Published in Cryobiology on December 12, 2006
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance. Comb Chem High Throughput Screen (2010) 1.18
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nat Protoc (2010) 1.18
Hepatocyte cryopreservation: is it time to change the strategy? World J Gastroenterol (2010) 0.98
Morphological and functional preservation of pre-antral follicles after vitrification of macaque ovarian tissue in a closed system. Hum Reprod (2013) 0.89
Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol (2014) 0.87
Synthetic polymers improve vitrification outcomes of macaque ovarian tissue as assessed by histological integrity and the in vitro development of secondary follicles. Cryobiology (2012) 0.83
Freezing/Thawing without Cryoprotectant Damages Native but not Decellularized Porcine Renal Tissue. Organogenesis (2015) 0.75
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol (2006) 2.59
Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics (2005) 1.46
Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models. Anal Chem (2012) 1.22
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nat Protoc (2010) 1.18
Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu. Toxicol Sci (2005) 1.09
A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab Chip (2010) 1.06
Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers. Liver Int (2006) 1.02
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. Am J Physiol Gastrointest Liver Physiol (2004) 1.00
Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. PLoS One (2013) 0.94
Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. Eur J Pharm Sci (2009) 0.93
Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies. Biotechnol Bioeng (2010) 0.93
Pharmacokinetic-pharmacodynamic modeling of the D₂ and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats. Pharm Res (2012) 0.92
Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses. Int J Oncol (2009) 0.92
Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology (2005) 0.91
AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver. Arch Toxicol (2012) 0.89
Microfluidic devices for in vitro studies on liver drug metabolism and toxicity. Integr Biol (Camb) (2011) 0.89
Analysis of bile acid-induced regulation of FXR target genes in human liver slices. Liver Int (2007) 0.88
Inhibition of bacterial ice nucleation by polyglycerol polymers. Cryobiology (2002) 0.88
Resistin is more abundant in liver than adipose tissue and is not up-regulated by lipopolysaccharide. J Clin Endocrinol Metab (2009) 0.88
Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharm Drug Dispos (2009) 0.87
Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: the use of PANSS total score and clinical utility. Schizophr Res (2013) 0.87
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D2 receptor occupancy of olanzapine in rats. Pharm Res (2011) 0.86
Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties. Inorg Chem (2014) 0.85
Human precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury. Chem Res Toxicol (2013) 0.85
Antigenotoxic effect of Xanthohumol in rat liver slices. Toxicol In Vitro (2007) 0.83
Structural models describing placebo treatment effects in schizophrenia and other neuropsychiatric disorders. Clin Pharmacokinet (2011) 0.83
Modelling and simulation of the Positive and Negative Syndrome Scale (PANSS) time course and dropout hazard in placebo arms of schizophrenia clinical trials. Clin Pharmacokinet (2012) 0.83
Ultrarapid nonsuture mated cuff technique for renal transplantation in rabbits. Microsurgery (2003) 0.82
Precision-cut fibrotic rat liver slices as a new model to test the effects of anti-fibrotic drugs in vitro. J Hepatol (2006) 0.82
Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo. Biopharm Drug Dispos (2010) 0.82
In vitro methods to study intestinal drug metabolism. Curr Drug Metab (2007) 0.82
Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Metab Dispos (2007) 0.82
Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations. Eur J Pharm Sci (2005) 0.82
A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies. J Pharmacol Toxicol Methods (2004) 0.81
Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity. Biotechnol Bioeng (2011) 0.81
A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor. Virology (2006) 0.81
Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations. Drug Metab Dispos (2006) 0.81
Comparative analysis of the human hepatic and adipose tissue transcriptomes during LPS-induced inflammation leads to the identification of differential biological pathways and candidate biomarkers. BMC Med Genomics (2011) 0.81
1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo. Biopharm Drug Dispos (2009) 0.81
Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction. Drug Metab Dispos (2006) 0.80
Cryopreservation of precision-cut tissue slices. Xenobiotica (2012) 0.80
Reduced ischemia-reoxygenation injury in rat intestine after luminal preservation with a tailored solution. Transplantation (2010) 0.80
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. Drug Metab Dispos (2005) 0.79
Normothermic blood perfusion of isolated rabbit kidneys. III. In vitro physiology of kidneys after perfusion with Euro-Collins solution or 7.5 M cryoprotectant (VS4). Transpl Int (2002) 0.79
The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicol In Vitro (2010) 0.79
Effects of cryoprotectant addition and washout methods on the viability of precision-cut liver slices. Cryobiology (2012) 0.79
Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos (2012) 0.79
Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression. Toxicol In Vitro (2009) 0.79
Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale. J Clin Psychopharmacol (2013) 0.78
Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice. Regul Toxicol Pharmacol (2011) 0.78
Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites. Arch Toxicol (2014) 0.78
Bilitranslocase is involved in the uptake of bromosulfophthalein in rat and human liver. Drug Metab Lett (2012) 0.78
Dopamine D2 receptor occupancy as a predictor of catalepsy in rats: a pharmacokinetic-pharmacodynamic modeling approach. Pharm Res (2014) 0.78
Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: part II: the use of subscales of the PANSS score. Schizophr Res (2013) 0.78
Analysis of gene expression changes to elucidate the mechanism of chilling injury in precision-cut liver slices. Toxicol In Vitro (2012) 0.78
Microfluidics enables small-scale tissue-based drug metabolism studies with scarce human tissue. J Lab Autom (2011) 0.77
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices. Chem Res Toxicol (2016) 0.77
Detection of xenobiotic-induced DNA damage by the comet assay applied to human and rat precision-cut liver slices. Toxicol In Vitro (2007) 0.77
On-line HPLC analysis system for metabolism and inhibition studies in precision-cut liver slices. Anal Chem (2010) 0.77
Cryopreservation of rat hippocampal slices by vitrification. Cryobiology (2006) 0.77
Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices. Xenobiotica (2012) 0.76
The influence of brain death on liver function. Liver Int (2005) 0.76
Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury. J Appl Toxicol (2013) 0.76
Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo. J Pharm Sci (2010) 0.76
Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury. Chem Res Toxicol (2012) 0.75
Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo. Toxicol In Vitro (2015) 0.75
Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia. Schizophr Res (2013) 0.75
Foreward. Special issue in memoriam: Armand M. Karow Jr., Ph.D. (1941-2007). Cryobiology (2010) 0.75
Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine. Drug Metab Dispos (2013) 0.75
Physiological evaluation of a rabbit kidney perfused with VS41A. Cryobiology (2003) 0.75
Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity. J Med Chem (2015) 0.75