Published in J Am Chem Soc on December 20, 2006
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
Transition-metal-catalyzed denitrogenative transannulation: converting triazoles into other heterocyclic systems. Angew Chem Int Ed Engl (2011) 1.08
Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry. Angew Chem Int Ed Engl (2012) 1.07
Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA. Nucleic Acids Res (2007) 1.02
In vivo veritas: using yeast to probe the biological functions of G-quadruplexes. Biochimie (2008) 0.97
Development of benzothiazole 'click-on' fluorogenic dyes. Bioorg Med Chem Lett (2010) 0.92
Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds. Biochimie (2008) 0.91
Recent advances in chemical proteomics: exploring the post-translational proteome. J Chem Biol (2008) 0.84
Triazole bridges as versatile linkers in electron donor-acceptor conjugates. J Am Chem Soc (2011) 0.84
Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. J Med Chem (2008) 0.82
1,4-linked 1,2,3-Triazole des-peptidic analogues of PNA (TzNA): Synthesis of TzNA oligomers by "click" reaction on solid phase and stabilization of derived triplexes with DNA. Artif DNA PNA XNA (2010) 0.79
Chiral ruthenium(II) polypyridyl complexes: stabilization of g-quadruplex DNA, inhibition of telomerase activity and cellular uptake. PLoS One (2012) 0.78
Small-molecule selectively recognizes human telomeric G-quadruplex DNA and regulates its conformational switch. Biophys J (2009) 0.76
Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
Information leaflet and antibiotic prescribing strategies for acute lower respiratory tract infection: a randomized controlled trial. JAMA (2005) 6.33
Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Res (2005) 5.34
Management of depression in UK general practice in relation to scores on depression severity questionnaires: analysis of medical record data. BMJ (2009) 4.93
Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial. Lancet Infect Dis (2012) 4.62
Antibiotics and topical nasal steroid for treatment of acute maxillary sinusitis: a randomized controlled trial. JAMA (2007) 4.39
Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults. AIDS (2002) 3.99
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial. BMJ (2002) 2.63
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
Delayed antibiotic prescribing strategies for respiratory tract infections in primary care: pragmatic, factorial, randomised controlled trial. BMJ (2014) 2.46
Predictors of suppurative complications for acute sore throat in primary care: prospective clinical cohort study. BMJ (2013) 2.41
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J Mol Biol (2002) 2.29
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A (2003) 2.24
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res (2005) 1.84
Randomised controlled trial of effect of leaflets to empower patients in consultations in primary care. BMJ (2004) 1.74
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
Developing clinical rules to predict urinary tract infection in primary care settings: sensitivity and specificity of near patient tests (dipsticks) and clinical scores. Br J Gen Pract (2006) 1.73
A randomized controlled trial of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving decitabine. Leuk Lymphoma (2012) 1.57
Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial. BMJ (2013) 1.51
Structure of a G-quadruplex-ligand complex. J Mol Biol (2003) 1.49
Implementing early infant diagnosis of HIV infection at the primary care level: experiences and challenges in Malawi. Bull World Health Organ (2012) 1.48
Efficient conversion of aromatic amines into azides: a one-pot synthesis of triazole linkages. Org Lett (2007) 1.41
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Structural basis for binding of porphyrin to human telomeres. Biochemistry (2007) 1.37
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol (2002) 1.33
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophys Chem (2006) 1.32
Text-messaging-enhanced HIV intervention for African American adolescents: a feasibility study. J Assoc Nurses AIDS Care (2012) 1.28
Demographic Change, Social Security Systems, and Savings. J Monet Econ (2007) 1.27
Structure of the first parallel DNA quadruplex-drug complex. J Am Chem Soc (2003) 1.26
Structural basis of DNA quadruplex recognition by an acridine drug. J Am Chem Soc (2008) 1.25
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res (2007) 1.24
Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors. Proc Natl Acad Sci U S A (2003) 1.21
Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc (2004) 1.18
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Res (2010) 1.16
Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophys J (2008) 1.16
Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. J Am Chem Soc (2006) 1.15
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. J Med Chem (2009) 1.15
Does a slower treatment rate impact the efficacy of extracorporeal shock wave lithotripsy for solitary kidney or ureteral stones? J Urol (2006) 1.14
