PubRank

Mekala Gunaratnam

Author PubWeight™ 20.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem 2006 1.11
2 Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. J Am Chem Soc 2006 0.93
3 Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes. J Med Chem 2011 0.88
4 Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorg Med Chem Lett 2008 0.88
5 Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. Bioorg Med Chem Lett 2010 0.88
6 TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. Anal Biochem 2008 0.87
7 Bioactive pyridine-N-oxide disulfides from Allium stipitatum. J Nat Prod 2009 0.87
8 Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. J Med Chem 2012 0.87
9 Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Mol Biosyst 2008 0.85
10 Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J Med Chem 2013 0.84
11 Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorg Med Chem Lett 2007 0.83
12 Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. J Am Chem Soc 2010 0.83
13 Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. J Med Chem 2008 0.82
14 Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives. Angew Chem Int Ed Engl 2007 0.81
15 Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex. J Am Chem Soc 2013 0.80
16 A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus. Int J Antimicrob Agents 2013 0.80
17 Biaryl polyamides as a new class of DNA quadruplex-binding ligands. Chem Commun (Camb) 2009 0.80
18 Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives. Bioorg Med Chem Lett 2012 0.79
19 New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity. Org Biomol Chem 2006 0.79
20 Discovery of new G-quadruplex binding chemotypes. Chem Commun (Camb) 2014 0.79
21 Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands. Bioorg Med Chem Lett 2013 0.78
22 Bioactive compounds from Carissa spinarum. Phytother Res 2012 0.77
23 Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors. Beilstein J Org Chem 2013 0.77
24 The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties. Chem Commun (Camb) 2012 0.76
25 Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Chem Commun (Camb) 2010 0.75
26 Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex. ChemMedChem 2015 0.75
27 The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds. Bioorg Med Chem 2013 0.75