Published in Curr Opin Chem Biol on December 27, 2006
Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell (2008) 3.64
Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach. Mol Cell Proteomics (2008) 1.60
Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates. Nat Protoc (2011) 1.24
Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nat Rev Drug Discov (2009) 1.21
Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Mol Cell Proteomics (2011) 1.20
Imaging and quantifying the dynamics of tumor-associated proteolysis. Clin Exp Metastasis (2008) 1.07
New perspective for phage display as an efficient and versatile technology of functional proteomics. Appl Microbiol Biotechnol (2009) 1.04
Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry. Nat Protoc (2011) 1.04
The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis. Biochem J (2013) 1.04
Comparative assessment of large-scale proteomic studies of apoptotic proteolysis. ACS Chem Biol (2009) 0.91
Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94. Biotechnol J (2007) 0.89
VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells. J Biol Chem (2011) 0.84
High-Throughput Multiplexed Peptide-Centric Profiling Illustrates Both Substrate Cleavage Redundancy and Specificity in the MMP Family. Chem Biol (2015) 0.83
Profiling protease activities by dynamic proteomics workflows. Proteomics (2012) 0.80
A SILAC-based approach identifies substrates of caspase-dependent cleavage upon TRAIL-induced apoptosis. Mol Cell Proteomics (2013) 0.80
Novel Biological Substrates of Human Kallikrein 7 Identified through Degradomics. J Biol Chem (2015) 0.79
Identification of calpain substrates by ORF phage display. Molecules (2011) 0.78
A sequence and structure based method to predict putative substrates, functions and regulatory networks of endo proteases. PLoS One (2009) 0.77
Proteolytic characteristics of cathepsin D related to the recognition and cleavage of its target proteins. PLoS One (2013) 0.76
Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling. J Biol Chem (2015) 0.76
Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways. Toxins (Basel) (2016) 0.76
Post-transcriptional regulation of fruit ripening and disease resistance in tomato by the vacuolar protease SlVPE3. Genome Biol (2017) 0.75
A bead-based cleavage method for large-scale identification of protease substrates. Sci Rep (2016) 0.75
Engineering peptide ligase specificity by proteomic identification of ligation sites. Nat Chem Biol (2017) 0.75
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity. Nat Protoc (2017) 0.75
Human and mouse proteases: a comparative genomic approach. Nat Rev Genet (2003) 4.02
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood (2002) 3.58
Protease degradomics: a new challenge for proteomics. Nat Rev Mol Cell Biol (2002) 3.17
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites. Nat Biotechnol (2008) 3.07
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet (2003) 2.69
HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration. Nat Neurosci (2003) 2.66
Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta (2009) 2.04
LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PLoS One (2007) 2.01
Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome. Mol Cell Proteomics (2007) 1.98
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products. Nat Biotechnol (2010) 1.98
Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proc Natl Acad Sci U S A (2004) 1.91
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res (2011) 1.76
Matrix metalloproteinase proteomics: substrates, targets, and therapy. Curr Opin Cell Biol (2009) 1.65
Matrix metalloproteinase processing of CXCL11/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding. J Biol Chem (2008) 1.55
Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome. Mol Cell Proteomics (2008) 1.55
The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. J Biol Chem (2006) 1.49
Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics. Mol Cell Proteomics (2010) 1.48
Missing the target: matrix metalloproteinase antitargets in inflammation and cancer. Trends Pharmacol Sci (2013) 1.47
Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech (2010) 1.35
Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding. Mol Cell Biol (2008) 1.35
Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics. Biochemistry (2009) 1.34
Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am J Pathol (2008) 1.33
The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases. Mol Biol Cell (2005) 1.30
Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis. Dev Dyn (2008) 1.29
Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice. J Am Chem Soc (2008) 1.28
The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes (2012) 1.27
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus. Hum Mol Genet (2008) 1.26
Proteome-wide analysis of protein carboxy termini: C terminomics. Nat Methods (2010) 1.26
Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates. Nat Protoc (2011) 1.24
Proteolytic host cell enzymes in gingival crevice fluid. Periodontol 2000 (2003) 1.23
TopFIND, a knowledgebase linking protein termini with function. Nat Methods (2011) 1.22
Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nat Rev Drug Discov (2009) 1.21
Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Mol Cell Proteomics (2011) 1.20
Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology. Trends Neurosci (2009) 1.18
A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis. Mol Biol Cell (2006) 1.18
Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A). Biochem J (2007) 1.16
Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration. Proc Natl Acad Sci U S A (2006) 1.12
Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Lett (2008) 1.10
Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts. J Cell Sci (2004) 1.09
Protease research in the era of systems biology. Biol Chem (2007) 1.08
Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets. Br J Pharmacol (2002) 1.08
Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts. Cancer Res (2002) 1.06
Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation. Sci Signal (2013) 1.06
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Cell Mol Life Sci (2012) 1.05
A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products. Mol Cell Proteomics (2010) 1.05
Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res (2014) 1.05
Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences. Biochemistry (2007) 1.05
Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry. Nat Protoc (2011) 1.04
Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities. J Biol Chem (2012) 1.04
TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function. Nucleic Acids Res (2011) 1.03
Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids. Biochemistry (2002) 1.02
Protease yoga: extreme flexibility of a matrix metalloproteinase. Structure (2007) 1.02
The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B. J Mol Biol (2008) 1.02
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. J Biol Chem (2011) 1.01
Protein TAILS: when termini tell tales of proteolysis and function. Curr Opin Chem Biol (2013) 1.01
Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical. Cancer Res (2005) 1.00
TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains. J Biol Chem (2006) 1.00
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice. J Biol Chem (2008) 0.98
Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression. Arthritis Rheum (2010) 0.98
CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J (2009) 0.97
Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites. Biol Chem (2011) 0.96
Protease proteomics: revealing protease in vivo functions using systems biology approaches. Mol Aspects Med (2008) 0.95
Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system. J Biol Chem (2013) 0.94
Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer. Cancer Res (2010) 0.93
Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency. J Biol Chem (2002) 0.93
Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength. Proc Natl Acad Sci U S A (2013) 0.92
Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16. J Biol Chem (2011) 0.92
Analysis of the degradome with the CLIP-CHIP microarray. Methods Mol Biol (2010) 0.92
Proteolytic post-translational modification of proteins: proteomic tools and methodology. Mol Cell Proteomics (2013) 0.91
Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. J Biol Chem (2011) 0.91
N- and C-terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification. Physiol Plant (2011) 0.90
Regulation of intercellular adhesion strength in fibroblasts. J Biol Chem (2004) 0.89
Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing. J Immunol (2006) 0.89
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. Biochem J (2009) 0.89
Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity. Biochem J (2014) 0.87
Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer. Cancer Res (2009) 0.87
Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. Biochim Biophys Acta (2007) 0.87
Identification of cellular MMP substrates using quantitative proteomics: isotope-coded affinity tags (ICAT) and isobaric tags for relative and absolute quantification (iTRAQ). Methods Mol Biol (2010) 0.87
Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism. J Biol Chem (2013) 0.87
Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase. Protein Sci (2005) 0.87
Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase. Biochemistry (2002) 0.86
Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids. PLoS One (2013) 0.85
Cell-based identification of natural substrates and cleavage sites for extracellular proteases by SILAC proteomics. Methods Mol Biol (2009) 0.85
Broad coverage identification of multiple proteolytic cleavage site sequences in complex high molecular weight proteins using quantitative proteomics as a complement to edman sequencing. Mol Cell Proteomics (2010) 0.84
Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment. FASEB J (2012) 0.83
CLIPPER: an add-on to the Trans-Proteomic Pipeline for the automated analysis of TAILS N-terminomics data. Biol Chem (2012) 0.83
Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection. J Virol (2015) 0.82
Chapter 13. Characterizing proteolytic processing of chemokines by mass spectrometry, biochemistry, neo-epitope antibodies and functional assays. Methods Enzymol (2009) 0.82
Identification of proteolytic products and natural protein N-termini by Terminal Amine Isotopic Labeling of Substrates (TAILS). Methods Mol Biol (2011) 0.82
Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates. Methods Mol Biol (2009) 0.81
Proteomic identification of cellular protease substrates using isobaric tags for relative and absolute quantification (iTRAQ). Curr Protoc Protein Sci (2007) 0.80
Site specific cleavage mediated by MMPs regulates function of agrin. PLoS One (2012) 0.78
Matrix metalloproteinase processing of signaling molecules to regulate inflammation. Periodontol 2000 (2013) 0.78