Published in Cancer Res on November 15, 1991
Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol (1995) 4.37
A new pathway for protein export in Saccharomyces cerevisiae. J Cell Biol (1996) 1.66
Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia (2009) 1.52
Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis. Am J Pathol (2003) 1.39
Angiogenin antagonists prevent tumor growth in vivo. Proc Natl Acad Sci U S A (1995) 1.39
Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. Proc Natl Acad Sci U S A (1998) 1.37
The role of the vascular phase in solid tumor growth: a historical review. Neoplasia (1999) 1.20
Tumour vasculature--a potential therapeutic target. Br J Cancer (1995) 1.14
Endothelial-monocyte activating polypeptide II, a novel antitumor cytokine that suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells. J Exp Med (1999) 1.13
Tumour Angiogenesis and Angiogenic Inhibitors: A Review. J Clin Diagn Res (2015) 1.09
Impact of fibroblast growth factor-2 on tumor microvascular architecture. A tridimensional morphometric study. Am J Pathol (1998) 1.02
Anti-tumor activity of a novel HS-mimetic-vascular endothelial growth factor binding small molecule. PLoS One (2012) 0.99
Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity. Br J Cancer (1992) 0.99
Suramin inhibits bFGF-induced endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane. Br J Cancer (1993) 0.97
Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation. Biochem J (1999) 0.96
Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts. Br J Cancer (1996) 0.92
Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possible mechanism of neovascularization in atherosclerotic plaques. J Clin Invest (1995) 0.91
A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts. Mol Cancer Ther (2012) 0.90
Isolation of a novel basic FGF-binding peptide with potent antiangiogenetic activity. J Cell Mol Med (2010) 0.86
Tumor angiogenesis. The future is now. Ann Surg (1995) 0.84
Basic fibroblast growth factor induction of neuronal ion channel expression in ascidian ectodermal blastomeres. J Physiol (1998) 0.82
The suppression of fibroblast growth factor 2/fibroblast growth factor 4-dependent tumour angiogenesis and growth by the anti-growth factor activity of dextran derivative (CMDB7). Br J Cancer (1998) 0.82
Modification of the volumetric growth responses and steady-state hypoxic fractions of xenografted DLD-2 human colon carcinomas by administration of basic fibroblast growth factor or suramin. Br J Cancer (1992) 0.81
Expression of basic fibroblast growth factor in intact and ulcerated human gastric mucosa. Gut (1998) 0.80
A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions. Br J Cancer (1994) 0.80
Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortium. Twin Res Hum Genet (2009) 0.79
Synergistic anti-tumor effect of recombinant chicken fibroblast growth factor receptor-1-mediated anti-angiogenesis and low-dose gemcitabine in a mouse colon adenocarcinoma model. World J Gastroenterol (2007) 0.78
Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2. Monoclon Antib Immunodiagn Immunother (2014) 0.77
Effect of fibroblast growth factor saporin mitotoxins on human bladder cell lines. Clin Exp Metastasis (1997) 0.76
Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma. Oncol Lett (2015) 0.76
Dual Therapeutic Action of a Neutralizing Anti-FGF2 Aptamer in Bone Disease and Bone Cancer Pain. Mol Ther (2016) 0.75
Biological indices in the assessment of breast cancer. Clin Mol Pathol (1995) 0.75
Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats. Clin Exp Metastasis (2005) 0.75
Therapeutic strategies with oral fluoropyrimidine anticancer agent, S-1 against oral cancer. Jpn Dent Sci Rev (2016) 0.75
VEGF and bFGF mRNA are expressed in ethylnitrosourea-induced experimental rat gliomas. Cell Mol Neurobiol (1997) 0.75
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell (1988) 9.04
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell (1999) 7.56
Structure and expression of a cloned cDNA for human interleukin-2. Nature (1983) 7.04
Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J (1998) 6.94
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A (2001) 6.70
A new protein containing an SH2 domain that inhibits JAK kinases. Nature (1997) 6.28
Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell (1989) 6.11
The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw. Nucleic Acids Res (1983) 5.41
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res (1999) 5.41
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature (1990) 5.15
The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms. Genes Dev (1993) 4.23
Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell (1987) 4.10
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell (1993) 4.04
Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes. Cell (1986) 3.88
Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Cell (1990) 3.58
Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene. Cell (1985) 3.57
Interferon-beta gene regulation: tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer. Cell (1987) 3.51
Structure of the human interleukin 2 gene. Proc Natl Acad Sci U S A (1983) 3.45
Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells (2001) 3.42
Human C4-binding protein. II. Role in proteolysis of C4b by C3b-inactivator. J Exp Med (1978) 2.98
Ultra-high resolution SPECT system using four pinhole collimators for small animal studies. J Nucl Med (1995) 2.87
Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med (2000) 2.79
Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1. J Immunol (1992) 2.79
Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J Exp Med (1992) 2.76
Atomic structure of nanoclusters in oxide-dispersion-strengthened steels. Nat Mater (2011) 2.73
Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator. Proc Natl Acad Sci U S A (1979) 2.73
Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nat Immunol (2000) 2.66
Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor. J Immunol (1992) 2.64
Total en bloc spondylectomy. A new surgical technique for primary malignant vertebral tumors. Spine (Phila Pa 1976) (1997) 2.62
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem Biophys Res Commun (1995) 2.42
Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis. Nucleic Acids Res (1991) 2.33
