Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

PubWeight™: 3.22‹?› | Rank: Top 1%

🔗 View Article (PMC 52390)

Published in Proc Natl Acad Sci U S A on September 01, 1991

Authors

T M Dawson1, D S Bredt, M Fotuhi, P M Hwang, S H Snyder

Author Affiliations

1: Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205.

Articles citing this

(truncated to the top 100)

Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49

Nitric oxide synthases in mammals. Biochem J (1994) 6.50

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A (1992) 4.32

Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol Med (1995) 2.15

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A (1995) 2.14

Classification of NPY-expressing neocortical interneurons. J Neurosci (2009) 1.90

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc Natl Acad Sci U S A (1992) 1.80

Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Genes Dev (2003) 1.71

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. Proc Natl Acad Sci U S A (1995) 1.70

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proc Natl Acad Sci U S A (1994) 1.59

Revisiting the role of neurons in neurovascular coupling. Front Neuroenergetics (2010) 1.48

Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase. Mol Med (1996) 1.45

Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A (2003) 1.42

Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase. Proc Natl Acad Sci U S A (1995) 1.41

A mechanism of paraquat toxicity involving nitric oxide synthase. Proc Natl Acad Sci U S A (1999) 1.38

Role of paraventricular nucleus in mediating sympathetic outflow in heart failure. Heart Fail Rev (2000) 1.38

Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase. Proc Natl Acad Sci U S A (2001) 1.37

Immunohistochemical analysis of primary sensory neurons latently infected with herpes simplex virus type 1. J Virol (2000) 1.36

Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell (2012) 1.28

Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proc Natl Acad Sci U S A (2005) 1.26

Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. J Virol (1996) 1.25

Genetic evidence for the neuronal nitric oxide synthase gene (NOS1) as a susceptibility locus for infantile pyloric stenosis. Am J Hum Genet (1996) 1.18

Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: partial colocalization with mature interneuron markers. Exp Neurol (2008) 1.15

Activity-dependent regulation of surface glucose transporter-3. J Neurosci (2011) 1.15

Nitric oxide, cGMP, and hormone regulation of active sodium transport. Proc Natl Acad Sci U S A (1994) 1.13

Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation. J Neural Transm (Vienna) (2011) 1.12

Marked increase in nitric oxide synthase mRNA in rat dorsal root ganglia after peripheral axotomy: in situ hybridization and functional studies. Proc Natl Acad Sci U S A (1992) 1.10

In situ detection of AP sites and DNA strand breaks bearing 3'-phosphate termini in ischemic mouse brain. FASEB J (2000) 1.06

Notable postnatal alterations in the myenteric plexus of normal human bowel. Gut (1999) 1.06

Study of NO and VIP as non-adrenergic non-cholinergic neurotransmitters in the pig gastric fundus. Br J Pharmacol (1995) 1.06

Nitric oxide synthase distribution in esophageal mucosa and hemodynamic changes in rats with cirrhosis. World J Gastroenterol (1999) 1.05

Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 1.05

Relaxation mechanisms induced by stimulation of nerves and by nitric oxide in sheep urethral muscle. J Physiol (1994) 1.03

Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat. Psychopharmacology (Berl) (2008) 1.02

Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells. EMBO J (1994) 1.01

Complex autonomous firing patterns of striatal low-threshold spike interneurons. J Neurophysiol (2012) 1.01

Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis. J Clin Invest (1999) 1.01

Protective actions of estrogen on angiotensin II-induced hypertension: role of central nitric oxide. Am J Physiol Heart Circ Physiol (2009) 1.00

Potentiation of Excitotoxicity in HIV-1 Associated Dementia and the Significance of Glutaminase. Clin Neurosci Res (2006) 0.99

Nitric oxide. Ann Rheum Dis (1996) 0.99

Pain modulation by nitric oxide in the spinal cord. Front Neurosci (2009) 0.97

Role of nitric oxide on motor behavior. Cell Mol Neurobiol (2005) 0.97

Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation. Proc Natl Acad Sci U S A (1993) 0.94

Neuronal nitric oxide synthase immunopositive neurons in cat claustrum--a light and electron microscopic study. J Mol Histol (2008) 0.93

Characterization of Type I and Type II nNOS-Expressing Interneurons in the Barrel Cortex of Mouse. Front Neural Circuits (2012) 0.93

Nerves that say NO: a new perspective on the human rectoanal inhibitory reflex. Ann R Coll Surg Engl (1996) 0.92

