Published in J Biol Chem on April 01, 1962
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev Cancer (2006) 3.52
Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli. Proc Natl Acad Sci U S A (1991) 2.75
Functional analysis of the LACERATA gene of Arabidopsis provides evidence for different roles of fatty acid omega -hydroxylation in development. Proc Natl Acad Sci U S A (2001) 2.34
Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res (2008) 1.83
Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation. Proc Natl Acad Sci U S A (1989) 1.75
Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase. Nat Protoc (2009) 1.44
Human cytochromes P450 in health and disease. Philos Trans R Soc Lond B Biol Sci (2013) 1.36
Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci (2010) 1.29
Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? Philos Trans R Soc Lond B Biol Sci (2013) 1.16
Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.12
A role of the putidaredoxin COOH-terminus in P-450cam (cytochrome m) hydroxylations. Proc Natl Acad Sci U S A (1974) 1.12
Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. Proc Natl Acad Sci U S A (1987) 1.10
Clinically relevant genetic variations in drug metabolizing enzymes. Curr Drug Metab (2011) 0.99
Spectroscopic features of cytochrome P450 reaction intermediates. Arch Biochem Biophys (2010) 0.98
Probing the transmembrane structure and topology of microsomal cytochrome-p450 by solid-state NMR on temperature-resistant bicelles. Sci Rep (2013) 0.93
Xenomic networks variability and adaptation traits in wood decaying fungi. Microb Biotechnol (2013) 0.93
Advances in mechanisms of activation and deactivation of environmental chemicals. Environ Health Perspect (1993) 0.91
Cytochrome P450 enzymes and drug metabolism--basic concepts and methods of assessment. Cell Mol Neurobiol (1999) 0.91
Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4. Arch Biochem Biophys (2008) 0.86
Membrane Interactions, Ligand-Dependent Dynamics, and Stability of Cytochrome P4503A4 in Lipid Nanodiscs. Biochemistry (2016) 0.83
The effects of development on the activity of drug-metabolizing enzymes in the liver of the rat. Biochem J (1970) 0.83
Functional zonation of the rat adrenal cortex: the development and maintenance. Proc Jpn Acad Ser B Phys Biol Sci (2014) 0.83
Phosphorylation of human cytochrome P450c17 by p38α selectively increases 17,20 lyase activity and androgen biosynthesis. J Biol Chem (2013) 0.82
Fatty acid signals in Bacillus megaterium are attenuated by cytochrome P-450-mediated hydroxylation. Biochem J (1997) 0.82
Natural allelic variations of xenobiotic-metabolizing enzymes affect sexual dimorphism in Oryzias latipes. Proc Biol Sci (2014) 0.81
Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes. J Biol Chem (2011) 0.80
Improvement in the handling of drug-drug interactions. Eur J Clin Pharmacol (2008) 0.80
Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model. Sci Rep (2016) 0.79
Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour. Biochem J (1988) 0.79
Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions. Chem Res Toxicol (2016) 0.78
CYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces. J Appl Microbiol (2014) 0.78
Substrate-dependent evolution of cytochrome P450: rapid turnover of the detoxification-type and conservation of the biosynthesis-type. PLoS One (2014) 0.78
The induction of microsomal electron transport enzymes. Mol Cell Biochem (1983) 0.78
Recent Structural Insights into Cytochrome P450 Function. Trends Pharmacol Sci (2016) 0.77
Recollection of the early years of the research on cytochrome P450. Proc Jpn Acad Ser B Phys Biol Sci (2011) 0.76
