Published in J Immunol on December 15, 2006
Cancer-related inflammation. J Clin Immunol (2012) 1.91
Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74. Proc Natl Acad Sci U S A (2011) 1.85
A functional heteromeric MIF receptor formed by CD74 and CXCR4. FEBS Lett (2009) 1.54
A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res (2008) 1.49
IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival. Proc Natl Acad Sci U S A (2007) 1.47
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation. Mol Cell Biol (2009) 1.43
Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem (2009) 1.39
Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link. QJM (2010) 1.29
The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A (2011) 1.29
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J Biol Chem (2007) 1.28
Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. BMC Cancer (2009) 1.26
The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. J Immunol (2009) 1.25
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. J Exp Med (2012) 1.23
Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry. Mol Cell Proteomics (2009) 1.21
Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase. J Immunol (2008) 1.21
Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74. J Biol Chem (2007) 1.14
Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer. Am J Pathol (2009) 1.13
Macrophage CD74 contributes to MIF-induced pulmonary inflammation. Respir Res (2009) 1.10
Macrophage migration inhibitory factor promotes colorectal cancer. Mol Med (2008) 1.08
The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors. J Biol Chem (2009) 1.07
Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses. Proc Natl Acad Sci U S A (2014) 1.06
Receptor agonists of macrophage migration inhibitory factor. Bioorg Med Chem Lett (2010) 1.06
Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation. Exp Mol Pathol (2009) 1.04
Identification of potential therapeutic targets in human head & neck squamous cell carcinoma. Head Neck Oncol (2009) 1.01
D-dopachrome tautomerase (D-DT or MIF-2): doubling the MIF cytokine family. Cytokine (2012) 1.01
Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109. Breast Cancer Res Treat (2009) 1.00
Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction. FASEB J (2010) 0.99
Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett (2010) 0.99
MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models. Cell Div (2007) 0.96
Tumorigenic potential of mononucleated small cells of Hodgkin lymphoma cell lines. Am J Pathol (2010) 0.95
Migration inhibitory factor enhances inflammation via CD74 in cartilage end plates with Modic type 1 changes on MRI. Clin Orthop Relat Res (2014) 0.94
Natriuretic peptide receptor a as a novel target for prostate cancer. Mol Cancer (2011) 0.91
CD74 is a survival receptor on colon epithelial cells. World J Gastroenterol (2010) 0.90
HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer. Cell Death Dis (2014) 0.89
Small interfering RNA (siRNA)-mediated knockdown of macrophage migration inhibitory factor (MIF) suppressed cyclin D1 expression and hepatocellular carcinoma cell proliferation. Oncotarget (2014) 0.88
A multi-targeted approach to suppress tumor-promoting inflammation. Semin Cancer Biol (2015) 0.87
Macrophage migratory inhibitory factor promotes bladder cancer progression via increasing proliferation and angiogenesis. Carcinogenesis (2013) 0.85
Overexpression of macrophage migration inhibitory factor in adenoid cystic carcinoma: correlation with enhanced metastatic potential. J Cancer Res Clin Oncol (2012) 0.85
Benzisothiazolones as modulators of macrophage migration inhibitory factor. Bioorg Med Chem Lett (2011) 0.85
Macrophage migration inhibitory factor produced by the tumour stroma but not by tumour cells regulates angiogenesis in the B16-F10 melanoma model. Br J Cancer (2012) 0.84
Involvement of CD74 in head and neck squamous cell carcinomas. J Cancer Res Clin Oncol (2014) 0.84
Restoration of contact inhibition in human glioblastoma cell lines after MIF knockdown. BMC Cancer (2009) 0.83
Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration. Acta Neuropathol Commun (2014) 0.83
Targeting neuroendocrine prostate cancer: molecular and clinical perspectives. Front Oncol (2015) 0.83
Homotrimeric macrophage migration inhibitory factor (MIF) drives inflammatory responses in the corneal epithelium by promoting caveolin-rich platform assembly in response to infection. J Biol Chem (2013) 0.83
Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1. Immunology (2008) 0.83
Tumorigenic role of orphan nuclear receptor NR0B1 in lung adenocarcinoma. Am J Pathol (2009) 0.83
A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF). Cell Death Dis (2014) 0.82
