PubRank

Joachim Frank

Author PubWeight™ 173.79‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Locking and unlocking of ribosomal motions. Cell 2003 6.59
2 Flexible fitting of atomic structures into electron microscopy maps using molecular dynamics. Structure 2008 5.97
3 Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization. Nat Methods 2006 5.73
4 SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs. Nat Protoc 2008 4.60
5 Outcome of the first electron microscopy validation task force meeting. Structure 2012 4.35
6 Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy. Nat Struct Biol 2003 3.77
7 Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. EMBO J 2004 3.69
8 Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy. Proc Natl Acad Sci U S A 2003 3.64
9 Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome. Mol Cell 2008 3.58
10 Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process. EMBO J 2002 3.57
11 Molecular architecture of the human pre-mRNA 3' processing complex. Mol Cell 2009 3.52
12 Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Nature 2004 3.31
13 Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature 2005 3.10
14 Study of the structural dynamics of the E coli 70S ribosome using real-space refinement. Cell 2003 3.03
15 The cryo-EM structure of a translation initiation complex from Escherichia coli. Cell 2005 2.91
16 Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Cell 2004 2.84
17 Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Proc Natl Acad Sci U S A 2009 2.69
18 Visualizing tmRNA entry into a stalled ribosome. Science 2003 2.67
19 Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation. EMBO J 2007 2.48
20 A cryo-electron microscopic study of ribosome-bound termination factor RF2. Nature 2003 2.42
21 Outcome of a workshop on archiving structural models of biological macromolecules. Structure 2006 2.32
22 Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep 2004 2.28
23 Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nat Struct Mol Biol 2004 2.27
24 The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure 2011 2.19
25 Estimation of variance in single-particle reconstruction using the bootstrap technique. J Struct Biol 2006 2.10
26 Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit. Nature 2013 1.95
27 A method of focused classification, based on the bootstrap 3D variance analysis, and its application to EF-G-dependent translocation. J Struct Biol 2006 1.95
28 Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy. Nat Methods 2007 1.92
29 Preparation of macromolecular complexes for cryo-electron microscopy. Nat Protoc 2007 1.90
30 RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors. Cell 2007 1.89
31 Determination of signal-to-noise ratios and spectral SNRs in cryo-EM low-dose imaging of molecules. J Struct Biol 2009 1.81
32 Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications. Proc Natl Acad Sci U S A 2004 1.81
33 Ribosome dynamics: insights from atomic structure modeling into cryo-electron microscopy maps. Annu Rev Biophys Biomol Struct 2006 1.71
34 Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. Cell 2013 1.68
35 High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome. Nature 2013 1.66
36 An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs. J Neurosci 2003 1.61
37 Automated acquisition of cryo-electron micrographs for single particle reconstruction on an FEI Tecnai electron microscope. J Struct Biol 2005 1.58
38 Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies. Mol Cell 2005 1.58
39 Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements. Mol Cell 2006 1.57
40 Dynamics of EF-G interaction with the ribosome explored by classification of a heterogeneous cryo-EM dataset. J Struct Biol 2004 1.46
41 Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu. Q Rev Biophys 2009 1.45
42 Structural characterization of mRNA-tRNA translocation intermediates. Proc Natl Acad Sci U S A 2012 1.42
43 Interaction of the G' domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM. Mol Cell 2005 1.38
44 Towards high-resolution three-dimensional imaging of native mammalian tissue: electron tomography of frozen-hydrated rat liver sections. J Struct Biol 2005 1.35
45 Unsupervised classification of single particles by cluster tracking in multi-dimensional space. J Struct Biol 2006 1.31
46 Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit. J Cell Biol 2010 1.30
47 Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication. EMBO J 2003 1.30
48 Transfer RNA in the hybrid P/E state: correlating molecular dynamics simulations with cryo-EM data. Proc Natl Acad Sci U S A 2007 1.29
49 SPIRE: the SPIDER reconstruction engine. J Struct Biol 2006 1.28
50 Exploration of parameters in cryo-EM leading to an improved density map of the E. coli ribosome. J Struct Biol 2008 1.28
51 Definition and estimation of resolution in single-particle reconstructions. Structure 2010 1.27
52 Particle-verification for single-particle, reference-based reconstruction using multivariate data analysis and classification. J Struct Biol 2008 1.27
53 Cryo-EM visualization of transfer messenger RNA with two SmpBs in a stalled ribosome. Proc Natl Acad Sci U S A 2006 1.24
54 Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. EMBO J 2008 1.21
