The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.

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🔗 View Article (PMID 17128211)

Published in Nat Rev Cancer on December 01, 2006

Authors

Daniel W Nebert1, Timothy P Dalton

Author Affiliations

1: Department of Environmental Health, and Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, Ohio 45267-0056, USA. dan.nebert@uc.edu

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Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase. Biochem Pharmacol (2007) 0.90

Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. Pharmacogenet Genomics (2005) 0.89

Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis. J Hepatol (2010) 0.89

Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochem Biophys Res Commun (2006) 0.88

For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. J Biol Chem (2006) 0.87

Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression. Biochem Biophys Res Commun (2011) 0.86

Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit. Free Radic Biol Med (2009) 0.86

Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress. Free Radic Biol Med (2003) 0.84

Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor. Dose Response (2006) 0.84

Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda. Biochem Pharmacol (2003) 0.84

Antioxidant perturbations in the olfactory mucosa of alachlor-treated rats. Biochem Pharmacol (2003) 0.82

Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron. Hepatology (2002) 0.82

Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochem Biophys Res Commun (2006) 0.81

Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse. Biochem Biophys Res Commun (2005) 0.80

Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele. Biochem Biophys Res Commun (2003) 0.80

Retrovirally expressed metal response element-binding transcription factor-1 normalizes metallothionein-1 gene expression and protects cells against zinc, but not cadmium, toxicity. Toxicol Appl Pharmacol (2002) 0.79

Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci (2005) 0.78

7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis (2006) 0.77

Preservation of the negative image of tooth enamel with dental impression material enhances morphometric measurements of gingival overgrowth. Microsc Res Tech (2003) 0.75