Published in J Biol Chem on January 02, 2007
A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein. Circ Res (2008) 1.66
Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway. Blood (2008) 1.47
Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions. Thromb Haemost (2012) 1.44
Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by α-thrombin. J Biol Chem (2013) 1.04
Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling. J Biol Chem (2008) 0.96
Calpain-mediated regulation of platelet signaling pathways. Curr Opin Hematol (2007) 0.95
Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4. J Biol Chem (2012) 0.93
Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets. Haematologica (2012) 0.92
Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading. J Thromb Haemost (2012) 0.90
Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles. Front Immunol (2015) 0.84
Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer. BMC Cancer (2016) 0.78
Three-Dimensional Environment Sustains Hematopoietic Stem Cell Differentiation into Platelet-Producing Megakaryocytes. PLoS One (2015) 0.77
Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation. BMC Complement Altern Med (2016) 0.76
The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling. J Thromb Haemost (2014) 0.76
Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis. Proc Natl Acad Sci U S A (2017) 0.75
Plasma Kallikrein enhances platelet aggregation response by subthreshold doses of ADP. Biochimie (2017) 0.75
Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost (2004) 4.26
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00
Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. Nat Genet (2012) 2.80
Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome. Nat Genet (2011) 1.91
Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res (2005) 1.89
New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol (2006) 1.72
Anticoagulant and antithrombotic properties of platelet protease nexin-1. Blood (2009) 1.62
The gray platelet syndrome: clinical spectrum of the disease. Blood Rev (2006) 1.59
Radiolabeled fucoidan as a p-selectin targeting agent for in vivo imaging of platelet-rich thrombus and endothelial activation. J Nucl Med (2011) 1.58
Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow. Blood (2009) 1.57
Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity. Arterioscler Thromb Vasc Biol (2011) 1.56
Platelets and wound healing. Front Biosci (2008) 1.56
Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment. Blood (2006) 1.56
Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia. Blood (2013) 1.51
Inherited thrombocytopenias. Haematologica (2007) 1.49
Progression of the prothrombotic state in aging Bmal1-deficient mice. Arterioscler Thromb Vasc Biol (2011) 1.43
Lethal hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type II. Blood (2006) 1.42
Thrombocytopenia after abciximab use results from different mechanisms. Thromb Haemost (2010) 1.39
Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome. Blood (2011) 1.37
A prototypic platelet septin and its participation in secretion. Proc Natl Acad Sci U S A (2002) 1.36
Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg (2005) 1.35
Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. Blood (2011) 1.34
Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood (2007) 1.30
Control of actin dynamics by p38 MAP kinase - Hsp27 distribution in the lamellipodium of smooth muscle cells. J Cell Sci (2004) 1.29
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med (2011) 1.27
Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes. Blood (2004) 1.25
Hyperalgesia and allodynia: peripheral mechanisms. Joint Bone Spine (2005) 1.22
Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A. Nat Commun (2013) 1.20
Platelet JNK1 is involved in secretion and thrombus formation. Blood (2010) 1.20
Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A (2009) 1.18
Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation. J Clin Invest (2014) 1.13
Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model. Exp Hematol (2002) 1.13
Involvement of the mitogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J Biol Chem (2007) 1.12
Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. Blood (2010) 1.12
Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice. J Clin Invest (2013) 1.11
Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay. Thromb Res (2009) 1.04
Platelet-associated CD154 in immune thrombocytopenic purpura. Blood (2004) 1.03
Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis. Blood (2002) 1.02
A novel alpha(v)beta (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis. Clin Exp Metastasis (2007) 1.02
Exploring the platelet proteome via combinatorial, hexapeptide ligand libraries. J Proteome Res (2007) 1.01
Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites. J Biol Chem (2004) 1.00
Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation. Blood (2007) 1.00
Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins. Exp Hematol (2009) 0.99
Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII. Blood (2005) 0.99
Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Circ Res (2007) 0.98
Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation. Arterioscler Thromb Vasc Biol (2004) 0.97
Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size. Blood (2004) 0.97
Neuropharmacological basis of rTMS-induced analgesia: the role of endogenous opioids. Pain (2010) 0.96
Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression. Blood (2012) 0.96
Differential Involvement of ERK2 and p38 in platelet adhesion to collagen. J Biol Chem (2005) 0.95
Bleeding risks associated with inheritance of the Quebec platelet disorder. Blood (2004) 0.95
New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura. Lancet (2009) 0.94
Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen. Blood (2004) 0.93
Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation. Thromb Haemost (2012) 0.92
In vitro and in vivo antiangiogenic properties of the serpin protease nexin-1. Mol Cell Biol (2012) 0.92
Non-invasive molecular imaging of fibrosis using a collagen-targeted peptidomimetic of the platelet collagen receptor glycoprotein VI. PLoS One (2009) 0.91
Platelet protease nexin-1, a serpin that strongly influences fibrinolysis and thrombolysis. Circulation (2011) 0.91
PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle. Arterioscler Thromb Vasc Biol (2004) 0.91
von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3. J Clin Invest (2013) 0.91
Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment. Expert Rev Hematol (2012) 0.90
Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions. Atherosclerosis (2005) 0.90
Platelet ERK2 activation by thrombin is dependent on calcium and conventional protein kinases C but not Raf-1 or B-Raf. FEBS Lett (2002) 0.90
Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood (2009) 0.89
Heterogeneity of platelet functional alterations in patients with filamin A mutations. Arterioscler Thromb Vasc Biol (2012) 0.89
Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation. FEBS Lett (2004) 0.89
Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin. Eur J Biochem (2003) 0.88
Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome. Blood (2004) 0.88
Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood. Arterioscler Thromb Vasc Biol (2002) 0.88
Recruitment of protein phosphatase 2A to dorsal ruffles by platelet-derived growth factor in smooth muscle cells: dephosphorylation of Hsp27. Exp Cell Res (2008) 0.87
Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology. Blood (2012) 0.87
Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms. Eur J Biochem (2004) 0.87
Crucial role for endoplasmic reticulum stress during megakaryocyte maturation. Arterioscler Thromb Vasc Biol (2013) 0.87
Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets. Biochim Biophys Acta (2008) 0.87
In vivo analysis of the role of O-glycosylations of von Willebrand factor. PLoS One (2012) 0.87
Macrophages and platelets are the major source of protease nexin-1 in human atherosclerotic plaque. Arterioscler Thromb Vasc Biol (2008) 0.87
A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia. Platelets (2002) 0.86
Dilation-dependent activation of platelets and prothrombin in human thoracic ascending aortic aneurysm. Arterioscler Thromb Vasc Biol (2008) 0.86