Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit.

PubWeight™: 1.30‹?› | Rank: Top 10%

🔗 View Article (PMC 2894450)

Published in J Cell Biol on June 28, 2010

Authors

Jayati Sengupta1, Cyril Bussiere, Jesper Pallesen, Matthew West, Arlen W Johnson, Joachim Frank

Author Affiliations

1: Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA.

Articles citing this

Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics (2013) 2.70

Ribosome assembly factors prevent premature translation initiation by 40S assembly intermediates. Science (2011) 2.01

Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export. Nature (2013) 1.92

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev (2011) 1.89

Defining the pathway of cytoplasmic maturation of the 60S ribosomal subunit. Mol Cell (2010) 1.79

Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits. Nat Struct Mol Biol (2012) 1.62

Cryo-EM structure of the archaeal 50S ribosomal subunit in complex with initiation factor 6 and implications for ribosome evolution. J Mol Biol (2012) 1.46

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel. Nat Struct Mol Biol (2012) 1.34

An overview of pre-ribosomal RNA processing in eukaryotes. Wiley Interdiscip Rev RNA (2014) 1.30

Mechanism of eIF6 release from the nascent 60S ribosomal subunit. Nat Struct Mol Biol (2015) 1.29

Quality control mechanisms during ribosome maturation. Trends Cell Biol (2013) 1.22

Nucleolar stress with and without p53. Nucleus (2014) 1.13

Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit. Nat Struct Mol Biol (2012) 1.12

Hierarchical recruitment into nascent ribosomes of assembly factors required for 27SB pre-rRNA processing in Saccharomyces cerevisiae. Nucleic Acids Res (2012) 1.09

A hierarchical model for assembly of eukaryotic 60S ribosomal subunit domains. Genes Dev (2014) 1.09

Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes. Nature (2016) 0.94

Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3. PLoS Genet (2014) 0.94

Mechanistic insight into eukaryotic 60S ribosomal subunit biogenesis by cryo-electron microscopy. RNA (2016) 0.89

The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits. EMBO Rep (2011) 0.88

The DEAH-box helicase Dhr1 dissociates U3 from the pre-rRNA to promote formation of the central pseudoknot. PLoS Biol (2015) 0.88

Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1. Nat Struct Mol Biol (2017) 0.87

Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis. EMBO J (2017) 0.86

Yeast ribosomal protein L40 assembles late into precursor 60 S ribosomes and is required for their cytoplasmic maturation. J Biol Chem (2012) 0.85

Assembly and nuclear export of pre-ribosomal particles in budding yeast. Chromosoma (2014) 0.85

CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis. Nucleus (2013) 0.83

Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1. Elife (2013) 0.82

Paradigms of ribosome synthesis: Lessons learned from ribosomal proteins. Translation (Austin) (2015) 0.81

Monosome formation during translation initiation requires the serine/arginine-rich protein Npl3. Mol Cell Biol (2013) 0.81

The chromatin regulator Brpf1 regulates embryo development and cell proliferation. J Biol Chem (2015) 0.80

Retention of OsNMD3 in the cytoplasm disturbs protein synthesis efficiency and affects plant development in rice. J Exp Bot (2014) 0.80

Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185. PLoS One (2015) 0.79

The DEAD-box Protein Rok1 Orchestrates 40S and 60S Ribosome Assembly by Promoting the Release of Rrp5 from Pre-40S Ribosomes to Allow for 60S Maturation. PLoS Biol (2016) 0.78

Carboxy terminal modifications of the P0 protein reveal alternative mechanisms of nuclear ribosomal stalk assembly. Nucleic Acids Res (2013) 0.78

Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit. Nat Struct Mol Biol (2016) 0.76

Joining the interface: a site for Nmd3 association on 60S ribosome subunits. J Cell Biol (2010) 0.75

Atomic modeling of the ITS2 ribosome assembly subcomplex from cryo-EM together with mass spectrometry-identified protein-protein crosslinks. Protein Sci (2016) 0.75

Placeholder factors in ribosome biogenesis: please, pave my way. Microb Cell (2017) 0.75

Articles cited by this

Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science (2000) 28.25

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89

Crystal structure of the ribosome at 5.5 A resolution. Science (2001) 18.21

Structures of the bacterial ribosome at 3.5 A resolution. Science (2005) 12.63

Locking and unlocking of ribosomal motions. Cell (2003) 6.59

Ribosome assembly in eukaryotes. Gene (2003) 5.37

Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions. Cell (2001) 5.01

The post-transcriptional steps of eukaryotic ribosome biogenesis. Cell Mol Life Sci (2008) 4.87

Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol (2007) 4.12

Solution structure of the E. coli 70S ribosome at 11.5 A resolution. Cell (2000) 3.99

Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic (2005) 3.83

The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit. J Mol Biol (2004) 3.73

Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p. Mol Cell Biol (2001) 3.60

Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J Cell Biol (2000) 3.36

Base pairing between U3 and the pre-ribosomal RNA is required for 18S rRNA synthesis. EMBO J (1995) 3.08

