Published in Toxicol In Vitro on September 25, 2007
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nat Protoc (2010) 1.18
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Mol Nutr Food Res (2011) 0.93
Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo. Mol Nutr Food Res (2013) 0.82
Effects of Tapinanthus globiferus and Zanthoxylum zanthoxyloides extracts on human leukocytes in vitro. J Intercult Ethnopharmacol (2014) 0.78
The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels. Front Physiol (2015) 0.78
Biological reactive intermediates (BRIs) formed from botanical dietary supplements. Chem Biol Interact (2010) 0.78
Vitamin C acts as a hepatoprotectant in carbofuran treated rat liver slices in vitro. Toxicol Rep (2017) 0.75
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol (2006) 2.59
Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models. Anal Chem (2012) 1.22
Titanium dioxide in our everyday life; is it safe? Radiol Oncol (2011) 1.22
Role of oxidative damage in the genotoxicity of arsenic. Free Radic Biol Med (2004) 1.19
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nat Protoc (2010) 1.18
Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu. Toxicol Sci (2005) 1.09
A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab Chip (2010) 1.06
Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers. Liver Int (2006) 1.02
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. Am J Physiol Gastrointest Liver Physiol (2004) 1.00
Development of human cell biosensor system for genotoxicity detection based on DNA damage-induced gene expression. Radiol Oncol (2010) 0.96
The role of reactive oxygen species in microcystin-LR-induced DNA damage. Toxicology (2004) 0.95
Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. PLoS One (2013) 0.94
Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. Eur J Pharm Sci (2009) 0.93
Combination of in vitro bioassays for the determination of cytotoxic and genotoxic potential of wastewater, surface water and drinking water samples. Chemosphere (2009) 0.93
Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies. Biotechnol Bioeng (2010) 0.93
Pharmacokinetic-pharmacodynamic modeling of the D₂ and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats. Pharm Res (2012) 0.92
Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses. Int J Oncol (2009) 0.92
Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology (2005) 0.91
5-Benzylidenethiazolidin-4-ones as multitarget inhibitors of bacterial Mur ligases. ChemMedChem (2010) 0.91
Effect of cysteine proteinase inhibitors on murine B16 melanoma cell invasion in vitro. Biol Chem (2002) 0.91
Patterns of microcystin-LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis. Toxicon (2007) 0.90
Organophosphorus pesticides enhance the genotoxicity of benzo(a)pyrene by modulating its metabolism. Mutat Res (2009) 0.89
AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver. Arch Toxicol (2012) 0.89
Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2. Toxicon (2003) 0.89
Microfluidic devices for in vitro studies on liver drug metabolism and toxicity. Integr Biol (Camb) (2011) 0.89
Analysis of bile acid-induced regulation of FXR target genes in human liver slices. Liver Int (2007) 0.88
Resistin is more abundant in liver than adipose tissue and is not up-regulated by lipopolysaccharide. J Clin Endocrinol Metab (2009) 0.88
Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharm Drug Dispos (2009) 0.87
Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: the use of PANSS total score and clinical utility. Schizophr Res (2013) 0.87
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D2 receptor occupancy of olanzapine in rats. Pharm Res (2011) 0.86
Human precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury. Chem Res Toxicol (2013) 0.85
Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification. Cryobiology (2006) 0.85
Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties. Inorg Chem (2014) 0.85
Effects of model organophosphorous pesticides on DNA damage and proliferation of HepG2 cells. Environ Mol Mutagen (2008) 0.84
Structural models describing placebo treatment effects in schizophrenia and other neuropsychiatric disorders. Clin Pharmacokinet (2011) 0.83
Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert-butyl hydroperoxide (t-BOOH) in HepG2 human hepatoma cells. Mutat Res (2007) 0.83
Alteration of intracellular GSH levels and its role in microcystin-LR-induced DNA damage in human hepatoma HepG2 cells. Mutat Res (2006) 0.83
An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres. Nanotechnology (2009) 0.83
Modelling and simulation of the Positive and Negative Syndrome Scale (PANSS) time course and dropout hazard in placebo arms of schizophrenia clinical trials. Clin Pharmacokinet (2012) 0.83
Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Metab Dispos (2007) 0.82
Precision-cut fibrotic rat liver slices as a new model to test the effects of anti-fibrotic drugs in vitro. J Hepatol (2006) 0.82
Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo. Biopharm Drug Dispos (2010) 0.82
In vitro methods to study intestinal drug metabolism. Curr Drug Metab (2007) 0.82
Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations. Eur J Pharm Sci (2005) 0.82
A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor. Virology (2006) 0.81
Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations. Drug Metab Dispos (2006) 0.81
Cadmium inhibits repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells. Mutat Res (2003) 0.81
Comparative analysis of the human hepatic and adipose tissue transcriptomes during LPS-induced inflammation leads to the identification of differential biological pathways and candidate biomarkers. BMC Med Genomics (2011) 0.81
1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo. Biopharm Drug Dispos (2009) 0.81
A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies. J Pharmacol Toxicol Methods (2004) 0.81
Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity. Biotechnol Bioeng (2011) 0.81
Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction. Drug Metab Dispos (2006) 0.80
Reduced ischemia-reoxygenation injury in rat intestine after luminal preservation with a tailored solution. Transplantation (2010) 0.80
Cryopreservation of precision-cut tissue slices. Xenobiotica (2012) 0.80
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. Drug Metab Dispos (2005) 0.79
In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors. Bioorg Med Chem Lett (2005) 0.79
Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos (2012) 0.79
The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicol In Vitro (2010) 0.79
Effects of cryoprotectant addition and washout methods on the viability of precision-cut liver slices. Cryobiology (2012) 0.79
Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression. Toxicol In Vitro (2009) 0.79
Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale. J Clin Psychopharmacol (2013) 0.78
Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites. Arch Toxicol (2014) 0.78
Analysis of gene expression changes to elucidate the mechanism of chilling injury in precision-cut liver slices. Toxicol In Vitro (2012) 0.78
Bilitranslocase is involved in the uptake of bromosulfophthalein in rat and human liver. Drug Metab Lett (2012) 0.78
Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice. Regul Toxicol Pharmacol (2011) 0.78
Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: part II: the use of subscales of the PANSS score. Schizophr Res (2013) 0.78
Dopamine D2 receptor occupancy as a predictor of catalepsy in rats: a pharmacokinetic-pharmacodynamic modeling approach. Pharm Res (2014) 0.78
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices. Chem Res Toxicol (2016) 0.77
Microfluidics enables small-scale tissue-based drug metabolism studies with scarce human tissue. J Lab Autom (2011) 0.77
On-line HPLC analysis system for metabolism and inhibition studies in precision-cut liver slices. Anal Chem (2010) 0.77
Detection of xenobiotic-induced DNA damage by the comet assay applied to human and rat precision-cut liver slices. Toxicol In Vitro (2007) 0.77
New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: inhibition of antigen 85C mycolyltransferase activity and cytotoxicity. J Enzyme Inhib Med Chem (2006) 0.77
Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol. Phytomedicine (2007) 0.77
Determination of xanthohumol in hops (Humulus lupulus L.) by nonaqueous CE. Electrophoresis (2007) 0.76
Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury. J Appl Toxicol (2013) 0.76
The influence of brain death on liver function. Liver Int (2005) 0.76
Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo. J Pharm Sci (2010) 0.76
Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices. Xenobiotica (2012) 0.76
Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury. Chem Res Toxicol (2012) 0.75
Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo. Toxicol In Vitro (2015) 0.75
Modulation of cytokine production by some phthalimido-desmuramyl dipeptides and their cytotoxicity. Farmaco (2004) 0.75
Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine. Drug Metab Dispos (2013) 0.75
Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia. Schizophr Res (2013) 0.75
Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity. J Med Chem (2015) 0.75
Metal binding of metallothioneins in human astrocytomas (U87 MG, IPDDC-2A). Biometals (2006) 0.75