Activity in mouse pedunculopontine tegmental nucleus reflects action and outcome in a decision-making task. J Neurophysiol (2013) 0.92

Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. Endocrinology (2010) 0.91

Neural changes accompanying tinnitus following unilateral acoustic trauma in the guinea pig. Eur J Neurosci (2014) 0.91

Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia. J Physiol (1995) 0.90

Nitric oxide synthase in pig lower urinary tract: immunohistochemistry, NADPH diaphorase histochemistry and functional effects. Br J Pharmacol (1993) 0.89

Nitric Oxide-Soluble Guanylyl Cyclase-Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease? Front Syst Neurosci (2011) 0.88

Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia. Br J Pharmacol (1993) 0.88

Auditory cortical axons contact commissural cells throughout the guinea pig inferior colliculus. Hear Res (2013) 0.87

The effect of nitric oxide on the efficacy of synaptic transmission through the chick ciliary ganglion. Br J Pharmacol (1993) 0.87

Nitrinergic and peptidergic innervation of the human oesophagus. Gut (1994) 0.87

Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism. Am J Pathol (1998) 0.87

Nitric oxide synthase activity in tissues of the bovine eye. Graefes Arch Clin Exp Ophthalmol (1997) 0.87

The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats. Korean J Physiol Pharmacol (2011) 0.86

Phenotype-specific expression of T-type calcium channels in neurons of the major pelvic ganglion of the adult male rat. J Physiol (1995) 0.86

Detection and comparison of nitric oxide in clinically normal horses and those with naturally acquired small intestinal strangulation obstruction. Can J Vet Res (1999) 0.86

Analysis of excitatory synapses in the guinea pig inferior colliculus: a study using electron microscopy and GABA immunocytochemistry. Neuroscience (2013) 0.86

Impact of dopamine-glutamate interactions on striatal neuronal nitric oxide synthase activity. Psychopharmacology (Berl) (2009) 0.85

NADPH diaphorase and nitric oxide synthase are expressed by the majority of intramural neurons in the neonatal guinea pig urinary bladder. J Anat (1994) 0.85

Arrest of endotoxin-induced hypotension by transforming growth factor beta1. Proc Natl Acad Sci U S A (1996) 0.85

Nitric oxide signaling in invertebrates. Invert Neurosci (1997) 0.85

Multiple embryonic origins of nitric oxide synthase-expressing GABAergic neurons of the neocortex. Front Neural Circuits (2012) 0.85

How to innervate a simple gut: familiar themes and unique aspects in the formation of the insect enteric nervous system. Dev Dyn (2007) 0.84

Neuronal nitric oxide synthase expression is lower in areas of the nucleus tractus solitarius excited by skeletal muscle reflexes in hypertensive rats. Am J Physiol Heart Circ Physiol (2013) 0.84

Distribution and morphology of nitrergic neurons across functional domains of the rat primary somatosensory cortex. Front Neural Circuits (2012) 0.84

Nitric oxide synthase activity and expression are decreased in the paraventricular nucleus of pregnant rats. Brain Res (2008) 0.84

Expression and activity of nitric oxide synthase isoforms in methamphetamine-induced striatal dopamine toxicity. J Pharmacol Exp Ther (2012) 0.84

Global analysis of S-nitrosylation sites in the wild type (APP) transgenic mouse brain-clues for synaptic pathology. Mol Cell Proteomics (2014) 0.83

Distribution of NADPH-diaphorase and AChE activity in the anterior leaflet of rat mitral valve. Eur J Histochem (2010) 0.83

Ultrastructural examination of the corticocollicular pathway in the guinea pig: a study using electron microscopy, neural tracers, and GABA immunocytochemistry. Front Neuroanat (2013) 0.83

Localization of nitric oxide synthase in rat trigeminal primary afferent neurons using NADPH-diaphorase histochemistry. J Mol Histol (2005) 0.82

Nitric oxide deficiency in the internal anal sphincter of patients with chronic anal fissure. Int J Colorectal Dis (2005) 0.82

Time dependent changes of striatal interneurons after focal cerebral ischemia in rats. J Neural Transm (Vienna) (2008) 0.82

Nitric oxide synthase in neurons of the gastrointestinal tract of an avian species, Coturnix coturnix. J Anat (1994) 0.82

Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interference. J Neurosci Methods (2009) 0.82

NADPH-diaphorase histochemical changes in the hippocampus, cerebellum and striatum are correlated with different modalities of exercise and watermaze performances. Exp Brain Res (2006) 0.81