Rapid kinetic methods to dissect steroidogenic cytochrome P450 reaction mechanisms. J Steroid Biochem Mol Biol (2015) 0.76
Insights into electron leakage in the reaction cycle of cytochrome P450 BM3 revealed by kinetic modeling and mutagenesis. Protein Sci (2015) 0.76
Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities. Microb Cell Fact (2016) 0.76
New trends in cytochrome p450 research at the half-century mark. J Biol Chem (2013) 0.75
Functional components of the liver microsomal enzyme system catalysing fatty acid, hydrocarbon and drug hydroxylation. Biochem J (1971) 0.75
The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function. Drug Metab Dispos (2016) 0.75
Cancer Activation and Polymorphisms of Human Cytochrome P450 1B1. Toxicol Res (2016) 0.75
Phenobarbital Meets Phosphorylation of Nuclear Receptors. Drug Metab Dispos (2017) 0.75
A professional and personal odyssey. J Biol Chem (2009) 0.75
In Memoriam: Osamu Hayaishi (1920 – 2015). J Lipid Res (2016) 0.75
Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole. Drug Metab Dispos (2016) 0.75
The Role of Astrocytes in Metabolism and Neurotoxicity of the Pyrrolizidine Alkaloid Monocrotaline, the Main Toxin of Crotalaria retusa. Front Pharmacol (2012) 0.75
Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development. Annu Rep Med Chem (2015) 0.75
Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1). Catal Sci Technol (2016) 0.75
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. J Biol Chem (1964) 24.57
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES. J Biol Chem (1964) 8.70
Reduction of chloromycetin by a cell-free bacterial extract and its relation to nitrite reduction. Nature (1951) 1.45
TREATMENT OF MALIGNANT GLIOMATA. J Neurosurg (1964) 1.09
The trend of tuberculosis in Japan during the period 1953-58. Comparison of the results of tuberculosis prevalence surveys. Bull World Health Organ (1962) 1.07
Characterization of hydroxy acids in depot fat after feeding of ricinoleic acid. Biochim Biophys Acta (1963) 1.06
Synthesis from sulphate and accumulation of S-sulphocysteine by a mutant strain of Aspergillus nidulans. Biochem J (1963) 1.05
Solubilization of aromatic hydroxylase system of liver microsomes and requirement of lipid-like factor. Biochim Biophys Acta (1960) 1.01
Purification and properties of cytochrome bl from Escherichia coli. J Biochem (1963) 0.96
Cysteine-S-sulphonate as an intermediate in microbiol synthesis of cysteine. Nature (1960) 0.94
Accumulation of phenylalanine by a phenylalanineless mutant of Escherichia coli. Science (1953) 0.93
Accumulation of S-sulphocysteine by a mutant strain of Aspergillus nidulans. Nature (1962) 0.91
Fractional solubilization of haemoproteins and partial purification of carbon monoxide-binding cytochrome from liver microsomes. Biochim Biophys Acta (1963) 0.91
Studies on laccases of lacquer trees. I. Comparison of laccases obtained from Rhus vernicifera and Rhus succedanea. J Biochem (1961) 0.91
Studies on laccases of lacquer trees. IV. Purification and properties of a blue protein obtained from latex of Rhus vernicifera. J Biochem (1961) 0.90
Solubilization and some properties of formic dehydrogenase from Escherichia coli. Biochem Biophys Res Commun (1961) 0.90
A flavoprotein oxidizing NADPH isolated from liver microsomes. Biochim Biophys Acta (1963) 0.87
STRICTURE OF THORACIC TRACHEA FOLLOWING CLOSED CHEST INJURIES. REPORT OF TWO CASES OF SUCCESSFUL TREATMENT BY PLASTIC REPAIR. J Thorac Cardiovasc Surg (1964) 0.85
COMPARISON OF CYTOCHROMES IN MYCOBACTERIA GROWN IN VITRO AND IN VIVO. J Bacteriol (1964) 0.84
