Published in Nat Methods on November 01, 2006
Tools for neuroanatomy and neurogenetics in Drosophila. Proc Natl Acad Sci U S A (2008) 6.35
The RNA polymerase II core promoter - the gateway to transcription. Curr Opin Cell Biol (2008) 3.50
Regulation of gene expression via the core promoter and the basal transcriptional machinery. Dev Biol (2009) 2.89
Engineered Promoters for Potent Transient Overexpression. PLoS One (2016) 1.99
Structural visualization of key steps in human transcription initiation. Nature (2013) 1.91
Perspectives on the RNA polymerase II core promoter. Wiley Interdiscip Rev Dev Biol (2011) 1.81
Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Nature (2016) 1.81
Human TFIID binds to core promoter DNA in a reorganized structural state. Cell (2013) 1.47
Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. Genome Biol (2009) 1.36
Synthetic design of strong promoters. Proc Natl Acad Sci U S A (2010) 1.27
Transcription initiation by human RNA polymerase II visualized at single-molecule resolution. Genes Dev (2012) 1.24
Core promoter T-blocks correlate with gene expression levels in C. elegans. Genome Res (2011) 1.14
Near-atomic resolution visualization of human transcription promoter opening. Nature (2016) 1.12
P-value-based regulatory motif discovery using positional weight matrices. Genome Res (2012) 1.09
Three key subregions contribute to the function of the downstream RNA polymerase II core promoter. Mol Cell Biol (2010) 1.04
DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation. Nucleic Acids Res (2009) 1.03
New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris. Curr Opin Biotechnol (2013) 1.01
Functionality of the GAL4/UAS system in Tribolium requires the use of endogenous core promoters. BMC Dev Biol (2010) 1.00
Transferring a synthetic gene circuit from yeast to mammalian cells. Nat Commun (2013) 0.97
The grammar of transcriptional regulation. Hum Genet (2014) 0.95
Drosophila TRF2 is a preferential core promoter regulator. Genes Dev (2014) 0.95
Highly redundant function of multiple AT-rich sequences as core promoter elements in the TATA-less RPS5 promoter of Saccharomyces cerevisiae. Nucleic Acids Res (2010) 0.94
Core promoter functions in the regulation of gene expression of Drosophila dorsal target genes. J Biol Chem (2014) 0.93
RNA polymerase III accurately initiates transcription from RNA polymerase II promoters in vitro. J Biol Chem (2014) 0.93
Synthetic core promoters for Pichia pastoris. ACS Synth Biol (2013) 0.90
Identification of kinase inhibitors that target transcription initiation by RNA polymerase II. Oncotarget (2011) 0.88
Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Cell Res (2014) 0.83
Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation. Elife (2015) 0.83
Core promoter-selective coregulators of transcription by RNA polymerase II. Transcription (2012) 0.83
Brain selective transgene expression in zebrafish using an NRSE derived motif. Front Neural Circuits (2012) 0.82
Novel core promoter elements in the oomycete pathogen Phytophthora infestans and their influence on expression detected by genome-wide analysis. BMC Genomics (2013) 0.82
Gsx1 expression defines neurons required for prepulse inhibition. Mol Psychiatry (2014) 0.81
Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution. Nat Biotechnol (2016) 0.81
Molecular-genetic imaging of cancer. Adv Cancer Res (2014) 0.81
Localized RNAi and ectopic gene expression in the medicinal leech. J Vis Exp (2008) 0.81
Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. J Biol Chem (2013) 0.80
Cryo-EM in the study of challenging systems: the human transcription pre-initiation complex. Curr Opin Struct Biol (2016) 0.79
Single molecule microscopy reveals mechanistic insight into RNA polymerase II preinitiation complex assembly and transcriptional activity. Nucleic Acids Res (2016) 0.79
Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells. Cell Stem Cell (2017) 0.78
Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis. Genes Dev (2016) 0.78
Regulatory interplay between TFIID's conformational transitions and its modular interaction with core promoter DNA. Transcription (2013) 0.78
Real-time monitoring of functional interactions between upstream and core promoter sequences in living cells of sea urchin embryos. Nucleic Acids Res (2007) 0.77
Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription. Mol Cell Biol (2014) 0.77
Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure. Dis Model Mech (2013) 0.77
ElemeNT: a computational tool for detecting core promoter elements. Transcription (2015) 0.77
The RNA polymerase II preinitiation complex. Through what pathway is the complex assembled? Transcription (2014) 0.77
DNA dynamics is likely to be a factor in the genomic nucleotide repeats expansions related to diseases. PLoS One (2011) 0.76
Single molecule studies of RNA polymerase II transcription in vitro. Transcription (2014) 0.75
Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories. Curr Genomics (2016) 0.75
Conserved Noncoding Sequences Regulate lhx5 Expression in the Zebrafish Forebrain. PLoS One (2015) 0.75
Eeny meeny miny moe, catch a transcript by the toe, or how to enumerate eukaryotic transcripts. Genes Dev (2012) 0.75
