leukocyte-endothelial interactions. Eur Surg Res (2002) 0.81
The influence of the C1-inhibitor BERINERT and the protein-free haemodialysate ACTIHAEMYL20% on the evolution of the depth of scald burns in a porcine model. Burns (1997) 0.81
Production of superoxide by human malignant melanoma cells. Melanoma Res (1998) 0.81
Expression of matrix-degrading cysteine proteinase cathepsin K in cholesteatoma. Mod Pathol (2001) 0.81
Interaction of human malignant melanoma tumor spheroids with endothelium and reconstituted basement membrane: modulation by RGDS. Int J Cancer (1993) 0.80
Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. Biochem Pharmacol (1996) 0.80
Heavy metal ion induction of adhesion molecules and cytokines in human endothelial cells: the role of NF-kappaB, I kappaB-alpha and AP-1. Pathobiology (1997) 0.80
Prognostic significance of tumor ploidy and histomorphological parameters in adenocarcinoma of Barrett's esophagus. Dig Surg (1999) 0.80
Prediction model of lymph node metastasis in superficial esophageal adenocarcinoma and squamous cell cancer including D2-40 immunostaining. J Surg Oncol (2009) 0.80
Osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: case report with novel data on histogenesis. Pancreas (2002) 0.80
Porous gelatin cryogels as cell delivery tool in tissue engineering. J Control Release (2006) 0.80
Alterations in chondrocyte morphology, proliferation and binding of 35SO4 due to Fe(III), Fe(II), ferritin and haemoglobin in vitro. Virchows Arch B Cell Pathol Incl Mol Pathol (1982) 0.80
[Effect of piroxicam on the structure and function of joint cartilage]. Z Rheumatol (1983) 0.80
Infected osteoradionecrosis of the mandible: follow-up study suggests deterioration in outcome for patients with Actinomyces-positive bone biopsies. Int J Oral Maxillofac Surg (2006) 0.80
["Hic gaudet mors succurere vitae", autopsy findings of the Mainz Institute of Pathology 1971-2010. An analysis on the occasion of the 100 year jubilee]. Pathologe (2014) 0.80
Comparative studies on vascular endothelium in vitro. I. Cytokine effects on the expression of adhesion molecules by human umbilical vein, saphenous vein and femoral artery endothelial cells. Pathobiology (1994) 0.79
Opioid influence on the adherence of granulocytes to human umbilical vein endothelial cells in vitro. Cell Biol Int Rep (1990) 0.79
Tissue factor expression during coculture of endothelial cells and monocytes. Exp Mol Pathol (1995) 0.79
In vitro and in vivo evaluation of a hydrophilized silicone intraocular lens. J Cataract Refract Surg (1992) 0.79
Cell-cycle control in cell-biomaterial interactions: expression of p53 and Ki67 in human umbilical vein endothelial cells in direct contact and extract testing of biomaterials. J Biomed Mater Res (2000) 0.79
Focal adhesions and assessment of cytotoxicity. J Biomed Mater Res (1999) 0.79
Improving cytocompatibility of Co28Cr6Mo by TiO2 coating: gene expression study in human endothelial cells. J R Soc Interface (2013) 0.79
Tissue reaction to sealing materials: different view at biocompatibility. Eur J Med Res (2010) 0.79
Toward modulating the architecture of hydrogel scaffolds: curtains versus channels. J Mater Sci Mater Med (2008) 0.79
[In vitro trials with single and co-cultures of osteoblasts and endothelial cells : evaluation of new biomaterials for bone reconstruction and regeneration]. Orthopade (2009) 0.78
Perspectives for the tissue engineering of cartilage from a biological and biomaterial point of view. J Appl Biomater Biomech (2010) 0.78