Nucleocytoplasmic transport: taking an inventory. Cell Mol Life Sci (2003) 2.97

Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. EMBO J (2005) 2.22

NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.08

Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. J Cell Sci (2003) 2.02

Maturation of eukaryotic ribosomes: acquisition of functionality. Trends Biochem Sci (2010) 1.93

Nuclear export and cytoplasmic maturation of ribosomal subunits. FEBS Lett (2007) 1.90

Escherichia coli 70 S ribosome at 15 A resolution by cryo-electron microscopy: localization of fMet-tRNAfMet and fitting of L1 protein. J Mol Biol (1998) 1.84

Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates. EMBO J (2003) 1.84

Defining the pathway of cytoplasmic maturation of the 60S ribosomal subunit. Mol Cell (2010) 1.79

Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2. Mol Cell (2007) 1.78

Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit. Mol Cell (2007) 1.60

Defining the order in which Nmd3p and Rpl10p load onto nascent 60S ribosomal subunits. Mol Cell Biol (2005) 1.55

Arx1 is a nuclear export receptor for the 60S ribosomal subunit in yeast. Mol Biol Cell (2007) 1.44

A surfeit of factors: why is ribosome assembly so much more complicated in eukaryotes than bacteria? RNA Biol (2004) 1.43

Electron microscopy and computer image averaging of ice-embedded large ribosomal subunits from Escherichia coli. J Mol Biol (1988) 1.40

Nascent 60S ribosomal subunits enter the free pool bound by Nmd3p. RNA (2000) 1.40

SnapShot: nuclear transport. Cell (2007) 1.11

Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit. J Biol Chem (2006) 0.97

Articles by these authors

Locking and unlocking of ribosomal motions. Cell (2003) 6.59

Flexible fitting of atomic structures into electron microscopy maps using molecular dynamics. Structure (2008) 5.97

Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization. Nat Methods (2006) 5.73

ER tubules mark sites of mitochondrial division. Science (2011) 5.45

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs. Nat Protoc (2008) 4.60

Outcome of the first electron microscopy validation task force meeting. Structure (2012) 4.35

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy. Nat Struct Biol (2003) 3.77

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. EMBO J (2004) 3.69

Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy. Proc Natl Acad Sci U S A (2003) 3.64

Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome. Mol Cell (2008) 3.58

Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process. EMBO J (2002) 3.57

Molecular architecture of the human pre-mRNA 3' processing complex. Mol Cell (2009) 3.52

The role of Rat1 in coupling mRNA 3'-end processing to transcription termination: implications for a unified allosteric-torpedo model. Genes Dev (2006) 3.36

Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Nature (2004) 3.31

Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature (2005) 3.10

Study of the structural dynamics of the E coli 70S ribosome using real-space refinement. Cell (2003) 3.03

The cryo-EM structure of a translation initiation complex from Escherichia coli. Cell (2005) 2.91

Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Cell (2004) 2.84

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Proc Natl Acad Sci U S A (2009) 2.69

Visualizing tmRNA entry into a stalled ribosome. Science (2003) 2.67

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet (2012) 2.64

Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation. EMBO J (2007) 2.48

A cryo-electron microscopic study of ribosome-bound termination factor RF2. Nature (2003) 2.42

Outcome of a workshop on archiving structural models of biological macromolecules. Structure (2006) 2.32

Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep (2004) 2.28

Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nat Struct Mol Biol (2004) 2.27

Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes. J Cell Biol (2006) 2.24

Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. EMBO J (2005) 2.22

The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure (2011) 2.19

Estimation of variance in single-particle reconstruction using the bootstrap technique. J Struct Biol (2006) 2.10

Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit. Nature (2013) 1.95

A method of focused classification, based on the bootstrap 3D variance analysis, and its application to EF-G-dependent translocation. J Struct Biol (2006) 1.95

Maturation of eukaryotic ribosomes: acquisition of functionality. Trends Biochem Sci (2010) 1.93

Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy. Nat Methods (2007) 1.92

Preparation of macromolecular complexes for cryo-electron microscopy. Nat Protoc (2007) 1.90

RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors. Cell (2007) 1.89

Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates. EMBO J (2003) 1.84

Determination of signal-to-noise ratios and spectral SNRs in cryo-EM low-dose imaging of molecules. J Struct Biol (2009) 1.81

Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol (2009) 1.81

Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications. Proc Natl Acad Sci U S A (2004) 1.81

Defining the pathway of cytoplasmic maturation of the 60S ribosomal subunit. Mol Cell (2010) 1.79

Ribosome dynamics: insights from atomic structure modeling into cryo-electron microscopy maps. Annu Rev Biophys Biomol Struct (2006) 1.71

Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. Cell (2013) 1.68

High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome. Nature (2013) 1.66

An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs. J Neurosci (2003) 1.61

Automated acquisition of cryo-electron micrographs for single particle reconstruction on an FEI Tecnai electron microscope. J Struct Biol (2005) 1.58

Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies. Mol Cell (2005) 1.58

Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements. Mol Cell (2006) 1.57

Defining the order in which Nmd3p and Rpl10p load onto nascent 60S ribosomal subunits. Mol Cell Biol (2005) 1.55

ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife (2013) 1.52

Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies. EMBO J (2007) 1.48

Dynamics of EF-G interaction with the ribosome explored by classification of a heterogeneous cryo-EM dataset. J Struct Biol (2004) 1.46

Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu. Q Rev Biophys (2009) 1.45

Arx1 is a nuclear export receptor for the 60S ribosomal subunit in yeast. Mol Biol Cell (2007) 1.44

Structural characterization of mRNA-tRNA translocation intermediates. Proc Natl Acad Sci U S A (2012) 1.42

The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis. Proc Natl Acad Sci U S A (2007) 1.42

Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway. Mol Biol Cell (2006) 1.38

Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits. Mol Cell Biol (2008) 1.38

Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature. Mol Biol Cell (2013) 1.38

Interaction of the G' domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM. Mol Cell (2005) 1.38

Towards high-resolution three-dimensional imaging of native mammalian tissue: electron tomography of frozen-hydrated rat liver sections. J Struct Biol (2005) 1.35

Performance of English stop smoking services in first 10 years: analysis of service monitoring data. BMJ (2013) 1.33

Regulators of Vps4 ATPase activity at endosomes differentially influence the size and rate of formation of intralumenal vesicles. Mol Biol Cell (2010) 1.32

Unsupervised classification of single particles by cluster tracking in multi-dimensional space. J Struct Biol (2006) 1.31

Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.30

Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication. EMBO J (2003) 1.30

Transfer RNA in the hybrid P/E state: correlating molecular dynamics simulations with cryo-EM data. Proc Natl Acad Sci U S A (2007) 1.29

SPIRE: the SPIDER reconstruction engine. J Struct Biol (2006) 1.28

Exploration of parameters in cryo-EM leading to an improved density map of the E. coli ribosome. J Struct Biol (2008) 1.28

Definition and estimation of resolution in single-particle reconstructions. Structure (2010) 1.27

Particle-verification for single-particle, reference-based reconstruction using multivariate data analysis and classification. J Struct Biol (2008) 1.27

Cryo-EM visualization of transfer messenger RNA with two SmpBs in a stalled ribosome. Proc Natl Acad Sci U S A (2006) 1.24

Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. EMBO J (2008) 1.21

Functional conformations of the L11-ribosomal RNA complex revealed by correlative analysis of cryo-EM and molecular dynamics simulations. RNA (2006) 1.20

Integrity of the P-site is probed during maturation of the 60S ribosomal subunit. J Cell Biol (2012) 1.20

Localization and dynamic behavior of ribosomal protein L30e. Nat Struct Mol Biol (2005) 1.18

Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast. J Cell Biol (2011) 1.17

Particle picking by segmentation: a comparative study with SPIDER-based manual particle picking. J Struct Biol (2005) 1.17

Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0. J Cell Biol (2009) 1.17

The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components. Proc Natl Acad Sci U S A (2005) 1.13

Electron tomographic analysis of frozen-hydrated tissue sections. J Struct Biol (2002) 1.11

Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM. J Mol Biol (2006) 1.11

Visualization of macromolecular complexes using cryo-electron microscopy with FEI Tecnai transmission electron microscopes. Nat Protoc (2008) 1.09

Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Mol Microbiol (2007) 1.09

An approach to examining model dependence in EM reconstructions using cross-validation. J Struct Biol (2003) 1.08

Visualizing the transfer-messenger RNA as the ribosome resumes translation. EMBO J (2010) 1.08

Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis. Proc Natl Acad Sci U S A (2014) 1.07

Structural insights into cognate versus near-cognate discrimination during decoding. EMBO J (2011) 1.07

Scaffolding as an organizing principle in trans-translation. The roles of small protein B and ribosomal protein S1. J Biol Chem (2006) 1.07

CLASSIFICATION BY BOOTSTRAPPING IN SINGLE PARTICLE METHODS. Proc IEEE Int Symp Biomed Imaging (2010) 1.07

Molecular dynamics of EF-G during translocation. Proteins (2011) 1.07

Mutational analysis of the ribosomal protein Rpl10 from yeast. J Biol Chem (2007) 1.06

Eukaryotic rpL10 drives ribosomal rotation. Nucleic Acids Res (2013) 1.05

Cryo-EM structure of the mammalian eukaryotic release factor eRF1-eRF3-associated termination complex. Proc Natl Acad Sci U S A (2012) 1.05

Structure of the mammalian ribosomal pre-termination complex associated with eRF1.eRF3.GDPNP. Nucleic Acids Res (2013) 1.02

The parallelization of SPIDER on distributed-memory computers using MPI. J Struct Biol (2006) 1.01