Structural dynamics and DNA interaction of human TFIID. Transcription (2016) 0.75
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
The RNA polymerase II core promoter. Annu Rev Biochem (2003) 9.37
Tools for neuroanatomy and neurogenetics in Drosophila. Proc Natl Acad Sci U S A (2008) 6.35
Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo. Nat Struct Mol Biol (2009) 4.64
The RNA polymerase II core promoter: a key component in the regulation of gene expression. Genes Dev (2002) 3.87
The RNA polymerase II core promoter - the gateway to transcription. Curr Opin Cell Biol (2008) 3.50
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest (2011) 3.23
Regulation of gene expression via the core promoter and the basal transcriptional machinery. Dev Biol (2009) 2.89
Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly. Nat Struct Mol Biol (2005) 2.80
CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo. Science (2007) 2.71
Chromatin remodeling by ATP-dependent molecular machines. Bioessays (2003) 2.57
HARP is an ATP-driven annealing helicase. Science (2008) 2.54
An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat Biotechnol (2003) 2.53
Worsening renal function: what is a clinically meaningful change in creatinine during hospitalization with heart failure? J Card Fail (2003) 2.45
The MTE, a new core promoter element for transcription by RNA polymerase II. Genes Dev (2004) 2.30
2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest (2013) 2.15
Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res (2011) 2.06
Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo. Genes Dev (2004) 2.01
Metabolic signatures of exercise in human plasma. Sci Transl Med (2010) 1.99
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA. Genes Dev (2009) 1.96
Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study. Circulation (2012) 1.95
Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am J Hum Genet (2012) 1.90
Strand pairing by Rad54 and Rad51 is enhanced by chromatin. Genes Dev (2002) 1.74
Biomarkers of cardiovascular stress and incident chronic kidney disease. Clin Chem (2013) 1.71
Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol (2007) 1.61
Influence of sex and hormone status on circulating natriuretic peptides. J Am Coll Cardiol (2011) 1.61
Chromatin assembly in vitro with purified recombinant ACF and NAP-1. Methods Enzymol (2003) 1.60
TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription. Genes Dev (2008) 1.57
Myocardial tissue tagging with cardiovascular magnetic resonance. J Cardiovasc Magn Reson (2009) 1.56
Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies. J Clin Endocrinol Metab (2011) 1.50
Self-administered vaginal swabs are a feasible alternative to physician-assisted cervical swabs for sexually transmitted infection screening in the emergency department. Acad Emerg Med (2009) 1.48
Chromatin assembly by DNA-translocating motors. Nat Rev Mol Cell Biol (2003) 1.48
Human TFIID binds to core promoter DNA in a reorganized structural state. Cell (2013) 1.47
Dynamics of ATP-dependent chromatin assembly by ACF. Nature (2002) 1.47
Clinical trial of an educational intervention to achieve recommended cholesterol levels in patients with coronary artery disease. Am Heart J (2004) 1.43
A combined epidemiologic and metabolomic approach improves CKD prediction. J Am Soc Nephrol (2013) 1.42
Caudal, a key developmental regulator, is a DPE-specific transcriptional factor. Genes Dev (2008) 1.41
Occupancy of the Drosophila hsp70 promoter by a subset of basal transcription factors diminishes upon transcriptional activation. Proc Natl Acad Sci U S A (2005) 1.39
Forced unraveling of nucleosomes assembled on heterogeneous DNA using core histones, NAP-1, and ACF. J Mol Biol (2005) 1.39
Rationale and design of a multicenter echocardiographic study to assess the relationship between cardiac structure and function and heart failure risk in a biracial cohort of community-dwelling elderly persons: the Atherosclerosis Risk in Communities study. Circ Cardiovasc Imaging (2013) 1.37
A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab (2013) 1.33
Metabolite profiles during oral glucose challenge. Diabetes (2013) 1.31
Cancer-drug discovery and cardiovascular surveillance. N Engl J Med (2013) 1.29
The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. Genes Dev (2010) 1.27
Strategies for the reconstitution of chromatin. Nat Methods (2004) 1.26
Identification of a rapidly formed nonnucleosomal histone-DNA intermediate that is converted into chromatin by ACF. Mol Cell (2011) 1.22
Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. Genetics (2007) 1.21
Hepatocellular carcinoma with intracavitary cardiac involvement: a case report and review of the literature. Am J Cardiol (2008) 1.17
HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. Mol Cell (2009) 1.14
Development of a long-acting insulin analog using albumin fusion technology. Diabetes (2005) 1.14
Biochemical analysis of chromatin containing recombinant Drosophila core histones. J Biol Chem (2001) 1.14
Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. Proc Natl Acad Sci U S A (2010) 1.13
