Published in Langmuir on March 04, 2003
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods (2005) 7.62
Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci (2009) 2.48
Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron (2010) 2.00
Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J (2010) 1.90
Biology on a chip: microfabrication for studying the behavior of cultured cells. Crit Rev Biomed Eng (2003) 1.42
A microfluidic chamber for analysis of neuron-to-cell spread and axonal transport of an alpha-herpesvirus. PLoS One (2008) 1.31
Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture. Lab Chip (2008) 1.30
Co-culture of neurons and glia in a novel microfluidic platform. J Neurosci Methods (2010) 1.21
Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices. Lab Chip (2010) 1.19
β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging (2009) 1.13
Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding. Lab Chip (2010) 1.13
Single-molecule imaging of NGF axonal transport in microfluidic devices. Lab Chip (2010) 1.09
Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics. Biomicrofluidics (2011) 1.03
β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. J Biol Chem (2013) 1.03
Integration of pre-aligned liquid metal electrodes for neural stimulation within a user-friendly microfluidic platform. Lab Chip (2013) 1.01
Optically resolving individual microtubules in live axons. Structure (2009) 1.01
Microfluidic platforms for mechanobiology. Lab Chip (2013) 0.97
3D in vitro modeling of the central nervous system. Prog Neurobiol (2014) 0.93
Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection. Lab Chip (2010) 0.89
Dual-compartment neurofluidic system for electrophysiological measurements in physically segregated and functionally connected neuronal cell culture. Front Neuroeng (2011) 0.86
An in vitro method to manipulate the direction and functional strength between neural populations. Front Neural Circuits (2015) 0.84
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients. Lab Chip (2015) 0.83
c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. J Biol Chem (2013) 0.82
The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates. J Cell Biol (2016) 0.82
Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons. Mol Neurobiol (2016) 0.80
MicroC(3): an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells. Integr Biol (Camb) (2015) 0.78
In vitro models of axon regeneration. Exp Neurol (2016) 0.78
Recording large extracellular spikes in microchannels along many axonal sites from individual neurons. PLoS One (2015) 0.78
Microfluidic culture platform for studying neuronal response to mild to very mild axonal stretch injury. Biomicrofluidics (2014) 0.77
Axonal Terminals Exposed to Amyloid-β May Not Lead to Pre-Synaptic Axonal Damage. J Alzheimers Dis (2015) 0.76
Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks. Front Neural Circuits (2016) 0.76
Cloning SU8 silicon masters using epoxy resins to increase feature replicability and production for cell culture devices. Biomicrofluidics (2015) 0.75
Compartmentalized Platforms for Neuro-Pharmacological Research. Curr Neuropharmacol (2016) 0.75
Preparation of neuronal co-cultures with single cell precision. J Vis Exp (2014) 0.75
Cortical Axons, Isolated in Channels, Display Activity-Dependent Signal Modulation as a Result of Targeted Stimulation. Front Neurosci (2016) 0.75
Culture of primary rat hippocampal neurons: design, analysis, and optimization of a microfluidic device for cell seeding, coherent growth, and solute delivery. Biomed Microdevices (2013) 0.75
Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. Front Neural Circuits (2016) 0.75
A new microfluidic device design for a defined positioning of neurons in vitro. Biomicrofluidics (2017) 0.75
JIP1 and JIP3 cooperate to mediate TrkB anterograde axonal transport by activating kinesin-1. Cell Mol Life Sci (2017) 0.75
μNeurocircuitry: Establishing in vitro models of neurocircuits with human neurons. Technology (Singap World Sci) (2017) 0.75
Soft lithography in biology and biochemistry. Annu Rev Biomed Eng (2001) 11.36
Patterning proteins and cells using soft lithography. Biomaterials (1999) 4.58
Local control of neurite development by nerve growth factor. Proc Natl Acad Sci U S A (1977) 4.06
Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis. Neurobiol Dis (1998) 1.81
Development of sympathetic neurons in compartmentalized cultures. Il Local control of neurite growth by nerve growth factor. Dev Biol (1982) 1.65
Identification of fluorescein-5'-isothiocyanate-modification sites in proteins by electrospray-ionization mass spectrometry. Bioconjug Chem (1999) 1.07
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (2003) 18.18
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods (2005) 7.62
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron (2004) 5.52
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener (2007) 4.15
Microfluidic culture platform for neuroscience research. Nat Protoc (2006) 4.02
Neurobiology of exercise. Obesity (Silver Spring) (2006) 3.39
Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab Chip (2005) 3.33
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci (2005) 3.27
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80
Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci (2009) 2.48
The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophys J (2007) 2.37
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem (2006) 2.33
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A (2008) 2.29