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry (2005) 1.12
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem (2006) 1.11
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol Cancer Ther (2004) 1.11
A randomised controlled trial of three pragmatic approaches to initiate increased physical activity in sedentary patients with risk factors for cardiovascular disease. Br J Gen Pract (2004) 1.11
A role for water molecules in DNA-ligand minor groove recognition. Acc Chem Res (2009) 1.10
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. J Med Chem (2008) 1.10
Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors. Proc Natl Acad Sci U S A (2003) 1.10
Effects of volume and site of blood draw on blood culture results. J Clin Microbiol (2009) 1.09
Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorg Chem (2008) 1.09
European Antibiotic Awareness Day 2012: TARGET antibiotics through guidance, education, and tools. Br J Gen Pract (2012) 1.09
Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Org Biomol Chem (2004) 1.09
The design of G-quadruplex ligands as telomerase inhibitors. Mini Rev Med Chem (2003) 1.08
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. J Mol Biol (2008) 1.08
Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. J Am Chem Soc (2010) 1.07
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. J Am Chem Soc (2002) 1.06
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res (2008) 1.06
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. J Med Chem (2003) 1.05
Identification of the lumbar interspinous spaces: palpation versus ultrasound. Anesth Analg (2008) 1.04
Characterization of a novel DNA minor-groove complex. Biophys J (2004) 1.04
A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of (+/-)-Alboatrin. Org Lett (2004) 1.03
Structural basis of telomeric RNA quadruplex--acridine ligand recognition. J Am Chem Soc (2011) 1.03
Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Res (2006) 1.02
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry (2006) 1.02
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res (2012) 1.01
Copper-catalyzed azide-alkyne cycloaddition: regioselective synthesis of 1,4,5-trisubstituted 1,2,3-triazoles. Angew Chem Int Ed Engl (2010) 1.01
Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. J Am Chem Soc (2012) 1.01
The Ime2 protein kinase enhances the disassociation of the Sum1 repressor from middle meiotic promoters. Mol Cell Biol (2009) 1.00
Striking association between urinary cadmium level and albuminuria among Torres Strait Islander people with diabetes. Environ Res (2007) 1.00
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. J Med Chem (2003) 0.99
Validating the prediction of lower urinary tract infection in primary care: sensitivity and specificity of urinary dipsticks and clinical scores in women. Br J Gen Pract (2010) 0.98
New synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of in situ generated nitrile imines and benzyne. Org Lett (2010) 0.98
Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett (2013) 0.98
Antibiotics: time to act. Br J Gen Pract (2013) 0.97
On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorg Med Chem Lett (2011) 0.97
Nasal self-swabbing for estimating the prevalence of Staphylococcus aureus in the community. J Med Microbiol (2012) 0.96
Mechanism of acridine-based telomerase inhibition and telomere shortening. Biochem Pharmacol (2007) 0.96
Natural and synthetic G-quadruplex interactive berberine derivatives. Bioorg Med Chem Lett (2006) 0.96
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg Med Chem Lett (2004) 0.95
Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes. J Phys Chem B (2009) 0.95
Water-mediated binding of agents that target the DNA minor groove. J Am Chem Soc (2011) 0.94
Selectivity in ligand recognition of G-quadruplex loops. Biochemistry (2009) 0.94
Longer term outcomes from a randomised trial of prescribing strategies in otitis media. Br J Gen Pract (2006) 0.94
Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. J Am Chem Soc (2006) 0.93
Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. Methods Mol Biol (2010) 0.93
Topical antifungal treatments for tinea cruris and tinea corporis. Cochrane Database Syst Rev (2014) 0.93
CD6 attenuates early and late signaling events, setting thresholds for T-cell activation. Eur J Immunol (2011) 0.93
A structural analysis of G-quadruplex/ligand interactions. Biochimie (2011) 0.92
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. J Am Chem Soc (2007) 0.92
Protein and drug interactions in the minor groove of DNA. Nucleic Acids Res (2002) 0.92
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents. J Med Chem (2010) 0.92
Point of care testing for urinary tract infection in primary care (POETIC): protocol for a randomised controlled trial of the clinical and cost effectiveness of FLEXICULT™ informed management of uncomplicated UTI in primary care. BMC Fam Pract (2014) 0.92
Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database. BMC Psychiatry (2013) 0.91
An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chem Commun (Camb) (2010) 0.91