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo) (1994) 2.28
Organization and transcription of the gluconate operon, gnt, of Bacillus subtilis. J Biol Chem (1986) 2.23
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature (1997) 2.20
The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50. EMBO J (1992) 2.19
Unique structure of murine interleukin-2 as deduced from cloned cDNAs. Nature (1985) 2.15
Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J Biol Chem (1997) 2.10
Betacellulin: a mitogen from pancreatic beta cell tumors. Science (1993) 2.10
Interleukin 2 (IL2) is assigned to human chromosome 4. Somat Cell Mol Genet (1984) 2.05
Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. J Biol Chem (1997) 2.03
Sequence of a cDNA coding for human IRF-1. Nucleic Acids Res (1989) 2.01
K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes. Proc Natl Acad Sci U S A (1990) 1.99
A novel membrane glycoprotein capable of inhibiting membrane attack by homologous complement. Int Immunol (1989) 1.98
The role of C4-binding protein and beta 1H in proteolysis of C4b and C3b. J Exp Med (1979) 1.97
Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am J Physiol (1989) 1.97
CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene (1993) 1.95
The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner. Mol Cell Biol (1993) 1.93
Closing-opening wedge osteotomy to correct angular kyphotic deformity by a single posterior approach. Spine (Phila Pa 1976) (2001) 1.93
Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4. Mol Cell Biol (1999) 1.91
A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. J Biol Chem (1996) 1.88
Primary intestinal lymphangiectasia successfully treated with octreotide. J Gastroenterol (2001) 1.87
Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry (2003) 1.86
New detection and separation method for amino acids by high-performance liquid chromatography. J Chromatogr (1981) 1.86
MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity (2001) 1.84
Domain structure of heparan sulfates from bovine organs. J Biol Chem (1996) 1.84
Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3). J Biochem (1996) 1.77
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. J Biol Chem (2000) 1.73
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol Cell Biol (2000) 1.72
Oxidative and nitrosative stress in acute renal ischemia. Am J Physiol Renal Physiol (2001) 1.71
A novel mechanism for disposing of effete epithelial cells in the small intestine of guinea pigs. Gastroenterology (1993) 1.71
Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J Exp Med (1993) 1.70
Monoclonal antibodies capable of causing hemolysis of neuraminidase-treated human erythrocytes by homologous complement. J Immunol (1989) 1.70
Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma. Clin Exp Immunol (1988) 1.69
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons. Blood (1998) 1.68
Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. Biochem Biophys Res Commun (1991) 1.67
Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. J Immunol (2000) 1.67
Cloning and expression of cDNA encoding human basic fibroblast growth factor. FEBS Lett (1987) 1.66
Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem (1997) 1.66
Identification and nucleotide sequence of the promoter region of the Bacillus subtilis gluconate operon. Nucleic Acids Res (1986) 1.64
Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ann Intern Med (2000) 1.64
Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470). Br J Cancer (1994) 1.60
Scanning electron microscopy of normal and rheumatoid articular cartilages. Arch Histol Jpn (1969) 1.59
Geometric frustration of icosahedron in metallic glasses. Science (2013) 1.59
IgG heavy-chain (Gm) allotypes and immune response to insulin in insulin-requiring diabetes mellitus. N Engl J Med (1981) 1.57
Effective thrombolysis without marked plasminemia after bolus intravenous administration of vampire bat salivary plasminogen activator in rabbits. Circulation (1991) 1.57
Crry, a complement regulatory protein, modulates renal interstitial disease induced by proteinuria. Kidney Int (1999) 1.57
New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) (1996) 1.56
Mechanism for increase of gastrin release by secretin in Zollinger-Ellison syndrome. Gastroenterology (1989) 1.56
A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-kappa B p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappa B site and CArG box. Oncogene (1993) 1.55
Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma. Cancer Genet Cytogenet (1997) 1.55
Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus. Biochem Biophys Res Commun (1998) 1.52
Diagnosis of a tear of the tibiofibular syndesmosis. The role of arthroscopy of the ankle. J Bone Joint Surg Br (2003) 1.51
Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension (1998) 1.50
Tumor antigens isolated from a patient with vitiligo and T-cell-infiltrated melanoma. Cancer Res (2001) 1.50
Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. J Biol Chem (1998) 1.49
Leukaemia of novel gastrointestinal T-lymphocyte population infected with HTLV-I. Lancet (1991) 1.48
A pilot case-control study on the alveolar bone density measurement in risk assessment for bisphosphonate-related osteonecrosis of the jaw. Osteoporos Int (2009) 1.48
Cut-off values determined for vertebral fracture by peripheral quantitative computed tomography in Japanese women. Osteoporos Int (2001) 1.48
Collecting duct carcinoma with long survival treated by partial nephrectomy. Int J Urol (2001) 1.48
Potent growth inhibition of human tumor cells in culture by arginine deiminase purified from a culture medium of a Mycoplasma-infected cell line. Cancer Res (1990) 1.48
Long-term beneficial effect of late reperfusion for acute anterior myocardial infarction with percutaneous transluminal coronary angioplasty. Circulation (1998) 1.47
Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells. Kidney Int (2006) 1.46
IgG heavy chain allotypes (Gm) in autoimmune diseases. Clin Exp Immunol (1980) 1.46
Expression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomas. Oncogene (2007) 1.46
Sequence analysis of the Plutella xylostella granulovirus genome. Virology (2000) 1.46
Formation of an intermediate compound with a B12H12 cluster: experimental and theoretical studies on magnesium borohydride Mg(BH4)2. Nanotechnology (2009) 1.46