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 2.28
Diffusion limits of an in vitro thick prevascularized tissue. Tissue Eng (2005) 2.15
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol (2003) 2.02
Patterned cell culture inside microfluidic devices. Lab Chip (2004) 1.89
Effective neutrophil chemotaxis is strongly influenced by mean IL-8 concentration. Biochem Biophys Res Commun (2004) 1.83
Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc (2002) 1.81
Engineering microscale cellular niches for three-dimensional multicellular co-cultures. Lab Chip (2009) 1.77
Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber. Biomed Microdevices (2007) 1.75
A parallel-gradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis. Biomed Microdevices (2006) 1.72
Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein. Nat Cell Biol (2009) 1.71
Biological applications of microfluidic gradient devices. Integr Biol (Camb) (2010) 1.67
Engineering of functional, perfusable 3D microvascular networks on a chip. Lab Chip (2013) 1.64
Unique dielectric properties distinguish stem cells and their differentiated progeny. Stem Cells (2007) 1.62
Vascular mimetics based on microfluidics for imaging the leukocyte--endothelial inflammatory response. Lab Chip (2007) 1.62
Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma (2005) 1.60
Generation of dynamic temporal and spatial concentration gradients using microfluidic devices. Lab Chip (2004) 1.60
Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. Nat Neurosci (2012) 1.60
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation (2012) 1.57
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide. J Immunol (2005) 1.56
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci (2004) 1.54
Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis (2002) 1.51
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci (2008) 1.49
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.48
Generation of stable complex gradients across two-dimensional surfaces and three-dimensional gels. Langmuir (2007) 1.48
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging (2005) 1.44
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. PLoS One (2008) 1.42
Multiparametric assessment of Cd²+ cytotoxicity using MTT-based microfluidic image cytometry. Cytometry A (2012) 1.41
Neutrophil migration in opposing chemoattractant gradients using microfluidic chemotaxis devices. Ann Biomed Eng (2005) 1.41
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation (2008) 1.38
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model. J Immunol (2011) 1.36
Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement (2009) 1.36
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem (2003) 1.32
Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull (2012) 1.32
A microfluidic chamber for analysis of neuron-to-cell spread and axonal transport of an alpha-herpesvirus. PLoS One (2008) 1.31
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J Neurosci (2007) 1.31
Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res (2007) 1.30
Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Hum Mol Genet (2006) 1.30
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers. J Biol Chem (2007) 1.30
The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci Lett (2004) 1.28
Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease. J Alzheimers Dis (2007) 1.28
A microfluidic multi-injector for gradient generation. Lab Chip (2006) 1.27
Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging (2007) 1.26
A hybrid microfluidic-vacuum device for direct interfacing with conventional cell culture methods. BMC Biotechnol (2007) 1.25
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24
Robust spatial sensing of mating pheromone gradients by yeast cells. PLoS One (2008) 1.24
In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices. Lab Chip (2012) 1.23
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis (2012) 1.20
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci (2007) 1.20
Dielectrophoresis switching with vertical sidewall electrodes for microfluidic flow cytometry. Lab Chip (2007) 1.20
Epidermal growth factor promotes breast cancer cell chemotaxis in CXCL12 gradients. Biotechnol Bioeng (2008) 1.20
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem (2007) 1.19
Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci (2003) 1.19
Microfluidic chambers for cell migration and neuroscience research. Methods Mol Biol (2006) 1.19
Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis (2010) 1.19
Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma (2004) 1.17
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging (2006) 1.17
Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One (2010) 1.15
Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites. Proc Natl Acad Sci U S A (2011) 1.15
β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging (2009) 1.13
Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. Eur J Immunol (2003) 1.12
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry (2002) 1.10
Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology (2013) 1.10
Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease. Neurobiol Aging (2012) 1.10
Advances in microfluidics-based experimental methods for neuroscience research. Lab Chip (2013) 1.09
Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice. Neurosci Lett (2003) 1.09
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch. Vaccine (2005) 1.09