Age-related changes of NADPH-diaphorase positivity in the rat rostral migratory stream. Cell Mol Neurobiol (2005) 0.81

Multiple nitric oxide synthase systems in adult rat thymus revealed using NADPH diaphorase histochemistry. Immunology (1994) 0.81

Nitric oxide-mediated modulation of the murine locomotor network. J Neurophysiol (2013) 0.81

Immunocytochemical profiles of inferior colliculus neurons in the rat and their changes with aging. Front Neural Circuits (2012) 0.81

Detection and characterisation of NAD(P)H-diaphorase activity in Dictyostelium discoideum cells (Protozoa). Eur J Histochem (2012) 0.81

Actions of compounds manipulating the nitric oxide system in the cat primary visual cortex. J Physiol (1997) 0.80

Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism. Redox Biol (2015) 0.80

Age-related neurochemical changes in the rhesus macaque inferior colliculus. Front Aging Neurosci (2014) 0.80

Age-related neurochemical changes in the rhesus macaque superior olivary complex. J Comp Neurol (2013) 0.80

Requirement of retinoic acid receptor β for genipin derivative-induced optic nerve regeneration in adult rat retina. PLoS One (2013) 0.80

Testosterone induction of male-typical sexual behavior is associated with increased preoptic NADPH diaphorase and citrulline production in female whiptail lizards. J Neurobiol (2006) 0.80

Coexpression of serotonin and nitric oxide in the raphe complex: cortical versus subcortical circuit. Anat Rec (Hoboken) (2010) 0.80

The association between neuronal nitric oxide synthase and neuronal sensitivity in the brain after brain injury. Ann N Y Acad Sci (2002) 0.80

Treatment of muscle mechanoreflex dysfunction in hypertension: effects of L-arginine dialysis in the nucleus tractus solitarii. Exp Physiol (2013) 0.79

Enteric nervous system and developmental abnormalities in childhood. Pediatr Surg Int (2006) 0.79

Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation. J Neurosci (2013) 0.79

Topographical distribution and morphology of NADPH-diaphorase-stained neurons in the human claustrum. Front Syst Neurosci (2014) 0.79

Interaction of heavy metal toxicants with brain constitutive nitric oxide synthase. Mol Cell Biochem (1996) 0.79

Contribution of nitric oxide-producing cells in normal and diabetic rat retina. Jpn J Ophthalmol (2005) 0.78

Articles cited by this

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A (1990) 10.40

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature (1991) 8.41

Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature (1990) 7.23

Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol (1989) 6.87

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A (1991) 5.70

Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol (1990) 5.14

Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci (1991) 4.66

Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci U S A (1991) 3.67

Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. J Biol Chem (1989) 3.42

Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem (1989) 3.31

Nitric oxide: biosynthesis and biological significance. Trends Biochem Sci (1989) 2.51

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature (1986) 2.29

Selective sparing of a class of striatal neurons in Huntington's disease. Science (1985) 2.16

Nitric oxide as a neuronal messenger. Trends Pharmacol Sci (1991) 2.06

Demonstration of a unique population of neurons with NADPH-diaphorase histochemistry. J Neurosci Methods (1983) 1.81

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase. J Neurosci (1988) 1.71

The fine localization of dehydrogenases in the nervous system. Z Zellforch Microsk Anat Histochem (1961) 1.51

Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Y neurons in ischemic gerbil striatum. Ann Neurol (1990) 1.43

Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease. Ann Neurol (1988) 1.33

Histochemical characterization of neuronal NADPH-diaphorase. J Histochem Cytochem (1989) 1.33

Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity. Science (1986) 1.31

The 1989 Ulf von Euler lecture. Studies on endothelium-dependent vasodilation and the endothelium-derived relaxing factor. Acta Physiol Scand (1990) 1.20

NADPH-diaphorase: a selective histochemical marker for striatal neurons containing both somatostatin- and avian pancreatic polypeptide (APP)-like immunoreactivities. J Comp Neurol (1983) 1.20

Demonstration and biochemical characterisation of rat brain NADPH-dependent diaphorase. J Neurochem (1988) 1.09

THE SOLITARY ACTIVE CELLS. HISTOCHEMICAL DEMONSTRATION OF DAMAGE-RESISTANT NERVE CELLS WITH A TPN-DIAPHORASE REACTION. Acta Neuropathol (1964) 1.00

Distribution of reduced-nicotinamide-adenine-dinucleotide-phosphate diaphorase-positive cells and fibers in the cat central nervous system. J Comp Neurol (1989) 0.97

