Published in Small GTPases on June 20, 2012
Rho GTPases in platelet function. J Thromb Haemost (2013) 1.15
p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arterioscler Thromb Vasc Biol (2013) 0.97
The Rac1 hypervariable region in targeting and signaling: a tail of many stories. Small GTPases (2013) 0.83
Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets. J Thromb Haemost (2014) 0.76
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
The pharmacology of mTOR inhibition. Sci Signal (2009) 5.36
A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans (2009) 4.37
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell (2002) 3.80
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med (2007) 3.66
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res (2011) 3.12
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest (2011) 3.00
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell (2010) 2.86
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell (2010) 2.56
Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol (2010) 2.43
GPVI and integrin alphaIIb beta3 signaling in platelets. J Thromb Haemost (2005) 2.42
The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell (1996) 2.39
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell (2011) 2.32
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem (2005) 2.07
Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci U S A (1998) 1.97
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood (2011) 1.88
Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol (1999) 1.72
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem (2007) 1.67
Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. J Biol Chem (2003) 1.50
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood (2011) 1.39
mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood (2006) 1.39
p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene (2011) 1.21
Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood (2002) 1.15
mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. J Biol Chem (2011) 1.14
mTOR signaling in cancer cell motility and tumor metastasis. Crit Rev Eukaryot Gene Expr (2010) 1.13
Role of mTOR signaling in intestinal cell migration. Am J Physiol Gastrointest Liver Physiol (2006) 1.03
RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem (2002) 1.01
New insights into the haemostatic function of platelets. Br J Haematol (2009) 1.01
Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. PLoS One (2011) 0.98
Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. Am J Physiol Heart Circ Physiol (2005) 0.92
Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase. Biochem Biophys Res Commun (1997) 0.92
Preparation and characterization of rapamycin-loaded PLGA coating stent. J Mater Sci Mater Med (2007) 0.89
Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets. Thromb Haemost (2001) 0.88
Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets. J Mol Signal (2011) 0.82
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI. Blood (2008) 1.89
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood (2010) 1.83
Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood (2014) 1.81
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arterioscler Thromb Vasc Biol (2007) 1.80
Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol (2009) 1.64
Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient. Front Oncol (2012) 1.54
Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation. Am J Physiol Cell Physiol (2013) 1.53
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging (2012) 1.53
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A (2008) 1.45
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood (2011) 1.39
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Microfluidics and coagulation biology. Annu Rev Biomed Eng (2013) 1.30
Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient. Front Oncol (2012) 1.26
Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscope. Phys Rev Lett (2012) 1.26
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS One (2010) 1.22
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood (2005) 1.19
Platelet shape change and spreading. Methods Mol Biol (2012) 1.13
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A (2009) 1.13
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood (2007) 1.12
Development of a Label-free Imaging Technique for the Quantification of Thrombus Formation. Cell Mol Bioeng (2012) 1.09
The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen. FEBS J (2007) 1.06
Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis. J Neuroimmunol (2010) 1.05
Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy. Am J Physiol Cell Physiol (2013) 0.97
p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arterioscler Thromb Vasc Biol (2013) 0.97
Distinct but critical roles for integrin alphaIIbbeta3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin. FEBS J (2006) 0.97
Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3. Biochem J (2007) 0.95
Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. Stroke (2011) 0.94
Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. J Leukoc Biol (2011) 0.93
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. Am J Physiol Cell Physiol (2013) 0.92
Do circulating tumor cells play a role in coagulation and thrombosis? Front Oncol (2012) 0.92
Modeling and simulation of procoagulant circulating tumor cells in flow. Front Oncol (2012) 0.92
Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis. Blood (2012) 0.91
Development of coagulation factor probes for the identification of procoagulant circulating tumor cells. Front Oncol (2012) 0.90
p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS One (2013) 0.89
Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress. Am J Physiol Cell Physiol (2009) 0.89
Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice. Transl Stroke Res (2012) 0.88
Distinct extracellular matrix microenvironments of progenitor and carotid endothelial cells. J Biomed Mater Res A (2009) 0.88
Physical biology in cancer. 2. The physical biology of circulating tumor cells. Am J Physiol Cell Physiol (2013) 0.87
GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arterioscler Thromb Vasc Biol (2006) 0.87
Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis. J Biol Chem (2012) 0.87
Minimal regulation of platelet activity by PECAM-1. Platelets (2007) 0.86
Preferential binding of platelets to monocytes over neutrophils under flow. Biochem Biophys Res Commun (2005) 0.86
Quantification of volume, mass, and density of thrombus formation using brightfield and differential interference contrast microscopy. J Biomed Opt (2013) 0.85
Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain receptor antibody. Tissue Eng Part C Methods (2008) 0.85
Single particle quantum dot imaging achieves ultrasensitive detection capabilities for Western immunoblot analysis. ACS Nano (2009) 0.85
Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. Am J Physiol Cell Physiol (2012) 0.83
Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography. Opt Lett (2012) 0.83
Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates. Sci Transl Med (2010) 0.81
Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis. Metab Brain Dis (2014) 0.81
Effect of sex difference on platelet adhesion, spreading and aggregate formation under flow. Thromb Haemost (2009) 0.80
Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells. Phys Biol (2013) 0.79
Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor. Phys Biol (2013) 0.79
Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear. Am J Physiol Cell Physiol (2013) 0.78
Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: implications for inflammatory demyelinating disease. Matrix Biol (2013) 0.78
Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis. J Cardiovasc Pharmacol (2002) 0.78
Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen. Thromb Haemost (2017) 0.78
Rac and Cdc42 team up for platelets. Blood (2013) 0.76
Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice. J Autoimmun (2012) 0.75
Breakup feared after filamin leaves GPIb. Blood (2011) 0.75