Distribution and clinical correlates of the interleukin receptor family member soluble ST2 in the Framingham Heart Study. Clin Chem (2012) 1.11
Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors. Blood (2013) 1.07
Dyssynchrony, contractile function, and response to cardiac resynchronization therapy. Circ Heart Fail (2011) 1.05
A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing. J Biol Chem (2004) 1.04
Three key subregions contribute to the function of the downstream RNA polymerase II core promoter. Mol Cell Biol (2010) 1.04
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. J Clin Invest (2013) 1.04
Binding of Acf1 to DNA involves a WAC motif and is important for ACF-mediated chromatin assembly. Mol Cell Biol (2002) 1.04
Long-term cardiovascular risks associated with an elevated heart rate: the Framingham Heart Study. J Am Heart Assoc (2014) 1.03
Secondary prevention of atherosclerotic cardiovascular disease in older adults: a scientific statement from the American Heart Association. Circulation (2013) 1.02
Reference limits for N-terminal-pro-B-type natriuretic peptide in healthy individuals (from the Framingham Heart Study). Am J Cardiol (2011) 1.00
ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling. Elife (2013) 0.99
Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex. Proc Natl Acad Sci U S A (2003) 0.99
Clinical and genetic correlates of growth differentiation factor 15 in the community. Clin Chem (2012) 0.99
Racial and ethnic differences in subclinical myocardial function: the Multi-Ethnic Study of Atherosclerosis. Heart (2011) 0.97
Reconstitution of chromatin transcription with purified components reveals a chromatin-specific repressive activity of p300. Nat Struct Mol Biol (2006) 0.95
Regional cardiac dysfunction and dyssynchrony in a murine model of afterload stress. PLoS One (2013) 0.92
Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: implications for screening. J Am Heart Assoc (2013) 0.92
The relationship between renal impairment and left ventricular structure, function, and ventricular-arterial interaction in hypertension. J Hypertens (2011) 0.89
Vitamin D status is not related to development of atrial fibrillation in the community. Am Heart J (2011) 0.89
Genetic and clinical correlates of early-outgrowth colony-forming units. Circ Cardiovasc Genet (2011) 0.89
Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction. Eur J Heart Fail (2014) 0.87
Reversible cardiomyopathy associated with sunitinib and sorafenib. N Engl J Med (2011) 0.86
Soluble ST2 predicts elevated SBP in the community. J Hypertens (2013) 0.86
Clinical problem-solving. When past is prologue. N Engl J Med (2009) 0.85
Recognizing and managing left ventricular dysfunction associated with therapeutic inhibition of the vascular endothelial growth factor signaling pathway. Curr Treat Options Cardiovasc Med (2014) 0.83
Cardiovascular complications of radiation therapy for thoracic malignancies: the role for non-invasive imaging for detection of cardiovascular disease. Eur Heart J (2013) 0.83
Cardio-oncology: it takes two to translate. Sci Transl Med (2013) 0.82
Assessment of right ventricular structure and function in mouse model of pulmonary artery constriction by transthoracic echocardiography. J Vis Exp (2014) 0.82
Relation of N-terminal pro-B-type natriuretic peptide with diastolic function in hypertensive heart disease. Am J Hypertens (2013) 0.81
Breast cancer therapies and cardiomyopathy. Med Clin North Am (2012) 0.81
Cardiac imaging to identify patients at risk for developing heart failure after myocardial infarction. Curr Heart Fail Rep (2005) 0.81
Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency. Eur Heart J (2012) 0.81
Secular trends in echocardiographic left ventricular mass in the community: the Framingham Heart Study. Heart (2013) 0.80
Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. J Biol Chem (2013) 0.80
Evidence against a genomic code for nucleosome positioning. Reply to "Nucleosome sequence preferences influence in vivo nucleosome organization.". Nat Struct Mol Biol (2010) 0.80
Circulating CD31+ leukocyte frequency is associated with cardiovascular risk factors. Atherosclerosis (2013) 0.79
Genetic loci associated with atrial fibrillation: relation to left atrial structure in the Framingham Heart Study. J Am Heart Assoc (2014) 0.78
Aortic root remodeling and risk of heart failure in the Framingham Heart study. JACC Heart Fail (2013) 0.78
Low risk sexual and drug-using behaviors among Latina women with AIDS in Los Angeles County. J Immigr Minor Health (2010) 0.77
Heart failure and breast cancer therapies: moving towards personalized risk assessment. J Am Heart Assoc (2014) 0.77
Branching out with DNA helicases. Curr Opin Genet Dev (2011) 0.77
Early and mid-term cardiovascular outcomes following TAVI: impact of pre-procedural transvalvular gradient. Int J Cardiol (2012) 0.77
Atherosclerosis imaging and heart failure. Heart Fail Rev (2006) 0.77
Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet (2017) 0.77
Ultrasonic assessment of myocardial microstructure. J Vis Exp (2014) 0.76
Cancer cachexia: getting to the heart of the matter. Eur Heart J (2013) 0.76
Cardiac target organ damage in hypertension: insights from epidemiology. Curr Hypertens Rep (2014) 0.76