Pre- and postoperative cardiopulmonary dynamics of the emphysematous bulla. J Thorac Cardiovasc Surg (1960) 0.83
[ASSIMILILATION OF INORGANIC SULFATE BY MICROORGANISMS]. Seikagaku (1965) 0.79
Studies on Habu snake venom. 2c. Studies on H beta-proteinase of Habu venom. Jpn J Microbiol (1960) 0.76
A study of abdominal tuberculosis; the third report; positive therapy against intestinal tuberculosis and its effects. Kekkaku (1952) 0.75
[Complete inhibition of the growth of the Yoshida sarcoma]. Gan (1953) 0.75
[On a clinical evaluation of tubercle bacillus phospholipid sensitivity to the agglutination reaction using kaolim. 1]. Boei Eisei (1962) 0.75
[CLINICAL STUDIES ON INTRACRANIAL PRESSURE-LOWERING AGENTS WITH SPECIAL REFERENCE TO HYPERTONIC UREA SOLUTION. 2]. No To Shinkei (1964) 0.75
[A STUDY ON THE IMPEDANCE OF THE MIDDLE EAR]. Nihon Jibiinkoka Gakkai Kaiho (1964) 0.75
[Recent trends in the surgery of pulmonary tuberculosis]. Geka Chiryo (1961) 0.75
Experimental and clinical chemotherapy of cancer with combined RC 4 and azulenoid. Gan (1957) 0.75
Correlation between Yoshida sarcoma and human neoplastic diseases in cancer chemotherapy studies. J Natl Cancer Inst (1959) 0.75
The growth of Yoshida sarcoma in the field of antigen-antibody reaction in rats [Japanese text]. Gan (1951) 0.75
Abdominal tuberculosis. II. Prognosis of the abdominal tuberculous patients who have received laparotomy. Kekkaku (1951) 0.75
[Complete inhibition of the growth of the Yoshida sarcoma. 3]. Gan (1954) 0.75
Studies on laccases of lacquer trees. III. Reconstruction of laccase from its protein and copper. J Biochem (1961) 0.75
[On venous pressure in the upper rectum]. Kyobu Geka (1961) 0.75
A study of abdominal tuberculosis. IV. Findings of relaparotomy. Kekkaku (1952) 0.75
Reactions of cytochrome b-1 and nitrate reductase in a preparation solubilized from Escherichia coli. J Biochem (1963) 0.75
[2 SURGICAL CASES OF INTRATHORACIC TRACHEAL STENOSIS AFTER THORACIC TRAUMA]. Kyobu Geka (1963) 0.75
METABOLISM OF HYDROXY FATTY ACIDS. III. CHARACTERIZATION OF HYDROXY ACIDS IN DEPOT FAT AFTER FEEDING OF RICINOLEIC ACID. J Biochem (1964) 0.75
Hemocyanin of Ommatostrephes sloani pacificus. J Biochem (1961) 0.75
[CALCIFIED PYOTHORAX]. Kyobu Geka (1965) 0.75
Correlation between Yoshida sarcoma and human neoplastic disease in cancer chemotherapy studies. J Natl Cancer Inst (1959) 0.75
Importance of an acetone-soluble fraction in aromatic hydroxylation by liver microsomes. Biochim Biophys Acta (1959) 0.75
A sulfite reductase from Aspergillus nidulans. J Biochem (1961) 0.75
PREVENTION OF SERUM HEPATITIS BY MEANS OF WHOLE BLOOD TRANSFUSION WITH PANS NO. 610 AND PANS-S. Kobe J Med Sci (1963) 0.75
[The origin of spontaneous pneumothorax and its treatment]. Kyobu Geka (1961) 0.75
FRIEND VIRUS ASCITES SARCOMA: A TRANSPLANTABLE ASCITES TUMOR VARIANT INDUCED FROM FRIEND'S VIRAL LEUKEMIA. Gan (1964) 0.75
Studies on laccases of lacquer trees. II. Copper exchange studies of Rhus vernicifera laccase using radioactive copper. J Biochem (1961) 0.75
[CLINICAL STUDIES ON INTRACRANIAL PRESSURE LOWERING AGENTS WITH SPECIAL REFERENCE TO HYPERTONIC UREA SOLUTION. I]. No To Shinkei (1964) 0.75
[EVALUATION OF THE SURGICAL TREATMENT OF LUNG ABSCESS]. Kyobu Geka (1964) 0.75
[Epidemiological relation between leprosy and tuberculosis]. Nihon Eiseigaku Zasshi (1961) 0.75
Complete inhibition of the growth of the Yoshida sarcoma. Gan (1952) 0.75
Experimental study of tracheal reconstruction. J Thorac Surg (1957) 0.75
[Complete inhibition of the growth of the Yoshida sarcoma]. Gan (1955) 0.75