Published in J Clin Invest on March 14, 2011
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell (2014) 3.03
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes (2012) 2.62
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature (2013) 2.57
Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol (2012) 2.39
2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest (2013) 2.15
Metabolic signatures of insulin resistance in 7,098 young adults. Diabetes (2012) 1.80
Circulating metabolite predictors of glycemia in middle-aged men and women. Diabetes Care (2012) 1.57
Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach. Diabetes (2013) 1.44
A combined epidemiologic and metabolomic approach improves CKD prediction. J Am Soc Nephrol (2013) 1.42
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell (2017) 1.38
Metabolic signature of CKD: the search continues. Am J Kidney Dis (2012) 1.38
Reproducibility of metabolomic profiles among men and women in 2 large cohort studies. Clin Chem (2013) 1.37
Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. Diabetes Care (2013) 1.35
Plasma lipid profiling in a large population-based cohort. J Lipid Res (2013) 1.35
A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab (2013) 1.33
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun (2015) 1.32
Metabolite profiles during oral glucose challenge. Diabetes (2013) 1.31
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes. PLoS One (2012) 1.28
Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes. J Clin Invest (2012) 1.25
Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation (2015) 1.25
A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc (2013) 1.15
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Mol Genet Metab (2011) 1.13
Defining the metabolome: size, flux, and regulation. Mol Cell (2015) 1.11
Placing epidemiological results in the context of multiplicity and typical correlations of exposures. J Epidemiol Community Health (2014) 1.11
Serum lipidomics profiling using LC-MS and high-energy collisional dissociation fragmentation: focus on triglyceride detection and characterization. Anal Chem (2011) 1.09
Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans. J Vis Exp (2013) 1.09
Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry. Trends Analyt Chem (2014) 1.08
Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One (2014) 1.08
Lipidomics of familial longevity. Aging Cell (2013) 1.05
Shotgun Lipidomics by Sequential Precursor Ion Fragmentation on a Hybrid Quadrupole Time-of-Flight Mass Spectrometer. Metabolites (2012) 1.03
Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes. Diabetes Care (2014) 1.02
Plasma lipid composition and risk of developing cardiovascular disease. PLoS One (2013) 0.99
Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice. Endocrinology (2012) 0.99
Clinical metabolomics paves the way towards future healthcare strategies. Br J Clin Pharmacol (2013) 0.95
Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids. Diabetologia (2013) 0.95
Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem (2013) 0.93
Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis. Diabetes Care (2016) 0.93
Inclusion of plasma lipid species improves classification of individuals at risk of type 2 diabetes. PLoS One (2013) 0.92
Metabolomics and diabetes: analytical and computational approaches. Diabetes (2015) 0.90
Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes. PLoS One (2016) 0.90
Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program. Diabetes (2016) 0.89
Distinct metabolomic signatures are associated with longevity in humans. Nat Commun (2015) 0.89
A short-term diet and exercise intervention ameliorates inflammation and markers of metabolic health in overweight/obese children. Am J Physiol Endocrinol Metab (2012) 0.88
Plasma sphingosine-1-phosphate is elevated in obesity. PLoS One (2013) 0.88
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis. PLoS Med (2016) 0.88
Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research. Curr Nutr Rep (2013) 0.87
A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes. Mol Cells (2015) 0.87
The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis. Nutrients (2015) 0.87
"Prediction is very hard, especially about the future": new biomarkers for type 2 diabetes? Diabetes (2013) 0.87
Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties. J Biol Chem (2013) 0.87
Role of nutrient-sensing signals in the pathogenesis of diabetic nephropathy. Biomed Res Int (2014) 0.87
Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects. PLoS One (2012) 0.86
Metabolomics Reveals Metabolically Healthy and Unhealthy Obese Individuals Differ in their Response to a Caloric Challenge. PLoS One (2015) 0.86
Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circ Res (2014) 0.86
Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. Aging (Albany NY) (2014) 0.86
Introduction to personalized medicine in diabetes mellitus. Rambam Maimonides Med J (2014) 0.85
Topographical body fat distribution links to amino acid and lipid metabolism in healthy obese women [corrected]. PLoS One (2013) 0.85
A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab (2014) 0.84
Perspectives on systems biology applications in diabetic kidney disease. J Cardiovasc Transl Res (2012) 0.84
Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity. Am J Physiol Endocrinol Metab (2014) 0.84
Biomolecular signatures of diabetic wound healing by structural mass spectrometry. Anal Chem (2013) 0.83
Edible Bird's Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats. J Diabetes Res (2015) 0.83
Applying metabolomics to uncover novel biology in ARDS. Am J Physiol Lung Cell Mol Physiol (2014) 0.83
Phenotypic flexibility as a measure of health: the optimal nutritional stress response test. Genes Nutr (2015) 0.82
Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterol Motil (2013) 0.82
Metabolomics and Metabolic Diseases: Where Do We Stand? Cell Metab (2016) 0.81
Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes. Genome Med (2015) 0.81
Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension. J Hypertens (2015) 0.81
Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission. PLoS One (2015) 0.81
Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques. PLoS One (2014) 0.80
Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet. Am J Clin Nutr (2017) 0.80
Obesity and psychotic disorders: uncovering common mechanisms through metabolomics. Dis Model Mech (2012) 0.79
An exome array study of the plasma metabolome. Nat Commun (2016) 0.78
Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb) (2013) 0.78
Intervention Trials with the Mediterranean Diet in Cardiovascular Prevention: Understanding Potential Mechanisms through Metabolomic Profiling. J Nutr (2016) 0.78
Association between insulin resistance and plasma amino acid profile in non-diabetic Japanese subjects. J Diabetes Investig (2015) 0.78
CMPF does not associate with impaired glucose metabolism in individuals with features of metabolic syndrome. PLoS One (2015) 0.78
Metabolite Profiles Predict Acute Kidney Injury and Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement. J Am Heart Assoc (2016) 0.78
Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: results from diverse cohorts. Lipids Health Dis (2016) 0.78
Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome. Sci Rep (2016) 0.78
Detection of Independent Associations of Plasma Lipidomic Parameters with Insulin Sensitivity Indices Using Data Mining Methodology. PLoS One (2016) 0.77
Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial. Circulation (2017) 0.77
Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up. J Endocrinol Invest (2014) 0.77
Metabolomics in the studies of islet autoimmunity and type 1 diabetes. Rev Diabet Stud (2012) 0.77
Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics. Cardiovasc Diabetol (2015) 0.77
HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation. PLoS One (2015) 0.76
Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study. Lipids Health Dis (2015) 0.76
Inflammatory-induced hibernation in the fetus: priming of fetal sheep metabolism correlates with developmental brain injury. PLoS One (2011) 0.76
Metabolomic prediction of diabetes and cardiovascular risk. Med Princ Pract (2012) 0.76
Comparing Identified and Statistically Significant Lipids and Polar Metabolites in 15-Year Old Serum and Dried Blood Spot Samples for Longitudinal Studies. Rapid Commun Mass Spectrom (2016) 0.75
Serum TAG analysis differentiates between genetic and obesity-associated NAFLD. Diabetes (2014) 0.75
Circulating MicroRNA-122 is Associated With the Risk of New-Onset Metabolic Syndrome and Type-2-Diabetes. Diabetes (2016) 0.75
HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Front Microbiol (2017) 0.75
Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study). Am J Cardiol (2016) 0.75
An Unbiased Lipidomics Approach Identifies Early Second Trimester Lipids Predictive of Maternal Glycemic Traits and Gestational Diabetes Mellitus. Diabetes Care (2016) 0.75
Metabolomic profiles as reliable biomarkers of dietary composition. Am J Clin Nutr (2017) 0.75
Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort. KI Rep (2016) 0.75
Identification of Shared and Unique Serum Lipid Profiles in Diabetes Mellitus and Myocardial Infarction. J Am Heart Assoc (2016) 0.75
Hyphenating size-exclusion chromatography with electrospray mass spectrometry; using on-line liquid-liquid extraction to study the lipid composition of lipoprotein particles. Rapid Commun Mass Spectrom (2015) 0.75
Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis. Transl Psychiatry (2016) 0.75
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia (1985) 109.13
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care (1997) 49.11
Prediction of coronary heart disease using risk factor categories. Circulation (1998) 48.81
An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol (1979) 18.84
Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol (1992) 17.17
Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Arch Intern Med (2007) 8.59
The emerging field of lipidomics. Nat Rev Drug Discov (2005) 4.69
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol (2008) 3.82
Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr (2004) 3.50
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog Lipid Res (2009) 2.80
Two risk-scoring systems for predicting incident diabetes mellitus in U.S. adults age 45 to 64 years. Ann Intern Med (2009) 2.55
Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr (2003) 2.41
Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab (2008) 2.32
Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. Am J Clin Nutr (2007) 2.26
Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol (1985) (2005) 2.16
Invited review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol (1985) (2002) 1.97
Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes. PLoS One (2009) 1.87
A prediction model for type 2 diabetes risk among Chinese people. Diabetologia (2008) 1.78
Lipidomics and lipid profiling in metabolomics. Curr Opin Lipidol (2007) 1.58
Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations. Diabetologia (2009) 1.53
Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med (2002) 1.52
National Cholesterol Education Program recommendations for triglyceride measurement: executive summary. The National Cholesterol Education Program Working Group on Lipoprotein Measurement. Clin Chem (1995) 1.51
The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters. Diabetes (1994) 1.49
Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. Diabetes Care (2009) 1.46
Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. PLoS One (2008) 1.31
Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. Prostaglandins Leukot Essent Fatty Acids (2003) 1.29
Gene regulation of mammalian desaturases. Biochem Soc Trans (2002) 1.16
Thematic review series: patient-oriented research. Recent advances in liver triacylglycerol and fatty acid metabolism using stable isotope labeling techniques. J Lipid Res (2006) 1.14
Cardiovascular disease risk factors predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes Care (2004) 1.10
How to study lipidomes. J Mol Endocrinol (2008) 1.06
The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis. Metabolism (2000) 0.84
Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med (2008) 57.29
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation (2011) 31.98
Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation (2012) 30.79
Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation (2013) 28.02
General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation (2008) 26.42
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (2006) 25.99
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2006) 19.43
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics (2008) 15.77
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
A mitochondrial protein compendium elucidates complex I disease biology. Cell (2008) 13.51
Vitamin D deficiency and risk of cardiovascular disease. Circulation (2008) 13.39
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation (2007) 12.79
Obesity and the risk of heart failure. N Engl J Med (2002) 12.58
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Long-term trends in the incidence of and survival with heart failure. N Engl J Med (2002) 10.37
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 10.24
Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol (2006) 10.14
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol (2007) 9.90
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med (2008) 9.68
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation (2010) 9.09
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 8.90
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation (2004) 8.80
Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Arch Intern Med (2007) 8.59
Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation (2002) 8.49
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension (2004) 8.27
Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association. Circulation (2009) 8.11
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61
Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol (2003) 7.47
Predictors of new-onset kidney disease in a community-based population. JAMA (2004) 7.45
Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study. Lancet (2009) 7.27
Plasma natriuretic peptide levels and the risk of cardiovascular events and death. N Engl J Med (2004) 7.12
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet (2010) 7.08
Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature (2011) 7.03
Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution. Mol Cell Proteomics (2007) 6.96
Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. JAMA (2007) 6.95
Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA (2002) 6.84