Published in Mol Biol Cell on June 23, 2010
CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem (2010) 1.58
Intragenic complementation of hepatitis C virus NS5A RNA replication-defective alleles. J Virol (2012) 0.92
The PML-Interacting Protein DAXX: Histone Loading Gets into the Picture. Front Oncol (2013) 0.91
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. J Cell Sci (2010) 0.86
Circular RNAs: the Emerging Class of Non-coding RNAs and Their Potential Role in Human Neurodegenerative Diseases. Mol Neurobiol (2016) 0.80
Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. J Biol Chem (2013) 0.78
Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis. J Mol Biol (2016) 0.77
HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell (2016) 0.76
Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature (1993) 11.54
Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol (2001) 10.69
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev (1994) 8.92
Function and regulation of CREB family transcription factors in the nervous system. Neuron (2002) 7.99
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev (1989) 7.47
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05
TORCs: transducers of regulated CREB activity. Mol Cell (2003) 4.42
CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell (1991) 4.11
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol (2002) 3.55
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol (2002) 3.24
What turns CREB on? Cell Signal (2004) 3.03
Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron (1998) 2.82
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell (2003) 2.42
CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron (2002) 2.29
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem (1998) 1.90
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A (2007) 1.58
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol (2004) 1.46
HIPK2: a multitalented partner for transcription factors in DNA damage response and development. Biochem Cell Biol (2007) 1.45
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J (2006) 1.37
Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci (2006) 1.36
HIPK2: a versatile switchboard regulating the transcription machinery and cell death. Cell Cycle (2007) 1.34
Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis. Exp Cell Res (2004) 1.25
Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. Cancer Res (2007) 1.16
Phosphorylation by the DHIPK2 protein kinase modulates the corepressor activity of Groucho. J Biol Chem (2005) 1.11
Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications. Mol Biol Cell (2009) 1.11
Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci U S A (2004) 1.07
PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. J Biol Chem (2007) 1.05
Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. J Biol Chem (2006) 1.04
RGS13 acts as a nuclear repressor of CREB. Mol Cell (2008) 1.02
PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. Blood (2008) 1.00
Phosphorylation-induced transient intrinsic structure in the kinase-inducible domain of CREB facilitates its recognition by the KIX domain of CBP. Proteins (2006) 0.98
Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage. J Biol Chem (2007) 0.95
Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34. Biochimie (2000) 0.94
Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells. J Cell Biochem (2007) 0.92
Transcriptional regulation of the mouse ferritin H gene. Involvement of p300/CBP adaptor proteins in FER-1 enhancer activity. J Biol Chem (1999) 0.91
Isolation and characterization of cDNAs for the protein kinase HIPK2. Biochim Biophys Acta (2001) 0.83
Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol (2003) 3.53
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J Mol Biol (2003) 3.17
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J (2003) 2.69
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol (2002) 2.47
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep (2001) 2.22
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem (2006) 2.19
Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol Cell Biol (2003) 2.03
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res (2005) 2.02
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid Redox Signal (2008) 1.73
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol (2006) 1.70
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem (2008) 1.67
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling. Mol Cell Biol (2003) 1.61
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol (2002) 1.53
Clinical significance of regulatory T-cell-related gene expression in peripheral blood after renal transplantation. Transplantation (2011) 1.47
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev (2002) 1.46
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. EMBO Rep (2004) 1.42
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. J Biol Chem (2006) 1.37
TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30
Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells. Mol Cell Biol (2006) 1.25
Inhibition of autophagy by TAB2 and TAB3. EMBO J (2011) 1.15
TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. J Biol Chem (2008) 1.13
Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications. Mol Biol Cell (2009) 1.11
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J Biol Chem (2006) 1.11
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem (2007) 1.08
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells (2005) 1.07
TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. J Cell Biol (2014) 1.07
TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium. J Immunol (2010) 1.07
TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling. J Biol Chem (2008) 1.06
PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. J Biol Chem (2007) 1.05
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon). J Biol Chem (2003) 1.05
Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression. Endocrinology (2005) 1.02
A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta. Biochem Biophys Res Commun (2003) 0.95
Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. Nucleic Acids Res (2002) 0.95
Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species. Proc Natl Acad Sci U S A (2012) 0.95
Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis. PLoS One (2009) 0.95
Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress. Free Radic Biol Med (2008) 0.94
Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation. Xenotransplantation (2010) 0.93
Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells. Cancer Res (2010) 0.93
Generation of a conditional mutant allele for Tab1 in mouse. Genesis (2008) 0.93
TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood (2012) 0.93
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem (2006) 0.92
Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells. J Biol Chem (2004) 0.91
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. FASEB J (2013) 0.90
Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest. J Biol Chem (2008) 0.90
Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress. Neurochem Int (2004) 0.89
TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem (2013) 0.87
Phosphorylation of 4E-BP1 predicts sensitivity to everolimus in gastric cancer cells. Cancer Lett (2013) 0.87
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. J Cell Sci (2010) 0.86
Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity. Bioorg Med Chem Lett (2003) 0.85
Production of cloned pigs expressing human thrombomodulin in endothelial cells. Xenotransplantation (2012) 0.84
Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization. Biochem J (2008) 0.82
Comparative analysis of drug action on B-cell proliferation and differentiation for mycophenolic acid, everolimus, and prednisolone. Transplantation (2014) 0.80
TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms. PLoS One (2012) 0.80
Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation. Mol Cell Biol (2013) 0.79
Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats. Int J Oncol (2006) 0.79
Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production. Xenotransplantation (2011) 0.78
Osmotic stress blocks NF-kappaB-dependent inflammatory responses by inhibiting ubiquitination of IkappaB. FEBS Lett (2007) 0.77
Role of AMP-activated protein kinase in ferritin H gene expression by resveratrol in human T cells. Biochemistry (2013) 0.77
Requirement for C-terminal extension to the RNA binding domain for efficient RNA binding by ribosomal protein L2. Biosci Biotechnol Biochem (2002) 0.77
Stimulation index for PCNA mRNA in peripheral blood as immune function monitoring after renal transplantation. Transplantation (2009) 0.76
Coordinate inhibition of cytokine-mediated induction of ferritin H, manganese superoxide dismutase, and interleukin-6 by the adenovirus E1A oncogene. J Biol Chem (2006) 0.76
Multicenter Phase II Study of a New Effective S-1 and Irinotecan Combination Schedule in Patients with Unresectable Metastatic or Recurrent Colorectal Cancer. Clin Med Insights Oncol (2013) 0.75
Functional difference between membrane-bound and soluble human thrombomodulin. Transplantation (2015) 0.75
Regional scale high resolution δ18O prediction in precipitation using MODIS EVI. PLoS One (2012) 0.75
The Performance Improvement of N2 Plasma Treatment on ZrO2 Gate Dielectric Thin-Film Transistors with Atmospheric Pressure Plasma-Enhanced Chemical Vapor Deposition IGZO Channel. J Nanosci Nanotechnol (2016) 0.75
Interactions of a lysozyme-monomethoxypolyethylene glycol conjugate with lipopolysaccharides and lipid bilayers and effects of conjugate on gram-negative bacteria. Biosci Biotechnol Biochem (2002) 0.75
Changes in ABCB1 mRNA Expression in Peripheral Blood Cells before and after Renal Transplantation. Biol Pharm Bull (2016) 0.75