Published in Blood on November 16, 2006
Platelets as cellular effectors of inflammation in vascular diseases. Circ Res (2013) 2.62
Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood (2011) 2.38
Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function. Arterioscler Thromb Vasc Biol (2008) 1.47
Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. J Biol Chem (2010) 1.47
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood (2011) 1.39
Protein synthesis by platelets: historical and new perspectives. J Thromb Haemost (2008) 1.38
Amicus or adversary: platelets in lung biology, acute injury, and inflammation. Am J Respir Cell Mol Biol (2008) 1.38
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol (2011) 1.26
Lipopolysaccharide is a direct agonist for platelet RNA splicing. J Immunol (2008) 1.24
Rho GTPases in platelet function. J Thromb Haemost (2013) 1.15
The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost (2011) 1.15
mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. J Biol Chem (2011) 1.14
Platelets and megakaryocytes contain functional nuclear factor-kappaB. Arterioscler Thromb Vasc Biol (2009) 1.13
Platelets in lung biology. Annu Rev Physiol (2012) 1.08
Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity. Am J Respir Crit Care Med (2009) 0.97
A tour through the transcriptional landscape of platelets. Blood (2014) 0.94
Platelets in inflammation and atherogenesis. Front Immunol (2015) 0.94
Platelet mRNA: the meaning behind the message. Curr Opin Hematol (2012) 0.93
Platelet tissue factor synthesis in type 2 diabetic patients is resistant to inhibition by insulin. Diabetes (2010) 0.93
Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop. J Immunol (2013) 0.91
Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm (2012) 0.90
Translational control in endothelial cells. J Vasc Surg (2007) 0.88
PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids. Blood (2009) 0.85
Platelets as central mediators of systemic inflammatory responses. Thromb Res (2010) 0.84
The platelet fibrinogen receptor: from megakaryocyte to the mortuary. JRSM Cardiovasc Dis (2012) 0.83
Alteration of the platelet transcriptome in chronic kidney disease. Thromb Haemost (2012) 0.83
Regulation of the mTOR-Rac1 axis in platelet function. Small GTPases (2012) 0.80
Dissection of autophagy in human platelets. Autophagy (2014) 0.80
Long-term mTOR inhibitors administration evokes altered calcium homeostasis and platelet dysfunction in kidney transplant patients. J Cell Mol Med (2013) 0.79
NFkappaB regulation of platelet function: no nucleus, no genes, no problem? J Thromb Haemost (2009) 0.79
Staphylococcus aureus α-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets. Toxins (Basel) (2011) 0.79
Pneumococcal Adhesins PavB and PspC Are Important for the Interplay with Human Thrombospondin-1. J Biol Chem (2015) 0.78
Leptin increases TNF-α expression and production through phospholipase D1 in Raw 264.7 cells. PLoS One (2014) 0.78
Slowed decay of mRNAs enhances platelet specific translation. Blood (2017) 0.78
Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity. PLoS One (2016) 0.77
Integrin αDβ2 (CD11d/CD18) is expressed by human circulating and tissue myeloid leukocytes and mediates inflammatory signaling. PLoS One (2014) 0.76
Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets. J Thromb Haemost (2014) 0.76
mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation. Blood (2016) 0.75
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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med (2002) 12.84
Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40
Platelets in atherothrombosis. Nat Med (2002) 5.81
Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood (2002) 4.72
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell (2005) 4.02
The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell (1990) 3.41
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell (1993) 3.35
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol (1999) 3.26
Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation (2006) 2.93
Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science (2004) 2.91
Pathology of acute and chronic coronary stenting in humans. Circulation (1999) 2.78
Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol (2001) 2.75
Defective platelet activation in G alpha(q)-deficient mice. Nature (1997) 2.67
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Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med (2006) 2.39
Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes. Mol Cell Proteomics (2003) 2.25
Inflammation and restenosis in the stent era. Arterioscler Thromb Vasc Biol (2002) 2.20
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Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function. Circ Res (2002) 2.10
Scientific and therapeutic advances in antiplatelet therapy. Nat Rev Drug Discov (2003) 2.06
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Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells. Cell (1989) 1.92
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The evolving role of platelets in inflammation. J Thromb Haemost (2003) 1.55
Drug-eluting stents: results, promises and problems. Int J Cardiol (2005) 1.41
Change in protein phenotype without a nucleus: translational control in platelets. Semin Thromb Hemost (2004) 1.41
Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. Blood (2003) 1.39
Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. EMBO J (1996) 1.33
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The Pl(A2) polymorphism of integrin beta(3) enhances outside-in signaling and adhesive functions. J Clin Invest (2000) 1.25
Platelets synthesize large amounts of active plasminogen activator inhibitor 1. Blood (2004) 1.25
Platelet genomics and proteomics in human health and disease. J Clin Invest (2005) 1.24
Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control. J Biol Chem (2001) 1.24
Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets. J Cell Biol (1999) 1.21
Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program. J Biol Chem (2000) 1.20
Isolation and characterization of hemolymph clotting factors in Drosophila melanogaster by a pullout method. Curr Biol (2004) 1.14
Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. J Exp Med (2004) 1.13
Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes. Proc Natl Acad Sci U S A (2001) 1.12
Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots. J Biol Chem (1997) 1.10
Analysis of SAGE data in human platelets: features of the transcriptome in an anucleate cell. Thromb Haemost (2006) 1.10
Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers. J Biol Chem (1994) 1.04
Bcl-3-mediated nuclear regulation of the NF-kappa B trans-activating factor. Immunol Today (1994) 1.04
mTOR: a mediator of intracellular homeostasis. Curr Top Microbiol Immunol (2004) 1.03
Circulating human blood platelets retain appreciable amounts of poly (A)+ RNA. Biochem Biophys Res Commun (1989) 1.01
Inhibition of clot lysis and decreased binding of tissue-type plasminogen activator as a consequence of clot retraction. Blood (1992) 1.00
Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells. Trends Cardiovasc Med (2005) 0.96
Platelets interact with fibrin only after activation. Blood (1985) 0.92
The effect of peptides and monoclonal antibodies that bind to platelet glycoprotein IIb-IIIa complex on the development of clot tension. Blood (1989) 0.89
Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3. Blood (1995) 0.89
Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn. Biochim Biophys Acta (2000) 0.88
Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets. Thromb Haemost (2001) 0.88
Selective association of the tyrosine kinases Src, Fyn, and Lyn with integrin-rich actin cytoskeletons of activated, nonaggregated platelets. Biochem Biophys Res Commun (1999) 0.85
Involvement of alpha v beta 3 integrin in mediating fibrin gel retraction. J Biol Chem (1995) 0.85
Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates. J Am Coll Cardiol (2002) 0.83
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Regulation of Bcl-3 through interaction with the Lck tyrosine kinase. Biochem Biophys Res Commun (2005) 0.80
Platelet-Independent defect in hemostasis associated with sirolimus use. Transplant Proc (2004) 0.79
Activity of pp60c-src and association of pp60c-src, pp54/58lyn, pp60fyn, and pp72syk with the cytoskeleton in platelets activated by collagen. IUBMB Life (2000) 0.77
Beta2 integrin modulates platelet caspase activation and life span in mice. Eur J Cell Biol (2001) 0.77
The acute respiratory distress syndrome. J Clin Invest (2012) 5.61
Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell (2005) 4.02
Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood (2009) 3.90
Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med (2003) 3.75
Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood (2011) 3.37
Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med (2010) 3.02
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc Natl Acad Sci U S A (2002) 3.01
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Platelets as cellular effectors of inflammation in vascular diseases. Circ Res (2013) 2.62
Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med (2006) 2.39
Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood (2011) 2.38
Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol (2002) 2.30
Anucleate platelets generate progeny. Blood (2010) 2.24
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Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem (2009) 2.13
Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function. Circ Res (2002) 2.10
An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis. PLoS One (2010) 2.08
VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock. Chest (2015) 1.99
The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology (2008) 1.88
Lysophosphatidic acid induces neointima formation through PPARgamma activation. J Exp Med (2004) 1.86
Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol (2003) 1.82
Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial. Am Heart J (2008) 1.80
Properties of a fetal multipotent neural stem cell (NEP cell). Dev Biol (2002) 1.75
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood (2013) 1.74
Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J Biol Chem (2005) 1.73
The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit Care Med (2002) 1.66
Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med (2003) 1.58
Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol (2004) 1.56
Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Lipid Res (2010) 1.53
The Society for Vascular Surgery Vascular Quality Initiative. J Vasc Surg (2012) 1.46
Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands. Curr Opin Hematol (2002) 1.43
Platelet-activating factor acetylhydrolase is increased in lung lavage fluid from patients with acute respiratory distress syndrome. Crit Care Med (2003) 1.43
The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax (2007) 1.41
Change in protein phenotype without a nucleus: translational control in platelets. Semin Thromb Hemost (2004) 1.41
Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. Crit Rev Clin Lab Sci (2003) 1.39
Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration. Thromb Haemost (2013) 1.39
Amicus or adversary: platelets in lung biology, acute injury, and inflammation. Am J Respir Cell Mol Biol (2008) 1.38
Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs. Am J Respir Crit Care Med (2005) 1.35
Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates. Circulation (2005) 1.33
Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat. Am J Respir Crit Care Med (2004) 1.31
The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie (2010) 1.30
Has the changing nature of vascular surgery adversely affected scholarly activity. J Vasc Surg (2003) 1.27
Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes. Circ Res (2007) 1.27
Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A (2004) 1.27
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol (2011) 1.26
Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles. J Immunol (2011) 1.25
Lipopolysaccharide is a direct agonist for platelet RNA splicing. J Immunol (2008) 1.24
Cytotoxic phospholipid oxidation products. Cell death from mitochondrial damage and the intrinsic caspase cascade. J Biol Chem (2007) 1.24
Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency. Am J Hum Genet (2013) 1.23
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Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles. J Biol Chem (2003) 1.18
Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest (2006) 1.18
Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy. PLoS Pathog (2010) 1.18
Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage. J Biol Chem (2005) 1.16
Sol Sherry lecture in thrombosis: molecular events in acute inflammation. Arterioscler Thromb Vasc Biol (2002) 1.16
Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease. Am J Physiol Lung Cell Mol Physiol (2007) 1.15
Endotoxin contamination of ovalbumin suppresses murine immunologic responses and development of airway hyper-reactivity. J Biol Chem (2003) 1.14
Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. J Exp Med (2004) 1.13
Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation (2003) 1.12
Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria. PLoS Pathog (2012) 1.11
Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog (2011) 1.11
National trauma databank analysis of mortality and limb loss in isolated lower extremity vascular trauma. J Vasc Surg (2011) 1.11
Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock (2006) 1.09
Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin. Oncogene (2004) 1.09
Platelets in lung biology. Annu Rev Physiol (2012) 1.08
Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2. Biochem Biophys Res Commun (2002) 1.08
Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein. J Biol Chem (2002) 1.08
Platelet-activating factor acetylhydrolase, and not paraoxonase-1, is the oxidized phospholipid hydrolase of high density lipoprotein particles. J Biol Chem (2002) 1.06