Published in Infect Immun on November 21, 2006
Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol (2010) 5.59
Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes. J Biol Chem (2009) 1.35
Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae. J Immunol (2009) 1.17
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol 2000 (2010) 1.15
Interleukin-1beta modulates proinflammatory cytokine production in human epithelial cells. Infect Immun (2008) 1.15
Bacterial invasion of epithelial cells and spreading in periodontal tissue. Periodontol 2000 (2010) 1.15
A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis. Infect Immun (2013) 1.12
Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity. PLoS One (2010) 1.10
Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA. Infect Immun (2007) 1.09
TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells. Eur J Immunol (2008) 0.99
Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function. Infect Immun (2010) 0.97
Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma. BMC Microbiol (2012) 0.94
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis. J Immunol (2009) 0.94
Porphyromonas gingivalis fimbriae. J Oral Microbiol (2013) 0.92
TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss. J Immunol (2011) 0.91
Scavenger receptor A is expressed by macrophages in response to Porphyromonas gingivalis, and participates in TNF-alpha expression. Oral Microbiol Immunol (2009) 0.81
Selective Toll--like receptor expression in human fetal lung. Pediatr Res (2010) 0.81
Porphyromonas gingivalis promotes monocyte migration by activating MMP-9. J Periodontal Res (2011) 0.79
A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice. Hypertens Res (2016) 0.78
Unique secreted-surface protein complex of Lactobacillus rhamnosus, identified by phage display. Microbiologyopen (2012) 0.78
Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes. PLoS One (2010) 0.76
Proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket. Sci Rep (2015) 0.75
Differential Expression and Roles of Secreted Frizzled-Related Protein 5 and the Wingless Homolog Wnt5a in Periodontitis. J Dent Res (2017) 0.75
Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev (1998) 6.28
Virulence factors of Porphyromonas gingivalis. Periodontol 2000 (1999) 3.36
Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats. J Bacteriol (1994) 2.59
The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius in destructive periodontal disease in adults. J Clin Periodontol (1986) 2.37
Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun (1997) 2.27
Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J Biol Chem (2003) 2.20
Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus. Cell Microbiol (2006) 1.67
Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase. Eur J Immunol (2005) 1.46
New concepts of destructive periodontal disease. J Clin Periodontol (1984) 1.43
Cytokine responses of oral epithelial cells to Porphyromonas gingivalis infection. J Dent Res (2000) 1.41
In or out: the invasiveness of oral bacteria. Periodontol 2000 (2002) 1.40
Porphyromonas gingivalis-epithelial cell interactions in periodontitis. J Dent Res (2006) 1.38
Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors. J Biol Chem (2005) 1.36
Expression and function of interleukin-6 in epithelial cells. J Cell Biochem (1991) 1.32
Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages. Infect Immun (2006) 1.28
Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2. Infect Immun (2001) 1.21
Bacterial fimbriae activate human peripheral blood monocytes utilizing TLR2, CD14 and CD11a/CD18 as cellular receptors. Eur J Immunol (2002) 1.18
Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis. Genes Immun (2006) 1.15
Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptors. Immunol Invest (2004) 1.11
In vivo induction of proinflammatory cytokines in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol (2002) 1.06
Parotid secretory protein is expressed and inducible in human gingival keratinocytes. J Periodontal Res (2005) 1.06
Purification of major fimbrial proteins of Porphyromonas gingivalis. Protein Expr Purif (1995) 1.05
Structure-function analysis of CD14 as a soluble receptor for lipopolysaccharide. J Biol Chem (2000) 1.01
Porphyromonas gingivalis fimbriae induce a 68-kilodalton phosphorylated protein in macrophages. Infect Immun (1994) 0.99
Endothelial and epithelial cells do not respond to complexes of peptidoglycan with soluble CD14 but are activated indirectly by peptidoglycan-induced tumor necrosis factor-alpha and interleukin-1 from monocytes. J Infect Dis (1998) 0.92
Porphyromonas gingivalis fimbria-stimulated bone resorption in vitro is inhibited by a tyrosine kinase inhibitor. Infect Immun (1995) 0.85
Interleukin-1 gene expression in macrophages induced by surface protein components of Porphyromonas gingivalis: role of tyrosine kinases in signal transduction. Oral Microbiol Immunol (1997) 0.84
