Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study.

PubWeight™: 0.87‹?›

🔗 View Article (PMC 1764755)

Published in BMC Cardiovasc Disord on December 20, 2006

Authors

Cristina D Ciornei1, Hans Tapper, Anders Bjartell, Nils H Sternby, Mikael Bodelsson

Author Affiliations

1: Department of Clinical Sciences, Division of Anaesthesiology and Intensive Care, Lund University, Lund, Sweden. cristina.ciornei@med.lu.se <cristina.ciornei@med.lu.se>

Articles cited by this

Caspases: the executioners of apoptosis. Biochem J (1997) 11.99

Atherosclerosis. the road ahead. Cell (2001) 11.88

Peptide antibiotics. Antimicrob Agents Chemother (1999) 5.76

LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med (2000) 4.68

Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A (1990) 3.90

Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. Proc Natl Acad Sci U S A (2004) 3.85

The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci U S A (1998) 3.83

Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood (2001) 3.49

Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J Invest Dermatol (2001) 3.39

Mode of action of linear amphipathic alpha-helical antimicrobial peptides. Biopolymers (1998) 3.25

An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest (2003) 3.19

The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood (2000) 3.09

The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem (1996) 3.08

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. Biochem J (1999) 2.93

Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J Biol Chem (1998) 2.91

FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc Natl Acad Sci U S A (1995) 2.89

Immune mechanisms in atherosclerosis. Arterioscler Thromb Vasc Biol (2001) 2.89

Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect Immun (1995) 2.87

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme. Am J Pathol (1995) 2.54

Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res (2000) 2.50

The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6. Infect Immun (1999) 2.35

Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun (2000) 2.24

hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules. FEBS Lett (1995) 2.18

Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis. J Clin Invest (1998) 2.02

An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma. J Immunol Methods (1997) 1.87

Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation. Proc Natl Acad Sci U S A (1991) 1.80

Apoptosis and related proteins in different stages of human atherosclerotic plaques. Circulation (1998) 1.77

An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7. J Immunol (2006) 1.55

Structural features and biological activities of the cathelicidin-derived antimicrobial peptides. Biopolymers (2000) 1.51

Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscler Thromb Vasc Biol (1996) 1.41

Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection. Am J Respir Crit Care Med (2002) 1.38

Collagen synthesis in atherosclerosis: too much and not enough. Cardiovasc Res (1999) 1.34

Mechanism of mammalian cell lysis mediated by peptide defensins. Evidence for an initial alteration of the plasma membrane. J Clin Invest (1991) 1.33

Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques. Cardiovasc Res (1999) 1.32

The human cationic antimicrobial protein (hCAP-18) is expressed in the epithelium of human epididymis, is present in seminal plasma at high concentrations, and is attached to spermatozoa. Infect Immun (2000) 1.30

Antimicrobial and chemoattractant activity, lipopolysaccharide neutralization, cytotoxicity, and inhibition by serum of analogs of human cathelicidin LL-37. Antimicrob Agents Chemother (2005) 1.28

Human blood-derived macrophages induce apoptosis in human plaque-derived vascular smooth muscle cells by Fas-ligand/Fas interactions. Arterioscler Thromb Vasc Biol (2001) 1.26

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol (2006) 1.25

Tumor necrosis factor-alpha promotes macrophage-induced vascular smooth muscle cell apoptosis by direct and autocrine mechanisms. Arterioscler Thromb Vasc Biol (2003) 1.22

Anti-microbial activity of human CAP18 peptides. Immunotechnology (1995) 1.15

Binding and phagocytosis of apoptotic vascular smooth muscle cells is mediated in part by exposure of phosphatidylserine. Circ Res (1995) 1.11

Human macrophage-induced vascular smooth muscle cell apoptosis requires NO enhancement of Fas/Fas-L interactions. Arterioscler Thromb Vasc Biol (2002) 1.09

Involvement of the antimicrobial peptide LL-37 in human atherosclerosis. Arterioscler Thromb Vasc Biol (2006) 1.09

Cytotoxicity and apoptosis mediated by two peptides of innate immunity. Cell Immunol (1998) 1.08

