Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide.

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85

The connection between C-reactive protein and atherosclerosis. Ann Med (2008) 1.29

C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells. J Immunol (2008) 1.21

Phosphoethanolamine-complexed C-reactive protein: a pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum. Clin Chim Acta (2008) 1.06

Identification of acidic pH-dependent ligands of pentameric C-reactive protein. J Biol Chem (2010) 0.96

Pathogen recognition by the long pentraxin PTX3. J Biomed Biotechnol (2011) 0.94

The protective function of human C-reactive protein in mouse models of Streptococcus pneumoniae infection. Endocr Metab Immune Disord Drug Targets (2008) 0.89

Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis. J Biol Chem (2011) 0.86

The "sweet" side of a long pentraxin: how glycosylation affects PTX3 functions in innate immunity and inflammation. Front Immunol (2013) 0.85

Probing the phosphocholine-binding site of human C-reactive protein by site-directed mutagenesis. J Biol Chem (1992) 0.85

Characterization of gene use and efficacy of mouse monoclonal antibodies to Streptococcus pneumoniae serotype 8. Clin Vaccine Immunol (2010) 0.83

The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection. J Biol Chem (2012) 0.81

C-reactive protein protects mice against pneumococcal infection via both phosphocholine-dependent and phosphocholine-independent mechanisms. Infect Immun (2015) 0.79

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS One (2016) 0.76

Higher risk for incident heart failure and cardiovascular mortality among community-dwelling octogenarians without pneumococcal vaccination. ESC Heart Fail (2015) 0.75

The phenomenon of the acute phase response. Ann N Y Acad Sci (1982) 6.14

Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin. J Immunol (1974) 5.35

Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Proc Soc Exp Biol Med (1971) 3.32

CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc Natl Acad Sci U S A (2005) 3.30

Human C-reactive protein: expression, structure, and function. Mol Immunol (2001) 2.79

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci U S A (2002) 2.72

Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein. J Exp Med (1998) 2.65

Interactions of C-reactive protein with the complement system. I. Protamine-induced consumption of complement in acute phase sera. J Exp Med (1974) 2.47

C-reactive protein is protective against Streptococcus pneumoniae infection in mice. J Exp Med (1981) 2.17

CRP after 2004. Mol Immunol (2004) 1.91

Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H. J Immunol (2002) 1.87

The major receptor for C-reactive protein on leukocytes is fcgamma receptor II. J Exp Med (1999) 1.84

A common site within factor H SCR 7 responsible for binding heparin, C-reactive protein and streptococcal M protein. Eur J Immunol (2003) 1.77

Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in mice. J Immunol (1982) 1.77

Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice. J Immunol (1995) 1.61

Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae. Infect Immun (1996) 1.60

The inhibitory effect of C-reactive protein on bacterial phosphorylcholine platelet-activating factor receptor-mediated adherence is blocked by surfactant. J Infect Dis (2002) 1.49

Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen. Proc Natl Acad Sci U S A (2000) 1.47

Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11. J Immunol (1999) 1.42

Blood clearance of Streptococcus pneumoniae by C-reactive protein. J Immunol (1987) 1.42

Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J Immunol (2002) 1.34

Dendritic cells and host resistance to infection. Cell Microbiol (2003) 1.24

C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. J Immunol (2002) 1.23

Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation. Biochem J (1990) 1.17

A C-reactive protein mutant that does not bind to phosphocholine and pneumococcal C-polysaccharide. J Immunol (2002) 1.14

Opsonic properties of C-reactive protein in vivo. J Immunol (1982) 1.13

Structural and functional anatomy of the globular domain of complement protein C1q. Immunol Lett (2004) 1.11

C-reactive protein reactivity with complement and effects on phagocytosis. Ann N Y Acad Sci (1982) 1.10

Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia. Proc Natl Acad Sci U S A (1997) 1.10

Genetic and functional analysis of the phosphorylcholine moiety of commensal Neisseria lipopolysaccharide. Mol Microbiol (2002) 1.09

Pathogens use carbohydrates to escape immunity induced by dendritic cells. Curr Opin Immunol (2004) 1.08

Topology and structure of the C1q-binding site on C-reactive protein. J Immunol (2001) 1.08

C-reactive protein binding to murine leukocytes requires Fc gamma receptors. J Immunol (2000) 1.06

C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G (FcgammaRI). Immunology (2002) 1.02

The role of the spleen in the protective effect of C-reactive protein in Streptococcus pneumoniae infection. Clin Exp Immunol (1983) 1.02

Binding of human C-reactive protein to bacteria. Infect Immun (1982) 1.02

Autoantibodies to C-reactive protein (CRP) and other acute-phase proteins in systemic autoimmune diseases. Clin Exp Immunol (1998) 1.01

Role of the property of C-reactive protein to activate the classical pathway of complement in protecting mice from pneumococcal infection. J Immunol (2006) 1.01

Interaction of calcium-bound C-reactive protein with fibronectin is controlled by pH: in vivo implications. J Biol Chem (2004) 1.00

C-reactive protein induces signaling through Fc gamma RIIa on HL-60 granulocytes. J Immunol (2002) 0.98

Human C-reactive protein is protective against fatal Salmonella enterica serovar typhimurium infection in transgenic mice. Infect Immun (2000) 0.97

Native and modified C-reactive protein bind different receptors on human neutrophils. Int J Biochem Cell Biol (2005) 0.90

Human C-reactive protein does not protect against acute lipopolysaccharide challenge in mice. J Immunol (2003) 0.89

Use of whole Streptococcus pneumoniae cells as a solid phase sorbent for C-reactive protein measurement by ELISA. J Immunol Methods (1985) 0.86

Tolerance and immunity to the inducible self antigen C-reactive protein in transgenic mice. Eur J Immunol (1995) 0.85

Difference in binding of killed and live Streptococcus pneumoniae serotypes by C-reactive protein. Scand J Immunol (1997) 0.85

New developments in dendritic cell-based vaccinations: RNA translated into clinics. Cancer Immunol Immunother (2005) 0.84

Binding and immunological properties of a synthetic peptide corresponding to the phosphorylcholine-binding region of C-reactive protein. Mol Immunol (1990) 0.82

An intact phosphocholine binding site is necessary for transgenic rabbit C-reactive protein to protect mice against challenge with platelet-activating factor. J Immunol (2005) 0.81