Articles by these authors

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A (1990) 10.40

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature (1991) 8.41

Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A (1992) 8.24

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A (1998) 8.03

PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95

Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature (1990) 7.23

Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell (1996) 6.42

PSD-95 involvement in maturation of excitatory synapses. Science (2000) 6.15

Analysis of human transcriptomes. Nat Genet (1999) 6.14

Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13

The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE (2001) 6.09

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci U S A (1989) 6.08

Opiate receptor: demonstration in nervous tissue. Science (1973) 6.06

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature (2001) 5.98

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A (1991) 5.70

Carbon monoxide: a putative neural messenger. Science (1993) 5.47

Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem (1994) 5.11

Targeted disruption of the neuronal nitric oxide synthase gene. Cell (1993) 5.02

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci U S A (1993) 4.73

Tat protein from human immunodeficiency virus forms a metal-linked dimer. Science (1988) 4.63

Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium. J Biol Chem (1987) 4.46

Solubilization, purification, and characterization of an inositol trisphosphate receptor. J Biol Chem (1988) 4.42

Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors. Proc Natl Acad Sci U S A (1968) 4.24

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell (1995) 4.21

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12

Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science (1976) 4.07

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Natl Acad Sci U S A (1992) 3.95

Nitric oxide, a novel neuronal messenger. Neuron (1992) 3.87

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science (1994) 3.86

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci U S A (1999) 3.85

Nitric oxide in skeletal muscle. Nature (1994) 3.78

Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron (1996) 3.75

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A (2000) 3.71

D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A (1995) 3.51

Nitric oxide: a physiologic mediator of penile erection. Science (1992) 3.39

Muscarinic cholinergic binding in rat brain. Proc Natl Acad Sci U S A (1974) 3.35

Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles. Nature (1989) 3.35

Properties of opiate-receptor binding in rat brain. Proc Natl Acad Sci U S A (1973) 3.34

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A (1996) 3.29

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A (1993) 3.24

Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase. Mol Pharmacol (1969) 3.21

Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem (1992) 3.21

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine. Proc Natl Acad Sci U S A (1980) 3.20

Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol (1993) 3.20

Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature (1995) 3.15

Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science (1999) 3.15

Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A (1999) 3.15

Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol (1993) 3.12

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron (1998) 3.09

Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A (1999) 3.07

Nitric oxide, a novel biologic messenger. Cell (1992) 3.04

A sensitive and specific fluorescence assay for tissue serotonin. Biochem Pharmacol (1965) 2.99

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem (1992) 2.97

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Chem (1993) 2.96

Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons. Nature (1989) 2.94

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. Cell (1995) 2.89

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol. Mol Pharmacol (1979) 2.89

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci U S A (1985) 2.85

Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci U S A (1999) 2.84

The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase. Cell (1992) 2.80

Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol (1999) 2.76

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A (1992) 2.72

A huntingtin-associated protein enriched in brain with implications for pathology. Nature (1995) 2.67

PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science (1996) 2.66

Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci U S A (1981) 2.66

Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. Neuron (1999) 2.64

Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors. Mol Pharmacol (1977) 2.64

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium. Proc Natl Acad Sci U S A (1988) 2.63

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron (1991) 2.60

Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines. Life Sci (1981) 2.58

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions. Proc Natl Acad Sci U S A (1988) 2.57

Does NSAID use modify cognitive trajectories in the elderly? The Cache County study. Neurology (2007) 2.56

PDZ proteins organize synaptic signaling pathways. Cell (1998) 2.51

Nitric oxide: a physiologic messenger. Ann Intern Med (1994) 2.50

The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants. J Biol Chem (1986) 2.50

A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol (1992) 2.47

PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem (1999) 2.42

Strychnine binding associated with glycine receptors of the central nervous system. Proc Natl Acad Sci U S A (1973) 2.37

High affinity transport of choline into synaptosomes of rat brain. J Neurochem (1973) 2.35

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. J Biol Chem (1992) 2.34

Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem Biophys Res Commun (1991) 2.33

Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system. Proc Natl Acad Sci U S A (1974) 2.29

Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc Natl Acad Sci U S A (1999) 2.27

Opiate agonists and antagonists discriminated by receptor binding in brain. Science (1973) 2.27

Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends Pharmacol Sci (1999) 2.25

Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J Neurosci (1994) 2.25

An endogenous morphine-like factor in mammalian brain. Life Sci (1975) 2.21