| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
A microfluidic culture platform for CNS axonal injury, regeneration and transport.
|
Nat Methods
|
2005
|
7.62
|
|
2
|
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome.
|
Neuron
|
2004
|
5.52
|
|
3
|
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
|
J Biol Chem
|
2006
|
2.33
|
|
4
|
Gene expression changes in the course of normal brain aging are sexually dimorphic.
|
Proc Natl Acad Sci U S A
|
2008
|
2.29
|
|
5
|
Patterned cell culture inside microfluidic devices.
|
Lab Chip
|
2004
|
1.89
|
|
6
|
Microfluidic Multicompartment Device for Neuroscience Research.
|
Langmuir
|
2003
|
1.72
|
|
7
|
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide.
|
J Immunol
|
2005
|
1.56
|
|
8
|
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.
|
J Neurosci
|
2008
|
1.49
|
|
9
|
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.
|
PLoS One
|
2008
|
1.42
|
|
10
|
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.
|
J Neuroinflammation
|
2008
|
1.38
|
|
11
|
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
|
J Immunol
|
2011
|
1.36
|
|
12
|
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.
|
J Neurosci
|
2007
|
1.31
|
|
13
|
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
|
J Biol Chem
|
2007
|
1.30
|
|
14
|
Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease.
|
J Alzheimers Dis
|
2007
|
1.28
|
|
15
|
Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene.
|
Eur J Immunol
|
2003
|
1.12
|
|
16
|
Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease.
|
Neurobiol Aging
|
2012
|
1.10
|
|
17
|
Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice.
|
Neurosci Lett
|
2003
|
1.09
|
|
18
|
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.
|
Vaccine
|
2005
|
1.09
|
|
19
|
Frontal cortex neuropathology in dementia pugilistica.
|
J Neurotrauma
|
2012
|
1.08
|
|
20
|
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
|
Acta Neuropathol
|
2014
|
1.07
|
|
21
|
Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant.
|
J Cell Biochem
|
2006
|
1.07
|
|
22
|
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death.
|
Neurobiol Dis
|
2003
|
1.03
|
|
23
|
Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.
|
J Neuroinflammation
|
2005
|
1.03
|
|
24
|
Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.
|
J Neurosci
|
2013
|
1.02
|
|
25
|
Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase.
|
J Neurosci
|
2012
|
1.01
|
|
26
|
Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice.
|
J Neurosci
|
2007
|
1.00
|
|
27
|
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
|
J Alzheimers Dis
|
2010
|
1.00
|
|
28
|
Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy.
|
Ann N Y Acad Sci
|
2010
|
0.99
|
|
29
|
A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain.
|
Acta Neuropathol
|
2009
|
0.98
|
|
30
|
Mixed cerebrovascular disease and the future of stroke prevention.
|
Transl Stroke Res
|
2012
|
0.97
|
|
31
|
Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.
|
J Neuroinflammation
|
2008
|
0.97
|
|
32
|
Novel approaches for immunotherapeutic intervention in Alzheimer's disease.
|
Neurochem Int
|
2006
|
0.96
|
|
33
|
Refinement of a DNA based Alzheimer's disease epitope vaccine in rabbits.
|
Hum Vaccin Immunother
|
2013
|
0.94
|
|
34
|
Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.
|
PLoS One
|
2013
|
0.94
|
|
35
|
DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype.
|
J Neuroimmunol
|
2008
|
0.94
|
|
36
|
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.
|
Am J Pathol
|
2011
|
0.93
|
|
37
|
Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.
|
Am J Pathol
|
2013
|
0.93
|
|
38
|
Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites.
|
J Immunol
|
2007
|
0.93
|
|
39
|
External force-assisted cell positioning inside microfluidic devices.
|
Biomed Microdevices
|
2007
|
0.92
|
|
40
|
The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain.
|
Neurochem Res
|
2003
|
0.92
|
|
41
|
Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma.
|
Cell Immunol
|
2011
|
0.91
|
|
42
|
Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy.
|
Stroke
|
2011
|
0.91
|
|
43
|
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
|
PLoS One
|
2011
|
0.90
|
|
44
|
Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses.
|
Neurodegener Dis
|
2012
|
0.90
|
|
45
|
Amyloid-β peptide binds to cytochrome C oxidase subunit 1.
|
PLoS One
|
2012
|
0.89
|
|
46
|
Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model.
|
J Neurosci
|
2009
|
0.89
|
|
47
|
An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease.
|
Neurobiol Aging
|
2011
|
0.88
|
|
48
|
The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice.
|
Am J Pathol
|
2013
|
0.86
|
|
49
|
Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part I.
|
CNS Neurol Disord Drug Targets
|
2009
|
0.86
|
|
50
|
Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
|
JAMA Neurol
|
2015
|
0.84
|
|
51
|
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.
|
Vaccine
|
2006
|
0.83
|
|
52
|
Mimotopes of conformational epitopes in fibrillar beta-amyloid.
|
J Neuroimmunol
|
2004
|
0.83
|
|
53
|
Abeta-immunotherapy for Alzheimer's disease using mannan-amyloid-Beta peptide immunoconjugates.
|
DNA Cell Biol
|
2006
|
0.82
|
|
54
|
Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization.
|
DNA Cell Biol
|
2008
|
0.82
|
|
55
|
Relapsing polychondritis with features of dementia with Lewy bodies.
|
Acta Neuropathol
|
2006
|
0.82
|
|
56
|
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta.
|
Neurobiol Dis
|
2010
|
0.81
|
|
57
|
Immunization with a vaccine that combines the expression of MUC1 and B7 co-stimulatory molecules prolongs the survival of mice and delays the appearance of mouse mammary tumors.
|
Clin Exp Metastasis
|
2003
|
0.80
|
|
58
|
Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide.
|
Mol Immunol
|
2010
|
0.80
|
|
59
|
Anti-11[E]-pyroglutamate-modified amyloid β antibodies cross-react with other pathological Aβ species: relevance for immunotherapy.
|
J Neuroimmunol
|
2010
|
0.80
|
|
60
|
BTX AgilePulse(TM) system is an effective electroporation device for intramuscular and intradermal delivery of DNA vaccine.
|
Curr Gene Ther
|
2014
|
0.78
|
|
61
|
Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part II.
|
CNS Neurol Disord Drug Targets
|
2009
|
0.78
|
|
62
|
Low concentrations of anti-Aβ antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology.
|
Hum Gene Ther
|
2010
|
0.78
|
|
63
|
Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome.
|
Neurosci Lett
|
2002
|
0.77
|
|
64
|
Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B).
|
Neurochem Int
|
2007
|
0.76
|