The Role of Macrophage Migration Inhibitory Factor (MIF) in Ultraviolet Radiation-Induced Carcinogenesis. Cancers (Basel) (2010) 0.82
Aza-derivatives of resveratrol are potent macrophage migration inhibitory factor inhibitors. Invest New Drugs (2011) 0.81
CD74: a new prognostic factor for patients with malignant pleural mesothelioma. Br J Cancer (2014) 0.81
Spatiotemporal patterns of macrophage migration inhibitory factor (Mif) expression in the mouse placenta. Reprod Biol Endocrinol (2010) 0.81
Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses. PLoS One (2013) 0.81
The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal-maternal interface. Semin Immunopathol (2007) 0.81
ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. Int J Oncol (2014) 0.80
Role of macrophage migration inhibitory factor in age-related lung disease. Am J Physiol Lung Cell Mol Physiol (2015) 0.80
Macrophage migration inhibitory factor: a multifunctional cytokine in rheumatic diseases. Arthritis (2010) 0.80
Chronic macrophage migration inhibitory factor exposure induces mesenchymal epithelial transition and promotes gastric and colon cancers. PLoS One (2014) 0.80
Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation. Cancer Lett (2009) 0.80
Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol (2010) 0.79
Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. PLoS One (2012) 0.79
Increased co-expression of macrophage migration inhibitory factor and matrix metalloproteinase 9 is associated with tumor recurrence of meningioma. Int J Med Sci (2013) 0.79
Inhibition of macrophage migration inhibitory factor reduces diabetic nephropathy in type II diabetes mice. Inflammation (2014) 0.79
Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat. PLoS One (2009) 0.78
Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer. Mol Med (2015) 0.78
Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. BMC Cancer (2015) 0.78
CD74 and intratumoral immune response in breast cancer. Oncotarget (2017) 0.77
Macrophage migration inhibitory factor inhibition is deleterious for high-fat diet-induced cardiac dysfunction. PLoS One (2013) 0.77
Transient transfection of macrophage migration inhibitory factor small interfering RNA disrupts the biological behavior of oral squamous carcinoma cells. Mol Med Rep (2015) 0.77
Glycosylation status of serum immunoglobulin G in patients with prostate diseases. Cancer Med (2016) 0.76
CD74 interferes with the expression of fas receptor on the surface of lymphoma cells. J Exp Clin Cancer Res (2014) 0.76
Macrophage migration inhibitory factor as a potential prognostic factor in gastric cancer. World J Gastroenterol (2015) 0.76
Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets. Oncol Lett (2016) 0.76
CHD7 promotes proliferation of neural stem cells mediated by MIF. Mol Brain (2016) 0.75
Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators. Int J Cancer (2016) 0.75
Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma. Oncotarget (2016) 0.75
Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer. Oncotarget (2016) 0.75
Androgen receptor facilitates the recruitment of macrophages in tumor microenvironment to promote upper urinary tract urothelial cell carcinoma progression. Am J Cancer Res (2016) 0.75
Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma. Oncotarget (2016) 0.75
Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy. Oncogene (2017) 0.75
Identification of differentially expressed inflammatory factors in Wilms tumors and their association with patient outcomes. Oncol Lett (2017) 0.75
Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med (2007) 5.28
MIF signal transduction initiated by binding to CD74. J Exp Med (2003) 4.79
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity (2006) 3.38
Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol (2004) 3.34
Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Proc Natl Acad Sci U S A (2001) 3.29
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature (2008) 2.96
Fibrocytes: emerging effector cells in chronic inflammation. Nat Rev Immunol (2011) 2.26
Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology (2005) 2.05
A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. J Immunol (2010) 1.91
Fibrocytes in health and disease. Exp Hematol (2010) 1.90
Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74. Proc Natl Acad Sci U S A (2011) 1.85
High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Res (2002) 1.84
The role of circulating fibrocytes in fibrosis. Curr Rheumatol Rep (2006) 1.78
The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol (2007) 1.73
Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists. Am J Surg Pathol (2010) 1.73
Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. J Biol Chem (2007) 1.71
