Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels.

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Published in Clin Cancer Res on December 01, 2006

Authors

Barbara A Helfrich1, David Raben, Marileila Varella-Garcia, Dan Gustafson, Daniel C Chan, Lynne Bemis, Chris Coldren, Anna Barón, Chan Zeng, Wilbur A Franklin, Fred R Hirsch, Adi Gazdar, John Minna, Paul A Bunn

Author Affiliations

1: Tobacco Related Malignancy Program, University of Colorado Cancer Center, Aurora, CO 80010, USA.

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