Published in Nucleic Acids Res on December 14, 2006
Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J Biol Chem (2010) 2.00
U2 snRNA is inducibly pseudouridylated at novel sites by Pus7p and snR81 RNP. EMBO J (2010) 1.52
Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast. RNA (2008) 1.21
Small Cajal body-specific RNAs of Drosophila function in the absence of Cajal bodies. Mol Biol Cell (2009) 1.14
Spliceosomal snRNA modifications and their function. RNA Biol (2010) 1.13
4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response. RNA Biol (2013) 0.97
A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation. Peptides (2010) 0.96
Functionality and substrate specificity of human box H/ACA guide RNAs. RNA (2008) 0.94
RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p. Genetics (2008) 0.93
Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP. Oncotarget (2014) 0.91
Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PLoS One (2011) 0.89
Pseudouridines in spliceosomal snRNAs. Protein Cell (2011) 0.88
RNA modifications: a mechanism that modulates gene expression. Methods Mol Biol (2010) 0.88
Novel small Cajal-body-specific RNAs identified in Drosophila: probing guide RNA function. RNA (2013) 0.86
Systems pharmacology assessment of the 5-fluorouracil pathway. Pharmacogenomics (2011) 0.84
Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cells. RNA (2011) 0.83
Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum. PLoS Negl Trop Dis (2013) 0.82
New insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cells. PLoS One (2013) 0.81
Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression. PLoS One (2012) 0.81
Functions and mechanisms of spliceosomal small nuclear RNA pseudouridylation. Wiley Interdiscip Rev RNA (2011) 0.81
Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET. RNA (2010) 0.79
Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation. World J Biol Chem (2014) 0.79
5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53. Oncotarget (2015) 0.77
Targeting nuclear thymidylate biosynthesis. Mol Aspects Med (2016) 0.75
Dual nature of pseudouridylation in U2 snRNA: Pus1p-dependent and Pus1p-independent activities in yeasts and higher eukaryotes. RNA (2017) 0.75
5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer (2003) 11.78
Fluorinated pyrimidines, a new class of tumour-inhibitory compounds. Nature (1957) 6.34
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. EMBO J (2002) 4.48
Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing. EMBO J (1998) 3.66
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev (1996) 3.61
Stabilization of RNA stacking by pseudouridine. Nucleic Acids Res (1995) 2.46
Ribosome structure and activity are altered in cells lacking snoRNPs that form pseudouridines in the peptidyl transferase center. Mol Cell (2003) 2.37
Crystal structure of unmodified tRNA(Gln) complexed with glutaminyl-tRNA synthetase and ATP suggests a possible role for pseudo-uridines in stabilization of RNA structure. Biochemistry (1994) 2.32
Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther (1990) 2.26
Pseudouridylation (Psi) of U2 snRNA in S. cerevisiae is catalyzed by an RNA-independent mechanism. EMBO J (2003) 1.82
Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine. Nat Struct Biol (2002) 1.79
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc Natl Acad Sci U S A (1997) 1.73
Modified nucleotides at the 5' end of human U2 snRNA are required for spliceosomal E-complex formation. RNA (2004) 1.63
Detection and quantitation of RNA base modifications. RNA (2004) 1.50
5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs. Mol Cell Biol (2004) 1.46
An H/ACA guide RNA directs U2 pseudouridylation at two different sites in the branchpoint recognition region in Xenopus oocytes. RNA (2002) 1.37
An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol (1997) 1.34
Pseudouridine formation in U2 small nuclear RNA. Proc Natl Acad Sci U S A (1994) 1.24
Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil. Cancer Res (1994) 1.19
Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells. Cancer Res (1979) 1.05
Inhibition of pre-mRNA splicing by 5-fluoro-, 5-chloro-, and 5-bromouridine. J Biol Chem (1989) 1.04
In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site. Nat Struct Mol Biol (2006) 1.00
5-Fluorouracil inhibits dihydrofolate reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells. J Biol Chem (1989) 0.99
Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing. J Biol Chem (1994) 0.98
5-Fluorouracil augmentation of dihydrofolate reductase gene transcripts containing intervening sequences in methotrexate-resistant KB cells. Mol Pharmacol (1986) 0.96
5-Fluorouracil substitution alters pre-mRNA splicing in vitro. J Biol Chem (1988) 0.92
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity. Biochem Pharmacol (1987) 0.90
Fluoropyrimidine-mediated changes in small nuclear RNA. J Biol Chem (1986) 0.86
Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells. Br J Cancer (1990) 0.85
Effects of 5-fluorouracil on cytotoxicity and RNA metabolism in human colonic carcinoma cells. Cancer Chemother Pharmacol (1989) 0.85
Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism. J Biol Chem (1986) 0.85
5-Fluorouracil augmentation of dihydrofolate reductase RNA containing contiguous exon and intron sequences in KB7B cells. J Biol Chem (1987) 0.84
The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro. Cancer Chemother Pharmacol (1986) 0.83
Modulation of 5-fluorouracil metabolism by thymidine. In vivo and in vitro studies on RNA-directed effects in rat liver and hepatoma. Biochem Pharmacol (1984) 0.83
5-fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells. J Biol Chem (1983) 0.82
Effects of 5-fluorouracil on globin mRNA synthesis in murine erythroleukemia cells. Biochemistry (1986) 0.82
Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA. Mol Pharmacol (1984) 0.82
RNA synthesis in the liver of rats treated with 5-fluorouracil. Arch Biochem Biophys (1967) 0.80
Precursor-dependent differences in the incorporation of fluorouracil in RNA. Mol Pharmacol (1986) 0.79
Pseudouridylation (Psi) of U2 snRNA in S. cerevisiae is catalyzed by an RNA-independent mechanism. EMBO J (2003) 1.82
Converting nonsense codons into sense codons by targeted pseudouridylation. Nature (2011) 1.74
U2 snRNA is inducibly pseudouridylated at novel sites by Pus7p and snR81 RNP. EMBO J (2010) 1.52
Detection and quantitation of RNA base modifications. RNA (2004) 1.50
Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism. EMBO J (2005) 1.47
An H/ACA guide RNA directs U2 pseudouridylation at two different sites in the branchpoint recognition region in Xenopus oocytes. RNA (2002) 1.37
The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs. RNA (2003) 1.33
Psi35 in the branch site recognition region of U2 small nuclear RNA is important for pre-mRNA splicing in Saccharomyces cerevisiae. J Biol Chem (2004) 1.32
RNA pseudouridylation: new insights into an old modification. Trends Biochem Sci (2013) 1.20
Spliceosomal snRNA modifications and their function. RNA Biol (2010) 1.13
Unusual base pairing during the decoding of a stop codon by the ribosome. Nature (2013) 1.11
Synthesis and labeling of RNA in vitro. Curr Protoc Mol Biol (2013) 0.99
Targeted pre-mRNA modification for gene silencing and regulation. Nat Methods (2007) 0.98
Functionality and substrate specificity of human box H/ACA guide RNAs. RNA (2008) 0.94
Targeted 2'-O methylation at a nucleotide within the pseudoknot of telomerase RNA reduces telomerase activity in vivo. Mol Cell Biol (2010) 0.92
A flexible RNA backbone within the polypyrimidine tract is required for U2AF65 binding and pre-mRNA splicing in vivo. Mol Cell Biol (2010) 0.91
Inducing nonsense suppression by targeted pseudouridylation. Nat Protoc (2012) 0.89
RNA modifications: a mechanism that modulates gene expression. Methods Mol Biol (2010) 0.88
Pseudouridines in spliceosomal snRNAs. Protein Cell (2011) 0.88
Regulation of pre-mRNA splicing in Xenopus oocytes by targeted 2'-O-methylation. RNA (2010) 0.87
Pre-mRNA splicing in the nuclei of Xenopus oocytes. Methods Mol Biol (2006) 0.86
Post-transcriptional modification of RNAs by artificial Box H/ACA and Box C/D RNPs. Methods Mol Biol (2011) 0.85
Functions and mechanisms of spliceosomal small nuclear RNA pseudouridylation. Wiley Interdiscip Rev RNA (2011) 0.81
Insight into the Protein Components of the Box H/ACA RNP. Curr Proteomics (2008) 0.79
Biochemical purification of box H/ACA RNPs involved in pseudouridylation. Methods Enzymol (2007) 0.77
Requirement for CRIF1 in RNA interference and Dicer-2 stability. RNA Biol (2014) 0.76
The most complex pseudouridylase. Structure (2006) 0.76
Purification of radiolabeled RNA products using denaturing gel electrophoresis. Curr Protoc Mol Biol (2014) 0.75
Quantitative analysis of RNA modifications. Methods Mol Biol (2010) 0.75