A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med (2006) 1.61
Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter. FEBS Lett (2003) 1.59
Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J Clin Invest (2007) 1.57
Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells. PLoS One (2009) 1.57
Advanced glycation endproducts in nondiabetic patients with obstructive sleep apnea. Sleep (2006) 1.57
Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart. Circulation (2010) 1.56
Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites. Proc Natl Acad Sci U S A (2002) 1.55
Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view. Mediators Inflamm (2013) 1.54
A functional heteromeric MIF receptor formed by CD74 and CXCR4. FEBS Lett (2009) 1.54
Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release. Endocrinology (2004) 1.54
Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proc Natl Acad Sci U S A (2012) 1.53
Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity. Cell Signal (2005) 1.53
The anemia of malaria infection: role of inflammatory cytokines. Curr Hematol Rep (2004) 1.53
Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor. Cell Res (2006) 1.51
A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res (2008) 1.49
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. Circ Res (2009) 1.49
Macrophage migration inhibitory factor (MIF): a promising biomarker. Drug News Perspect (2010) 1.48
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J Immunol (2009) 1.48
Endotoxin-induced myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization. Circ Res (2005) 1.48
Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion. J Clin Invest (2009) 1.48
IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival. Proc Natl Acad Sci U S A (2007) 1.47
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation. Mol Cell Biol (2009) 1.43
Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell (2011) 1.39
Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem (2009) 1.39
Macrophage migration inhibitory factor. Crit Care Med (2002) 1.36
Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma. Arthritis Rheum (2006) 1.35
CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. J Immunol (2007) 1.32
Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF). Atherosclerosis (2006) 1.31
Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells. BMC Cancer (2004) 1.30
Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression. J Biol Chem (2006) 1.30
The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A (2011) 1.29
Macrophage migration inhibitory factor. Expert Opin Ther Targets (2003) 1.28
Macrophage migration inhibitory factor and autism spectrum disorders. Pediatrics (2008) 1.27
Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor. Arthritis Rheum (2003) 1.26
Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer. Clin Cancer Res (2005) 1.26
The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. J Immunol (2009) 1.25
Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity. J Med Chem (2002) 1.25
Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation (2004) 1.25
Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J Infect Dis (2007) 1.25
Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis. Arthritis Rheum (2003) 1.24
Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice. Arthritis Rheum (2011) 1.24
Nephrogenic fibrosing dermopathy: suspect identified, motive unclear. Am J Dermatopathol (2003) 1.24
Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies. Nucleic Acids Res (2005) 1.24
Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D. J Immunol (2008) 1.23
Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation. J Mol Cell Cardiol (2011) 1.22
Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol (2008) 1.22
Advanced glycation end products and endothelial dysfunction in type 2 diabetes. Diabetes Care (2002) 1.22
The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. FASEB J (2009) 1.22
Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase. J Immunol (2008) 1.21
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A (2010) 1.21
High-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation: predictive value for cancer in current practice. Am J Surg Pathol (2005) 1.20
Macrophage migration inhibitory factor: an intracellular inhibitor of angiotensin II-induced increases in neuronal activity. J Neurosci (2004) 1.20
Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator. Immunol Cell Biol (2003) 1.19
Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase. J Immunol (2011) 1.19
AGEs activate mesangial TGF-beta-Smad signaling via an angiotensin II type I receptor interaction. Kidney Int (2004) 1.19