Published in Biotechnol J on May 01, 2007
Calpain chronicle--an enzyme family under multidisciplinary characterization. Proc Jpn Acad Ser B Phys Biol Sci (2011) 1.21
Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance. Neuromuscul Disord (2008) 1.09
Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles. J Mol Biol (2011) 1.05
Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy. J Clin Invest (2010) 0.99
Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle. PLoS One (2010) 0.98
Gene expression profiling in limb-girdle muscular dystrophy 2A. PLoS One (2008) 0.93
Skeletal muscle-specific calpain is an intracellular Na+-dependent protease. J Biol Chem (2010) 0.88
The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation. Proc Natl Acad Sci U S A (2014) 0.78
Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array. Mol Cell Proteomics (2016) 0.77
Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. PLoS One (2015) 0.76
Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics (2004) 19.05
The calpain system. Physiol Rev (2003) 9.95
Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A. Cell (1995) 4.41
Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol (1990) 3.76
Structure and physiological function of calpains. Biochem J (1997) 2.62
Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol (2000) 2.23
Search for cancer markers from endometrial tissues using differentially labeled tags iTRAQ and cICAT with multidimensional liquid chromatography and tandem mass spectrometry. J Proteome Res (2005) 2.22
Structure, activation, and biology of calpain. Diabetes (2004) 2.16
Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome. Mol Cell Proteomics (2007) 1.98
Disruption of the mouse mu-calpain gene reveals an essential role in platelet function. Mol Cell Biol (2001) 1.97
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature (2002) 1.97
Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicans. Mol Biol Cell (2004) 1.93
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells. Blood (2006) 1.92
Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle. J Biol Chem (1993) 1.52
Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology. Hum Mol Genet (2002) 1.49
Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway. Mol Cell Biol (2005) 1.43
Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol Cell Proteomics (2005) 1.42
m-Calpain is required for preimplantation embryonic development in mice. BMC Dev Biol (2006) 1.37
Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A. J Biol Chem (1998) 1.36
Spatial resolution of fodrin proteolysis in postischemic brain. J Biol Chem (1993) 1.35
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. J Biol Chem (2005) 1.34
Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway. Hum Mol Genet (2005) 1.33
Calpain inhibition: a therapeutic strategy targeting multiple disease states. Curr Pharm Des (2006) 1.33
Calpain 3 is activated through autolysis within the active site and lyses sarcomeric and sarcolemmal components. Mol Cell Biol (2003) 1.32
Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans. J Cell Biol (2006) 1.30
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem (2005) 1.25
Proteomic discovery of protease substrates. Curr Opin Chem Biol (2006) 1.25
Calpain 3: a key regulator of the sarcomere? FEBS J (2006) 1.22
Purification of native p94, a muscle-specific calpain, and characterization of its autolysis. Biochem J (1998) 1.16
Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem (2005) 1.15
Enhancement of calcium sensitivity of lipocortin I in phospholipid binding induced by limited proteolysis and phosphorylation at the amino terminus as analyzed by phospholipid affinity column chromatography. J Biol Chem (1989) 1.15
The calpain small subunit gene is essential: its inactivation results in embryonic lethality. IUBMB Life (2000) 1.14
Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3. J Biol Chem (2003) 1.11
Molecular and cellular basis of calpainopathy (limb girdle muscular dystrophy type 2A). Biochim Biophys Acta (2006) 1.05
Regulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiation. Mol Cell Biol (2006) 1.03
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system. J Biol Chem (2006) 1.01
Role of proteases in the pathophysiology of cardiac disease. Mol Cell Biochem (2004) 0.96
Identification of putative in vivo substrates of calpain 3 by comparative proteomics of overexpressing transgenic and nontransgenic mice. Proteomics (2006) 0.93
Calpain 3 is expressed in astrocytes of rat and Microcebus brain. J Chem Neuroanat (2003) 0.89
Characterization of a new p94-like calpain form in human lymphocytes. Biochem J (2003) 0.88
Protein-chemical identification of the major cleavage sites of the Ca2+ proteinase on murine vimentin, the mesenchymal intermediate filament protein. Biol Chem Hoppe Seyler (1986) 0.88
Comparative study of [Three] LC-MALDI workflows for the analysis of complex proteomic samples. J Proteome Res (2005) 0.86
Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene. FEBS Lett (2003) 0.85
Biochemical background of the VO2 on-kinetics in skeletal muscles. J Physiol Sci (2006) 0.83
Spatial resolution of calpain-catalyzed proteolysis in focal cerebral ischemia. Brain Res (2005) 0.83
Proteolysis of N-ethylmaleimide-modified aldolase loaded into erythrocyte ghosts: prevention by inhibitors of calpain. Biochem J (1989) 0.79
Identification of endogenous substrates for Drosophila calpain from a salt-extracted fraction of Drosophila ovaries. J Biochem (1997) 0.77
A direct nanoflow liquid chromatography-tandem mass spectrometry system for interaction proteomics. Anal Chem (2002) 2.18
Structure, activation, and biology of calpain. Diabetes (2004) 2.16
Retracted Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol Cell (2002) 1.75
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease. J Biol Chem (2003) 1.53
Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice. Arthritis Rheum (2011) 1.50
Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway. Mol Cell Biol (2005) 1.43
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol (2007) 1.41
Calpains: an elaborate proteolytic system. Biochim Biophys Acta (2011) 1.38
Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome. J Biol Chem (2003) 1.36
Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region. J Biol Chem (2006) 1.31
Association of human DNA helicase RecQ5beta with RNA polymerase II and its possible role in transcription. Biochem J (2008) 1.20
Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23. Biochem Biophys Res Commun (2002) 1.20