Retracted Constitutive expression of a bacterial pattern recognition receptor, CD14, in human salivary glands and secretion as a soluble form in saliva. Clin Diagn Lab Immunol (2003) 0.84
Dense fimbrial meshwork enhances Porphyromonas gingivalis adhesiveness: a scanning electron microscopic study. J Periodontal Res (2007) 0.82
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol (2012) 2.48
The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol (2008) 2.21
Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. J Clin Periodontol (2011) 2.11
Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss. Sci Transl Med (2014) 1.94
Microbial hijacking of complement-toll-like receptor crosstalk. Sci Signal (2010) 1.91
Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages. J Immunol (2007) 1.90
The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J Immunol (2010) 1.64
Use of saliva-based nano-biochip tests for acute myocardial infarction at the point of care: a feasibility study. Clin Chem (2009) 1.51
Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase. Eur J Immunol (2005) 1.46
TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae. J Immunol (2006) 1.45
IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta. J Immunol (2008) 1.36
Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes. J Biol Chem (2009) 1.35
Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J Immunol (2012) 1.35
Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells. Cell Microbiol (2007) 1.32
Optimization of the ligature-induced periodontitis model in mice. J Immunol Methods (2013) 1.23
The A subunit of type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2. J Immunol (2007) 1.18
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis. J Periodontal Res (2003) 1.16
In vitro modeling of host-parasite interactions: the 'subgingival' biofilm challenge of primary human epithelial cells. BMC Microbiol (2009) 1.15
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol 2000 (2010) 1.15
Interleukin-1beta modulates proinflammatory cytokine production in human epithelial cells. Infect Immun (2008) 1.15
Periodontal health and systemic disorders. J Can Dent Assoc (2002) 1.11
Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin. J Biol Chem (2007) 1.10
Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA. Infect Immun (2007) 1.09
Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. Eur J Clin Invest (2015) 1.08
Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. J Immunol (2009) 1.06
Parotid secretory protein is expressed and inducible in human gingival keratinocytes. J Periodontal Res (2005) 1.06
Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J Clin Periodontol (2010) 1.05
Effect of genetic variability on the inflammatory response to periodontal infection. J Clin Periodontol (2005) 1.04
Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer. J Immunol (2009) 1.04
Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mech Ageing Dev (2009) 1.03
The role of glycogen synthase kinase 3 in regulating IFN-β-mediated IL-10 production. J Immunol (2010) 1.02
Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti-citrullinated peptide antibody titres. J Clin Periodontol (2013) 1.02
Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection. Infect Immun (2002) 1.00
Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis. Cell Microbiol (2013) 1.00
Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism. BMC Microbiol (2009) 1.00
Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. J Periodontol (2010) 0.99
Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages. Cell Microbiol (2008) 0.99
Heat-labile enterotoxins as adjuvants or anti-inflammatory agents. Immunol Invest (2010) 0.99
TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells. Eur J Immunol (2008) 0.99
Innate cellular responses to the periodontal biofilm. Front Oral Biol (2011) 0.98
Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I). Glycobiology (2009) 0.96
Effects of smoking and gingival inflammation on salivary antioxidant capacity. J Clin Periodontol (2006) 0.96
Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis. Infect Immun (2009) 0.95
In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli. Vaccine (2009) 0.95
Porphyromonas gingivalis enhances FasL expression via up-regulation of NFkappaB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells. Microbiology (2006) 0.95
Nonsurgical mechanical treatment strategies for periodontal disease. Dent Clin North Am (2010) 0.93
Basic biology and role of interleukin-17 in immunity and inflammation. Periodontol 2000 (2015) 0.92
Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I). Clin Vaccine Immunol (2010) 0.91
Mammalian target of rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes. Mol Immunol (2010) 0.90
Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis. Virulence (2015) 0.89
LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb. Vaccine (2010) 0.89
Is periodontitis associated with an increased risk of coronary heart disease and preterm and/or low birth weight births? J Clin Periodontol (2002) 0.89
Salivary antioxidants in patients with type 1 or 2 diabetes and inflammatory periodontal disease: a case-control study. J Periodontol (2009) 0.89
Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int (2013) 0.88
Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra). J Periodontol (2006) 0.88
Childhood obesity and skeletal maturation assessed with Fishman's hand-wrist analysis. Am J Orthod Dentofacial Orthop (2007) 0.88
Nutrition, inflammation, and periodontal disease. Nutrition (2003) 0.87
Toll gates to periodontal host modulation and vaccine therapy. Periodontol 2000 (2009) 0.87
Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin. Thromb Haemost (2013) 0.87
TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin. J Leukoc Biol (2011) 0.87
P. gingivalis modulates keratinocytes through FOXO transcription factors. PLoS One (2013) 0.86
Sphingosine 1-phosphate 1 and TLR4 mediate IFN-beta expression in human gingival epithelial cells. J Immunol (2008) 0.86
Enhanced antigen uptake by dendritic cells induced by the B pentamer of the type II heat-labile enterotoxin LT-IIa requires engagement of TLR2. Vaccine (2010) 0.85
Gingival crevicular fluid IL-6, tPA, PAI-2, albumin levels following initial periodontal treatment in chronic periodontitis patients with or without type 2 diabetes. Inflamm Res (2010) 0.85
Antigenic experience dictates functional role of glycogen synthase kinase-3 in human CD4+ T cell responses. J Immunol (2008) 0.85
c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells. J Immunol (2009) 0.85
Porphyromonas gingivalis influences actin degradation within epithelial cells during invasion and apoptosis. Cell Microbiol (2012) 0.84
Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells. Biochem Biophys Res Commun (2003) 0.84
Host response in aggressive periodontitis. Periodontol 2000 (2014) 0.84
Identification and characterization of a nonimmunoglobulin factor in human saliva that inhibits Streptococcus mutans glucosyltransferase. Infect Immun (2002) 0.83
Plasminogen activator system in smokers and non-smokers with and without periodontal disease. J Clin Periodontol (2005) 0.83
Immunogenicity of Salmonella vector vaccines expressing SBR of Streptococcus mutans under the control of a T7-nirB (dual) promoter system. Vaccine (2006) 0.82
Neutrophils rescue gingival epithelial cells from bacterial-induced apoptosis. J Leukoc Biol (2009) 0.81
Polymicrobial infections, biofilms, and beyond. J Clin Periodontol (2009) 0.80
Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. J Periodontol (2005) 0.79
Dietary supplementation of omega-3 fatty acid and circulating levels of interleukin-1beta, osteocalcin, and C-reactive protein in rats. J Periodontol (2006) 0.79
Structure-activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding. Acta Crystallogr D Biol Crystallogr (2012) 0.79
Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb Haemost (2015) 0.78
Immunohistochemical evaluation of Ki-67 expression and apoptosis in cyclosporin A-induced gingival overgrowth. J Periodontol (2007) 0.78
Editorial: A Toll gate to escape T cells. J Leukoc Biol (2013) 0.77
Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors. Curr Opin Hematol (2016) 0.77
Innate immunity mechanisms. Adv Exp Med Biol (2012) 0.77
Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes. PLoS One (2010) 0.76
Reducing variability and choosing ideal subjects for experimental gingivitis studies. J Clin Periodontol (2005) 0.76
Seventh European Workshop on Periodontology of the European Academy of Periodontology at the Parador at la Granja, Segovia, Spain. J Clin Periodontol (2011) 0.76
Single-visit, full-mouth ultrasonic debridement: a paradigm shift in periodontal therapy? J Clin Periodontol (2005) 0.75
Denis F. Kinane, BDS, PhD. A conversation with the new dean of Penn Dental Medicine. Penn Dent J (Phila) (2009) 0.75
Letter of welcome: 2004 Annual Scientific Meeting of the International Society for the Prevention of Tobacco Induced Diseases. Tob Induc Dis (2004) 0.75
Endothelial cell-specific overexpression of developmental endothelial locus-1 does not influence atherosclerosis development in ApoE(-/-) mice. Thromb Haemost (2017) 0.75
Sixth European Workshop on Periodontology of the European Academy of Periodontology at the Charterhouse at Ittingen, Thurgau, Switzerland. J Clin Periodontol (2008) 0.75
Effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. J Periodontol (2006) 0.75
Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation. Thromb Haemost (2017) 0.75
Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later. Periodontol 2000 (2017) 0.75
The XXIV International Complement Workshop (ICW) on October 10-15, 2012. Preface. Immunobiology (2012) 0.75