The regulation of vascular smooth muscle cell apoptosis. Cardiovasc Res (2000) 1.04

Diverse molecular provocation of programmed cell death. Trends Biochem Sci (1996) 1.04

Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37. Am J Respir Cell Mol Biol (2005) 1.02

Chlamydia pneumoniae and vascular disease: an update. J Vasc Surg (2006) 1.00

C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells. Cancer Lett (2004) 0.98

Pathophysiology of coronary thrombosis: role of plaque rupture and plaque erosion. Prog Cardiovasc Dis (2002) 0.98

Oxidized low density lipoprotein induces apoptosis via generation of reactive oxygen species in vascular smooth muscle cells. Cardiovasc Res (2001) 0.96

Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death. Cardiovasc Res (2000) 0.93

Interaction of CAP18-derived peptides with membranes made from endotoxins or phospholipids. Biophys J (2001) 0.91

Effects of human cathelicidin antimicrobial peptide LL-37 on lipopolysaccharide-induced nitric oxide release from rat aorta in vitro. Acta Anaesthesiol Scand (2003) 0.90

Bactericidal/permeability-increasing protein inhibits endotoxin-induced vascular nitric oxide synthesis. Acta Anaesthesiol Scand (2002) 0.85

Phenotypic change of endothelin receptor subtype in cultured rat vascular smooth muscle cells. Endocrinology (1994) 0.85

DNA synthesis and apoptosis in smooth muscle cells from a model of genetic hypertension. Hypertension (2000) 0.83

Apoptosis in vascular smooth muscle cells: role of cell shrinkage. Biochem Biophys Res Commun (1996) 0.83

Articles by these authors

Active surveillance for low-risk prostate cancer worldwide: the PRIAS study. Eur Urol (2012) 4.48

Prostate specific antigen concentration at age 60 and death or metastasis from prostate cancer: case-control study. BMJ (2010) 4.42

Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study. BMJ (2013) 3.51

Insignificant prostate cancer and active surveillance: from definition to clinical implications. Eur Urol (2009) 2.97

ETS gene fusions in prostate cancer: from discovery to daily clinical practice. Eur Urol (2009) 2.91

Downsides of robot-assisted laparoscopic radical prostatectomy: limitations and complications. Eur Urol (2009) 2.76

Castration-resistant prostate cancer: from new pathophysiology to new treatment targets. Eur Urol (2009) 2.72

Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. Eur Urol (2007) 2.42

A novel automated platform for quantifying the extent of skeletal tumour involvement in prostate cancer patients using the Bone Scan Index. Eur Urol (2012) 2.27

Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37. Mol Microbiol (2002) 2.21

The mutational landscape of prostate cancer. Eur Urol (2013) 2.14

Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies. World J Gastroenterol (2006) 1.95

Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer. BJU Int (2008) 1.88

Evaluation of multiple risk-associated single nucleotide polymorphisms versus prostate-specific antigen at baseline to predict prostate cancer in unscreened men. Eur Urol (2011) 1.85

Systematic analysis of microRNAs targeting the androgen receptor in prostate cancer cells. Cancer Res (2011) 1.82

Advances in magnetic resonance imaging: how they are changing the management of prostate cancer. Eur Urol (2011) 1.63

Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors. J Leukoc Biol (2010) 1.62

A contemporary update on pathology reporting for prostate cancer: biopsy and radical prostatectomy specimens. Eur Urol (2012) 1.56

Functional properties of RYR1 mutations identified in Swedish patients with malignant hyperthermia and central core disease. Anesth Analg (2010) 1.55

Expression of somatostatin receptor subtypes 2 and 4 in human benign prostatic hyperplasia and prostatic cancer. Prostate (2002) 1.54

Epigenetics in prostate cancer: biologic and clinical relevance. Eur Urol (2011) 1.49

Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. Int J Cancer (2008) 1.48

A systematic review of the volume-outcome relationship for radical prostatectomy. Eur Urol (2013) 1.48

Expression and signaling activity of Wnt-5a/discoidin domain receptor-1 and Syk plays distinct but decisive roles in breast cancer patient survival. Clin Cancer Res (2005) 1.41