Proteomic snapshot analyses of preribosomal ribonucleoprotein complexes formed at various stages of ribosome biogenesis in yeast and mammalian cells. Mass Spectrom Rev (2003) 1.16
Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling. J Mol Biol (2004) 1.15
Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3. J Biol Chem (2003) 1.11
Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle. J Biol Chem (2008) 1.10
Calpain cleavage prediction using multiple kernel learning. PLoS One (2011) 1.09
Single-incision thoracoscopic surgery using a chest wall pulley for lung excision in patients with primary spontaneous pneumothorax. Surg Today (2014) 1.08
Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes. J Biol Chem (2002) 1.08
Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade. Mol Cell (2008) 1.07
Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles. J Mol Biol (2011) 1.05
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly. Nat Med (2009) 1.04
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. PLoS Genet (2010) 1.03
Differential contribution of NFATc2 and NFATc1 to TNF-alpha gene expression in T cells. J Immunol (2008) 1.02
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system. J Biol Chem (2006) 1.01
CaMPDB: a resource for calpain and modulatory proteolysis. Genome Inform (2010) 1.01
Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther (2009) 1.01
Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy. J Clin Invest (2010) 0.99
Single-cell chemical lysis method for analyses of intracellular molecules using an array of picoliter-scale microwells. Anal Chem (2008) 0.98
Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. J Biol Chem (2006) 0.98
Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy. J Gen Physiol (2014) 0.96
Neoculin as a new taste-modifying protein occurring in the fruit of Curculigo latifolia. Biosci Biotechnol Biochem (2004) 0.94
Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain. J Biol Chem (2007) 0.94
Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner. J Immunol (2005) 0.92
Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1. J Cell Sci (2011) 0.92
Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. Bioorg Med Chem (2004) 0.90
Possible functions of p94 in connectin-mediated signaling pathways in skeletal muscle cells. J Muscle Res Cell Motil (2005) 0.89
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol Ther (2002) 0.89
Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage. Mol Cell Proteomics (2009) 0.89
Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int Immunol (2007) 0.89
Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor. Neuroreport (2006) 0.89
Skeletal muscle-specific calpain is an intracellular Na+-dependent protease. J Biol Chem (2010) 0.88
Testicular proteins associated with the germ cell-marker, TEX101: involvement of cellubrevin in TEX101-trafficking to the cell surface during spermatogenesis. Biochem Biophys Res Commun (2006) 0.88
Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23. Biochem Biophys Res Commun (2002) 0.88
C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells. J Biol Chem (2002) 0.87
Crystal structure of neoculin: insights into its sweetness and taste-modifying activity. J Mol Biol (2006) 0.86
Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila. PLoS One (2012) 0.86
Intravitreal injection or topical eye-drop application of a μ-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa. Biochim Biophys Acta (2012) 0.85
Role of mast cells in the development of renal fibrosis: use of mast cell-deficient rats. Kidney Int (2004) 0.85
NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Nucleic Acids Res (2006) 0.85
Calpain-6 deficiency promotes skeletal muscle development and regeneration. PLoS Genet (2013) 0.85
Extracellular production of neoculin, a sweet-tasting heterodimeric protein with taste-modifying activity, by Aspergillus oryzae. Appl Environ Microbiol (2006) 0.85
Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene. FEBS Lett (2003) 0.85
Volatiles emitted from the leaves of Laurus nobilis L. improve vigilance performance in visual discrimination task. Biomed Res (2011) 0.84
Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. J Biol Chem (2006) 0.84
GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements. FEBS Lett (2004) 0.83
Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains. J Biol Chem (2007) 0.83
Degradation of fodrin by m-calpain in fibroblasts adhering to fibrillar collagen I gel. J Biochem (2004) 0.82
Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode. Anal Biochem (2005) 0.82
DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway. Biochem Biophys Res Commun (2012) 0.82
Correlation between mRNA expression of Th1/Th2 cytokines and their specific transcription factors in human helper T-cell clones. Immunol Cell Biol (2005) 0.82
Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis. Arthritis Rheum (2013) 0.81
MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss. J Cell Biochem (2011) 0.81
Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis. J Reprod Immunol (2011) 0.80
Flexibility analysis and structure comparison of two crystal forms of calcium-free human m-calpain. Biol Chem (2002) 0.80
PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1. J Mol Biol (2013) 0.80
Muscle-specific calpain-3 is phosphorylated in its unique insertion region for enrichment in a myofibril fraction. Genes Cells (2014) 0.80
Efficient expression and purification of recombinant human m-calpain using an Escherichia coli expression system at low temperature. J Biochem (2012) 0.80
Does the severity of the LGMD2A phenotype in compound heterozygotes depend on the combination of mutations? Muscle Nerve (2011) 0.79
Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse. Biol Reprod (2009) 0.79
Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients. Int Arch Allergy Immunol (2005) 0.79
Calpain system regulates the differentiation of adult primitive mesenchymal ST-13 adipocytes. Endocrinology (2006) 0.78
IL-4 gene transcription in human T cells is suppressed by T-bet. Int Arch Allergy Immunol (2007) 0.78
A cysteine residue near the propionate side chain of heme is the radical site in ascorbate peroxidase. FEBS J (2007) 0.78
The importance of conserved amino acid residues in p94 protease sub-domain IIb and the IS2 region for constitutive autolysis. FEBS Lett (2008) 0.78
Efficient expression and purification of recombinant human μ-calpain using an Escherichia coli expression system. Genes Cells (2013) 0.78
T-box 21 transcription factor is responsible for distorted T(H)2 differentiation in human peripheral CD4+ T cells. J Allergy Clin Immunol (2009) 0.78