55 Functional conformations of the L11-ribosomal RNA complex revealed by correlative analysis of cryo-EM and molecular dynamics simulations. RNA 2006 1.20
56 Integrity of the P-site is probed during maturation of the 60S ribosomal subunit. J Cell Biol 2012 1.20
57 Localization and dynamic behavior of ribosomal protein L30e. Nat Struct Mol Biol 2005 1.18
58 Particle picking by segmentation: a comparative study with SPIDER-based manual particle picking. J Struct Biol 2005 1.17
59 The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components. Proc Natl Acad Sci U S A 2005 1.13
60 Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM. J Mol Biol 2006 1.11
61 Electron tomographic analysis of frozen-hydrated tissue sections. J Struct Biol 2002 1.11
62 Visualization of macromolecular complexes using cryo-electron microscopy with FEI Tecnai transmission electron microscopes. Nat Protoc 2008 1.09
63 Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Mol Microbiol 2007 1.09
64 Visualizing the transfer-messenger RNA as the ribosome resumes translation. EMBO J 2010 1.08
65 An approach to examining model dependence in EM reconstructions using cross-validation. J Struct Biol 2003 1.08
66 CLASSIFICATION BY BOOTSTRAPPING IN SINGLE PARTICLE METHODS. Proc IEEE Int Symp Biomed Imaging 2010 1.07
67 Structural insights into cognate versus near-cognate discrimination during decoding. EMBO J 2011 1.07
68 Scaffolding as an organizing principle in trans-translation. The roles of small protein B and ribosomal protein S1. J Biol Chem 2006 1.07
69 Molecular dynamics of EF-G during translocation. Proteins 2011 1.07
70 Cryo-EM structure of the mammalian eukaryotic release factor eRF1-eRF3-associated termination complex. Proc Natl Acad Sci U S A 2012 1.05
71 Structure of the mammalian ribosomal pre-termination complex associated with eRF1.eRF3.GDPNP. Nucleic Acids Res 2013 1.02
72 The parallelization of SPIDER on distributed-memory computers using MPI. J Struct Biol 2006 1.01
73 Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits. J Mol Biol 2007 1.00
74 Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy. J Mol Biol 2008 0.99
75 A twisted tRNA intermediate sets the threshold for decoding. RNA 2003 0.99
76 A clarification of the terms used in comparing semi-automated particle selection algorithms in cryo-EM. J Struct Biol 2011 0.97
77 Molding atomic structures into intermediate-resolution cryo-EM density maps of ribosomal complexes using real-space refinement. Structure 2005 0.97
78 Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM. Nucleic Acids Res 2009 0.97
79 Co- and post-translational translocation through the protein-conducting channel: analogous mechanisms at work? Nat Struct Mol Biol 2006 0.97
80 Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation. Proc Natl Acad Sci U S A 2011 0.95
81 Recent progress in the crystallographic studies of photosystem II. Chemphyschem 2010 0.95
82 Folding kinetics and structure of OEP16. Biophys J 2004 0.90
83 Time-dependent insulin oligomer reaction pathway prior to fibril formation: cooling and seeding. Proteins 2009 0.89
84 Reference-free particle selection enhanced with semi-supervised machine learning for cryo-electron microscopy. J Struct Biol 2011 0.89
85 Size determination of cyanobacterial and higher plant photosystem II by gel permeation chromatography, light scattering, and ultracentrifugation. Biochemistry 2005 0.88
86 Comparison of fungal 80 S ribosomes by cryo-EM reveals diversity in structure and conformation of rRNA expansion segments. J Mol Biol 2007 0.88
87 Mechanism of tetracycline resistance by ribosomal protection protein Tet(O). Nat Commun 2013 0.86
88 A model for co-translational translocation: ribosome-regulated nascent polypeptide translocation at the protein-conducting channel. FEBS Lett 2006 0.85
89 The group II intron ribonucleoprotein precursor is a large, loosely packed structure. Nucleic Acids Res 2010 0.85
90 Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome. J Struct Biol 2012 0.85
91 Structure of frozen-hydrated triad junctions: a case study in motif searching inside tomograms. J Struct Biol 2008 0.84
92 Visualization of a group II intron in the 23S rRNA of a stable ribosome. Proc Natl Acad Sci U S A 2006 0.83
93 Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1. Elife 2013 0.82
94 A library of RNA bridges. Nat Chem Biol 2006 0.81
95 Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis. J Mol Biol 2004 0.80
96 An assay for local quality in cryo-electron micrographs of single particles. Ultramicroscopy 2002 0.79
97 Interactions of trimeric purine nucleoside phosphorylases with ground state analogues--calorimetric and fluorimetric studies. Nucleosides Nucleotides Nucleic Acids 2003 0.78
98 Displaying 3D data on RNA secondary structures: coloRNA. J Struct Biol 2006 0.78
99 Quantitative Connection between Ensemble Thermodynamics and Single-Molecule Kinetics: A Case Study Using Cryogenic Electron Microscopy and Single-Molecule Fluorescence Resonance Energy Transfer Investigations of the Ribosome. J Phys Chem B 2015 0.77
100 From DNA to proteins via the ribosome: structural insights into the workings of the translation machinery. Hum Genomics 2010 0.76
101 tmRNA on its way through the ribosome: two steps of resume, and what next? RNA Biol 2011 0.76
102 Problems with the transorientation hypothesis. RNA 2002 0.75