Contemporary role of prostate cancer antigen 3 in the management of prostate cancer. Eur Urol (2011) 1.36

Positive surgical margins in radical prostatectomy: outlining the problem and its long-term consequences. Eur Urol (2008) 1.35

Phagosome dynamics during phagocytosis by neutrophils. J Leukoc Biol (2011) 1.33

miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions. Int J Cancer (2010) 1.32

The learning curve for laparoscopic radical prostatectomy: an international multicenter study. J Urol (2010) 1.30

Streptococcus pyogenes expressing M and M-like surface proteins are phagocytosed but survive inside human neutrophils. Cell Microbiol (2003) 1.29

Antimicrobial and chemoattractant activity, lipopolysaccharide neutralization, cytotoxicity, and inhibition by serum of analogs of human cathelicidin LL-37. Antimicrob Agents Chemother (2005) 1.28

Tumor markers in prostate cancer I: blood-based markers. Acta Oncol (2011) 1.28

SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas. Am J Surg Pathol (2011) 1.27

Increased levels of glycosaminoglycans during septic shock: relation to mortality and the antibacterial actions of plasma. Shock (2008) 1.25

Prevalence and risk of pulmonary embolism in patients with intracardiac thrombosis: a population-based study of 23 796 consecutive autopsies. Eur Heart J (2005) 1.19

Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. J Natl Cancer Inst (2008) 1.18

Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues. Mol Hum Reprod (2002) 1.16

FGF-8 is involved in bone metastasis of prostate cancer. Int J Cancer (2008) 1.13

Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res (2013) 1.12

A panel of kallikrein marker predicts prostate cancer in a large, population-based cohort followed for 15 years without screening. Cancer Epidemiol Biomarkers Prev (2010) 1.12

Trousseau's syndrome - what is the evidence? A population-based autopsy study. Thromb Haemost (2006) 1.09

Upregulation of miR-96 enhances cellular proliferation of prostate cancer cells through FOXO1. PLoS One (2013) 1.09

Isolation of bacteria-containing phagosomes by magnetic selection. BMC Cell Biol (2008) 1.07

Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. J Leukoc Biol (2006) 1.07

beta-Microseminoprotein binds CRISP-3 in human seminal plasma. Biochem Biophys Res Commun (2005) 1.07

miQ--a novel microRNA based diagnostic and prognostic tool for prostate cancer. Int J Cancer (2012) 1.06

Streptococcus pyogenes bacteria modulate membrane traffic in human neutrophils and selectively inhibit azurophilic granule fusion with phagosomes. Cell Microbiol (2006) 1.06

A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden). Cancer Causes Control (2007) 1.05

The proinflammatory CXC-chemokines GRO-alpha/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids. Int J Colorectal Dis (2007) 1.04

Elevated plasma levels of antimicrobial polypeptides in patients with severe sepsis. J Innate Immun (2010) 1.03

REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer. Nucleic Acids Res (2013) 1.02

Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells. PLoS One (2011) 1.02

Dietary intakes of carbohydrates in relation to prostate cancer risk: a prospective study in the Malmö Diet and Cancer cohort. Am J Clin Nutr (2012) 1.02

Elastase-producing Pseudomonas aeruginosa degrade plasma proteins and extracellular products of human skin and fibroblasts, and inhibit fibroblast growth. Microb Pathog (2003) 1.02

Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells. Cell Microbiol (2010) 1.01

Functional magnetic resonance imaging in prostate cancer. Eur Urol (2009) 1.01

High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression. Diagn Pathol (2011) 1.00

Localization of human neutrophil interleukin-8 (CXCL-8) to organelle(s) distinct from the classical granules and secretory vesicles. J Leukoc Biol (2005) 1.00

Tumour markers in prostate cancer III: biomarkers in urine. Acta Oncol (2011) 0.99

A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. Oncogene (2005) 0.99

Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays. Mol Cell Proteomics (2010) 0.99

Elevated level of Wnt5a protein in localized prostate cancer tissue is associated with better outcome. PLoS One (2011) 0.99

Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. Int J Cancer (2004) 0.98

The antibacterial chemokine MIG/CXCL9 is constitutively expressed in epithelial cells of the male urogenital tract and is present in seminal plasma. J Interferon Cytokine Res (2008) 0.98

Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. Prostate (2008) 0.98

β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity. Nat Cell Biol (2012) 0.97

Male infertility and prostate cancer risk: a nested case-control study. Cancer Causes Control (2010) 0.97

Evaluation of the prognostic significance of MSMB and CRISP3 in prostate cancer using automated image analysis. Mod Pathol (2011) 0.97

Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tract. J Androl (2005) 0.97

In silico identification and biological evaluation of antimicrobial peptides based on human cathelicidin LL-37. Antimicrob Agents Chemother (2006) 0.97

Relative concentrations of hK2/PSA mRNA in benign and malignant prostatic tissue. Prostate (2005) 0.96

Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways. PLoS One (2009) 0.96

The lipocalin alpha1-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species. Free Radic Res (2008) 0.95

Spontaneous intracranial hypotension resulting in coma: case report. Neurosurgery (2006) 0.95

Detection of circulating and endothelial cell polymers of Z and wild type alpha 1-antitrypsin by a monoclonal antibody. J Biol Chem (2002) 0.93

Anti-thrombin is expressed in the benign prostatic epithelium and in prostate cancer and is capable of forming complexes with prostate-specific antigen and human glandular kallikrein 2. Am J Pathol (2002) 0.92

Streptococcus pyogenes and phagocytic killing. Nat Med (2002) 0.91

Increased serum levels of tumour-associated trypsin inhibitor independently predict a poor prognosis in colorectal cancer patients. BMC Cancer (2010) 0.91

Fc gamma R-mediated phagocytosis stimulates localized pinocytosis in human neutrophils. J Immunol (2002) 0.90

Expression of protein C inhibitor (PCI) in benign and malignant prostatic tissues. Prostate (2003) 0.90

Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines. Urol Oncol (2009) 0.89

Expression of prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) in ileum and other extraprostatic tissues. Int J Cancer (2005) 0.87

The tetraspanin CD63 is involved in granule targeting of neutrophil elastase. Blood (2008) 0.87

Human eosinophils produce the T cell-attracting chemokines MIG and IP-10 upon stimulation with IFN-gamma. J Leukoc Biol (2004) 0.87

Aberrant expression of cystatin C in prostate cancer is associated with neuroendocrine differentiation. BJU Int (2006) 0.87

Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. Exp Cell Res (2007) 0.87

Expression and immunolocalisation of neutral endopeptidase in prostate cancer. Eur Urol (2003) 0.84

Cystatin C is highly expressed in the human male reproductive system. J Androl (2004) 0.84

Low expression of SHP-2 is associated with less favorable prostate cancer outcomes. Tumour Biol (2012) 0.84

Phagocytosis of Streptococcus pyogenes by all-trans retinoic acid-differentiated HL-60 cells: roles of azurophilic granules and NADPH oxidase. PLoS One (2009) 0.84

Signaling to localized degranulation in neutrophils adherent to immune complexes. J Leukoc Biol (2002) 0.84

A compartmental model for biokinetics and dosimetry of 18F-choline in prostate cancer patients. J Nucl Med (2012) 0.83

Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. Am J Pathol (2005) 0.83

ENSAM: Europium Nanoparticles for Signal enhancement of Antibody Microarrays on nanoporous silicon. J Proteome Res (2008) 0.83

Different requirements for early and late phases of azurophilic granule-phagosome fusion. Traffic (2009) 0.83

A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue. Biol Chem (2007) 0.82

Expression and production of the CXC chemokine growth-related oncogene-alpha by human eosinophils. J Immunol (2003) 0.82

Increased apparatus dead space and tidal volume increase blood concentrations of oxygen and sevoflurane in overweight patients: a randomised controlled clinical study. Eur J Anaesthesiol (2011) 0.81

Monitoring of atherosclerosis. Int J Cardiol (2004) 0.81