Published in Hepatology on January 01, 2007
Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells. Infect Immun (2008) 1.66
Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production. J Immunol (2010) 1.31
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc Natl Acad Sci U S A (2014) 1.30
Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2. J Neuroinflammation (2008) 1.30
Multifaceted roles of PGE2 in inflammation and cancer. Semin Immunopathol (2012) 1.29
Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury. J Immunol (2008) 1.07
Effect of polyI:C cotreatment on halothane-induced liver injury in mice. Hepatology (2009) 0.98
PGI2 as a regulator of inflammatory diseases. Mediators Inflamm (2012) 0.94
The cardinal role of the phospholipase A(2)/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E(2) (PCPP) axis in inflammostasis. Inflamm Res (2011) 0.93
Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress. Am J Physiol Heart Circ Physiol (2008) 0.81
COX-2 in liver, from regeneration to hepatocarcinogenesis: what we have learned from animal models? World J Gastroenterol (2010) 0.79
Complex roles of cyclo-oxygenase 2 in hepatitis. Gut (2007) 0.79
Helicobacter hepaticus induces an inflammatory response in primary human hepatocytes. PLoS One (2014) 0.76
Differential Contributions of Alcohol and the Nicotine-Derived Nitrosamine Ketone (NNK) to Insulin and Insulin-Like Growth Factor Resistance in the Adolescent Rat Brain. Alcohol Alcohol (2015) 0.76
Leishmania donovani-Induced Prostaglandin E2 Generation Is Critically Dependent on Host Toll-Like Receptor 2-Cytosolic Phospholipase A2 Signaling. Infect Immun (2016) 0.75
The efficacy of parecoxib on systemic inflammatory response associated with cardiopulmonary bypass during cardiac surgery. Br J Clin Pharmacol (2013) 0.75
Hepatic NK cell-mediated hypersensitivity to ConA-induced liver injury in mouse liver expressing hepatitis C virus polyprotein. Oncotarget (2016) 0.75
Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res (2002) 2.20
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med (2013) 2.19
Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol (2008) 1.93
Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J (2007) 1.93
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci (2006) 1.75
Mechanisms of drug-induced liver injury. AAPS J (2006) 1.65
The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice. Gastroenterology (2004) 1.58
Mechanisms of immune-mediated liver injury. Toxicol Sci (2010) 1.48
Mechanism of cyclooxygenase-2 upregulation in late preconditioning. J Mol Cell Cardiol (2003) 1.45
The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. Toxicol Lett (2009) 1.42
Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology (2008) 1.41
Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis C virus immunity. Hepatology (2012) 1.41
Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis. Am J Pathol (2002) 1.39
Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Hepatology (2010) 1.33
Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. J Immunol (2005) 1.30
Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2. J Neuroinflammation (2008) 1.30
Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J Neurochem (2004) 1.24
Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. Mol Carcinog (2007) 1.24
Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis (2004) 1.22
Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice. Am J Respir Crit Care Med (2003) 1.19
Role of neutrophils in a mouse model of halothane-induced liver injury. Hepatology (2006) 1.19
Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice. Cardiovasc Res (2006) 1.17
Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. Cancer Res (2003) 1.16
Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology (2011) 1.13
Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling. Mol Pharmacol (2004) 1.10
Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4. Cancer Res (2007) 1.08
Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2. Prostaglandins Other Lipid Mediat (2002) 1.04
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol (2013) 1.04
Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus. J Clin Invest (2002) 1.03
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. Carcinogenesis (2009) 1.02
Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages. Part Fibre Toxicol (2012) 0.99
Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis. J Neurochem (2006) 0.99
Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice. Toxicol Appl Pharmacol (2004) 0.98
Effect of polyI:C cotreatment on halothane-induced liver injury in mice. Hepatology (2009) 0.98
Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog (2013) 0.97
MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration. FASEB J (2005) 0.96
Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain. Genome Biol (2007) 0.96
The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways. J Biol Chem (2010) 0.96
Cyclooxygenase enzymes in allergic inflammation and asthma. Prostaglandins Leukot Essent Fatty Acids (2003) 0.95
Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury. Hepatology (2013) 0.94
Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse. J Neurochem (2006) 0.94
Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol (2013) 0.92
Lactoferrin protects against acetaminophen-induced liver injury in mice. Hepatology (2010) 0.91
Covalent binding of the nitroso metabolite of sulfamethoxazole is important in induction of drug-specific T-cell responses in vivo. Mol Pharmacol (2008) 0.91
E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. J Immunol (2004) 0.91
Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstriction. Hypertension (2005) 0.91
Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation. J Hepatol (2013) 0.90
Involvement of natural killer T cells in halothane-induced liver injury in mice. Biochem Pharmacol (2010) 0.90
Current challenges and controversies in drug-induced liver injury. Drug Saf (2012) 0.90
A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors. Prostaglandins Other Lipid Mediat (2007) 0.89
Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure. Mol Carcinog (2007) 0.88
Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. Am J Respir Cell Mol Biol (2013) 0.88
A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. Cancer Lett (2009) 0.87
Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses. Am J Physiol Regul Integr Comp Physiol (2005) 0.87
Video-assisted thoracoscopic surgery (VATS) for patients with solitary fibrous tumors of the pleura. J Thorac Oncol (2010) 0.85
A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin. Mol Carcinog (2007) 0.85
Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro. Toxicol Appl Pharmacol (2009) 0.85
The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin. Mol Carcinog (2011) 0.85
Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivo. FASEB J (2003) 0.85
β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice. Circ Res (2013) 0.84
Atherogenic diet causes lethal ileo-ceco-colitis in cyclooxygenase-2 deficient mice. Prostaglandins Other Lipid Mediat (2007) 0.83
Altered brain lipid composition in cyclooxygenase-2 knockout mouse. J Lipid Res (2007) 0.83
Damage-associated molecular patterns: their impact on the liver and beyond during acetaminophen overdose. Hepatology (2012) 0.83
Exacerbation of acetaminophen-induced disturbances of liver sinusoidal endothelial cells in the absence of Kupffer cells in mice. Toxicol Lett (2010) 0.83
Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation. J Infect Dis (2006) 0.82
Drug-induced liver injury. Handb Exp Pharmacol (2010) 0.82
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation. Carcinogenesis (2012) 0.81
Macrophages an£1 Alcohol-Related Liver Inflammation. Alcohol Res (2015) 0.80
PGE2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition. Mol Neurobiol (2014) 0.80
A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice. Mol Carcinog (2011) 0.79
Lactoferrin protects against concanavalin A-induced liver injury in mice. Liver Int (2010) 0.79
Mechanistic perspectives on sulfonamide-induced cutaneous drug reactions. Curr Opin Allergy Clin Immunol (2002) 0.78
Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouse. Brain Res Mol Brain Res (2005) 0.78
19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Mol Pharmacol (2014) 0.77
Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration. J Clin Invest (2016) 0.77
Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicol Lett (2010) 0.75
Development of a screening assay to evaluate the potential of drugs to cause immune-mediated hypersensitivity reactions. J Immunotoxicol (2013) 0.75
Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1 gene by arginine vasopressin. Mol Cell Endocrinol (2013) 0.75